Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Iron  (as Dried Ferrous Sulfate)
45 mg
250%

The product is found useful for the following medical conditions

Nausea details

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 14 Reviews
8.8
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.

Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
9
No dizziness, nausea
Most Useful Review
8 people found this helpful
I bought the "slow-release iron, 60 tablets" for my sister. It's an excellent product; I've not encountered such strong dietary supplements in ages. This inexpensive 21st Century brand did not disappoint – no dizziness or nausea at all! I have a new appreciation for this company. I will continue using this slow-release iron supplement.

Back Pain details

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 6 Reviews
8.6
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.

Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.

Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.

Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
9
No back pain
Most Useful Review
90 people found this helpful
I have used this vitamin for two months, and the difference is remarkable! I no longer suffer from joint or back pain. My skin has improved, and my mood and energy are excellent. I highly recommend this supplement for enhancing health and well-being.

Bone Pain details

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
We explored the effectiveness of alendronate, a common drug for osteoporosis, in treating bone pain and improving bone health in patients with thalassemia. This randomized controlled trial involved men and premenopausal women, who were given either alendronate or a placebo for 12 months.

We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
9
Reduced bone pain
Most Useful Review
89 people found this helpful
I ordered vitamin 31 recently, and my life has improved significantly. I’ve lost around 6 pounds, and my appetite is better. I can now sleep comfortably at night without all the bone pain. Vitamin 31 has alleviated my chronic pain from sciatica and other health issues. Thank you, Dr. Clemens.

Cardiovascular Disease details

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.5
Our investigation focused on the impact of iron deficiency in patients with worsening chronic heart failure, seeking clarity on how it affects their condition and recovery. We enrolled 163 patients from multiple centers who were hospitalized for this serious health issue. By evaluating iron deficiency at discharge, we distinguished those affected by low iron levels and compared various health indicators between groups.

We discovered that over half of the patients, 54.6%, had iron deficiency. Those with lower iron were more likely to exhibit signs of congestion and were categorized into more advanced heart failure classes. Interestingly, their levels of NT-proBNP, a crucial marker associated with heart failure, were significantly higher upon admission and didn’t improve much during their hospital stay.

While we found that mortality rates within 30 days had no significant difference between patients with and without iron deficiency, a notable increase in deaths was observed at 90 days post-discharge for those with iron deficiency. This suggests that iron levels could potentially influence recovery, especially in the longer term.

In conclusion, patients dealing with both chronic heart failure and iron deficiency showed more unresolved symptoms and poorer outcomes post-discharge. These findings highlight the importance of monitoring iron levels in patients facing heart issues, paving the way for future studies into treatment effectiveness and potential benefits of iron therapies.
9
Iron deficiency eliminated
Most Useful Review
2 people found this helpful
Iron is crucial for various bodily functions, such as energy metabolism and DNA repair. It maintains immune system strength, enabling the body to combat infections, and plays a role in tissue growth. A deficiency can result in iron deficiency anaemia. These capsules contain natural ingredients and are of medium size. My iron deficiency has been resolved.

Leg Cramps details

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 7 Reviews
8.5
We explored the effects of iron deficiency (ID) in patients on maintenance hemodialysis, especially regarding common symptoms like leg cramps. The study included 154 patients, all of whom had reached target hemoglobin levels, which means they were not anemic. This allowed us to focus on the impact of ID without the confounding factor of low hemoglobin.

Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.

The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
9
No more cramps
Most Useful Review
8 people found this helpful
I ordered iron for my mother, who suffers from leg cramps due to anaemia. This budget-friendly product has shown noticeable improvements in her condition. Within two days, her leg cramps vanished, and she has experienced no symptoms since starting the pills. The small, dark red tablets are easy to swallow and cause no side effects. I will certainly order more!

Heart Disease details

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.4
We investigated the role of iron treatment in managing heart disease, particularly its isolated effects. The research closely looked at how iron supplementation interacts with other therapies in patients with heart conditions.

Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.

Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
9
Trusted product
Most Useful Review
Greetings from Ukraine! I support this product wholeheartedly. The taste and scent are neutral, and I’m very pleased with the quality. I choose this brand because I've trusted it for years, and it was recommended by my doctor. After following the prescription, my iron levels improved, which is crucial for treating heart disease.

Autoimmune Disorder details

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 11 Reviews
8.3
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.

Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.

This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
9
Boosted mental health
Most Useful Review
91 people found this helpful
I've been taking this vitamin for a couple of months and have experienced a significant enhancement in my overall health. I feel more alert and energised, which greatly benefits my creative thinking. It’s particularly useful for those with mental health conditions, including autoimmune disorders. I highly recommend it!

Headache details

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 4 Reviews
8.3
We explored whether iron deficiency anemia is connected to chronic daily headaches in a group of 100 patients compared to an equal number of controls.

The study revealed a significant link between iron deficiency anemia and chronic daily headaches. Interestingly, those with severe anemia experienced more intense headache symptoms.

While other iron-related factors were associated with headaches, the type and duration of headaches did not seem to vary significantly among patients.
7.5
Improved mood
Most Useful Review
100 people found this helpful
I've been taking this vitamin for nearly a week now, and my overall health and mood have markedly improved. I don't suffer from headaches as often and feel more energised during the day. I'm quite fond of this vitamin; it contains the ingredients that enhance my quality of life, health, and well-being without any side effects.

