Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-12 (as Cyanocobalamin)
2,500 mcg
104,167%
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Most Useful Reviews
9.5
Improved sleep quality
In recent years, I have experienced chronic fatigue and nerve tingling, which have impeded my normal work activities. The doctor suggested a higher dosage of vitamin B12, and after over a month, the nerve pain gradually vanished. I now enjoy good sleep quality and feel less fatigued. This is vital for my health. 21st Century B12 is a high-dose and cost-effective product that I will continue to use.
9.5
Significant energy boost
The Amazing B12 Sublingual Tablets have been transformative for my energy levels! As someone who often suffers from fatigue, these tablets have become essential in my daily life. The convenience of sublingual administration is splendid; I simply place a tablet under my tongue, where it quickly dissolves, allowing for immediate absorption. Since I began taking them, I have experienced a noticeable enhancement in my energy throughout the day, eliminating that mid-afternoon slump. I feel more focused and alert during lengthy meetings. Most importantly, the energy boost feels natural and sustained, without jitters or crashes. The tablets also taste pleasant, making them easy to take. I wholeheartedly recommend B12 Sublingual Tablets for anyone dealing with chronic fatigue or seeking natural energy support.
7.5
Product helps fatigue
I have been battling chronic fatigue for a long time, and I have occasionally received vitamin B12 injections. Currently, there is a shortage of injections in this country, so I purchased this product, which helps alleviate my fatigue.
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.8
- All Researches
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
8
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
8
We explored the effects of frequent vitamin B12 injections in patients suffering from chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). The study included 38 patients who received B12 injections at least weekly for a period ranging from six months to several years.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
8
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved sleep quality
In recent years, I have experienced chronic fatigue and nerve tingling, which have impeded my normal work activities. The doctor suggested a higher dosage of vitamin B12, and after over a month, the nerve pain gradually vanished. I now enjoy good sleep quality and feel less fatigued. This is vital for my health. 21st Century B12 is a high-dose and cost-effective product that I will continue to use.
9.5
Significant energy boost
The Amazing B12 Sublingual Tablets have been transformative for my energy levels! As someone who often suffers from fatigue, these tablets have become essential in my daily life. The convenience of sublingual administration is splendid; I simply place a tablet under my tongue, where it quickly dissolves, allowing for immediate absorption. Since I began taking them, I have experienced a noticeable enhancement in my energy throughout the day, eliminating that mid-afternoon slump. I feel more focused and alert during lengthy meetings. Most importantly, the energy boost feels natural and sustained, without jitters or crashes. The tablets also taste pleasant, making them easy to take. I wholeheartedly recommend B12 Sublingual Tablets for anyone dealing with chronic fatigue or seeking natural energy support.
7.5
Product helps fatigue
I have been battling chronic fatigue for a long time, and I have occasionally received vitamin B12 injections. Currently, there is a shortage of injections in this country, so I purchased this product, which helps alleviate my fatigue.
Frequently Asked Questions
9.5
Improved sleep quality
In recent years, I have experienced chronic fatigue and nerve tingling, which have impeded my normal work activities. The doctor suggested a higher dosage of vitamin B12, and after over a month, the nerve pain gradually vanished. I now enjoy good sleep quality and feel less fatigued. This is vital for my health. 21st Century B12 is a high-dose and cost-effective product that I will continue to use.
9.5
Significant energy boost
The Amazing B12 Sublingual Tablets have been transformative for my energy levels! As someone who often suffers from fatigue, these tablets have become essential in my daily life. The convenience of sublingual administration is splendid; I simply place a tablet under my tongue, where it quickly dissolves, allowing for immediate absorption. Since I began taking them, I have experienced a noticeable enhancement in my energy throughout the day, eliminating that mid-afternoon slump. I feel more focused and alert during lengthy meetings. Most importantly, the energy boost feels natural and sustained, without jitters or crashes. The tablets also taste pleasant, making them easy to take. I wholeheartedly recommend B12 Sublingual Tablets for anyone dealing with chronic fatigue or seeking natural energy support.
7.5
Product helps fatigue
I have been battling chronic fatigue for a long time, and I have occasionally received vitamin B12 injections. Currently, there is a shortage of injections in this country, so I purchased this product, which helps alleviate my fatigue.
8
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
8
We explored the effects of frequent vitamin B12 injections in patients suffering from chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). The study included 38 patients who received B12 injections at least weekly for a period ranging from six months to several years.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
7
Vitamin B12 shows unclear benefits
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
References
- van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. doi:10.3389/fphar.2019.01102
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648
- van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. doi:10.3389/fphar.2019.01102
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648
- Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
- Devitt NF. Chronic fatigue syndrome. JAMA. 1998;279:432.
- Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
- Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.
- Demitrack MA, Engleberg NC. Chronic fatigue syndrome. Curr Ther Endocrinol Metab. 1994;5:135.
