21st Century Melatonin Quick Dissolve

Melatonin ineffective for CFS symptoms

Questionable

Based on 7 Researches

Williams G, Waterhouse J, Mugarza J, Minors D, Hayden K. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest. 2002;32:831.

We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.

Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.

9.5

Mood improvement

Most Useful Review

Excellent! I had never taken a vitamin before, but since starting this product, I've noticed a reduction in my chronic fatigue and moodiness. After just a few weeks, I could tell my body felt different. This vitamin has truly enhanced my health, immunity, quality of life, and mood.

We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.

The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.

Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.

9.5

Effective sleep aid

Most Useful Review

Good dosage! It’s great for helping you sleep and does its job well. My grandmother suffers from persistent insomnia; she tried taking half a pill, but it wasn't sufficient. A whole pill enables her to fall asleep without problems.

High Cholesterol details

Quality sleep achieved

I initially purchased melatonin from a pharmacy for myself, but this product appeared more affordable. The substantial dosage allows for division into smaller ones. Approximately 30-40 minutes before bedtime, I place it under my tongue and enter a prolonged, restful sleep. After lactation, my sleep was severely disrupted. This medication has been helpful. Additionally, melatonin possesses antioxidant properties in animals, also noted in plants. As melatonin is mainly produced at night during sleep, it is referred to as the "sleep hormone". The large dosage has a pleasant berry flavour and the dragees are conveniently sized and dissolve quickly.

Swollen Lymph Nodes details

Highly recommended product

Excellent! A superb product. The quality is remarkable, and the delivery speed is impressive. I highly recommend the site.

Autism details

I love this product for my kids who have autism; it is essential for their sleep. Without it, they struggle to drift off.

Brain Tumor details

Fast acting, these tablets help my brain relax for a good night’s sleep without the fog in the morning. Their high potency allows me to return to sleep if I wake during the night. I trust this brand for its quality and affordability, with no unpleasant chemicals and high-quality ingredients.

Cancer details

Greater alertness achieved

Finally, I've found a solution for a restful night. Initially sceptical, by the fifth day, I became a firm believer. I now enjoy undisturbed sleep and awaken headache-free. A recent CT scan revealed eccentric calcification in my Pineal Gland, and I’m awaiting a PET scan due to my metastatic breast cancer, unsure if the metastasis has affected my brain. I had not slept well in over a year and now feel revitalised, more alert, with the brain fog lifted.

Chest Pain details

I typically struggle with sleeping due to spinal cord pain, but this product assists me in getting off to sleep without needing extra pain management medication. I am very impressed after years of insomnia caused by night pain.

Cold details

Melatonin mitigates banana cold injury

Moderately Effective

Based on 16 Researches

Wu Y, Bai L, Dai X, Ba L, Wan J, et al. Comparative transcriptomic analysis reveals the reactive oxygen species metabolism involving in melatonin-alleviated chilling injury in postharvest banana fruit. Plant Physiol Biochem. 2025;222:109693. doi:10.1016/j.plaphy.2025.109693

We explored how melatonin treatment affects chilling injury in bananas during cold storage. The study revealed that bananas treated with 500 μmol L of melatonin significantly reduced the signs of chilling injury compared to untreated control fruits during 96 hours of storage.

We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.

A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.

Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.

8.8

Avoids common cold

Most Useful Review

This vitamin is a superior quality supplement that has made a noticeable difference in my life. I’ve experienced improvements in both my work performance and mood. This supplement has helped me avoid the common cold. It’s fantastic for the whole family!

Constipation details

Relieved my constipation

A great supplement. Quality, ingredients, size, and packaging are all excellent. It enhances digestion through microbiome support, and my constipation has improved. The lack of taste is a plus. I recommend this product for its good price and numerous benefits, including better sleep, joint support, and overall health.

Fibromyalgia details

I purchased this for my insomnia linked to fibromyalgia. It's an excellent product that enables me to fall asleep easily, sleep through the night despite the pain, and wake up feeling refreshed.

