Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Pantothenic Acid (Vitamin B-5) (From Calcium Pantothenate)
500 mg
10,000%
Calcium (From Calcium Pantothenate)
45 mg
3%
The product is found useful for the following medical conditions
Adrenal Gland Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 246 Reviews
8.8
10
Support for stress
Most Useful Review
I have taken Pantothenic acid, 500 mg capsules for adrenal support for 30 years. I find it helps greatly with stress management. There are no issues with headaches or irritation. This nutrient aids in coping with daily stress, and I feel benefits within half an hour. Combining it with Ester C boosts its effectiveness.
Brain Tumor details
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
USERS' SCORE
Good
Based on 5 Reviews
8.8
9
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
9.5
Effective natural remedy
Most Useful Review
My daughter was diagnosed with ADHD several years ago, and I was initially opposed to medication. My husband, knowledgeable about natural supplements, introduced her to DMAE and Pantothenic Acid (Vitamin B5), which seem to work better than any ADHD medication available. Now at 16, she takes 3 DMAE 250mg capsules and 3 Pantothenic Acid 500mg capsules daily. The difference is noticeable; everyone can tell when she hasn’t taken her vitamins!
Food Poisoning details
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
USERS' SCORE
Good
Based on 10 Reviews
8.8
9
Calcium's importance in spore germination
We explored how calcium affects spore germination, which is crucial in the context of food poisoning. The research aimed to understand if calcium, particularly in a complex with dipicolinic acid (Ca-DPA), could initiate spore germination, as previous studies suggested it played a vital role.
Through our experiments, we observed that while Ca-DPA effectively stimulated spore germination, dipicolinic acid alone did not produce the same effect. This indicates that calcium is essential for promoting germination. Moreover, we found that not only calcium salts but also other divalent cations like manganese and magnesium contributed to this process, while zinc did not.
Interestingly, the study revealed that endogenous calcium and magnesium stored within spores were not critical for germination induction. Instead, it was the external calcium and manganese that proved necessary. Overall, our findings suggest that exogenous sources of divalent cations are more significant in triggering spore germination than the spores' internal reserves.
Through our experiments, we observed that while Ca-DPA effectively stimulated spore germination, dipicolinic acid alone did not produce the same effect. This indicates that calcium is essential for promoting germination. Moreover, we found that not only calcium salts but also other divalent cations like manganese and magnesium contributed to this process, while zinc did not.
Interestingly, the study revealed that endogenous calcium and magnesium stored within spores were not critical for germination induction. Instead, it was the external calcium and manganese that proved necessary. Overall, our findings suggest that exogenous sources of divalent cations are more significant in triggering spore germination than the spores' internal reserves.
9.5
Improved skin health
Most Useful Review
This amazing supplement helps with my adult hormonal cystic acne. I tried numerous topicals and used Differin for a year, yet nothing delivered such impressive results. I've cut down on sugar, milk, and caffeine while taking 2.5g (5 capsules) twice daily before meals. It has also aided in bowel healing, soothing my skin, reducing redness, and even calming my mood. This is truly a treasure!
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 694 Reviews
8.7
4
We explored the role of extracellular calcium and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) in the functioning of sebaceous glands, with a focus on their implications for acne treatment. In our study, we looked at how different concentrations of calcium affect the morphology, cell count, and lipid production of SZ95 sebocytes, both in controlled lab conditions and in clinical observations of acne patients.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
Our findings revealed that when exposed to low levels of calcium, there was an increase in lipogenesis—this means the cells produced more lipids or oils. However, as we raised the extracellular calcium levels, we noted that the number of sebocytes increased, and their shape became more like epithelial cells, while lipid production decreased. Importantly, low calcium also led to a decrease in E-cadherin, a protein vital for cell adherence, which seemed to correlate with increased cell detachment and apoptosis, or cell death.
We also noted that 1,25(OH)2D3 appears to suppress oil production while simultaneously triggering autophagy, a process that helps cells clean out damaged components. In the clinical study involving acne patients, we observed no significant abnormalities in serum calcium levels, but younger patients had lower 1,25(OH)2D3 levels than older individuals.
