Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
9
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
8
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
Most Useful Reviews
7.5
Cell growth support
22 people found this helpful
Folic acid is a vital B vitamin essential for DNA construction in all cells. A recommended dosage is one 400 mg tablet daily during the fertility period. It promotes new cell formation, contributing to smooth skin, thick hair, and strong nails. It's important to combine it with B12 and B6 for optimal absorption and metabolic rate, also helping to reduce the risk of heart attack and strengthen blood vessel walls.
Read More
9
Heart health supplement
8 people found this helpful
This is an excellent vitamin supplement for maintaining heart health.
Read More
7.5
Affordable option
3 people found this helpful
My cardiologist recommended folic acid for heart function support. I sought affordable options and found 21st Century's product on iHerb to be great. The packaging is convenient and tablets are easy to swallow. The quality remains intact, with prompt delivery time.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
5.6
- All Researches
9
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
Read More
9
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Read More
8
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
Read More
8
We examined the effects of folic acid fortification on preventing diseases, particularly heart attacks, and its related medical costs. The introduction of mandatory folate fortification in various countries has shown remarkable cost savings and improved health outcomes. Our study in Sakado City involved individuals with specific genetic markers and demonstrated a notable reduction in homocysteine levels, which is linked to heart health.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
While there was an increase in folate levels, the decrease in heart attack rates wasn't specified as significant. Overall, mandatory folic acid fortification is cost-effective and may reduce heart attack incidents, supporting its broader implementation in Japan.
Read More
8
We examined the link between multivitamin use, including folic acid, and the risk of heart attacks in women. Our study followed 31,671 women without heart disease and evaluated their supplement usage over ten years.
We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.
More research is needed to fully understand these results and confirm our findings.
We discovered that those taking multivitamins had a lower chance of experiencing a heart attack, especially if they used them for over five years. However, in women with a prior history of heart disease, multivitamins didn’t show the same benefit.
More research is needed to fully understand these results and confirm our findings.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Cell growth support
22 people found this helpful
Folic acid is a vital B vitamin essential for DNA construction in all cells. A recommended dosage is one 400 mg tablet daily during the fertility period. It promotes new cell formation, contributing to smooth skin, thick hair, and strong nails. It's important to combine it with B12 and B6 for optimal absorption and metabolic rate, also helping to reduce the risk of heart attack and strengthen blood vessel walls.
Read More
9
Heart health supplement
8 people found this helpful
This is an excellent vitamin supplement for maintaining heart health.
Read More
7.5
Affordable option
3 people found this helpful
My cardiologist recommended folic acid for heart function support. I sought affordable options and found 21st Century's product on iHerb to be great. The packaging is convenient and tablets are easy to swallow. The quality remains intact, with prompt delivery time.
Read More
9
Vascular improvement
1 people found this helpful
Folic acid is essential for heart and blood vessel support. My doctor prescribed it due to poor blood clotting test results. These vitamins worked well for me—convenient size and dosage, excellent quality. I feel a boost in energy and improvement in my nervous system.
Read More
7.5
Healthy choice
I believe this is a wonderful product, especially for those over 40 or with heart problems. It's beneficial for the arteries and excellent for athletes, helping to prevent strokes and heart attacks. The dosage guidelines are clear, and the packaging lasts a good while. The ingredients are of high quality, making this folic acid truly worthwhile.
Read More
Frequently Asked Questions
9
Vascular improvement
1 people found this helpful
Folic acid is essential for heart and blood vessel support. My doctor prescribed it due to poor blood clotting test results. These vitamins worked well for me—convenient size and dosage, excellent quality. I feel a boost in energy and improvement in my nervous system.
9
Heart health supplement
8 people found this helpful
This is an excellent vitamin supplement for maintaining heart health.
0
Ineffective product
8 people found this helpful
I was dissatisfied with this product. It did not benefit me at all, and I later discovered it contains methyl tetrahydrofolic acid, which is useless unless taken in the correct form. Even if I maintain a healthy diet, this folic acid offers no benefits, particularly for pregnant women. I urge others to check for "Methyl tetrahydrofolate" or "Methyl folic" instead of just "folic acid". Be cautious and avoid my mistake.
8
Improved energy
22 people found this helpful
I found this folic acid to be excellent. The quality is remarkable and the quantity is sufficient for over three months. It effectively addressed my folic acid deficiency and lethargy, providing me with energy while enhancing my hair, skin, and nails. There were no side effects. This product significantly supported my nervous system, which is crucial for metabolism. It's very palatable, and I intend to purchase it again.
