Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Pantothenic Acid (as d-Calcium Pantothenate)
500 mg
10,000%
Calcium (as d-Calcium Pantothenate)
49 mg
4%
Top Medical Research Studies
9
TMEM16A targeting mitigates asthma
We explored how targeting TMEM16A, a calcium-activated chloride channel, can potentially improve asthma symptoms. In a thoughtfully designed study using guinea pigs with allergic asthma induced by ovalbumin, we treated the animals with a specific blocker, CaCCinh-A01, delivered through inhalation.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
Read More
7
Calcium channels and asthma response
This research delves into how certain calcium channels impact airway smooth muscle (ASM) contractions, particularly in relation to asthma and conditions like COPD. We found that the activation of M2 muscarinic receptors enhances the contractions caused by cholinergic nerve stimulation in ASM. This response was notably reversed when we used specific blockers, including nifedipine for L-type calcium channels and Ani9 for Ano1 calcium-activated chloride channels.
Our experiments showed that while the contraction response was sustained with carbachol, blocking M3 receptors transformed these contractions into oscillatory movements. However, when we looked closer at the effects of M2 receptors, we noticed that these oscillations disappeared entirely in M2 receptor knockout mice. This suggests a crucial role for M2 receptors in these processes.
Additionally, reducing the calcium buffering effect of sarcoplasmic endoplasmic reticulum Ca ATPases (SERCA) led to even greater contractions. It’s worth mentioning that our findings indicate a significant involvement of calcium channels in these reactions, pointing out the potential mechanisms behind allergic responses in asthma. Overall, while this study provides valuable insights into calcium’s role in ASM contractions, it does not specifically indicate that calcium treatments could effectively alleviate asthma symptoms on their own.
Our experiments showed that while the contraction response was sustained with carbachol, blocking M3 receptors transformed these contractions into oscillatory movements. However, when we looked closer at the effects of M2 receptors, we noticed that these oscillations disappeared entirely in M2 receptor knockout mice. This suggests a crucial role for M2 receptors in these processes.
Additionally, reducing the calcium buffering effect of sarcoplasmic endoplasmic reticulum Ca ATPases (SERCA) led to even greater contractions. It’s worth mentioning that our findings indicate a significant involvement of calcium channels in these reactions, pointing out the potential mechanisms behind allergic responses in asthma. Overall, while this study provides valuable insights into calcium’s role in ASM contractions, it does not specifically indicate that calcium treatments could effectively alleviate asthma symptoms on their own.
Read More
Most Useful Reviews
7.5
Improves breathing
After battling back acne for years, this vitamin helped reduce breakouts, and I also noticed significant improvement in my breathing quality due to asthma. Stress management also benefited as it regulates cortisol levels.
Read More
9
Effective for allergies
10 people found this helpful
This vitamin significantly helped my husband, who had asthma and allergies to dogs. Following its use, his allergy symptoms have diminished considerably. I highly recommend it, particularly pantethine as an alternative, although it is more expensive.
Read More
9
Asthma relief
6 people found this helpful
This vitamin has proven effective for my asthma attacks and works well alongside vitamin C. It's incredibly beneficial for my adrenal health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
9
TMEM16A targeting mitigates asthma
We explored how targeting TMEM16A, a calcium-activated chloride channel, can potentially improve asthma symptoms. In a thoughtfully designed study using guinea pigs with allergic asthma induced by ovalbumin, we treated the animals with a specific blocker, CaCCinh-A01, delivered through inhalation.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
Read More
7
Calcium channels and asthma response
This research delves into how certain calcium channels impact airway smooth muscle (ASM) contractions, particularly in relation to asthma and conditions like COPD. We found that the activation of M2 muscarinic receptors enhances the contractions caused by cholinergic nerve stimulation in ASM. This response was notably reversed when we used specific blockers, including nifedipine for L-type calcium channels and Ani9 for Ano1 calcium-activated chloride channels.
Our experiments showed that while the contraction response was sustained with carbachol, blocking M3 receptors transformed these contractions into oscillatory movements. However, when we looked closer at the effects of M2 receptors, we noticed that these oscillations disappeared entirely in M2 receptor knockout mice. This suggests a crucial role for M2 receptors in these processes.
Additionally, reducing the calcium buffering effect of sarcoplasmic endoplasmic reticulum Ca ATPases (SERCA) led to even greater contractions. It’s worth mentioning that our findings indicate a significant involvement of calcium channels in these reactions, pointing out the potential mechanisms behind allergic responses in asthma. Overall, while this study provides valuable insights into calcium’s role in ASM contractions, it does not specifically indicate that calcium treatments could effectively alleviate asthma symptoms on their own.