This suggests that both calcium and vitamin D have a role in acne development, but there wasn't a clear, standalone benefit of calcium treatment for managing acne. Instead, the combination of increased calcium and decreased vitamin D might contribute to the problems seen in younger patients with acne. Overall, our research highlights the complex interplay between these nutrients and sebaceous gland function, offering important insights for potential acne therapies.
9.5
Significant acne reduction
Most Useful Review
Thank GOD my terrible acne face improved finally after 12 years! I struggled with oily skin and painful acne since the age of 15. It's been very depressing feeling antisocial and often being stared at. Despite trying numerous remedies, my skin remained oily, red, and covered in large acne. Thankfully, after taking pantothenic acid for about three weeks, I noticed my oiliness decreased significantly, and my acne healed much more quickly than before. By the third week, I was taking 7g daily and enjoyed a remarkable reduction in both oiliness and acne; I now have fewer than six red bumps. Although I still have scars and large pores, I'm content with the improvements!
Autoimmune Disorder details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 18 Reviews
8.7
9.5
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
10
Acne cleared completely
Most Useful Review
I achieved complete clearance of my cystic acne within 6 months thanks to pantothenic acid, which significantly reduced sebum production. Starting at 1000 mg daily for 3 months allowed my acne to decrease by 70-80%. Increasing my dosage to 1500 mg daily cleared my skin almost entirely. I've been on it for nearly a year now, and my skin remains clear.
Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.7
9.5
Minimises discomfort
Most Useful Review
Great! I take this when I have a cold sore. It works wonderfully to reduce both discomfort and duration.
Eczema details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.3
USERS' SCORE
Good
Based on 4 Reviews
8.7
5
We explored the connection between dietary calcium intake and the occurrence of eczema in adults using data from the National Health and Nutrition Examination Survey conducted in 2005-2006. Our aim was to see if there’s a relationship between how much calcium adults consume and the likelihood of developing eczema, a common skin condition.
In this observational study, we analyzed responses from 4,086 adults, of whom 266 reported having eczema. Our statistical analysis revealed an interesting pattern: we found that individuals in the third quartile of calcium intake had a significantly higher risk of eczema compared to those in the first quartile. Essentially, our results suggested that as dietary calcium intake increased, so did the prevalence of eczema—up to a certain point.
We identified an inverted U-shaped relationship between calcium intake and eczema prevalence. Specifically, an increase in calcium intake was associated with a higher occurrence of eczema until calcium levels reached a logarithmic value of 7.089. Thus, moderating calcium intake may help reduce the incidence of eczema.
These findings indicate that while calcium is essential for health, excessive consumption may not always be beneficial, particularly in relation to skin conditions like eczema. Further research is necessary to explore this relationship more deeply and determine the best levels of calcium intake for preventing eczema.
In this observational study, we analyzed responses from 4,086 adults, of whom 266 reported having eczema. Our statistical analysis revealed an interesting pattern: we found that individuals in the third quartile of calcium intake had a significantly higher risk of eczema compared to those in the first quartile. Essentially, our results suggested that as dietary calcium intake increased, so did the prevalence of eczema—up to a certain point.
We identified an inverted U-shaped relationship between calcium intake and eczema prevalence. Specifically, an increase in calcium intake was associated with a higher occurrence of eczema until calcium levels reached a logarithmic value of 7.089. Thus, moderating calcium intake may help reduce the incidence of eczema.
These findings indicate that while calcium is essential for health, excessive consumption may not always be beneficial, particularly in relation to skin conditions like eczema. Further research is necessary to explore this relationship more deeply and determine the best levels of calcium intake for preventing eczema.
9.5
Reduced skin stiffness
Most Useful Review
Fantastic! My eczema has drastically decreased, and the stiffness of my greasy skin has improved over time. The reduction in skin stiffness has been remarkable since I began using this product alongside glutathione.
Gout details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.7
9.5
Manages symptoms
Most Useful Review
It keeps gout at bay; a great and good quality product. I bought it for my husband, who suffers from occasional gout. He takes one tablet a week, and it seems to help. He increases to three a week if he feels a bout coming on due to stress or a protein-rich diet.
