Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.7
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
Quercetin (as Quercetin Dihydrate)(Dimorphandra mollis) (seed pod)
500 mg
â€
Bromelain (from pineapple stem)(2400 GDU/gram)
250 mg
â€
Top Medical Research Studies
9
We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Read More
9
Quercetin shows promise for asthma
We explored the impact of quercetin, a natural plant compound, on asthma by testing its anti-inflammatory and antioxidant properties in a controlled study with rats. Asthma was induced in the rats using a substance called ovalbumin, and they were divided into four groups: a control group, an asthma group treated with a saline solution, another asthma group treated with dexamethasone (a common asthma medication), and a group treated with quercetin.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
Read More
9
We explored how quercetin, a natural compound, may help alleviate asthma symptoms. The focus was on its potential role regarding periostin, a protein linked to inflammatory responses in the lungs, and its interaction with the TGF-β1/Smad pathway, a key signaling system in asthma.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
Read More
Most Useful Reviews
10
Miracle for asthma
100 people found this helpful
I discarded my inhalers! This product is genuinely miraculous. Initially sceptical, having suffered from asthma for 26 years, I started the pills and only took two in the evening. I slept well without waking up wheezing. After a few days, I increased to two more in the morning, and it did wonders! I now take 2 pills twice daily and no longer need to think about my inhaler. I couldn't be happier with this product.
Read More
7.5
Best for adult asthma
6 people found this helpful
It works for me. I suffer from adult-onset asthma, and this has been a tremendous help. I also use butterbur and follow an anti-inflammatory diet, which has resulted in much better management than medication.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.7
- All Researches
9
We explored how quercetin, a natural compound found in fruits and vegetables, can impact asthma symptoms. Using an ovalbumin-induced mouse model of asthma, we aimed to uncover whether quercetin can help inhibit a process known as ferroptosis, potentially offering a new therapeutic approach for asthma sufferers.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Our findings showed that quercetin effectively reduced inflammation in the asthmatic mice. Specifically, it lowered levels of inflammatory factors such as IL-4, IL-5, and IL-13—substances typically elevated during an asthma attack. Notably, we also observed that quercetin increased the levels of superoxide dismutase, an important antioxidant, while decreasing malondialdehyde and ferric ions that are associated with oxidative stress.
Additionally, quercetin appeared to boost the expression of key proteins involved in defending against oxidative stress, specifically SIRT1, Nrf2, and HO-1. This suggests that quercetin not only helps combat inflammation but may also protect against cellular damage within the lungs. Overall, our study indicates that quercetin holds promise as a beneficial treatment for asthma by addressing both inflammatory and oxidative stress pathways.
Read More
9
We explored the potential of quercetin, a key component of Bushenyiqi decoction (BYD), in treating asthma. Through a combination of network pharmacology and experimental validation, we examined its effects on asthma symptoms and the underlying mechanisms behind them.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
Our research highlighted that BYD significantly improves airway responsiveness and decreases inflammation in allergic asthma mice. We identified quercetin, along with other active ingredients in BYD, as critical players in targeting specific genes related to asthma, particularly interleukin 6 (IL-6), epidermal growth factor receptor (EGFR), and hypoxia-inducible factor 1 alpha (HIF1A).
The phosphatidylinositol-3-kinase/AKT signaling pathway also emerged as crucial in this process. Our findings suggest that quercetin contributes to reducing inflammation and respiratory symptoms in asthma by regulating these targets.
Overall, this investigation underscores the importance of quercetin as a valuable element of BYD in mitigating asthma-related inflammation, providing new insights into traditional Chinese medicine's effective strategies.
Read More
9
Quercetin reduces airway inflammation
We aimed to investigate the potential benefits of quercetin, a natural compound, in addressing airway hyperreactivity and inflammation in newborn rats exposed to high levels of oxygen. High oxygen environments often lead to lung injuries and increased airway sensitivity, mimicking some aspects of asthma.
To conduct this study, we divided young rats into groups exposed to either high oxygen or regular air for a week. Some of these groups received quercetin injections, while others did not. By measuring the contraction of tracheal smooth muscles in response to a specific chemical, we noted significant improvements in those treated with quercetin.
Specifically, quercetin reduced the excessive contraction observed in the high-oxygen groups and restored relaxation in the muscles, suggesting a protective effect. We also found that quercetin treatment lowered inflammation markers in the lungs, which is significant, given that inflammation often exacerbates asthma symptoms.
Overall, our findings indicate that quercetin could play a valuable role in managing airway hyperreactivity and associated inflammation, presenting a promising avenue for future therapies aimed at young patients with similar breathing issues.
To conduct this study, we divided young rats into groups exposed to either high oxygen or regular air for a week. Some of these groups received quercetin injections, while others did not. By measuring the contraction of tracheal smooth muscles in response to a specific chemical, we noted significant improvements in those treated with quercetin.
Specifically, quercetin reduced the excessive contraction observed in the high-oxygen groups and restored relaxation in the muscles, suggesting a protective effect. We also found that quercetin treatment lowered inflammation markers in the lungs, which is significant, given that inflammation often exacerbates asthma symptoms.
Overall, our findings indicate that quercetin could play a valuable role in managing airway hyperreactivity and associated inflammation, presenting a promising avenue for future therapies aimed at young patients with similar breathing issues.