Attention Deficit Hyperactivity Disorder details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.2
7.5
Increased energy
Most Useful Review
41 people found this helpful
I really appreciate this iron preparation; it's quite straightforward. I take one tablet at breakfast, washed down with fruit juice. If I lack juice, I take a vitamin C tablet with it. I advise against consuming dairy within an hour of taking iron, as it reduces the effectiveness. By the second day, my drowsiness had started to fade. I felt energised and motivated to do more. Thank you to the manufacturer for this product.

Dizziness details

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 26 Reviews
8.2
We studied the impact of iron treatment on dizziness experienced by a 42-year-old woman suffering from severe iron deficiency anemia due to menometrorrhagia. Throughout her hospital stay, she received blood transfusions and intravenous iron, which played a critical role in addressing her debilitating symptoms.

Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.

Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
9
Significant improvement
Most Useful Review
32 people found this helpful
I suffer from mild anaemia, experiencing weakness and dizziness. This supplement exceeded my expectations! After taking it, my haemoglobin rose to 128, which is a record for me. I've felt more energetic and haven't feared fainting for a month. I take it with vitamins C and A. Its price is very reasonable, and I highly recommend it.

Hair Loss details

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 16 Reviews
8.2
We explored the link between serum ferritin levels and androgenetic alopecia (AGA) among individuals at a dermatology clinic in Nigeria. Our study included 114 participants, divided evenly between those with AGA and healthy individuals. We found that people with AGA had significantly lower serum ferritin levels, suggesting that iron deficiency may impact hair growth. However, while low iron might play a role, genetic factors also contribute to AGA.
9
Significant improvement
Most Useful Review
5 people found this helpful
There was a latent iron deficiency with a ferritin level of 3, leading to fatigue, lack of strength, and hair loss in patches. I followed the doctor’s regimen with B12 and vitamin C for 6 weeks, taking 50 mg each morning. My ferritin increased to 25, I regained strength, blood parameters improved, and the areas of hair loss began to heal. At first, I took 90 mg, which caused loose stools, so I reduced it to 45 mg, which resolved the issue. The drug helped significantly.

High Cholesterol details

SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.3
USERS' SCORE
Good
Based on 6 Reviews
8.2
We examined the relationship between essential and toxic elements in the plasma of institutionalized older adults and their cholesterol levels. Focusing on a group of 149 Brazilian seniors living in nursing homes, our goal was to understand how these elements influence lipid profiles and blood sugar levels.

Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.

These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
9
Normalised hemoglobin levels
Most Useful Review
12 people found this helpful
After trying many iron supplements, this one was the best for its taste, price, and quality. One package sufficed to replenish my iron, raising my hemoglobin to normal within a month. I've not seen this level with chronic anaemia for ages. The price was attractive at 200 rubles, so I ordered one for my husband as well. The information is in English, but it's easy to research online.

Anemia details

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 53 Reviews
8.1
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
9
Great helper
Most Useful Review
214 people found this helpful
Excellent iron supplement. It significantly aids in combating anemia without any side effects, even when taken on an empty stomach.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 20 Reviews
8.1
We explored the effects of iron supplementation on individuals suffering from iron deficiency, specifically looking at its impact on symptoms like chronic fatigue syndrome (CFS). This was done through a well-structured study involving 176 blood donors who were iron deficient, with a randomized controlled trial design.

Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.

The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
9
Quick results
Most Useful Review
10 people found this helpful
An excellent supplement! Its quality is superior, and it's gentle on the stomach. I noticed a difference in my symptoms of iron deficiency after less than a week. The small pills are easy to swallow.

Liver Disease details

SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.1
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.

Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.

Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
7.5
Restores iron levels
Most Useful Review
After using this iron supplement, my family’s blood tests showed that iron deficiency was resolved. I take it with vitamin C. It has also been beneficial for my family members suffering from moyamoya disease and has improved symptoms like vertigo in the elderly.

Skin Cancer details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 74 Reviews
7.6
9
No side effects
Most Useful Review
8 people found this helpful
After ordering iron for my mother, who has struggled with anaemia all her life, I noticed noticeable improvements almost immediately. Her muscle cramps disappeared within two days, and she experienced no side effects from this product, which is often an issue with others. I will order more for sure!

Blood Clot details

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.4
We explored how magnetizable stent-grafts can improve healing in carotid artery pseudoaneurysms by investigating their ability to capture blood outgrowth endothelial cells.

In a porcine model, we compared magnetic stent-grafts with standard non-magnetic ones. The results showed that the magnetic stent-grafts not only occluded all nine pseudoaneurysms but also achieved better cell capture and endothelial growth.

Essentially, the magnetic properties enhanced the healing process, leading to less thrombosis compared to non-magnetic counterparts. This innovative approach could reduce complications associated with these medical devices.
9
Normal haemoglobin levels
Most Useful Review
2 people found this helpful
In 2012-2014, I suffered from acute leukaemia (blood cancer). I consistently had low haemoglobin and ferritin levels. I tried various iron supplements, but they caused side effects and stool issues. A friend recommended 21st Century iron, and I loved the capsule size and quality of ingredients. My haemoglobin levels are now consistently normal. I recommend it to everyone.

Constipation details

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6
USERS' SCORE
Moderately Good
Based on 38 Reviews
7.2
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.

We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.

These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
9
No constipation!
Most Useful Review
6 people found this helpful
I’ve noticed improvements in my energy, especially during menstruation, and I’ve not experienced any constipation, unlike with other iron supplements. The small size of the tablets makes them easy to take.
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