Hair Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 33 Reviews
8.7
9.5
Improved scalp environment
Most Useful Review
Pantothenic acid, a member of the B vitamin family, supports the metabolism of proteins, carbohydrates, and fats. A 500mg dosage aids in female androgenetic alopecia and male pattern baldness by suppressing excessive sebum production and preventing hair loss and thinning. Besides enhancing hair growth, it can also beautify the skin by preventing roughness and acne. It raises good cholesterol, eliminates bad cholesterol, and boosts blood circulation, thus improving hair quality by better distributing nutrients and oxygen to the scalp.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.7
9.5
Reduces stiffness
Most Useful Review
REDUCES MORNING STIFFNESS & PAIN I have rheumatoid arthritis affecting various joints, particularly my wrists and lower back. I came across articles on medicinal approaches for RA pain relief, including Pantothenic Acid. After taking one capsule daily with dinner for a few days, I've noticed a significant reduction in morning stiffness and pain. I used to feel stiff after sitting for a while, but that has improved! This natural method aids my RA, especially in my wrists, though it’s not a complete solution. For more insight, check my reviews, including Doctor’s Best "Curcumin C3 Complex", Now “Opti-Zinc”, and Now “EGCg-Green Tea”.
Reflux details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
We examined a combination product of carbonate antacids—specifically calcium carbonate and magnesium carbonate—with an extract from Opuntia ficus-indica, commonly known as prickly pear. This study looked at how this product could potentially protect esophageal cells from damage caused by both acidic and non-acidic reflux.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
9.5
Symptom relief
Most Useful Review
Because I have a sensitive stomach, I take it with greasy foods and when I take niacin. I initially purchased it to prevent irritability, but it appears to be more effective for easing stomach upset. My reflux esophagitis has significantly improved.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.7
9.5
Sleep improvement
Most Useful Review
I've been taking 1500 mg of this adrenal extract twice daily for insomnia for three weeks. Now, I'm enjoying 7-9 hours of sleep, which feels heavenly! I’ve been advised that once my sleep pattern is stable, I may taper off or stop these supplements.
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Swelling reduction
Most Useful Review
I take Vitamin B5 for my adrenal glands alongside inositol, and I've found that the swelling has subsided significantly. The diuretic effect is quite strong.
Acne Rosacea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.6
8.3
Decreased acne
Most Useful Review
I have noticed a marked decrease in my acne. Since entering my 40s, I developed acne rosacea, which was worsening recently. However, after the acne vanished, I saw a review and decided to purchase this product. I took one capsule a day, and within a week, I felt a significant improvement.
Allergies details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8.6
10
Relieved allergies
Most Useful Review
Wonderful! My allergies have been relieved!
Athlete’s Foot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Heat relief
Most Useful Review
Excellent! It arrived quickly at a very affordable price, with a large pot containing 250 capsules of 500mg. It was well packaged and sealed, and I wasn't taxed upon delivery. I purchased it for 240 reais, paying 18 reais for shipping plus 15 IOF. This well-regarded brand is effective. I've been taking one capsule daily to thicken my hair, and after just a week, the heat I experienced in my feet at night has ceased. Dr. Lair Ribeiro recommended it.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 25 Reviews
8.6
9.5
Positive mind shift
Most Useful Review
Upon starting pantothenic acid, I felt lighter the next morning. Continuously taking it improved my mood and eliminated the dullness I experienced, proving effective for my adrenal fatigue. My mind feels more positive, and I appreciate how it has contributed to my overall well-being.
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Notable energy increase
Most Useful Review
This pantothenic acid from NOW Foods is of exceptional quality and its ingredients are reliable. The package arrived in perfect condition and is well sealed. Since I started using it, I've noticed a substantial increase in my energy along with an improvement in my metabolism, making me feel significantly better daily. Additionally, it supports the nervous system and enhances the effects of folic acid, which is beneficial. It has also mitigated the flushing caused by niacin, which previously troubled me. I will certainly continue taking this product at any age and highly recommend it!
Headache details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
We explored the connection between calcium treatment and headaches, particularly in patients with reversible cerebral vasoconstriction syndrome (RCVS). In this case, we observed a healthy young woman who had been using escitalopram for a long time. She presented with bilateral neurological deficits, and after treatment with intra-arterial calcium channel blockers, her symptoms improved significantly.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
9.5
Headaches alleviated
Most Useful Review
I wanted to meet my expectations sooner. I bought this after hearing about its ability to suppress sebum. I take 12 tablets a day, and after two months, I no longer have a shiny face or worry about acne. On bad days, I used to experience headaches and low blood pressure, but since I started taking this product, I have been headache-free. I'm keen to continue using it!
