Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1,000 mg
1,111%
Top Medical Research Studies
7
We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.
So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.
Read More
8
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Read More
Most Useful Reviews
7.5
Colds remedy
I ordered these for a friend who uses them during cold season for prevention and at the first signs of illness. They are essential and help quickly combat colds and alleviate their severity.
Read More
6
Health protection
I take these in courses during the autumn-winter months to stave off respiratory infections. They help maintain good health, and if I do catch a bug, I recover faster and with a milder illness. The tablets are large and challenging to swallow.
Read More
6
Supports heart health
39 people found this helpful
The last time I purchased this supplement in gelatin capsules, it was challenging to notice any immediate difference. I take it to support my heart and appreciate the effect it has. When I tried to increase the dosage, my heartbeat became erratic. I am grateful to IHERB and all the reviewers; their insights significantly aid me in choosing supplements, especially since it seems doctors aren't always reliable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
- All Researches
9
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
Read More
8
We observed how a mother’s diet during pregnancy, particularly a high-fat diet (HFD), can significantly impact the heart development of her offspring. In our exploration, we found that pregnant mice exposed to HFD suffered metabolic changes, leading to issues like non-compaction cardiomyopathy (NCC) in their embryos. This was marked by low levels of a molecule called 5-hydroxymethylcytosine (5hmC) and changes in chromatin accessibility in the heart tissues of the embryos.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Interestingly, we discovered that when we supplemented these mice with vitamin C, it helped to reduce the harmful effects linked to HFD. This seems to work by restoring iron levels in a form that helps certain enzymes, known as Tet enzymes, function better. Through our genetic investigations, we confirmed that vitamin C boosts Tet activity, a crucial factor for heart health, particularly under stress from a poor diet.
Our findings emphasize the critical importance of balanced maternal nutrition. They show how choices like including vitamin C can play a protective role in heart development, especially when faced with the challenges of a high-fat diet.
Read More
8
Combined antioxidants may benefit heart
We explored the potential of a combined antioxidant therapy that includes vitamin C to address myocardial reperfusion injury—a condition that can worsen heart damage after blood flow is restored following ischemia. In a Phase 1 clinical trial involving healthy participants, we tested whether this therapy could be safely administered while also examining the effects on oxidative stress, a key factor in heart injury.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Participants were randomly assigned to receive either the combined antioxidant therapy or a placebo. We provided two different doses of the therapy through an intravenous infusion lasting 90 minutes. Monitoring included collecting blood samples to measure levels of the antioxidants, including vitamin C, and assessing any adverse effects.
We observed that both doses of the antioxidant therapy significantly increased the concentration of the drugs in the bloodstream compared to placebo. Interestingly, while a few mild adverse events were reported, they were not serious, suggesting that the therapy is safe for human use. The therapy did show promise in boosting antioxidant levels in the blood.
However, it's essential to note that while vitamin C is part of this combined treatment, the study did not isolate its effects specifically. Thus, we can't draw definitive conclusions about vitamin C alone in treating heart disease. The findings suggest that this combined approach might hold potential for future therapies in managing acute myocardial infarction.
Read More
8
We explored the effects of a novel water-soluble derivative of ascorbic acid, known as BM-164, on heart health under conditions of ischemia and reperfusion in rat hearts. This study aimed to combine the cardiovascular benefits of hydrogen sulfide (HS) with the antioxidant properties of ascorbic acid.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Through a series of tests, we found that BM-164 significantly reduced the incidence of harmful heart rhythms known as ventricular fibrillation from 79% to 31%. Moreover, the size of heart tissue damage, often referred to as infarct size, was decreased from 28% to 14% in the group treated with BM-164.
However, we also noted that while heart function improvements, such as coronary flow and heart rate, didn't show significant differences compared to a drug-free control group. Further analysis of cellular processes revealed increased levels of autophagy-related proteins, which could explain the heart-protective effects of BM-164, while markers of apoptosis didn’t show notable changes.
In conclusion, BM-164 showcases considerable potential in providing cardiac protection during injury caused by ischemia and reperfusion, showing advantages over untreated and simply ascorbic acid-treated hearts.
Read More
8
We explored how ascorbic acid, commonly known as vitamin C, plays a role in cardiac allograft vasculopathy (CAV), a condition that can develop after heart transplants. CAV is characterized by progressive damage to the heart's blood vessels, leading to serious complications.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Recent studies, particularly on rodent models, have shown exciting findings. Ascorbic acid appears to boost the activity of an enzyme called TET2, which helps reduce the death of vascular smooth muscle cells and the thickening of blood vessel walls. This is important because when TET2 is suppressed, as can occur with interferon γ during CAV, it can contribute to the disease's progression.
