Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
8
We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
Read More
8
Silibinin shows promise in arthritis
We explored the impact of silibinin, derived from silybum marianum, on immune responses related to rheumatoid arthritis. The study included both healthy individuals and patients with active arthritis to assess how silibinin affects T cell functions.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Read More
8
We explored the potential benefits of milk thistle oil, known scientifically as Silybum marianum, in managing arthritis and providing antioxidant support. The study used oil extracted from seeds at different maturity stages and measured its effects using well-established tests for both antioxidant and anti-arthritic activities.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Read More
Most Useful Reviews
7.5
Reduced pain effectively
8 people found this helpful
Working. I have to take various supplements and medications due to arthritis. It's tough on my liver, but after a week of this product, I noticed a reduction in both weight and pain. I recommend it.
Read More
9
Improved liver tests
Silymarin is outstanding for liver support. A friend with arthritis saw improvements in her liver tests after taking it while on strong medication. I highly recommend it.
Read More
7.5
Liver protection noted
This helps protect my liver enzymes. I've been using it regularly for about four months while taking medication for arthritis, and it has made a positive difference.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
8
Silymarin shows potential for arthritis
We explored the potential benefits of silymarin and silibinin for managing rheumatoid arthritis (RA) and osteoarthritis (OA) symptoms through a systematic review of 21 relevant studies.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
Read More
8
Silibinin shows promise in arthritis
We explored the impact of silibinin, derived from silybum marianum, on immune responses related to rheumatoid arthritis. The study included both healthy individuals and patients with active arthritis to assess how silibinin affects T cell functions.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Our findings revealed that silibinin enhances ERβ expression, leading to increased apoptosis and decreased proliferation of T lymphocytes. Additionally, it reduced pro-inflammatory cytokines associated with arthritis and down-modulated miR-155, a key player in autoimmune processes.
While these results suggest that silibinin has potential as an immunosuppressive treatment tool, further research is necessary to fully understand its role in arthritis management.
Read More
8
We explored the potential benefits of milk thistle oil, known scientifically as Silybum marianum, in managing arthritis and providing antioxidant support. The study used oil extracted from seeds at different maturity stages and measured its effects using well-established tests for both antioxidant and anti-arthritic activities.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Our findings indicate that milk thistle oil demonstrates promising anti-arthritic properties, likely due to its policosanol content. This suggests that it could be a valuable natural alternative for people seeking relief from arthritis and related oxidative stress issues.
However, it's important to note that while results are encouraging, further research is necessary to fully understand its effectiveness and practical applications.
Read More
8
We examined the impact of silymarin, specifically the Livergol® tablet, on rheumatoid arthritis (RA) symptoms in a group of 44 stable patients over 90 days. Using the Disease Activity Score (DAS-28) to track changes, we found that adding silymarin to standard treatments led to a significant reduction in symptoms. The average scores dropped from 3.02 to 2.3, suggesting that silymarin may have anti-inflammatory and antioxidant benefits for RA patients. However, further research with larger samples and cytokine measurements is necessary to fully understand how it works.
Read More
8
We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced pain effectively
8 people found this helpful
Working. I have to take various supplements and medications due to arthritis. It's tough on my liver, but after a week of this product, I noticed a reduction in both weight and pain. I recommend it.
Read More
9
Improved liver tests
Silymarin is outstanding for liver support. A friend with arthritis saw improvements in her liver tests after taking it while on strong medication. I highly recommend it.
Read More
7.5
Liver protection noted
This helps protect my liver enzymes. I've been using it regularly for about four months while taking medication for arthritis, and it has made a positive difference.
Read More
7.5
Stress relief found
Excellent quality and ingredients. I purchased this to alleviate liver stress caused by my arthritis medication. It has helped reduce stress levels and aids in regulating bile.
Read More
7.5
Convenient dosage
I use Now Foods’ Liver Refresh alongside my other supplements for arthritis. It's a convenient capsule format and provides effective liver support while I monitor my health.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Ghahfarrokhi SH, Heidari-Soureshjani S, Sherwin CMT, Azadegan-Dehkordi Z. Efficacy and Mechanisms of , Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review. Curr Rheumatol Rev. 2024;20:414. doi:10.2174/0115733971266397231122080247
- Dupuis ML, Conti F, Maselli A, Pagano MT, Ruggieri A, et al. The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis. Front Immunol. 2018;9:1903. doi:10.3389/fimmu.2018.01903
- Harrabi S, Ferchichi A, Bacheli A, Fellah H. Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages. Lipids Health Dis. 2018;17:82. doi:10.1186/s12944-018-0682-z
- Shavandi M, Moini A, Shakiba Y, Mashkorinia A, Dehghani M, et al. Silymarin (Livergol®) Decreases Disease Activity Score in Patients with Rheumatoid Arthritis: A Non-randomized Single-arm Clinical Trial. Iran J Allergy Asthma Immunol. 2017;16:99.
- Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000;7:21.
