Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Pantothenic Acid (Vitamin B-5) (From Calcium Pantothenate)
500 mg
10,000%
Calcium (From Calcium Pantothenate)
45 mg
3%
Top Medical Research Studies
9
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
9
We investigated the role of T-type calcium channels in medulloblastoma, a particularly aggressive brain tumor that primarily affects children. The study utilized various methodologies, including bulk and single-cell RNA sequencing, to assess T-type calcium channel expression.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Most Useful Reviews
9
Effective natural remedy
50 people found this helpful
My daughter was diagnosed with ADHD several years ago, and I was initially opposed to medication. My husband, knowledgeable about natural supplements, introduced her to DMAE and Pantothenic Acid (Vitamin B5), which seem to work better than any ADHD medication available. Now at 16, she takes 3 DMAE 250mg capsules and 3 Pantothenic Acid 500mg capsules daily. The difference is noticeable; everyone can tell when she hasn’t taken her vitamins!
9
Exceptional brain support
Great brain booster!
7.5
Improved energy levels
4 people found this helpful
After starting Vitamin B5 alongside other supplements, I’ve noticed immediate benefits; my sleep has improved, my energy levels have surged, and my mood is much better. I find the packaging convenient and the capsules easy to swallow. I am thoroughly satisfied with this manufacturer’s quality. If this review was helpful, please like it. Thank you!
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
- All Researches
9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
9
We investigated the role of T-type calcium channels in medulloblastoma, a particularly aggressive brain tumor that primarily affects children. The study utilized various methodologies, including bulk and single-cell RNA sequencing, to assess T-type calcium channel expression.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
9
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective natural remedy
50 people found this helpful
My daughter was diagnosed with ADHD several years ago, and I was initially opposed to medication. My husband, knowledgeable about natural supplements, introduced her to DMAE and Pantothenic Acid (Vitamin B5), which seem to work better than any ADHD medication available. Now at 16, she takes 3 DMAE 250mg capsules and 3 Pantothenic Acid 500mg capsules daily. The difference is noticeable; everyone can tell when she hasn’t taken her vitamins!
9
Exceptional brain support
Great brain booster!
7.5
Improved energy levels
4 people found this helpful
After starting Vitamin B5 alongside other supplements, I’ve noticed immediate benefits; my sleep has improved, my energy levels have surged, and my mood is much better. I find the packaging convenient and the capsules easy to swallow. I am thoroughly satisfied with this manufacturer’s quality. If this review was helpful, please like it. Thank you!
7.5
Life-changing combination
1 people found this helpful
I'm thrilled with the impact this product has had on my life! I take it 2-3 times a day with 500mg DMAE and Natural Brain Enhancers, which helps me concentrate while working under pressure. If I skip my routine, I can feel it by mid-afternoon. After reading about its effectiveness for ADHD, I decided to try this combo; it has significantly improved my life. I've always struggled with mild hyperactivity and short attention spans, leading to anxiety. I will definitely continue this regimen.
6
Supports overall health
Pantothenic acid, upon ingestion, converts into pantethine, aiding vital oxidation processes. It assists in synthesising fatty acids and cholesterol and is crucial in producing adrenal hormones and antibodies for immune support. Additionally, it is essential in treating various health conditions and is invaluable for brain function by synthesising neurotransmitters that facilitate communication between neurons and muscles. Utilizing Vitamin B5 effectively combats aging and helps alleviate hangover symptoms.
Frequently Asked Questions
9
Effective natural remedy
50 people found this helpful
My daughter was diagnosed with ADHD several years ago, and I was initially opposed to medication. My husband, knowledgeable about natural supplements, introduced her to DMAE and Pantothenic Acid (Vitamin B5), which seem to work better than any ADHD medication available. Now at 16, she takes 3 DMAE 250mg capsules and 3 Pantothenic Acid 500mg capsules daily. The difference is noticeable; everyone can tell when she hasn’t taken her vitamins!
7.5
Life-changing combination
1 people found this helpful
I'm thrilled with the impact this product has had on my life! I take it 2-3 times a day with 500mg DMAE and Natural Brain Enhancers, which helps me concentrate while working under pressure. If I skip my routine, I can feel it by mid-afternoon. After reading about its effectiveness for ADHD, I decided to try this combo; it has significantly improved my life. I've always struggled with mild hyperactivity and short attention spans, leading to anxiety. I will definitely continue this regimen.
7.5
Improved energy levels
4 people found this helpful
After starting Vitamin B5 alongside other supplements, I’ve noticed immediate benefits; my sleep has improved, my energy levels have surged, and my mood is much better. I find the packaging convenient and the capsules easy to swallow. I am thoroughly satisfied with this manufacturer’s quality. If this review was helpful, please like it. Thank you!
9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
9
We investigated the role of T-type calcium channels in medulloblastoma, a particularly aggressive brain tumor that primarily affects children. The study utilized various methodologies, including bulk and single-cell RNA sequencing, to assess T-type calcium channel expression.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
References
- Sun S, Qian S, Wang R, Zhao M, Li R, et al. Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming. Sci Transl Med. 2025;17:eado0020. doi:10.1126/scitranslmed.ado0020
- Dube CJ, Lai M, Zhang Y, Saha S, Yener U, et al. T-type calcium channels regulate medulloblastoma and can be targeted for therapy. J Neurooncol. 2025. doi:10.1007/s11060-025-04967-5
- Li S, Li W, Miao Y, Gao M, Jia Y, et al. Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth. Sci Transl Med. 2024;16:eadn6763. doi:10.1126/scitranslmed.adn6763