Ascorbic acid doesn't just stop there; it also helps improve the overall health of the endothelium— the thin layer of cells lining the blood vessels. By decreasing harmful reactive oxygen species and preventing excessive growth of smooth muscle cells, vitamin C shows promise in tackling the adverse effects of CAV.
However, while initial findings, including a small clinical trial, suggest potential benefits, much more research is needed. We must see larger, controlled studies to truly understand how effective ascorbic acid can be in managing heart transplant recipients' long-term health.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Colds remedy
I ordered these for a friend who uses them during cold season for prevention and at the first signs of illness. They are essential and help quickly combat colds and alleviate their severity.
Read More
6
Health protection
I take these in courses during the autumn-winter months to stave off respiratory infections. They help maintain good health, and if I do catch a bug, I recover faster and with a milder illness. The tablets are large and challenging to swallow.
Read More
6
Supports heart health
39 people found this helpful
The last time I purchased this supplement in gelatin capsules, it was challenging to notice any immediate difference. I take it to support my heart and appreciate the effect it has. When I tried to increase the dosage, my heartbeat became erratic. I am grateful to IHERB and all the reviewers; their insights significantly aid me in choosing supplements, especially since it seems doctors aren't always reliable.
Read More
7.5
Effective in prevention
2 people found this helpful
Good Vitamin C! I take two tablets each morning and evening at the initial stage of heart disease, and they work effectively. Previously, I purchased from another brand, which was 2.5-3 times pricier, but these are just as good. I experienced no allergic reactions. Overall, a good effect.
Read More
7.5
Value for money
1 people found this helpful
Vitamin C at an excellent price! I take two tablets each morning and evening at the initial stage of heart disease, and they work wonderfully. Previously, I bought a more expensive brand, but these yield the same results. There were no allergic reactions. A good effect.
Read More
Frequently Asked Questions
7.5
Effective in prevention
2 people found this helpful
Good Vitamin C! I take two tablets each morning and evening at the initial stage of heart disease, and they work effectively. Previously, I purchased from another brand, which was 2.5-3 times pricier, but these are just as good. I experienced no allergic reactions. Overall, a good effect.
6
Supports heart health
39 people found this helpful
The last time I purchased this supplement in gelatin capsules, it was challenging to notice any immediate difference. I take it to support my heart and appreciate the effect it has. When I tried to increase the dosage, my heartbeat became erratic. I am grateful to IHERB and all the reviewers; their insights significantly aid me in choosing supplements, especially since it seems doctors aren't always reliable.
7.5
Colds remedy
I ordered these for a friend who uses them during cold season for prevention and at the first signs of illness. They are essential and help quickly combat colds and alleviate their severity.
6
Health protection
I take these in courses during the autumn-winter months to stave off respiratory infections. They help maintain good health, and if I do catch a bug, I recover faster and with a milder illness. The tablets are large and challenging to swallow.
7.5
Value for money
1 people found this helpful
Vitamin C at an excellent price! I take two tablets each morning and evening at the initial stage of heart disease, and they work wonderfully. Previously, I bought a more expensive brand, but these yield the same results. There were no allergic reactions. A good effect.
7
Vitamin C boosts NK cell function
We delved into how vitamin C, specifically ascorbic acid, influences the behavior of natural killer (NK) cells in patients with coronary artery disease (CAD). Our exploration involved isolating NK cells from 29 CAD patients and stimulating them with various factors, including vitamin C, to analyze their growth and proliferation. Notably, the results indicated that nearly all NK cells responded positively to vitamin C, showcasing a significant boost in their ability to proliferate. This suggests that vitamin C could play a role in enhancing the immune function of these cells, which is particularly important for those vulnerable to heart disease.
Moreover, we observed a correlation between the serum levels of lactate dehydrogenase (LDH) and NK cell activity. Specifically, higher LDH levels appeared to be linked to a decreased NK cell proliferation response when stimulated with interleukins, which are signaling molecules crucial for immune responses. This finding raises interesting questions about the role of LDH not just as a marker for cell damage, but potentially as an influencing factor in immune regulation.
In summary, our findings point to vitamin C's potential to enhance NK cell proliferation in CAD patients. Furthermore, the serum LDH levels could serve as a valuable indicator of NK cell function, suggesting a complex interplay between immune response and heart disease. Overall, these insights may open new avenues for integrating vitamin C into treatment regimens for improving immune health in heart disease.
