We investigated whether quercetin, a natural plant compound, could help combat common cold caused by rhinovirus (RV). In our study, quercetin reduced RV replication and inflammation in airway cells both in laboratory settings and in mice. When given before or after infection, quercetin limited the virus's ability to replicate and decreased harmful immune responses.
While our findings are promising, indicating that quercetin acts at various points in the virus's lifecycle, we recognize the need for further research to solidify its effectiveness in treating or preventing common colds.
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8
Quercetin shows promise against HRV2
Anti-human rhinovirus 2 activity and mode of action of quercetin-7-glucoside from Lagerstroemia speciosa.
We investigated how quercetin 7-glucoside (Q7G), sourced from Lagerstroemia speciosa, affects human rhinovirus 2 (HRV2), a leading cause of the common cold. Utilizing a method to reduce cytopathic effects, we found that Q7G significantly reduced HRV2 replication by blocking the virus's early infection stage.
Interestingly, compared to ribavirin, a known antiviral, Q7G showed stronger efficacy, suggesting its potential as a treatment for HRV2. While these results are promising, further research is needed to assess the practicality of using Q7G in common cold therapies.
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Quercetin's antiviral potential confirmed
Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis.
We explored the role of flavonoid compounds, like quercetin, in reducing the frequency and severity of upper respiratory tract infections (URTIs) in healthy adults. An in-depth review of 14 studies showed that flavonoid supplementation notably reduced the incidence of URTIs by 33% and sick days by 40%.
However, we noted that changes in immune markers were minimal, indicating that while there are advantages in reducing infections, the immune response may not be significantly affected.
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Quercetin reduces rhinovirus effects
Quercetin inhibits rhinovirus replication in vitro and in vivo.
We investigated whether quercetin, a natural plant compound, could help combat common cold caused by rhinovirus (RV). In our study, quercetin reduced RV replication and inflammation in airway cells both in laboratory settings and in mice. When given before or after infection, quercetin limited the virus's ability to replicate and decreased harmful immune responses.
While our findings are promising, indicating that quercetin acts at various points in the virus's lifecycle, we recognize the need for further research to solidify its effectiveness in treating or preventing common colds.
Read More
8
Quercetin's antiviral potential confirmed
Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis.
We explored the effects of quercetin-3-methyl ether, a natural flavonoid, on the common cold virus, specifically human rhinovirus 1B (HRV1B).
In our study, we found that this compound not only inhibited the virus's replication in human cells but also targeted the early stages of infection.
Additionally, quercetin enhanced early cell death to help combat the virus's immune evasion tactics.
While our findings highlight its potential as a new antiviral agent, further research is necessary to confirm its effectiveness in broader treatments.
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8
Quercetin shows promise against viruses
Effectiveness of supplementation with quercetin-type flavonols for treatment of viral lower respiratory tract infections: Systematic review and meta-analysis of preclinical studies.
We explored the effectiveness of quercetin-type flavonols in combating viral lower respiratory infections through a systematic review of 11 preclinical studies.
Our findings highlighted quercetin's impressive antiviral activity, showing lower mortality rates and reduced viral loads in infected animals.
Moreover, quercetin appeared to alleviate inflammation and mucus production, suggesting a multifaceted benefit for respiratory health. Overall, quercetin could be a promising option for those facing respiratory viral challenges.
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8
Quercetin shows promise against HRV2
Anti-human rhinovirus 2 activity and mode of action of quercetin-7-glucoside from Lagerstroemia speciosa.
We investigated how quercetin 7-glucoside (Q7G), sourced from Lagerstroemia speciosa, affects human rhinovirus 2 (HRV2), a leading cause of the common cold. Utilizing a method to reduce cytopathic effects, we found that Q7G significantly reduced HRV2 replication by blocking the virus's early infection stage.
Interestingly, compared to ribavirin, a known antiviral, Q7G showed stronger efficacy, suggesting its potential as a treatment for HRV2. While these results are promising, further research is needed to assess the practicality of using Q7G in common cold therapies.
Great product! I usually take it with zinc, and it helps combat Common Colds while keeping my immune system robust.
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6
Helpful for allergies
I used it to alleviate my cold allergies, and it was helpful.
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References
Song JH, Mun SH, Mishra S, Kim SR, Yang H, et al. Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis. Biomol Ther (Seoul). 2025;33:388. 10.4062/biomolther.2024.204
Cho H, Kim S, Lee SH, Park Y. Effect of onion ( L.) peel extract on natural killer cell and cytokines in a randomized, double-blind, placebo-controlled trial. Nutr Res Pract. 2024;18:33. 10.4162/nrp.2024.18.1.33
Brito JCM, Lima WG, Cordeiro LPB, da Cruz Nizer WS. Effectiveness of supplementation with quercetin-type flavonols for treatment of viral lower respiratory tract infections: Systematic review and meta-analysis of preclinical studies. Phytother Res. 2021;35:4930. 10.1002/ptr.7122
Xander N, Reddy Vari H, Eskandar R, Li W, Bolla S, et al. Rhinovirus-Induced SIRT-1 via TLR2 Regulates Subsequent Type I and Type III IFN Responses in Airway Epithelial Cells. J Immunol. 2019;203:2508. 10.4049/jimmunol.1900165
Somerville VS, Braakhuis AJ, Hopkins WG. Effect of Flavonoids on Upper Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis. Adv Nutr. 2016;7:488. 10.3945/an.115.010538
Song JH, Park KS, Kwon DH, Choi HJ. Anti-human rhinovirus 2 activity and mode of action of quercetin-7-glucoside from Lagerstroemia speciosa. J Med Food. 2013;16:274. 10.1089/jmf.2012.2290
Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, et al. Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral Res. 2012;94:258. 10.1016/j.antiviral.2012.03.005