Read More
9
Quercetin shows promise for asthma
We explored the impact of quercetin, a natural plant compound, on asthma by testing its anti-inflammatory and antioxidant properties in a controlled study with rats. Asthma was induced in the rats using a substance called ovalbumin, and they were divided into four groups: a control group, an asthma group treated with a saline solution, another asthma group treated with dexamethasone (a common asthma medication), and a group treated with quercetin.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
After one week of daily injections of quercetin and dexamethasone, we noted significant changes in various biological markers. Quercetin appeared to lower the expression of several inflammatory factors linked to asthma, such as Gata-3 and TNF-α. It also positively influenced oxidative stress by reducing levels of malondialdehyde, a marker of cell damage, while boosting antioxidants in both the serum and lung tissue.
Our findings suggest that quercetin does more than just alleviate inflammatory responses; it also enhances the body's defenses against oxidative stress, particularly in the lungs. Overall, quercetin shows great potential as an effective treatment for asthma, helping to manage both inflammation and oxidative stress at the tissue level.
Read More
9
We explored how quercetin, a natural compound, may help alleviate asthma symptoms. The focus was on its potential role regarding periostin, a protein linked to inflammatory responses in the lungs, and its interaction with the TGF-β1/Smad pathway, a key signaling system in asthma.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
To gain insights, we constructed a model using mice sensitized to ovalbumin—an allergen that triggers asthma—and administered quercetin among other treatments. We carefully observed changes in inflammatory responses, airway remodeling, and hyperresponsiveness, using various tests and analyses to measure inflammation markers and proteins involved in airway fibrosis.
Our findings revealed that quercetin significantly reduced the levels of periostin and inhibited airway inflammation and fibrosis. It also showed a tendency to reduce airway hyperreactivity, suggesting that quercetin works through suppressing the TGF-β1/Smad signaling pathway.
Overall, our study supports quercetin as a promising candidate for asthma treatment, highlighting how it effectively targets specific pathways involved in the disease, offering a protective effect against its symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Miracle for asthma
100 people found this helpful
I discarded my inhalers! This product is genuinely miraculous. Initially sceptical, having suffered from asthma for 26 years, I started the pills and only took two in the evening. I slept well without waking up wheezing. After a few days, I increased to two more in the morning, and it did wonders! I now take 2 pills twice daily and no longer need to think about my inhaler. I couldn't be happier with this product.
Read More
7.5
Best for adult asthma
6 people found this helpful
It works for me. I suffer from adult-onset asthma, and this has been a tremendous help. I also use butterbur and follow an anti-inflammatory diet, which has resulted in much better management than medication.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sun B, Cai F, Yu L, An R, Wei B, et al. Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease. Transl Pediatr. 2024;13:1747. 10.21037/tp-24-193
- Wang Y, Sui Y, Yao J, Jiang H, Tian Q, et al. Herb-CMap: a multimodal fusion framework for deciphering the mechanisms of action in traditional Chinese medicine using Suhuang antitussive capsule as a case study. Brief Bioinform. 2024;25. 10.1093/bib/bbae362
- Qin Z, Chen Y, Liu N, Wang Y, Su L, et al. Mechanisms of Bushenyiqi decoction in the treatment of asthma: an investigation based on network pharmacology with experimental validation. Front Pharmacol. 2024;15:1361379. 10.3389/fphar.2024.1361379
- Kryeziu I, Reçica S, Thaçi Q, Kurshumliu F, Hadzi-Petrushev N, et al. Quercetin supplementation attenuates airway hyperreactivity and restores airway relaxation in rat pups exposed to hyperoxia. Exp Biol Med (Maywood). 2023;248:1492. 10.1177/15353702231199468
- Rajizadeh MA, Bejeshk MA, Doustimotlagh AH, Najafipour H, Eftekhari M, et al. The Alleviating Impacts of Quercetin on Inflammation and Oxidant-antioxidant Imbalance in Rats with Allergic Asthma. Iran J Allergy Asthma Immunol. 2023;22:138. 10.18502/ijaai.v22i2.12675
- Fang Y, Jin W, Guo Z, Hao J. Quercetin Alleviates Asthma-Induced Airway Inflammation and Remodeling through Downregulating Periostin via Blocking TGF-β1/Smad Pathway. Pharmacology. 2023;108:432. 10.1159/000530703
- Liu X, Yu Y, Wu Y, Luo A, Yang M, et al. A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment. Phytomedicine. 2023;114:154783. 10.1016/j.phymed.2023.154783
- Wang Y, Wan R, Peng W, Zhao X, Bai W, et al. Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation. Eur J Pharmacol. 2023;938:175407. 10.1016/j.ejphar.2022.175407
- Yang Y, Lai Q, Wang C, Zhou G. Protective Effects of Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice. Evid Based Complement Alternat Med. 2022;2022:7609785. 10.1155/2022/7609785
- Zhang BB, Zeng MN, Zhang QQ, Wang R, Jia JF, et al. [Mechanism of "Ephedrae Herba-Descurainiae Semen Lepidii Semen" combination in treatment of bronchial asthma based on network pharmacology and experimental verification]. Zhongguo Zhong Yao Za Zhi. 2022;47:4996. 10.19540/j.cnki.cjcmm.20220211.403