Food Poisoning details

I highly recommend this for children with autism and/or ADHD. These are amazing. My neurodivergent children struggle not only with sleeping but also with winding down. These dissolve on the tongue and have a pleasant taste, which is a win given my children's avoidant restrictive food intake disorder and sensory processing difficulties. Administering them 30 minutes before bedtime ensures they drift off readily. This method is much more effective than relying on pharmaceutical medication, with no adverse side effects. The brand is also reliable and of good quality. 10/10 recommend.

Leg Cramps details

Aids recovery from cramps

I used these after leg days at the gym, and they assist me in recovering and sleeping better. I've noticed a marked improvement in managing my leg cramps.

Menopause details

Melatonin aids perimenopausal relief

Based on 10 Researches

Zhang J, Jiang B. Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study. J Healthc Eng. 2023;2023:2198804. doi:10.1155/2023/2198804

We evaluated the effects of melatonin treatment on emotion, sleep, and quality of life in 100 healthy perimenopausal women. Participants were divided into two groups: one receiving melatonin and the other a placebo over three cycles.

After analyzing various hormonal levels and using questionnaires to assess perimenopausal symptoms, sleep quality, anxiety, and mood, we found that melatonin significantly alleviated climacteric symptoms.

Participants reported improved sleep, enhanced mood, and a better overall quality of life without serious side effects.

9.5

Restful nights

Most Useful Review

I recommend it, as I used to wake up frequently at night due to the heat of menopause. Now, since taking melatonin, I awaken feeling thoroughly rested. My daughter has also started taking it, and despite having to rise at 5 in the morning to teach, she reports waking up feeling refreshed.

Anxiety details

Melatonin reduces pediatric anxiety, pain

Based on 7 Researches

Rahafard S, Akbari Jokar Z, Hosseini SA, Alaee E. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial. Ann Med Surg (Lond). 2024;86:5811. doi:10.1097/MS9.0000000000002163

We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.

The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.

While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.

9.5

Stimulates immune response

Most Useful Review

Melatonin also boosts the immune system by activating the thymus and thyroid glands. It effectively reduces anxiety and improves my emotional state. When under stress, it helps by lowering adrenaline and other hormones, showcasing its remarkable anti-stress properties.

Cardiovascular Disease details

This solution is essential for those suffering from insomnia and restless sleep. I take it half an hour before bedtime, ensuring to switch off the lights and avoid my mobile. Thankfully, my sleep has improved and my insomnia has lessened. This method can help others achieve more continuous sleep through the night.

Chronic Cough details

Excellent! I have suffered from chronic insomnia for years, especially on special occasions, but the issue has been resolved. I highly recommend it – never underestimate the effect of a low concentration.

Autoimmune Disorder details

Melatonin improves MS-related symptoms

Based on 16 Researches

Jallouli S, Jallouli D, Damak M, Sakka S, Ghroubi S, et al. 12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial. Metab Brain Dis. 2024;40:52. doi:10.1007/s11011-024-01428-2

We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.

We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.

This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.

9.5

Quick sleep solution

Most Useful Review

I was astonished! I discovered this supplement about four months ago through an advertisement. A sublingual tablet does the trick in 15-20 minutes, making my eyes heavy and helping me fall asleep quickly. My sleep is calm and even with melatonin. I also shared it with my mother, who struggles with night shifts, and she found it very helpful. I can confidently state it works!

Insomnia details

Li X, Chen Y, Shao H, Yan Z, Wang Y, et al. Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation. Int J Biol Macromol. 2025;301:140500. doi:10.1016/j.ijbiomac.2025.140500

Based on 23 Researches

Melatonin delivery enhances sleep

We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.

Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.

Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.

We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.

9.5

Effective for insomnia

Most Useful Review

This melatonin works well for my grandmother, who suffers from constant insomnia. A whole pill does the trick and helps her fall asleep without problems. I'm pleased with the dosage.

Allergies details

I noticed its effects after a week; before bed, I take one pill, and it helps my body recover overnight. Sometimes, I can take it during the day and still get sufficient sleep in five to six hours. I'm satisfied with the product, as it has a pleasant taste, doesn’t cause soreness, and hasn’t triggered my allergies. After a month and a half, though, a break for a couple of weeks is advisable to restore melatonin levels.

