Last update
3/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
Quercetin (as Quercetin Dihydrate)(Dimorphandra mollis) (seed pod)
500 mg
â€
Bromelain (from pineapple stem)(2400 GDU/gram)
250 mg
â€
Top Medical Research Studies
8
We observed that quercetin, a powerful antioxidant, plays a significant role in helping grapes withstand cold temperatures. In our study, we found that grapes exposed to low temperatures accumulate more quercetin, which in turn enhances their cold resistance.
By applying exogenous quercetin, we noted a marked improvement in the grapes' ability to endure low-temperature stress. Our research revealed that a key gene, VvFLS1, responsible for quercetin synthesis is upregulated when grapes experience cold conditions.
We also discovered that VvbZIP22, a protein that binds to the VvFLS1 promoter, is crucial for mediating this process. When we overexpressed VvbZIP22 in grapes, it resulted in higher levels of quercetin and improved cold resistance, further confirming its pivotal role in the plant's adaptation to harsh environments.
Through these findings, we highlighted the importance of quercetin in enhancing grape survival during cold spells, showcasing a vital link between plant biology and climate resilience.
By applying exogenous quercetin, we noted a marked improvement in the grapes' ability to endure low-temperature stress. Our research revealed that a key gene, VvFLS1, responsible for quercetin synthesis is upregulated when grapes experience cold conditions.
We also discovered that VvbZIP22, a protein that binds to the VvFLS1 promoter, is crucial for mediating this process. When we overexpressed VvbZIP22 in grapes, it resulted in higher levels of quercetin and improved cold resistance, further confirming its pivotal role in the plant's adaptation to harsh environments.
Through these findings, we highlighted the importance of quercetin in enhancing grape survival during cold spells, showcasing a vital link between plant biology and climate resilience.
Read More
8
Quercetin limits HRV1B replication
We investigated how quercetin-3-methyl ether, a natural flavonoid, impacts human rhinovirus 1B (HRV1B), which is responsible for the common cold and can worsen conditions like asthma. Our research involved testing this compound in HeLa cells to see if it could reduce viral replication and the damage associated with the virus.
In our experiments, quercetin-3-methyl ether significantly inhibited the replication of HRV1B in a concentration-dependent way, which means that higher doses produced better results. We also found that this compound enhanced early apoptosis—essentially, the process by which infected cells shut down in response to the virus—during the critical early stages of infection. This seemed to counteract HRV1B's tactics to evade the immune response.
Additionally, when we administered quercetin-3-methyl ether to mice infected with HRV1B, we observed a noteworthy reduction in viral RNA levels and inflammation in their lung tissues, suggesting a potential therapeutic effect. Our findings enhance the understanding of quercetin-3-methyl ether as a novel agent against HRV1B, pointing towards promising strategies for managing cold-related illnesses and their complications.
In our experiments, quercetin-3-methyl ether significantly inhibited the replication of HRV1B in a concentration-dependent way, which means that higher doses produced better results. We also found that this compound enhanced early apoptosis—essentially, the process by which infected cells shut down in response to the virus—during the critical early stages of infection. This seemed to counteract HRV1B's tactics to evade the immune response.
Additionally, when we administered quercetin-3-methyl ether to mice infected with HRV1B, we observed a noteworthy reduction in viral RNA levels and inflammation in their lung tissues, suggesting a potential therapeutic effect. Our findings enhance the understanding of quercetin-3-methyl ether as a novel agent against HRV1B, pointing towards promising strategies for managing cold-related illnesses and their complications.
Read More
9
We explored how the combination of quercetin (QE) and sucrose (Suc) improves the preservation of porcine liver grafts affected by warm ischemia followed by cold storage. Our study involved two groups of porcine livers: one preserved with the standard University of Wisconsin (UW) solution and the other with the UW solution enhanced with QE and Suc.
After preserving the livers for six hours, we subjected them to a simulated reperfusion model using saline-diluted autologous blood. To measure success, we looked at several indicators of liver health, including specific enzyme levels and histological changes.
