Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Good
Based on 9 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Melatonin
10 mg
**
Top Medical Research Studies
2
We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
Read More
8
We examined the impact of melatonin on 29 patients with chronic fatigue syndrome (CFS) who had a late Dim Light Melatonin onset (DLMO). Over three months, patients took 5 mg of melatonin five hours before their DLMO.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Read More
8
We investigated how antioxidants, including melatonin, impact chronic fatigue syndrome (CFS) using a mouse model. In our study, mice were subjected to daily swimming, mimicking fatigue symptoms. We found that melatonin, along with other antioxidants, significantly reduced immobility periods, indicating a potential benefit. Biochemical tests showed that these treatments lessened oxidative stress in the brain, restoring important antioxidant enzyme levels. Overall, the results point to antioxidants, including melatonin, as promising candidates for managing CFS symptoms.
Read More
Most Useful Reviews
9
Mood improvement
100 people found this helpful
Excellent! I had never taken a vitamin before, but since starting this product, I've noticed a reduction in my chronic fatigue and moodiness. After just a few weeks, I could tell my body felt different. This vitamin has truly enhanced my health, immunity, quality of life, and mood.
Read More
9
Insomnia resolution
3 people found this helpful
Excellent! I have suffered from chronic insomnia for years, especially on stressful days, but this issue has now been resolved. I wholeheartedly recommend it; it is very effective.
Read More
9
Enhanced activity
Excellent! This melatonin is a great addition; it alleviates chronic sleep deprivation, fatigue, and stress. After two weeks of taking it, I've felt significantly better and more active. I think the dosage of 10mg is perfect, and I recommend it for anyone facing similar issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
- All Researches
8
Melatonin and zinc may reduce fatigue
We conducted a 16-week, randomized, double-blind trial to investigate the impact of melatonin combined with zinc on fatigue symptoms in individuals with chronic fatigue syndrome (ME/CFS).
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
Read More
8
We examined the impact of melatonin on 29 patients with chronic fatigue syndrome (CFS) who had a late Dim Light Melatonin onset (DLMO). Over three months, patients took 5 mg of melatonin five hours before their DLMO.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Read More
8
We investigated how antioxidants, including melatonin, impact chronic fatigue syndrome (CFS) using a mouse model. In our study, mice were subjected to daily swimming, mimicking fatigue symptoms. We found that melatonin, along with other antioxidants, significantly reduced immobility periods, indicating a potential benefit. Biochemical tests showed that these treatments lessened oxidative stress in the brain, restoring important antioxidant enzyme levels. Overall, the results point to antioxidants, including melatonin, as promising candidates for managing CFS symptoms.
Read More
7
Melatonin shows mixed benefits for fatigue
We sought to understand how melatonin supplementation affects chronic fatigue syndrome among multiple sclerosis (MS) patients. In our study, 102 patients were divided into groups based on their treatment types and supplemented with melatonin for 90 days.
We found that melatonin significantly reduced plasma lipid hydroperoxide levels, which may relate to chronic fatigue in MS. However, homocysteine levels showed no significant change across the groups after treatment. Overall, while melatonin appeared beneficial in lowering certain biomarkers, it did not significantly alleviate fatigue symptoms in all MS patients.
We found that melatonin significantly reduced plasma lipid hydroperoxide levels, which may relate to chronic fatigue in MS. However, homocysteine levels showed no significant change across the groups after treatment. Overall, while melatonin appeared beneficial in lowering certain biomarkers, it did not significantly alleviate fatigue symptoms in all MS patients.
Read More
7
We explored the effects of melatonin on chronic fatigue syndrome (CFS) in patients with Parkinson's disease. Our study involved 30 patients at different stages of the disease.
After treatment, we observed a significant 21% reduction in fatigue severity. Not only did sleep quality improve, but there was also a decrease in anxiety and an enhancement in overall quality of life.
However, we found no noteworthy changes in motor or cognitive functions, nor in depression levels. Melatonin appears promising as part of a treatment plan for CFS and sleep issues in these patients.
After treatment, we observed a significant 21% reduction in fatigue severity. Not only did sleep quality improve, but there was also a decrease in anxiety and an enhancement in overall quality of life.
However, we found no noteworthy changes in motor or cognitive functions, nor in depression levels. Melatonin appears promising as part of a treatment plan for CFS and sleep issues in these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Mood improvement
100 people found this helpful
Excellent! I had never taken a vitamin before, but since starting this product, I've noticed a reduction in my chronic fatigue and moodiness. After just a few weeks, I could tell my body felt different. This vitamin has truly enhanced my health, immunity, quality of life, and mood.
