Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
9
We examined the effects of silibinin, a component of the milk thistle plant, on memory impairment linked to amyloid beta-induced oxidative stress in mice. After administering silibinin alongside amyloid beta, we observed promising results; silibinin appeared to prevent memory loss and reduced oxidative damage in the mice's brains.
Our findings suggest that silibinin could be a beneficial treatment for protecting against cognitive decline in Alzheimer's disease. This could open new pathways in the search for effective therapies.
Our findings suggest that silibinin could be a beneficial treatment for protecting against cognitive decline in Alzheimer's disease. This could open new pathways in the search for effective therapies.
Read More
9
We explored how silibinin, derived from Silybum marianum, may help combat Alzheimer's disease, particularly the sporadic form that affects most patients. Using a model involving murine hippocampal neurons and rats, we found that silibinin improves cell survival and reduces cognitive decline linked to Alzheimer's.
Those treated with silibinin displayed a notable decrease in neuroinflammation and oxidative stress—two key contributors to Alzheimer’s. It achieves this by regulating proteins involved in cell death. However, it remains essential to continue research to fully understand its benefits and mechanisms before considering practical applications.
Those treated with silibinin displayed a notable decrease in neuroinflammation and oxidative stress—two key contributors to Alzheimer’s. It achieves this by regulating proteins involved in cell death. However, it remains essential to continue research to fully understand its benefits and mechanisms before considering practical applications.
Read More
9
We investigated how silibinin, a compound from Silybum marianum, influences Alzheimer’s disease by targeting N-methyl-D-aspartate receptors (NMDARs). Through various tests on rat models and neurons, we found that silibinin can protect against cell damage caused by streptozotocin (STZ), while specifically inhibiting the GluN2B subunit of NMDARs. This inhibition may help improve learning and memory by positively affecting signaling pathways related to brain function, showcasing silibinin's potential in Alzheimer’s treatment.
Read More
Most Useful Reviews
8.3
Neuroprotective properties
Since ancient times, milk thistle has been used for neurological diseases. Today, it treats conditions like Parkinson's and Alzheimer’s. Its anti-inflammatory and antioxidant properties may provide neuroprotective effects.
Read More
8.8
Potential benefits noted
I ordered this milk thistle product and will review it after testing. Milk thistle is believed to support liver health and may help with Alzheimer's by reducing oxidative factors. It also has potential benefits for skin, asthma, cognition, immune function, blood sugar control, heart health, and weight loss. Though there are side effects like bloating and nausea, I look forward to exploring its benefits.
Read More
8.8
Support for liver
This really works! It helps my mum’s liver and resolves her indigestion after meals. I've heard it might slow down the progression of Alzheimer's too. I hope it proves effective!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
- All Researches
9
We explored how silibinin, derived from Silybum marianum, may help combat Alzheimer's disease, particularly the sporadic form that affects most patients. Using a model involving murine hippocampal neurons and rats, we found that silibinin improves cell survival and reduces cognitive decline linked to Alzheimer's.
Those treated with silibinin displayed a notable decrease in neuroinflammation and oxidative stress—two key contributors to Alzheimer’s. It achieves this by regulating proteins involved in cell death. However, it remains essential to continue research to fully understand its benefits and mechanisms before considering practical applications.
Those treated with silibinin displayed a notable decrease in neuroinflammation and oxidative stress—two key contributors to Alzheimer’s. It achieves this by regulating proteins involved in cell death. However, it remains essential to continue research to fully understand its benefits and mechanisms before considering practical applications.
Read More
9
We investigated how silibinin, a compound from Silybum marianum, influences Alzheimer’s disease by targeting N-methyl-D-aspartate receptors (NMDARs). Through various tests on rat models and neurons, we found that silibinin can protect against cell damage caused by streptozotocin (STZ), while specifically inhibiting the GluN2B subunit of NMDARs. This inhibition may help improve learning and memory by positively affecting signaling pathways related to brain function, showcasing silibinin's potential in Alzheimer’s treatment.
Read More
9
We observed that isosilybin, a compound from Silybum marianum, could help reduce oxidative stress linked to Alzheimer's disease. In our study, isosilybin significantly decreased harmful reactive oxygen species and other markers of cell damage in HT-22 hippocampal cells.
It also boosted the production of critical antioxidant proteins through the activation of NRF2/ARE signaling pathways. While the results are promising, it is important to note that the study mainly focused on cellular models, and further in vivo research is needed to confirm these findings in actual Alzheimer’s patients.
It also boosted the production of critical antioxidant proteins through the activation of NRF2/ARE signaling pathways. While the results are promising, it is important to note that the study mainly focused on cellular models, and further in vivo research is needed to confirm these findings in actual Alzheimer’s patients.
