Last update
5/21/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
7
We investigated how carnitine and folic acid supplementation could mitigate bone pain and fatigue in patients with beta-thalassemia minor. The study involved 73 participants, who received specific supplement combinations over three months.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Read More
Most Useful Reviews
9
Reduced bone pain
18 people found this helpful
Most advisors recommend this product for pregnancy. As a young unmarried woman, I found it beneficial for long hair and nails, strengthening them and alleviating symptoms of bone pain. It also resolved my constipation and regularised my period without delay or cramps. I took one pill daily after breakfast for two months and saw impressive results. The quantity is plentiful, the price is low, and the pills are small and easy to swallow. Stay hydrated for the best results.
Read More
7.5
Alleviated bone pain
6 people found this helpful
Excellent! It significantly helps with my back pain when paired with B12 from the same brand. Folic acid reduces the risk of deficiencies in the brain and spine, crucial for the early stages of pregnancy when bone pain may be more common. Please give this review a like. Blessings!
Read More
7.5
Eliminated bone pain
After a month of taking the medication, my menstrual-related bone pain vanished. I occasionally take this supplement.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
7
We investigated how carnitine and folic acid supplementation could mitigate bone pain and fatigue in patients with beta-thalassemia minor. The study involved 73 participants, who received specific supplement combinations over three months.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced bone pain
18 people found this helpful
Most advisors recommend this product for pregnancy. As a young unmarried woman, I found it beneficial for long hair and nails, strengthening them and alleviating symptoms of bone pain. It also resolved my constipation and regularised my period without delay or cramps. I took one pill daily after breakfast for two months and saw impressive results. The quantity is plentiful, the price is low, and the pills are small and easy to swallow. Stay hydrated for the best results.
Read More
7.5
Alleviated bone pain
6 people found this helpful
Excellent! It significantly helps with my back pain when paired with B12 from the same brand. Folic acid reduces the risk of deficiencies in the brain and spine, crucial for the early stages of pregnancy when bone pain may be more common. Please give this review a like. Blessings!
Read More
7.5
Eliminated bone pain
After a month of taking the medication, my menstrual-related bone pain vanished. I occasionally take this supplement.
Read More
2
Minimal bone pain effect
2 people found this helpful
I bought this to help with my bone pain during menstruation, but I didn't notice much improvement. I'm disappointed.
Read More
2
Increased bone pain
My son has been drinking this, but it causes stomach pain even when his stomach is full, unlike other folic acid products.
Read More
Frequently Asked Questions
7.5
Eliminated bone pain
After a month of taking the medication, my menstrual-related bone pain vanished. I occasionally take this supplement.
9
Reduced bone pain
18 people found this helpful
Most advisors recommend this product for pregnancy. As a young unmarried woman, I found it beneficial for long hair and nails, strengthening them and alleviating symptoms of bone pain. It also resolved my constipation and regularised my period without delay or cramps. I took one pill daily after breakfast for two months and saw impressive results. The quantity is plentiful, the price is low, and the pills are small and easy to swallow. Stay hydrated for the best results.
2
Minimal bone pain effect
2 people found this helpful
I bought this to help with my bone pain during menstruation, but I didn't notice much improvement. I'm disappointed.
7.5
Alleviated bone pain
6 people found this helpful
Excellent! It significantly helps with my back pain when paired with B12 from the same brand. Folic acid reduces the risk of deficiencies in the brain and spine, crucial for the early stages of pregnancy when bone pain may be more common. Please give this review a like. Blessings!
7
We investigated how carnitine and folic acid supplementation could mitigate bone pain and fatigue in patients with beta-thalassemia minor. The study involved 73 participants, who received specific supplement combinations over three months.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
References
- Tabei SM, Mazloom M, Shahriari M, Zareifar S, Azimi A, et al. Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects. Pediatr Hematol Oncol. 2013;30:742. 10.3109/08880018.2013.771388
- Gu YJ, Qian HY, Zhou F, Zhang L, Chen L, et al. Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats. Brain Res. 2023;1811:148405. 10.1016/j.brainres.2023.148405
- Fathi Maroufi N, Ghorbanihaghjo A, Sayyah Melli M, Vaezi M, Hekmati Azar Mehrabani Z, et al. Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy. Iran J Public Health. 2017;46:517. PubMed
