Last update
5/24/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.8
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Serving Per Container: 120
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Top Medical Research Studies
0
CoQ10 ineffective for mitochondrial sleep apnea
We examined a rare case of mitochondrial encephalomyopathy featuring multiple complications including sleep apnea, cerebellar ataxia, and peripheral neuropathy—a combination never before documented in medical literature. The patient received six months of coenzyme Q10 therapy to address the underlying mitochondrial dysfunction.
Unfortunately, the treatment proved ineffective. Neither the cerebellar ataxia nor the abnormal pyruvate metabolism improved with CoQ10 supplementation. While sleep apnea was identified as a significant prognostic factor in this mitochondrial disorder, the supplement failed to alleviate this serious breathing complication or other associated symptoms.
Unfortunately, the treatment proved ineffective. Neither the cerebellar ataxia nor the abnormal pyruvate metabolism improved with CoQ10 supplementation. While sleep apnea was identified as a significant prognostic factor in this mitochondrial disorder, the supplement failed to alleviate this serious breathing complication or other associated symptoms.
Read More
9.5
Coenzyme Q10 in sleep apnea study
We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
Read More
Most Useful Reviews
9
Improved sleep quality
3 people found this helpful
Useful, I have AIT. Thanks to iHerb and the reviews, I decided to order Q10 100mg. In the first week, I felt a bit strange, with a buzzing in my head. However, I then felt rejuvenated; my sleep returned to normal, and I wake joyfully in the morning (anyone with AIT will understand). I have ample energy now, no longer feel drowsy during the day, and, crucially, my blood pressure normalised. On the advice of Omega, I also take MK 7 and D. I genuinely appreciate the improvements in my quality of life.
Read More
9
Improved mood and memory
1 people found this helpful
Appointed by the doctor, this worked wonderfully for my 80-year-old mother. It improved her memory, sleep, and mood significantly!
Read More
9
Reduced palpitations
I trust this brand. The formula of this Q10 is very safe, which is a significant reason for my choice. I recommend that individuals over 40 start supplementing with coenzyme Q10, as mitochondrial energy demands increase with age. I have Hashimoto’s and occasionally experience heart palpitations at night; however, it’s remarkable that as long as I take Q10, the palpitations vanish! For a healthy person, one capsule is usually sufficient; if heart function is subpar, two capsules can be taken.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.8
- All Researches
9.5
Coenzyme Q10 in sleep apnea study
We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).
Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
Read More
0
CoQ10 ineffective for mitochondrial sleep apnea
We examined a rare case of mitochondrial encephalomyopathy featuring multiple complications including sleep apnea, cerebellar ataxia, and peripheral neuropathy—a combination never before documented in medical literature. The patient received six months of coenzyme Q10 therapy to address the underlying mitochondrial dysfunction.
Unfortunately, the treatment proved ineffective. Neither the cerebellar ataxia nor the abnormal pyruvate metabolism improved with CoQ10 supplementation. While sleep apnea was identified as a significant prognostic factor in this mitochondrial disorder, the supplement failed to alleviate this serious breathing complication or other associated symptoms.
Unfortunately, the treatment proved ineffective. Neither the cerebellar ataxia nor the abnormal pyruvate metabolism improved with CoQ10 supplementation. While sleep apnea was identified as a significant prognostic factor in this mitochondrial disorder, the supplement failed to alleviate this serious breathing complication or other associated symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved sleep quality
3 people found this helpful
Useful, I have AIT. Thanks to iHerb and the reviews, I decided to order Q10 100mg. In the first week, I felt a bit strange, with a buzzing in my head. However, I then felt rejuvenated; my sleep returned to normal, and I wake joyfully in the morning (anyone with AIT will understand). I have ample energy now, no longer feel drowsy during the day, and, crucially, my blood pressure normalised. On the advice of Omega, I also take MK 7 and D. I genuinely appreciate the improvements in my quality of life.
Read More
9
Improved mood and memory
1 people found this helpful
Appointed by the doctor, this worked wonderfully for my 80-year-old mother. It improved her memory, sleep, and mood significantly!
Read More
9
Reduced palpitations
I trust this brand. The formula of this Q10 is very safe, which is a significant reason for my choice. I recommend that individuals over 40 start supplementing with coenzyme Q10, as mitochondrial energy demands increase with age. I have Hashimoto’s and occasionally experience heart palpitations at night; however, it’s remarkable that as long as I take Q10, the palpitations vanish! For a healthy person, one capsule is usually sufficient; if heart function is subpar, two capsules can be taken.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Tatsumi C, Takahashi M, Yorifuji S, Nishikawa Y, Kitaguchi M, et al. Mitochondrial encephalomyopathy with sleep apnea. Eur Neurol. 1988;28:64. PubMed
- Mermigkis C, Bouloukaki I, Mastorodemos V, Plaitakis A, Alogdianakis V, et al. Medical treatment with thiamine, coenzyme Q, vitamins E and C, and carnitine improved obstructive sleep apnea in an adult case of Leigh disease. Sleep Breath. 2013;17:1129. 10.1007/s11325-013-0816-5