Heart Attack details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
We explored how calcium signaling influences heart cell proliferation, particularly after injuries like heart attacks. Our study centered on the L-Type Calcium Channel (LTCC) and how its inhibition might help heart cells regenerate. Remarkably, when we inhibited LTCC—either through pharmacological means or by enhancing the activity of an inherent inhibitor called RRAD—we observed significant boosts in heart cell activity.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
9.5
Stress-free life
Most Useful Review
God answered my prayers. I used to constantly seek out restrooms to wipe away excessive facial oil, feeling embarrassed no matter the delicious food before me. My hands were perpetually moist, attempting to absorb this oil. Despite my normal lifestyle and good family skin, I found myself scratching at the oozing sebum, feeling helpless. Now, thanks to "Pantothenic acid," I experience a significant reduction in my oiliness, leading to a more stress-free life. My load has lifted, leaving me exhilarated during days when everything feels special.
Hypothyroidism details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 3 Reviews
8.6
3
We aimed to understand how calcium levels in saliva are affected in individuals with hypothyroidism. As one of the most common thyroid disorders, hypothyroidism can lead to various oral health issues, including a higher likelihood of dental caries and periodontal disease.
Our study measured the salivary calcium levels in patients diagnosed with hypothyroidism and found that these levels were significantly lower compared to healthy individuals. It's important to note, however, that we did not find any meaningful connections between the salivary calcium concentrations and the levels of thyroid hormones (TSH and T4) in the blood.
While a decrease in salivary calcium might explain the increased dental problems in hypothyroidism patients, the study did not explore any potential benefits of calcium treatment for this condition. Thus, it remains unclear whether calcium supplementation could effectively improve the overall health outcomes associated with hypothyroidism.
Our study measured the salivary calcium levels in patients diagnosed with hypothyroidism and found that these levels were significantly lower compared to healthy individuals. It's important to note, however, that we did not find any meaningful connections between the salivary calcium concentrations and the levels of thyroid hormones (TSH and T4) in the blood.
While a decrease in salivary calcium might explain the increased dental problems in hypothyroidism patients, the study did not explore any potential benefits of calcium treatment for this condition. Thus, it remains unclear whether calcium supplementation could effectively improve the overall health outcomes associated with hypothyroidism.
9.5
Excellent product
Most Useful Review
An excellent product for hypothyroidism. It is unfortunate that I can't purchase it any longer.
Kidney Stones details
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 2 Reviews
8.6
5
We explored the connections between calcium levels and kidney stones using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2013 to 2018, along with more advanced genetic analyses. Our aim was to understand how the levels of 25-hydroxyvitamin D, calcium, and alkaline phosphatase (ALP) might influence the risk of developing kidney stones.
While observational analyses suggested a relationship between ALP levels and kidney stones, we found that calcium levels did not display a significant association with kidney stones when looking at the data directly. However, utilizing Mendelian randomization analysis, we observed a potential causal link, indicating that elevated calcium levels could indeed raise the risk of developing kidney stones.
The key takeaway from our research is that while observational studies show no strong link between calcium and kidney stones, our genetic analysis implies that higher calcium may contribute to stone formation. Our work provides valuable insights and directions for future studies focused on preventing and treating this painful condition.
While observational analyses suggested a relationship between ALP levels and kidney stones, we found that calcium levels did not display a significant association with kidney stones when looking at the data directly. However, utilizing Mendelian randomization analysis, we observed a potential causal link, indicating that elevated calcium levels could indeed raise the risk of developing kidney stones.
The key takeaway from our research is that while observational studies show no strong link between calcium and kidney stones, our genetic analysis implies that higher calcium may contribute to stone formation. Our work provides valuable insights and directions for future studies focused on preventing and treating this painful condition.
9
Supports kidney function
Most Useful Review
Working to support the kidneys, this vitamin B is effective. For those sceptical about its benefits for the kidneys, I recommend researching further; you might be surprised. If you appreciated my review, please click "yes".
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
9.5
Leg cramps relieved
Most Useful Review
I have been taking Pantothenic Acid for RLS, and it works brilliantly. Combined with B-100 and Cellmins Potassium & Magnesium, I can finally sleep through the night without my legs jumping. This treatment has been effective both day and night.