Moreover, we observed a correlation between the serum levels of lactate dehydrogenase (LDH) and NK cell activity. Specifically, higher LDH levels appeared to be linked to a decreased NK cell proliferation response when stimulated with interleukins, which are signaling molecules crucial for immune responses. This finding raises interesting questions about the role of LDH not just as a marker for cell damage, but potentially as an influencing factor in immune regulation.
In summary, our findings point to vitamin C's potential to enhance NK cell proliferation in CAD patients. Furthermore, the serum LDH levels could serve as a valuable indicator of NK cell function, suggesting a complex interplay between immune response and heart disease. Overall, these insights may open new avenues for integrating vitamin C into treatment regimens for improving immune health in heart disease.
9
We investigated the effects of Vitamin C on heart disease, particularly in the context of sepsis-induced cardiac injury. In a carefully designed study, we utilized a rat model, dividing thirty female Sprague-Dawley rats into several groups to evaluate the individual and combined impacts of Vitamin C and Coenzyme Q10. Each group received oral treatments for ten days before we induced polymicrobial sepsis through cecal ligation and puncture.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
After we euthanized the animals and analyzed the specimens, we found that the combination of Vitamin C and Coenzyme Q10 significantly reduced oxidative stress markers and improved antioxidative parameters. Notably, the treatments also led to a decrease in pro-inflammatory cytokines and improved cardiac indicators, suggesting that Vitamin C has a beneficial role when paired with Coenzyme Q10 in mitigating cardiac injury during sepsis.
While we observed improved outcomes with the combined treatment, the study design means we couldn’t definitively attribute these positive effects solely to Vitamin C. In fact, Coenzyme Q10 sometimes showcased even greater advantages. Overall, our findings hint at the potential of Vitamin C, especially when combined with Coenzyme Q10, to serve as an effective approach against cardiac injuries in sepsis.
7
We explored whether vitamin C could play a significant role in preventing heart transplant rejection and cardiac allograft vasculopathy (CAV), both of which are serious complications faced by post-heart transplant patients. Given the increasing burden of cardiovascular diseases, finding effective and affordable treatment options is crucial.
Our review indicates that vitamin C, well known for its antioxidant properties, may offer a cost-effective alternative to conventional medications used in post-heart transplant care. These traditional treatments, such as immunosuppressants and statins, are often expensive and can come with troublesome side effects that diminish quality of life for patients.
Collectively, the findings from several studies suggest that vitamin C could assist in preventing and managing HTR and CAV while minimizing adverse effects. However, we recommend conducting more rigorous clinical trials and molecular studies to carefully evaluate vitamin C's effectiveness and potential in the context of heart transplant recovery plans.
Our review indicates that vitamin C, well known for its antioxidant properties, may offer a cost-effective alternative to conventional medications used in post-heart transplant care. These traditional treatments, such as immunosuppressants and statins, are often expensive and can come with troublesome side effects that diminish quality of life for patients.
Collectively, the findings from several studies suggest that vitamin C could assist in preventing and managing HTR and CAV while minimizing adverse effects. However, we recommend conducting more rigorous clinical trials and molecular studies to carefully evaluate vitamin C's effectiveness and potential in the context of heart transplant recovery plans.
References
- Guo X, Xiao T, Lin L, Gao Q, Lai B, et al. Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients. Front Immunol. 2024;15:1436747. doi:10.3389/fimmu.2024.1436747
- Yang Y, Rivera L, Fang S, Cavalier M, Suris A, et al. Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development. iScience. 2024;27:110631. doi:10.1016/j.isci.2024.110631
- Gajardo Cortez AIJ, Lillo-Moya J, San-Martín-Martinez D, Pozo-Martinez J, Morales P, et al. Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans. Clin Pharmacol Drug Dev. 2024;13:1051. doi:10.1002/cpdd.1443
- Tánczos B, Vass V, Szabó E, Lovas M, Kattoub RG, et al. Effects of HS-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts. Eur J Pharm Sci. 2024;195:106721. doi:10.1016/j.ejps.2024.106721
- Üstündağ H, Demir Ö, Huyut MT, Yüce N. Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats. Sci Rep. 2024;14:3098. doi:10.1038/s41598-024-52932-5
- Kenedy IJ, Kabuhaya JF, Mashauri HL. Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration. Health Sci Rep. 2023;6:e1687. doi:10.1002/hsr2.1687
- Chang A, Martin KA, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. Clin Transplant. 2023;37:e15153. doi:10.1111/ctr.15153
- Manolis AA, Manolis T, Melita H, Manolis AS. Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1. Curr Vasc Pharmacol. 2023;21:378. doi:10.2174/1570161121666230912155548
