Medical Researches
Likely Very Effective
Based on 3 Researches
Gelatin improves alopecia treatmentHair follicle targeting via gelatin coated transferosomes loaded with tofacitinib citrate for enhanced treatment of alopecia areata: Clinical evaluation of alopecia areata patients.
High relevance due to treatment impact.
We explored the potential of gelatin-coated transferosomes as a targeted delivery system for tofacitinib, a medication that shows promise in treating alopecia areata, an autoimmune condition causing hair loss. Our study involved seven patients with stubborn lesions, and we applied the specially formulated transferosomal gel directly to their affected areas.
The results were encouraging. After 12 weeks of treatment, we observed noticeable hair regrowth in all participants, with improvements of up to 80%. This suggests that the gelatin-coated transferosomes can effectively deliver tofacitinib to the hair follicles, enhancing its therapeutic effect.
Overall, this study demonstrates a novel approach to treating alopecia areata by combining targeted drug delivery with a medication known for its effectiveness. It provides a hopeful outlook for individuals struggling with this challenging condition, validating the use of gelatin in boosting treatment outcomes.
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We explored the role of gelatin in a new microneedle design aimed at treating hair loss. These swellable microneedles, designed with an air-pocket structure, were engineered to implant easily into the skin while reducing the risk of infection. This one-step molding process allowed the microneedles to hold minoxidil, a common treatment for hair loss.
During our research, we observed that the microneedles could effectively release 90% of the minoxidil they contained over a span of 48 hours. This delivery method displayed higher efficiency in animal studies compared to traditional topical applications. However, while gelatin played a crucial role in the structure and function of the microneedles, we cannot draw definitive conclusions about its individual effect on hair loss itself.
Overall, the promising results suggest that this innovative microneedle approach could offer a convenient and efficient way for administering hair loss treatments, though more focused research on gelatin alone would be necessary to evaluate its direct impact on hair growth.
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Gelatin enhances hair growth efficacyPromotion of hair growth by a conditioned medium from human umbilical cord mesenchymal stem cells cultivated in a 3D scaffold of gelatin sponge.
Highly relevant to gelatin usage
We aimed to investigate whether a conditioned medium (CM) derived from human umbilical cord mesenchymal stem cells (HuMSCs) cultivated in a gelatin sponge could effectively promote hair growth. In our study, we compared two methods of culturing HuMSCs: the traditional monolayer and the novel three-dimensional (3D) approach using gelatin sponge.
Our findings revealed that the 3D culture significantly enhanced the production of key growth factors, including vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), keratinocyte growth factor (KGF), and hepatocyte growth factor (HGF). These factors are crucial for hair regeneration and skin health.
When we tested the conditioned medium and HuMSCs through injections into the back skin of mice experiencing hair loss, we noticed promising results. Both treatments stimulated hair regrowth, but the CM from the gelatin sponge culture showed even greater effects, leading to longer hair and improved growth rates. Notably, this treatment also promoted skin angiogenesis, which likely aided faster hair regrowth.
In summary, our exploration indicates that the use of gelatin-sponge-cultivated stem cell secretions can significantly bolster hair growth and support skin health in our mouse model.
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