Nausea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Nausea improved
Most Useful Review
Very pleased! Fast delivery, high-quality and convenient packaging, with nothing damaged. The capsules are a bit large, but swallowing isn’t an issue; they taste like citrus, and I enjoy taking them. I take 1 capsule daily with meals, alongside vitamin D3+K2, magnesium, and vitamin B6. After 10 days, I've begun to notice benefits; I used to suffer from frequent headaches, nausea, and fatigue throughout the day. Now, my energy has increased, headaches have ceased, and my mood is excellent. I recommend it, particularly for those interested in fitness or adhering to a diet.
Rosacea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.6
8.3
Significant improvement
Most Useful Review
I have seen a decrease in my acne. Since entering my 40s, I developed rosacea, which had recently worsened. After the acne cleared, I watched a review and decided to purchase this product. I took one capsule a day, and I felt a noticeable improvement within about a week.
Weight Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.6
8.8
Positive weight loss
Most Useful Review
I would like to share my review of pantothenic acid, which I have used before and ordered again. Pantothenic acid, or vitamin B5, is essential for our body, playing an important role in the metabolism of carbohydrates, fats, and proteins, as well as in energy production. Since I began taking it, I have noticed positive changes in my weight loss process. Additionally, it improved my digestion, helping me absorb nutrients better and reducing bloating after meals. My hair has become stronger and shinier, and there's been less hair loss. My skin is also healthier and less prone to acne. Pantothenic acid was safe for me, and I recommend it for those seeking natural ways to support healthy skin and hair.
Anxiety details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
9.5
Reduced anxiety
Most Useful Review
I have been advised by my therapist that this may significantly reduce anxiety.
Arthritis details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
8.8
Relieves arthritis pain
Most Useful Review
The dietary supplement is relatively safe but could be cleaner. Pantothenic acid effectively relieves arthritis pain and supports overall health during illnesses.
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
Supports adrenal function
Most Useful Review
A staple for adrenal health and appearance; this B vitamin, B5, truly improves one's facial appearance. It assists with adrenal function and anxiety, particularly for those enduring chronic stress. Dr. Axe states that it's essential for those with adrenal fatigue. Vitamin B5 plays a role in cortisol production, which is vital for motivation and focus. The dosage from NOW Foods is potent, tasteless, and easy to swallow. I always keep these on hand.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 5 Reviews
8.5
9
We conducted a double-blind, randomized clinical trial involving 76 patients diagnosed with diarrhea-predominant irritable bowel syndrome (IBS) to evaluate the effectiveness of a dried extract combined with calcium treatment. Participants were split into two groups: one receiving a placebo, and the other receiving a combination of 75 mg of the dried extract and 175 mg of dibasic calcium phosphate (calcium).
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
8.8
Bowel movements improved
Most Useful Review
I believe this product is beneficial for constipation. Although not commonly mentioned, using it with lactic acid bacteria seems to enhance bowel movements. It feels like pantothenic acid stimulates my intestines, and it also helps regulate sebum. I would advise against taking large amounts during dry seasons.
Liver Disease details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Significantly reduces shine
Most Useful Review
Initially hesitant to comment, after a month of use, I noticed my oily skin no longer shines and my makeup stays intact, even after a party. I recommend this for anyone with excessively oily skin; it truly changes lives.
Tinnitus details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
Relieved tinnitus
Most Useful Review
Low haemoglobin. I've been taking the medication, and it has alleviated my tinnitus and dizziness. I’m pleased with its quality and find it convenient to take.
Whooping Cough details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
In our investigation, we explored the effects of calcium, particularly when paired with albumin, on the production of a crucial toxin linked to whooping cough, known as adenylate cyclase toxin (ACT). This toxin plays a significant role in the ability of the bacteria to establish an infection.
We observed that when the bacteria responsible for whooping cough were grown in a serum-rich environment, a clear increase in ACT levels was noted. Interestingly, the combination of albumin and physiological levels of calcium appeared to be essential in enhancing the amount of ACT and its release into the surrounding environment.
This increase was also seen in respiratory secretions, which naturally contain albumin, mimicking the effects we noted with serum. Importantly, we determined that the observed increase in ACT was not due to changes in the bacteria's genetic regulation or a specific protein activation process, suggesting a unique interaction between the bacteria and components found in the host's environment.
