Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Thiamin (as Thiamin Mononitrate, Vitamin B-1)
100 mg
8,333%
Riboflavin (Vitamin B-2)
100 mg
7,692%
Niacin (as Niacinamide)
100 mg
625%
Vitamin B-6 (as Pyridoxine HCl)
100 mg
5,882%
Folate
667 mcg DFE(400 mcg Folic Acid
167%
Vitamin B-12 (as Cyanocobalamin)
100 mcg
4,167%
Biotin
100 mcg
333%
Pantothenic Acid (as d-Calcium Pantothenate)
100 mg
2,000%
Calcium (as Calcium Carbonate & Dicalcium Phosphate)
124 mg
10%
Top Medical Research Studies
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
Read More
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
Read More
8
We explored the impact of long-term vitamin B1 (VB1) maintenance on heart failure (HF) outcomes through a study involving 88 patients. These patients were divided into three groups based on their VB1 levels: a control group with normal levels, a group receiving short-term supplementation, and a group focused on long-term maintenance of normal levels.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
Read More
Most Useful Reviews
9
Reduces fatigue
5 people found this helpful
This time-release vitamin B is excellent and surprisingly affordable. I felt the effects the day after starting the supplement! I no longer experience mid-day sleepiness, which has significantly helped me during the day. Prior to this, I tried another vitamin B that wasn't time-released, but its effectiveness paled in comparison. This product has truly worked wonders!
Read More
8.5
Improves cycle health
5 people found this helpful
These vitamins improved my menstrual cycle after numerous doctor visits. They normalise the nervous and cardiovascular systems, enhance emotional health, and support stress management. Additionally, they assist with cell growth, energy metabolism, and immunity, considerably increasing my body's resistance to illnesses, including heart disease.
Read More
7.5
Supports mental health
5 people found this helpful
Very effective for maintaining mental health! I chose these vitamins based on their quality and composition. They support the nervous system, and I recommend them for anyone facing excessive stress. With a good variety of vitamins, including Biotin for nails and hair, B12 and B6 for nerve restoration, and folic acid, they exceed the daily recommendations. Overall, they make an excellent supplement to one's diet. Thank you!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
- All Researches
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
Read More
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
Read More
8
We investigated how a specific gene variation (MTHFR C677T) influences the outcome for patients with coronary heart disease and hypertension receiving folic acid and enalapril.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
Read More
8
In our exploration of TANGO2-deficiency disorder, we found that cardiac arrhythmias linked to this genetic condition are often resistant to standard treatments.
Using innovative patient-derived stem cell models, we identified that high doses of folate (vitamin B9) can significantly reduce arrhythmias.
Clinical data also indicated that multivitamin and B complex intake may lower the risk of serious heart issues in affected individuals.
This suggests that B vitamins might offer a life-saving strategy for managing dangerous cardiac events in patients with this disorder.
Using innovative patient-derived stem cell models, we identified that high doses of folate (vitamin B9) can significantly reduce arrhythmias.
Clinical data also indicated that multivitamin and B complex intake may lower the risk of serious heart issues in affected individuals.
This suggests that B vitamins might offer a life-saving strategy for managing dangerous cardiac events in patients with this disorder.
Read More
8
We explored the impact of long-term vitamin B1 (VB1) maintenance on heart failure (HF) outcomes through a study involving 88 patients. These patients were divided into three groups based on their VB1 levels: a control group with normal levels, a group receiving short-term supplementation, and a group focused on long-term maintenance of normal levels.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces fatigue
5 people found this helpful
This time-release vitamin B is excellent and surprisingly affordable. I felt the effects the day after starting the supplement! I no longer experience mid-day sleepiness, which has significantly helped me during the day. Prior to this, I tried another vitamin B that wasn't time-released, but its effectiveness paled in comparison. This product has truly worked wonders!
Read More
8.5
Improves cycle health
5 people found this helpful
These vitamins improved my menstrual cycle after numerous doctor visits. They normalise the nervous and cardiovascular systems, enhance emotional health, and support stress management. Additionally, they assist with cell growth, energy metabolism, and immunity, considerably increasing my body's resistance to illnesses, including heart disease.
Read More
7.5
Supports mental health
5 people found this helpful
Very effective for maintaining mental health! I chose these vitamins based on their quality and composition. They support the nervous system, and I recommend them for anyone facing excessive stress. With a good variety of vitamins, including Biotin for nails and hair, B12 and B6 for nerve restoration, and folic acid, they exceed the daily recommendations. Overall, they make an excellent supplement to one's diet. Thank you!
Read More
7.5
Heart disease support
3 people found this helpful
A pharmacist recommended this product to me, and it has been fantastic. As a heart patient, I was advised to incorporate it into my diet for a healthier inner body.
Read More
Frequently Asked Questions
9
Reduces fatigue
5 people found this helpful
This time-release vitamin B is excellent and surprisingly affordable. I felt the effects the day after starting the supplement! I no longer experience mid-day sleepiness, which has significantly helped me during the day. Prior to this, I tried another vitamin B that wasn't time-released, but its effectiveness paled in comparison. This product has truly worked wonders!
8.5
Improves cycle health
5 people found this helpful
These vitamins improved my menstrual cycle after numerous doctor visits. They normalise the nervous and cardiovascular systems, enhance emotional health, and support stress management. Additionally, they assist with cell growth, energy metabolism, and immunity, considerably increasing my body's resistance to illnesses, including heart disease.
7.5
Heart disease support
3 people found this helpful
A pharmacist recommended this product to me, and it has been fantastic. As a heart patient, I was advised to incorporate it into my diet for a healthier inner body.
7.5
Supports mental health
5 people found this helpful
Very effective for maintaining mental health! I chose these vitamins based on their quality and composition. They support the nervous system, and I recommend them for anyone facing excessive stress. With a good variety of vitamins, including Biotin for nails and hair, B12 and B6 for nerve restoration, and folic acid, they exceed the daily recommendations. Overall, they make an excellent supplement to one's diet. Thank you!
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
8
We investigated how a specific gene variation (MTHFR C677T) influences the outcome for patients with coronary heart disease and hypertension receiving folic acid and enalapril.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
Over 540 patients were studied, dividing them into groups that received folic acid or standard treatment.
Our results revealed that patients who took folic acid had better outcomes, including lower rates of cardiovascular events, compared to those who did not. This indicates that folic acid supplementation may enhance treatment success for these high-risk patients.
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
8
We explored the impact of long-term vitamin B1 (VB1) maintenance on heart failure (HF) outcomes through a study involving 88 patients. These patients were divided into three groups based on their VB1 levels: a control group with normal levels, a group receiving short-term supplementation, and a group focused on long-term maintenance of normal levels.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
The results showed that those who maintained normal VB1 levels experienced better health outcomes compared to those in the other groups. Our findings indicate that consistent VB1 management could be crucial for enhancing HF therapy and reducing risks of hospitalization and cardiovascular death.
References
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. doi:10.1016/j.tjnut.2024.08.006
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
- Morimoto J, Satogami K, Naraoka T, Taruya A, Tanaka A. Long-Term Maintenance of Normal Serum Vitamin B Levels Is Associated with Better Outcomes in Patients with Heart Failure. Int Heart J. 2024;65:458. doi:10.1536/ihj.23-550
