' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
8
Folate improves cold agglutinin anemia
Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection.
Effects of folate treatment noted
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
Most Useful Reviews
8.8
Feeling better overall
I started feeling cold and depressed, so I researched and learned that a folic acid deficiency could lead to depression. I began taking it as a supplement. After about a month, I haven't caught a cold, which suggests it’s working well. My mood has also improved.
Read More
8
Less colds noted
Excellent! I have been taking these vitamins for a few weeks now and feel like this is the start of something new. I no longer feel tired and in pain, and my mood has considerably improved! I even noticed that I am less likely to catch a cold than before. These vitamins are remarkable!
Read More
8
Less colds noted
I have been taking these vitamins for a few weeks now and feel like this is the start of something new. I no longer feel tired and in pain, and my mood is much better! I've even noticed that I am less likely to catch a cold than before. These vitamins are incredible!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Folate improves cold agglutinin anemia
Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection.
Effects of folate treatment noted
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Feeling better overall
I started feeling cold and depressed, so I researched and learned that a folic acid deficiency could lead to depression. I began taking it as a supplement. After about a month, I haven't caught a cold, which suggests it’s working well. My mood has also improved.
8
Less colds noted
Excellent! I have been taking these vitamins for a few weeks now and feel like this is the start of something new. I no longer feel tired and in pain, and my mood has considerably improved! I even noticed that I am less likely to catch a cold than before. These vitamins are remarkable!
Read More
8
Less colds noted
I have been taking these vitamins for a few weeks now and feel like this is the start of something new. I no longer feel tired and in pain, and my mood is much better! I've even noticed that I am less likely to catch a cold than before. These vitamins are incredible!