Read More
9
We examined the effects of silibinin, a component of the milk thistle plant, on memory impairment linked to amyloid beta-induced oxidative stress in mice. After administering silibinin alongside amyloid beta, we observed promising results; silibinin appeared to prevent memory loss and reduced oxidative damage in the mice's brains.
Our findings suggest that silibinin could be a beneficial treatment for protecting against cognitive decline in Alzheimer's disease. This could open new pathways in the search for effective therapies.
Our findings suggest that silibinin could be a beneficial treatment for protecting against cognitive decline in Alzheimer's disease. This could open new pathways in the search for effective therapies.
Read More
8
We explored the effects of silibinin, a compound from the milk thistle plant, on cognitive impairment related to Alzheimer's disease. By using a mouse model injected with formaldehyde, we administered silibinin orally for three weeks. The results indicated that silibinin significantly improved memory performance in various cognitive tests, suggesting its ability to reduce cognitive deficits.
While we found promising evidence of its antioxidative effects and potential in enhancing certain signaling pathways, the exact mechanisms remain unclear. Overall, silibinin holds potential as a candidate for improving cognitive health related to Alzheimer’s.
While we found promising evidence of its antioxidative effects and potential in enhancing certain signaling pathways, the exact mechanisms remain unclear. Overall, silibinin holds potential as a candidate for improving cognitive health related to Alzheimer’s.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Neuroprotective properties
Since ancient times, milk thistle has been used for neurological diseases. Today, it treats conditions like Parkinson's and Alzheimer’s. Its anti-inflammatory and antioxidant properties may provide neuroprotective effects.
Read More
8.8
Potential benefits noted
I ordered this milk thistle product and will review it after testing. Milk thistle is believed to support liver health and may help with Alzheimer's by reducing oxidative factors. It also has potential benefits for skin, asthma, cognition, immune function, blood sugar control, heart health, and weight loss. Though there are side effects like bloating and nausea, I look forward to exploring its benefits.
Read More
8.8
Support for liver
This really works! It helps my mum’s liver and resolves her indigestion after meals. I've heard it might slow down the progression of Alzheimer's too. I hope it proves effective!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liu P, Chen W, Kang Y, Wang C, Wang X, et al. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. Arch Biochem Biophys. 2023;744:109691. doi:10.1016/j.abb.2023.109691
- Liu P, Wang C, Chen W, Kang Y, Liu W, et al. Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models. Phytomedicine. 2023;109:154594. doi:10.1016/j.phymed.2022.154594
- Wei P, Li X, Wang S, Dong Y, Yin H, et al. Silibinin Ameliorates Formaldehyde-Induced Cognitive Impairment by Inhibiting Oxidative Stress. Oxid Med Cell Longev. 2022;2022:5981353. doi:10.1155/2022/5981353
- Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP. Impact of Silibinin A on Bioenergetics in PC12APP Cells and Mitochondrial Membrane Properties in Murine Brain Mitochondria. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10101520
- Liu P, Cui L, Liu B, Liu W, Hayashi T, et al. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiol Behav. 2020;213:112689. doi:10.1016/j.physbeh.2019.112689
- Nazir N, Karim N, Abdel-Halim H, Khan I, Wadood SF, et al. Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice. J Ethnopharmacol. 2018;210:198. doi:10.1016/j.jep.2017.08.026
- Song X, Liu B, Cui L, Zhou B, Liu W, et al. Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. Physiol Behav. 2017;179:487. doi:10.1016/j.physbeh.2017.07.023
- Zhou J, Chao G, Li Y, Wu M, Zhong S, et al. Activation of NRF2/ARE by isosilybin alleviates Aβ25-35-induced oxidative stress injury in HT-22 cells. Neurosci Lett. 2016;632:92. doi:10.1016/j.neulet.2016.08.043
- Duan S, Guan X, Lin R, Liu X, Yan Y, et al. Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer's disease. Neurobiol Aging. 2015;36:1792. doi:10.1016/j.neurobiolaging.2015.02.002
- Kumar J, Park KC, Awasthi A, Prasad B. Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model. CNS Neurol Disord Drug Targets. 2015;14:295.
- Zhang Y, Yang DH, Zhang YT, Chen XM, Li LL, et al. Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II. Fitoterapia. 2014;92:61. doi:10.1016/j.fitote.2013.10.001
- Yin F, Liu J, Ji X, Wang Y, Zidichouski J, et al. Silibinin: a novel inhibitor of Aβ aggregation. Neurochem Int. 2011;58:399. doi:10.1016/j.neuint.2010.12.017
- Lu P, Mamiya T, Lu LL, Mouri A, Zou L, et al. Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice. Br J Pharmacol. 2009;157:1270. doi:10.1111/j.1476-5381.2009.00295.x