Overall, our findings highlight this albumin and calcium interaction as a significant aspect of how the body’s biological environment influences whooping cough infection dynamics. Further research could shed light on potential therapeutic approaches considering this novel interaction.
We observed that when the bacteria responsible for whooping cough were grown in a serum-rich environment, a clear increase in ACT levels was noted. Interestingly, the combination of albumin and physiological levels of calcium appeared to be essential in enhancing the amount of ACT and its release into the surrounding environment.
This increase was also seen in respiratory secretions, which naturally contain albumin, mimicking the effects we noted with serum. Importantly, we determined that the observed increase in ACT was not due to changes in the bacteria's genetic regulation or a specific protein activation process, suggesting a unique interaction between the bacteria and components found in the host's environment.
Overall, our findings highlight this albumin and calcium interaction as a significant aspect of how the body’s biological environment influences whooping cough infection dynamics. Further research could shed light on potential therapeutic approaches considering this novel interaction.
8.8
Improved respiratory function
Most Useful Review
Immunity increases significantly. The whooping cough did not dissipate initially, but after one can, it resolved. There was a marked effect on my respiratory system.
Back Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.4
9
We explored the impact of calcium and vitamin D supplementation combined with sling core stabilization training on back pain in a 70-year-old female patient suffering from osteoporosis. The patient engaged in this form of exercise three times a week, focusing on strengthening the deep muscles of her spine.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
9.5
Discontinued product
Most Useful Review
Please Bring It Back!!!! This is the only remedy that cleared my acne, and it's now discontinued! I desperately need it back on the market!
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 6 Reviews
8.4
7
Calcium's limited impact on hypertension
We sought to understand how calcium affects hypertension and cardiovascular disease risk. Through a thorough review of existing literature, we evaluated data from a significant number of studies, focusing on the effects of calcium, magnesium, and vitamin D supplements on blood pressure levels and pulse rates.
Our analysis revealed that while calcium supplementation was linked to a noteworthy drop in diastolic blood pressure (the bottom number in blood pressure readings), it did not show a significant impact on systolic blood pressure (the top number) or pulse rate. This indicates that calcium could play a role in managing the lower blood pressure readings but may not be entirely effective on its own regarding overall blood pressure control.
Additionally, we identified that magnesium also contributed positively by reducing diastolic blood pressure, whereas vitamin D exhibited a broader beneficial effect by lowering both systolic and diastolic blood pressure. Despite these encouraging results for magnesium and vitamin D, calcium’s isolated effectiveness in addressing hypertension remains limited.
Overall, while calcium may help with certain aspects of blood pressure management, its role in controlling hypertension is not as clear-cut as we might hope.
Our analysis revealed that while calcium supplementation was linked to a noteworthy drop in diastolic blood pressure (the bottom number in blood pressure readings), it did not show a significant impact on systolic blood pressure (the top number) or pulse rate. This indicates that calcium could play a role in managing the lower blood pressure readings but may not be entirely effective on its own regarding overall blood pressure control.
Additionally, we identified that magnesium also contributed positively by reducing diastolic blood pressure, whereas vitamin D exhibited a broader beneficial effect by lowering both systolic and diastolic blood pressure. Despite these encouraging results for magnesium and vitamin D, calcium’s isolated effectiveness in addressing hypertension remains limited.
Overall, while calcium may help with certain aspects of blood pressure management, its role in controlling hypertension is not as clear-cut as we might hope.
9.5
Stimulates hormones
Most Useful Review
The most significant property of vitamin B5 is its capability to stimulate the production of adrenal hormones - glucocorticoids, which makes it a potent tool for the treatment of conditions such as arthritis, colitis, allergies, and cardiovascular disease.
Cold Sores details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.4
7
Calcium spirulan may help cold sores
We investigated the potential of calcium spirulan, a compound derived from the microalga Spirulina platensis, to help prevent cold sores caused by the herpes simplex virus type 1 (HSV-1). In a thorough study, we assessed the effectiveness of this sulfated polysaccharide both in laboratory tests and through a practical trial involving people with recurring herpes labialis, also known as cold sores.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
9.5
Skin condition improved
Most Useful Review
Change to the skin! I consume it with lactic acid bacteria. At first, I took significantly more than recommended (two tablets after each meal) but experienced no side effects. My skin has dramatically improved, with fewer blemishes and breakouts, so I no longer worry. I maintain good skin even with just one tablet daily. I've also noticed an increase in my immunity, and my previous cold has improved too! The cost is reasonable, and I will continue taking it!