7.5
Fertility success
2 people found this helpful
Thanks to this folic acid preparation, I became a father for the first time! I had been healthy but struggled with infertility after marriage. Since taking this supplement, everything changed. It also proves beneficial for heart muscle and the nervous system.
7.5
Cell growth support
22 people found this helpful
Folic acid is a vital B vitamin essential for DNA construction in all cells. A recommended dosage is one 400 mg tablet daily during the fertility period. It promotes new cell formation, contributing to smooth skin, thick hair, and strong nails. It's important to combine it with B12 and B6 for optimal absorption and metabolic rate, also helping to reduce the risk of heart attack and strengthen blood vessel walls.
7.5
Normal heart function
1 people found this helpful
Great price and dosage! Folic acid is vital for heart function, reducing the risk of heart attack, and strengthens blood vessel walls along with red and white blood cell production.
7.5
Affordable option
3 people found this helpful
My cardiologist recommended folic acid for heart function support. I sought affordable options and found 21st Century's product on iHerb to be great. The packaging is convenient and tablets are easy to swallow. The quality remains intact, with prompt delivery time.
6
Gluten-free supplement
1 people found this helpful
This gluten-free vitamin supplement is excellent for heart health. Adults are recommended to take one tablet daily with any meal. The quality is assured through laboratory testing, and it's free from added sugars and preservatives.
8
We explored how dietary intake of folate, along with vitamins B6 and B12, impacts heart health in a large UK cohort of 115,664 participants aged 40-70.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
After following up until 2018, we found that higher folate intake was linked to a 5% reduction in the risk of cardiovascular disease events and a 10% reduction in cardiovascular mortality. These findings suggest that increasing our folate intake could be an effective strategy for heart disease prevention.
However, it's essential to note that other vitamins did not show a significant effect on these outcomes.
4
We aimed to determine the effectiveness of folic acid in preventing cardiovascular disease (CVD) through an updated meta-analysis of 26 randomized controlled trials involving nearly 59,000 participants. Our findings revealed that folic acid supplementation did not significantly impact the risk of CVD, coronary heart disease, or overall mortality.
Interestingly, there was a slight trend showing potential stroke risk reduction, although results were not conclusive. Overall, while supplementation may carry some modest benefits for stroke prevention, it does not appear to significantly reduce the risk of heart-related issues.
Interestingly, there was a slight trend showing potential stroke risk reduction, although results were not conclusive. Overall, while supplementation may carry some modest benefits for stroke prevention, it does not appear to significantly reduce the risk of heart-related issues.
7
We investigated how folic acid (FA) might safeguard against heart damage induced by isoprenaline (ISO) in rats. Adult male Wistar albino rats received FA pretreatment for seven days before ISO was administered to mimic heart injury.
Our results showed that FA pretreatment helped reduce harmful markers indicating heart damage and oxidative stress. Specifically, FA lowered levels of homocysteine and improved antioxidant enzyme activities, suggesting a protective effect.
Ultimately, while FA demonstrated some benefits in this model, further research is needed to assess its real-world applications for heart health.
Our results showed that FA pretreatment helped reduce harmful markers indicating heart damage and oxidative stress. Specifically, FA lowered levels of homocysteine and improved antioxidant enzyme activities, suggesting a protective effect.
Ultimately, while FA demonstrated some benefits in this model, further research is needed to assess its real-world applications for heart health.
2
Folic acid has no heart benefits
We conducted a double-blind, randomized controlled trial involving 12,064 survivors of heart attacks to see if reducing homocysteine levels with folic acid and vitamin B12 would improve heart health. Over nearly seven years, we found that while the treatment did lower homocysteine levels significantly, it did not lead to a decrease in major vascular events such as heart attacks or strokes compared to the placebo group. Importantly, there were no harmful effects regarding cancer incidence linked to the supplementation.
7
We investigated how folate supplementation affects heart attack risk by digging into the evidence from various studies. In reviewing a collection of 884 randomized controlled trials, it was found that folic acid, which is a form of vitamin B9, had a significant impact on reducing the chances of strokes, with a relative risk reduction of about 16%. However, the studies did not show similar benefits for heart attacks specifically, suggesting that while folate may have protective effects against certain cardiovascular events, its impact on heart attacks remains unclear.