Our experiments showed that while the contraction response was sustained with carbachol, blocking M3 receptors transformed these contractions into oscillatory movements. However, when we looked closer at the effects of M2 receptors, we noticed that these oscillations disappeared entirely in M2 receptor knockout mice. This suggests a crucial role for M2 receptors in these processes.
Additionally, reducing the calcium buffering effect of sarcoplasmic endoplasmic reticulum Ca ATPases (SERCA) led to even greater contractions. It’s worth mentioning that our findings indicate a significant involvement of calcium channels in these reactions, pointing out the potential mechanisms behind allergic responses in asthma. Overall, while this study provides valuable insights into calcium’s role in ASM contractions, it does not specifically indicate that calcium treatments could effectively alleviate asthma symptoms on their own.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improves breathing
After battling back acne for years, this vitamin helped reduce breakouts, and I also noticed significant improvement in my breathing quality due to asthma. Stress management also benefited as it regulates cortisol levels.
Read More
9
Effective for allergies
10 people found this helpful
This vitamin significantly helped my husband, who had asthma and allergies to dogs. Following its use, his allergy symptoms have diminished considerably. I highly recommend it, particularly pantethine as an alternative, although it is more expensive.
Read More
9
Asthma relief
6 people found this helpful
This vitamin has proven effective for my asthma attacks and works well alongside vitamin C. It's incredibly beneficial for my adrenal health.
Read More
Frequently Asked Questions
7.5
Improves breathing
After battling back acne for years, this vitamin helped reduce breakouts, and I also noticed significant improvement in my breathing quality due to asthma. Stress management also benefited as it regulates cortisol levels.
9
Effective for allergies
10 people found this helpful
This vitamin significantly helped my husband, who had asthma and allergies to dogs. Following its use, his allergy symptoms have diminished considerably. I highly recommend it, particularly pantethine as an alternative, although it is more expensive.
9
Asthma relief
6 people found this helpful
This vitamin has proven effective for my asthma attacks and works well alongside vitamin C. It's incredibly beneficial for my adrenal health.
9
TMEM16A targeting mitigates asthma
We explored how targeting TMEM16A, a calcium-activated chloride channel, can potentially improve asthma symptoms. In a thoughtfully designed study using guinea pigs with allergic asthma induced by ovalbumin, we treated the animals with a specific blocker, CaCCinh-A01, delivered through inhalation.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
7
Calcium channels and asthma response
This research delves into how certain calcium channels impact airway smooth muscle (ASM) contractions, particularly in relation to asthma and conditions like COPD. We found that the activation of M2 muscarinic receptors enhances the contractions caused by cholinergic nerve stimulation in ASM. This response was notably reversed when we used specific blockers, including nifedipine for L-type calcium channels and Ani9 for Ano1 calcium-activated chloride channels.
Our experiments showed that while the contraction response was sustained with carbachol, blocking M3 receptors transformed these contractions into oscillatory movements. However, when we looked closer at the effects of M2 receptors, we noticed that these oscillations disappeared entirely in M2 receptor knockout mice. This suggests a crucial role for M2 receptors in these processes.
Additionally, reducing the calcium buffering effect of sarcoplasmic endoplasmic reticulum Ca ATPases (SERCA) led to even greater contractions. It’s worth mentioning that our findings indicate a significant involvement of calcium channels in these reactions, pointing out the potential mechanisms behind allergic responses in asthma. Overall, while this study provides valuable insights into calcium’s role in ASM contractions, it does not specifically indicate that calcium treatments could effectively alleviate asthma symptoms on their own.
Our experiments showed that while the contraction response was sustained with carbachol, blocking M3 receptors transformed these contractions into oscillatory movements. However, when we looked closer at the effects of M2 receptors, we noticed that these oscillations disappeared entirely in M2 receptor knockout mice. This suggests a crucial role for M2 receptors in these processes.
Additionally, reducing the calcium buffering effect of sarcoplasmic endoplasmic reticulum Ca ATPases (SERCA) led to even greater contractions. It’s worth mentioning that our findings indicate a significant involvement of calcium channels in these reactions, pointing out the potential mechanisms behind allergic responses in asthma. Overall, while this study provides valuable insights into calcium’s role in ASM contractions, it does not specifically indicate that calcium treatments could effectively alleviate asthma symptoms on their own.
References
- Ghosh S, Alkawadri T, McGarvey LP, Hollywood MA, Thornbury KD, et al. Role of voltage-gated Ca channels and Ano1 Ca-activated Cl channels in M2 muscarinic receptor-dependent contractions of murine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2025;328:L301. 10.1152/ajplung.00188.2024
- Mažerik J, Gondáš E, Dohál M, Smieško L, Jošková M, et al. Targeting TMEM16A ion channels suppresses airway hyperreactivity, inflammation, and remodeling in an experimental Guinea pig asthma model. J Pharmacol Sci. 2024;156:239. 10.1016/j.jphs.2024.10.004