The results were promising! The livers treated with QE and Suc showed significantly lower levels of enzymes indicating liver damage compared to those using just the UW solution. Additionally, the histological analysis revealed fewer signs of injury in the QE and Suc group, showcasing their potential in reducing cold injury in liver grafts after ischemia.
Overall, our findings indicate that adding quercetin and sucrose to the preservation solution can effectively protect liver grafts from damage caused by cold storage, especially in cases of donation after circulatory death.
After preserving the livers for six hours, we subjected them to a simulated reperfusion model using saline-diluted autologous blood. To measure success, we looked at several indicators of liver health, including specific enzyme levels and histological changes.
The results were promising! The livers treated with QE and Suc showed significantly lower levels of enzymes indicating liver damage compared to those using just the UW solution. Additionally, the histological analysis revealed fewer signs of injury in the QE and Suc group, showcasing their potential in reducing cold injury in liver grafts after ischemia.
Overall, our findings indicate that adding quercetin and sucrose to the preservation solution can effectively protect liver grafts from damage caused by cold storage, especially in cases of donation after circulatory death.
Read More
Most Useful Reviews
9
No more sinusitis
121 people found this helpful
After suffering from chronic sinusitis and Eustachian tube dysfunction, I sought alternatives to antibiotics. Since using this product, I have experienced no sinusitis and clear ears. It’s effective for colds too, ensuring my sinuses remain clear. However, be cautious with dosage due to potential kidney issues.
Read More
7.5
Sinus issues improved
2 people found this helpful
I started taking these supplements in November, and my severe sinus problems have improved significantly. I’ve been cold-free since then. I will know for sure by April, but I genuinely believe it works.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
We explored how the combination of quercetin (QE) and sucrose (Suc) improves the preservation of porcine liver grafts affected by warm ischemia followed by cold storage. Our study involved two groups of porcine livers: one preserved with the standard University of Wisconsin (UW) solution and the other with the UW solution enhanced with QE and Suc.
After preserving the livers for six hours, we subjected them to a simulated reperfusion model using saline-diluted autologous blood. To measure success, we looked at several indicators of liver health, including specific enzyme levels and histological changes.
The results were promising! The livers treated with QE and Suc showed significantly lower levels of enzymes indicating liver damage compared to those using just the UW solution. Additionally, the histological analysis revealed fewer signs of injury in the QE and Suc group, showcasing their potential in reducing cold injury in liver grafts after ischemia.
Overall, our findings indicate that adding quercetin and sucrose to the preservation solution can effectively protect liver grafts from damage caused by cold storage, especially in cases of donation after circulatory death.
After preserving the livers for six hours, we subjected them to a simulated reperfusion model using saline-diluted autologous blood. To measure success, we looked at several indicators of liver health, including specific enzyme levels and histological changes.
The results were promising! The livers treated with QE and Suc showed significantly lower levels of enzymes indicating liver damage compared to those using just the UW solution. Additionally, the histological analysis revealed fewer signs of injury in the QE and Suc group, showcasing their potential in reducing cold injury in liver grafts after ischemia.
Overall, our findings indicate that adding quercetin and sucrose to the preservation solution can effectively protect liver grafts from damage caused by cold storage, especially in cases of donation after circulatory death.
Read More
8
Quercetin limits HRV1B replication
We investigated how quercetin-3-methyl ether, a natural flavonoid, impacts human rhinovirus 1B (HRV1B), which is responsible for the common cold and can worsen conditions like asthma. Our research involved testing this compound in HeLa cells to see if it could reduce viral replication and the damage associated with the virus.
In our experiments, quercetin-3-methyl ether significantly inhibited the replication of HRV1B in a concentration-dependent way, which means that higher doses produced better results. We also found that this compound enhanced early apoptosis—essentially, the process by which infected cells shut down in response to the virus—during the critical early stages of infection. This seemed to counteract HRV1B's tactics to evade the immune response.