Ear Infection details

Ucuncu H, Aktan B, Ozabacigil F, Buyukokuroglu ME, Akyuz M, et al. Protective effect of melatonin on experimental otitis media with effusion in guinea pigs. Ann Clin Lab Sci. 2004;34:341.

Based on 2 Researches

Melatonin reduces oxidative stress

Our study examined the effects of melatonin on oxidative stress in ear infections, using guinea pigs. We divided them into four groups—one control group, one receiving histamine to induce ear infection, and two groups pretreated with either melatonin or methylprednisolone before infection onset.

We found that melatonin significantly reduced oxidative stress markers compared to untreated infections. While both treatments helped, melatonin showed a more pronounced protective effect against infection-related damage. This suggests that melatonin could be a promising option for managing ear infections through its antioxidant capabilities.

8.8

Useful for sleep

Most Useful Review

Excellent melatonin! I have been troubled by early rising for work and my inability to fall asleep. I take it 20 minutes before bed, and even if I’m not feeling sleepy, I begin to feel drowsy after 15 minutes. It certainly aids in helping me sleep on time; however, the ear infection issue still lingers, as I continue to wake during the night.

Pelvic Pain details

Relieves urinary pain

Amazing quality; I cannot do without it when I experience pain and a burning sensation during urination. I combine it with corn silk, cranberries, and britica. It’s not addictive, but don’t delay taking it. It provides energy and strength, suitable for adults.

Flu details

Melatonin mitigates flu-induced lung injury

Based on 3 Researches

Huo C, Tang Y, Li X, Han D, Gu Q, et al. Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression. PLoS Pathog. 2023;19:e1011406. doi:10.1371/journal.ppat.1011406

We explored the potential of melatonin as a treatment for H1N1 flu infection. In our study, we found that melatonin, a powerful antioxidant and anti-inflammatory compound, could significantly protect against the flu in both laboratory tests and in living mice.

Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.

We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.

9.5

Effective and fast

Most Useful Review

Excellent influence, works swiftly and is effective.

Multiple Sclerosis details

Game changer experience

Excellent product; I couldn't recommend it more highly. I have ordered these multiple times and they have significantly changed my sleep pattern. After taking them, I find it much easier to fall asleep and wake up feeling refreshed, which is something I cannot achieve without them. I take 2 tablets about 30 minutes before bed, and I sleep like a baby.

Back Pain details

It assists in returning to sleep when I wake at dawn. I recommend it.

Heartburn details

Not useful, heartburn

I do not recommend this product as it has not been effective for sleep. It causes heartburn, making it unhelpful for me.

Dizziness details

Melatonin's impact on dizziness

Mamoon B, Nawaz A, Khattak MI, Amir F, Akbar A, et al. Addressing Sleep Disorders in Psychiatry: Comparing the Use of Melatonin, Trazodone, and Doxepin. Cureus. 2024;16:e76507. doi:10.7759/cureus.76507

We assessed how melatonin affects dizziness in patients dealing with sleep disturbances tied to psychiatric conditions. In a study with 175 participants, we found that melatonin was slightly less effective than trazodone and doxepin in improving overall sleep quality. However, it stood out for having a low incidence of adverse effects. Specifically, the rates of dizziness associated with melatonin use were measured, showing a relatively low occurrence.

While it did not provide the most substantial improvement in sleep quality, melatonin showed promise in enhancing tolerability among users. Only 10% of participants reported dizziness, which indicates that melatonin might be a safer option for those worried about side effects from more potent medications. By choosing melatonin, patients can potentially find a balance between managing sleep disturbances while minimizing unwanted symptoms like dizziness.

Overall, we observed that for individuals focused on avoiding adverse effects, melatonin serves as a viable alternative within this treatment landscape. Its effectiveness in curbing dizziness contributes to discussions on how best to treat sleep disorders in psychiatric patients without compromising their comfort.

Rapid effects, no dizziness

Most Useful Review

It works quickly and does not induce dizziness.

Headache details