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 22 Reviews
8.4
9.5
Effective acne treatment
Most Useful Review
Taking the supplement for my acne has been beneficial. The taste is neutral and easy to swallow since I take about 3-4 capsules daily. After consistently taking 5-6 pills a day for 2 months, I noticed the reduction of my hormonal acne. Once I lowered my dosage to 3-4 pills, those large, painful spots that once left scars never returned. I'm pleased with the results, and the package lasts quite a while.
Hives details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
We set out to understand how a combination of mizolastine and proteoglycan affects chronic urticaria, a condition often marked by itchy hives. In our study, we divided participants into two groups: one receiving a combination treatment that included mizolastine and proteoglycan, while the other group was treated with a similar regimen minus proteoglycan.
Over the course of four weeks, those in the treatment group experienced a significant drop in their symptoms, with 44 out of 56 showing a decline of 60% or more on the symptoms decline index. Notably, this group also had a lower relapse rate over the following two months compared to the control group.
Although calcium gluconate was part of the treatment, we found it challenging to isolate its direct impact on the improvement of hives since other factors were at play in the combined treatment approach. Overall, the results suggest that while calcium was included in the regimen, it was the combination of mizolastine and proteoglycan that primarily led to the observed improvements.
Over the course of four weeks, those in the treatment group experienced a significant drop in their symptoms, with 44 out of 56 showing a decline of 60% or more on the symptoms decline index. Notably, this group also had a lower relapse rate over the following two months compared to the control group.
Although calcium gluconate was part of the treatment, we found it challenging to isolate its direct impact on the improvement of hives since other factors were at play in the combined treatment approach. Overall, the results suggest that while calcium was included in the regimen, it was the combination of mizolastine and proteoglycan that primarily led to the observed improvements.
7.5
Slight improvement
Most Useful Review
My skin is perpetually oily, regardless of the season, and I also struggle with acne, so I keep using pantothenic acid. It's difficult to notice the effects of supplements, but I’ve found that taking two capsules in the morning and at night helps reduce sebum. While it's not a perfect solution, it's certainly better than doing nothing. I also experience hives, and I believe that has improved since I started this regimen.
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
Clear difference observed
Most Useful Review
I tried it for the first time after being influenced by an influencer. I've battled oily skin since high school, but after starting this supplement, I noticed a clear difference. I also take vitamin C. The tablet often gets stuck in my throat, but I manage it with water.
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 5 Reviews
8.3
8
We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
6.3
Child's health improved
Most Useful Review
I feel good about taking Pantothenic acid to manage my high cholesterol and support my child's health! A molecular nutritionist recommended it, and after reading many positive reviews, I decided to try it. My child's illness has improved and is now in remission. I haven’t had a blood test yet, but I am hopeful about continuing this supplement.
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.3
8
Calcium maltobionate supports bone health
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
8.8
Increases energy
Most Useful Review
I bought this during my menopause as I felt exhausted. Drinking it in the morning keeps me energised throughout the day. I plan to repurchase it once I run out.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.3
8.3
Head itch relief
Most Useful Review
I purchased this based on recommendations that it reduces sebum. After starting to take one vitamin C tablet in the morning and evening, I noticed on the third day that my head no longer itched. My skin seems noticeably less oily. I've got sensitive skin prone to atopic dermatitis from oil fields, resulting in rashes from my sweat and sebum. Even with thorough shampooing, I get itchy within 24 hours. Therefore, I take a bath daily for my head and twice for my body, but now my head doesn't itch, and my scalp remains non-sticky! My makeup stays intact; this supplement has become essential for me.
High Cholesterol details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 13 Reviews
8.2
9
We examined the effects of embelin, a compound derived from the dried berries of Embelia ribes, on cholesterol levels by focusing on its relationship with calcium in liver cells. Our analysis showed that embelin treatment aids in regulating cholesterol metabolism by influencing key proteins associated with cholesterol clearance.