Additionally, our analysis highlighted that while some micronutrients demonstrated positive effects on cardiovascular health, others did not yield significant results. Notably, while folate is beneficial for stroke risk, it did not show a clear advantage for heart attack prevention. Therefore, it's essential to consider the broader context of micronutrient intake and cardiovascular health, keeping in mind the need for balanced supplementation to potentially improve overall cardiometabolic health.
Additionally, our analysis highlighted that while some micronutrients demonstrated positive effects on cardiovascular health, others did not yield significant results. Notably, while folate is beneficial for stroke risk, it did not show a clear advantage for heart attack prevention. Therefore, it's essential to consider the broader context of micronutrient intake and cardiovascular health, keeping in mind the need for balanced supplementation to potentially improve overall cardiometabolic health.
4
We explored the relationship between a specific metabolite, homocysteine thiolactone, and heart attack risk in patients with suspected coronary artery disease. In a detailed study with 2049 participants, we randomized groups to receive varying combinations of folic acid and B vitamins or a placebo.
Our findings revealed that while higher levels of homocysteine thiolactone were linked to an increased risk of acute myocardial infarction, the supplementation with B vitamins did not significantly change this association. This suggests that folic acid might not have the protective effect on heart attacks we hoped for.
Our findings revealed that while higher levels of homocysteine thiolactone were linked to an increased risk of acute myocardial infarction, the supplementation with B vitamins did not significantly change this association. This suggests that folic acid might not have the protective effect on heart attacks we hoped for.
References
- Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. doi:10.1088/2057-1976/ad40b2
- Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. doi:10.1556/2060.2023.00291
- Zhang B, Dong H, Xu Y, Xu D, Sun H, et al. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort. Eur J Clin Nutr. 2023;77:299. doi:10.1038/s41430-022-01206-2
- Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, et al. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Ann Intern Med. 2019;171:190. doi:10.7326/M19-0341
- Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. doi:10.1111/joim.12834
- Li H, Gao J, Shang Y, Hua Y, Ye M, et al. Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction. ACS Appl Mater Interfaces. 2018;10:24459. doi:10.1021/acsami.8b08659
- Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612. doi:10.1002/14651858.CD006612.pub5
- Kagawa Y, Hiraoka M, Kageyama M, Kontai Y, Yurimoto M, et al. Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification. Congenit Anom (Kyoto). 2017;57:157. doi:10.1111/cga.12215
- Nigwekar SU, Kang A, Zoungas S, Cass A, Gallagher MP, et al. Interventions for lowering plasma homocysteine levels in dialysis patients. Cochrane Database Syst Rev. 2016;2016:CD004683. doi:10.1002/14651858.CD004683.pub4
- Söderström E, Eliasson M, Johnson O, Hallmans G, Weinehall L, et al. Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population. Lipids Health Dis. 2013;12:74. doi:10.1186/1476-511X-12-74
- Yang HT, Lee M, Hong KS, Ovbiagele B, Saver JL. Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials. Eur J Intern Med. 2012;23:745. doi:10.1016/j.ejim.2012.07.004
- Mujibul Haq AM, M Giasuddin AS, Huque MM. Serum total homocysteine and lipoprotein (a) levels in acute myocardial infarction and their response to treatment with vitamins. J Coll Physicians Surg Pak. 2011;21:266.
- Rautiainen S, Akesson A, Levitan EB, Morgenstern R, Mittleman MA, et al. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr. 2010;92:1251. doi:10.3945/ajcn.2010.29371
- Qipshidze N, Tyagi N, Sen U, Givvimani S, Metreveli N, et al. Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;299:H1484. doi:10.1152/ajpheart.00577.2010
- Ebbing M, Bønaa KH, Arnesen E, Ueland PM, Nordrehaug JE, et al. Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J Intern Med. 2010;268:367. doi:10.1111/j.1365-2796.2010.02259.x
- Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, et al. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA. 2010;303:2486. doi:10.1001/jama.2010.840
- Ni Y, Hua Y, He Z, Hu W, Chen Z, et al. Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction. J Biomater Appl. 2024;39:139. doi:10.1177/08853282241251610
- An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. doi:10.1016/j.jacc.2022.09.048
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. doi:10.1371/journal.pone.0275956
- Twum F, Morte N, Wei Y, Nkemjika S, Liu F, et al. Red blood cell folate and cardiovascular deaths among hypertensive adults, an 18-year follow-up of a national cohort. Hypertens Res. 2020;43:938. doi:10.1038/s41440-020-0482-5
- Saad Shaukat MH, Toledo-Garcia A, Torosoff M. Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C). Cureus. 2019;11:e5344. doi:10.7759/cureus.5344