Additionally, when we administered quercetin-3-methyl ether to mice infected with HRV1B, we observed a noteworthy reduction in viral RNA levels and inflammation in their lung tissues, suggesting a potential therapeutic effect. Our findings enhance the understanding of quercetin-3-methyl ether as a novel agent against HRV1B, pointing towards promising strategies for managing cold-related illnesses and their complications.
In our experiments, quercetin-3-methyl ether significantly inhibited the replication of HRV1B in a concentration-dependent way, which means that higher doses produced better results. We also found that this compound enhanced early apoptosis—essentially, the process by which infected cells shut down in response to the virus—during the critical early stages of infection. This seemed to counteract HRV1B's tactics to evade the immune response.
Additionally, when we administered quercetin-3-methyl ether to mice infected with HRV1B, we observed a noteworthy reduction in viral RNA levels and inflammation in their lung tissues, suggesting a potential therapeutic effect. Our findings enhance the understanding of quercetin-3-methyl ether as a novel agent against HRV1B, pointing towards promising strategies for managing cold-related illnesses and their complications.
Read More
8
We observed that quercetin, a powerful antioxidant, plays a significant role in helping grapes withstand cold temperatures. In our study, we found that grapes exposed to low temperatures accumulate more quercetin, which in turn enhances their cold resistance.
By applying exogenous quercetin, we noted a marked improvement in the grapes' ability to endure low-temperature stress. Our research revealed that a key gene, VvFLS1, responsible for quercetin synthesis is upregulated when grapes experience cold conditions.
We also discovered that VvbZIP22, a protein that binds to the VvFLS1 promoter, is crucial for mediating this process. When we overexpressed VvbZIP22 in grapes, it resulted in higher levels of quercetin and improved cold resistance, further confirming its pivotal role in the plant's adaptation to harsh environments.
Through these findings, we highlighted the importance of quercetin in enhancing grape survival during cold spells, showcasing a vital link between plant biology and climate resilience.
By applying exogenous quercetin, we noted a marked improvement in the grapes' ability to endure low-temperature stress. Our research revealed that a key gene, VvFLS1, responsible for quercetin synthesis is upregulated when grapes experience cold conditions.
We also discovered that VvbZIP22, a protein that binds to the VvFLS1 promoter, is crucial for mediating this process. When we overexpressed VvbZIP22 in grapes, it resulted in higher levels of quercetin and improved cold resistance, further confirming its pivotal role in the plant's adaptation to harsh environments.
Through these findings, we highlighted the importance of quercetin in enhancing grape survival during cold spells, showcasing a vital link between plant biology and climate resilience.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
No more sinusitis
121 people found this helpful
After suffering from chronic sinusitis and Eustachian tube dysfunction, I sought alternatives to antibiotics. Since using this product, I have experienced no sinusitis and clear ears. It’s effective for colds too, ensuring my sinuses remain clear. However, be cautious with dosage due to potential kidney issues.
Read More
7.5
Sinus issues improved
2 people found this helpful
I started taking these supplements in November, and my severe sinus problems have improved significantly. I’ve been cold-free since then. I will know for sure by April, but I genuinely believe it works.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Song JH, Mun SH, Mishra S, Kim SR, Yang H, et al. Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis. Biomol Ther (Seoul). 2025;33:388. 10.4062/biomolther.2024.204
- Liu G, Zhang Z, Tian Y, Yang J, Xu X, et al. VvbZIP22 regulates quercetin synthesis to enhances cold resistance in grape. Plant Sci. 2025;350:112293. 10.1016/j.plantsci.2024.112293
- Otani M, Ishii D, Iwata H, Satake Y, Okada Y, et al. Preservation Efficacy of a Quercetin and Sucrose Solution for Warm Ischemically Damaged Porcine Liver Grafts. Transplant Proc. 2023;55:2212. 10.1016/j.transproceed.2023.07.031
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