The study highlighted how embelin can elevate calcium levels within the endoplasmic reticulum (ER), which is essential for proper cellular function. By increasing calcium, we observed a decrease in the activity of a protein known as PCSK9, which typically hinders the liver's ability to remove low-density lipoprotein (LDL) cholesterol from circulation.
By regulating the levels of SREBP2, another protein linked to cholesterol control, embelin ultimately enhances the liver's capacity to clear LDL from the bloodstream. This mechanism reveals that calcium plays an important role, particularly in how embelin mediates cholesterol levels through its effects on proteins involved in cholesterol metabolism.
Overall, the findings suggest that embelin may offer a natural avenue for improving cholesterol management, particularly in the context of cardiovascular health.
The study highlighted how embelin can elevate calcium levels within the endoplasmic reticulum (ER), which is essential for proper cellular function. By increasing calcium, we observed a decrease in the activity of a protein known as PCSK9, which typically hinders the liver's ability to remove low-density lipoprotein (LDL) cholesterol from circulation.
By regulating the levels of SREBP2, another protein linked to cholesterol control, embelin ultimately enhances the liver's capacity to clear LDL from the bloodstream. This mechanism reveals that calcium plays an important role, particularly in how embelin mediates cholesterol levels through its effects on proteins involved in cholesterol metabolism.
Overall, the findings suggest that embelin may offer a natural avenue for improving cholesterol management, particularly in the context of cardiovascular health.
8.8
Aids fat metabolism
Most Useful Review
Aiding in fat metabolism and cholesterol management, I find this product effective. I take it with inositol after dinner and have noticed an increase in energy levels along with satisfactory results.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.2
9
We looked into how Vitamin B2 supplementation might help with migraines, focusing on its potential to reduce the number of migraine days, duration, frequency, and pain scores.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
8.8
Reduced migraines
Most Useful Review
The quality of both the packaging and the ingredients is commendable. I take it alongside vitamin B12 for better digestibility, and I've noticed that my migraines have decreased significantly.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.4
7
We explored how calcium intake relates to constipation, particularly focusing on individuals with metabolic syndrome, a condition that significantly impacts health. Using data from the National Health and Nutrition Examination Survey conducted between 2005 and 2010, we assessed the dietary habits of participants and looked at how often they experienced constipation.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
8.3
Constipation relief
Most Useful Review
I purchased this product due to oily skin. While I haven't noticed a reduction in sebum, my constipation has vanished! The capsules are manageable in size, odourless, and very easy to swallow.
Diarrhea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.1
8
We investigated how extracts from light, medium, and dark roasted coffee beans affect contractions in the ileum, which is part of the intestine. The aim was to see if these coffee extracts could help manage gastrointestinal motility disorders like diarrhea.
During our experiments, we noticed that all coffee extracts reduced spontaneous contractions of rat ileum tissue in a dose-dependent manner. However, it was the light coffee extract that stood out, showing the most significant reduction in ileal contractions, especially at higher concentrations.
Our findings suggested that the antispasmodic effects of light coffee might be linked to its ability to inhibit calcium influx or interfere with calcium signaling pathways, which are crucial in muscle contractions. We found that certain compounds in the light coffee, such as chlorogenic acid and caffeine, likely contributed to this effect. Overall, our study indicates that light-roasted coffee has the potential to help manage conditions related to intestinal spasms and diarrhea.
During our experiments, we noticed that all coffee extracts reduced spontaneous contractions of rat ileum tissue in a dose-dependent manner. However, it was the light coffee extract that stood out, showing the most significant reduction in ileal contractions, especially at higher concentrations.
Our findings suggested that the antispasmodic effects of light coffee might be linked to its ability to inhibit calcium influx or interfere with calcium signaling pathways, which are crucial in muscle contractions. We found that certain compounds in the light coffee, such as chlorogenic acid and caffeine, likely contributed to this effect. Overall, our study indicates that light-roasted coffee has the potential to help manage conditions related to intestinal spasms and diarrhea.
8
Cleared cystic acne
Most Useful Review
This has nearly cleared my cystic acne, which I'm very grateful for. To achieve this, I continue taking high dosages—12 tablets in the morning and 12 at night—starting the first week with 6 in the morning and 6 at night. While it effectively clears my skin, I initially experienced mild diarrhea as a side effect. The potency is impressive, and it also supports my nervous system.