Read More
9
Insomnia resolution
3 people found this helpful
Excellent! I have suffered from chronic insomnia for years, especially on stressful days, but this issue has now been resolved. I wholeheartedly recommend it; it is very effective.
Read More
9
Enhanced activity
Excellent! This melatonin is a great addition; it alleviates chronic sleep deprivation, fatigue, and stress. After two weeks of taking it, I've felt significantly better and more active. I think the dosage of 10mg is perfect, and I recommend it for anyone facing similar issues.
Read More
7.5
Reduced fatigue
2 people found this helpful
I was pleasantly surprised after reading the positive reviews. From the first use, both my mother and I experienced excellent results. Getting out of bed in the morning required some persuasion, but I woke up without any chronic fatigue or weakness. I gladly recommend this product.
Read More
9
Improved sleep quality
This product has greatly benefited my chronic sleep issues. It is easy to take and has a pleasant taste, leaving me without any hungover or lethargic sensation the following morning. The packaging is good, and delivery to Australia was prompt. Although I am hesitant to recommend sleep products, I find this to be one of the best I have tried.
Read More
Frequently Asked Questions
9
Mood improvement
100 people found this helpful
Excellent! I had never taken a vitamin before, but since starting this product, I've noticed a reduction in my chronic fatigue and moodiness. After just a few weeks, I could tell my body felt different. This vitamin has truly enhanced my health, immunity, quality of life, and mood.
9
Enhanced activity
Excellent! This melatonin is a great addition; it alleviates chronic sleep deprivation, fatigue, and stress. After two weeks of taking it, I've felt significantly better and more active. I think the dosage of 10mg is perfect, and I recommend it for anyone facing similar issues.
7.5
Reduced fatigue
2 people found this helpful
I was pleasantly surprised after reading the positive reviews. From the first use, both my mother and I experienced excellent results. Getting out of bed in the morning required some persuasion, but I woke up without any chronic fatigue or weakness. I gladly recommend this product.
9
Insomnia resolution
3 people found this helpful
Excellent! I have suffered from chronic insomnia for years, especially on stressful days, but this issue has now been resolved. I wholeheartedly recommend it; it is very effective.
9
Enhanced morning rest
I take this at night due to significant fatigue, and I wake up feeling perfectly rested. The tablets are small and taste nice, with benefits that are undeniable. The dosage is substantial, intended for special situations, and the quality is excellent from a proven manufacturer.
8
Melatonin and zinc may reduce fatigue
We conducted a 16-week, randomized, double-blind trial to investigate the impact of melatonin combined with zinc on fatigue symptoms in individuals with chronic fatigue syndrome (ME/CFS).
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
8
We examined the impact of melatonin on 29 patients with chronic fatigue syndrome (CFS) who had a late Dim Light Melatonin onset (DLMO). Over three months, patients took 5 mg of melatonin five hours before their DLMO.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
2
We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
2
We explored the impact of melatonin on patients with chronic fatigue syndrome (CFS), focusing on heart rate and blood pressure rhythms. Our study involved 18 CFS patients and measured their ambulatory blood pressure against age-matched controls.
While we saw heightened circadian rhythm amplitudes in CFS patients, melatonin did not improve nighttime blood pressure levels—instead, it worsened hypotension. However, inopamil showed promise in addressing nighttime blood pressure issues.
Ultimately, this suggests that melatonin may not be beneficial for those suffering from CFS.
While we saw heightened circadian rhythm amplitudes in CFS patients, melatonin did not improve nighttime blood pressure levels—instead, it worsened hypotension. However, inopamil showed promise in addressing nighttime blood pressure issues.
Ultimately, this suggests that melatonin may not be beneficial for those suffering from CFS.
References
- Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. 10.3390/antiox10071010
- Adamczyk-Sowa M, Sowa P, Adamczyk J, Niedziela N, Misiolek H, et al. Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone. J Physiol Pharmacol. 2016;67:235.
- Datieva VK, Rosinskaia AV, Levin OS. [The use of melatonin in the treatment of chronic fatigue syndrome and circadian rhythm disorders in Parkinson's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113:77.
- van Heukelom RO, Prins JB, Smits MG, Bleijenberg G. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur J Neurol. 2006;13:55.
- Singh A, Naidu PS, Gupta S, Kulkarni SK. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. J Med Food. 2002;5:211.
- Williams G, Waterhouse J, Mugarza J, Minors D, Hayden K. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest. 2002;32:831.
- van de Luit L, van der Meulen J, Cleophas TJ, Zwinderman AH. Amplified amplitudes of circadian rhythms and nighttime hypotension in patients with chronic fatigue syndrome: improvement by inopamil but not by melatonin. Angiology. 1998;49:903.
