Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (from 405 mg Zinc Gluconate)
50 mg
455%
Top Medical Research Studies
8
We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.
The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.
Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.
The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.
Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.
Read More
7
This study investigated how zinc levels relate to arthritis severity and oxidative DNA damage among individuals with rheumatoid arthritis. We gathered data from 264 patients and 192 healthy individuals to understand the interplay between zinc levels, disease activity, and oxidative stress markers like 8-hydroxy-2-deoxyguanosine (8-OHdG).
Our findings revealed that patients with rheumatoid arthritis had notably higher levels of 8-OHdG, which indicates increased oxidative DNA damage. Alarmingly, these patients also exhibited lower zinc levels compared to the healthy group. Those with diminished zinc levels showed even more significant DNA damage than those with normal zinc levels.
Additionally, we noticed that patients with lower disease activity experienced less oxidative DNA damage. Interestingly, there was a significant negative correlation between serum zinc levels and disease activity scores, suggesting that higher zinc levels may be linked to better disease management. Thus, it seems that maintaining adequate zinc levels could be crucial for reducing oxidative stress and damage in rheumatoid arthritis patients.
Our findings revealed that patients with rheumatoid arthritis had notably higher levels of 8-OHdG, which indicates increased oxidative DNA damage. Alarmingly, these patients also exhibited lower zinc levels compared to the healthy group. Those with diminished zinc levels showed even more significant DNA damage than those with normal zinc levels.
Additionally, we noticed that patients with lower disease activity experienced less oxidative DNA damage. Interestingly, there was a significant negative correlation between serum zinc levels and disease activity scores, suggesting that higher zinc levels may be linked to better disease management. Thus, it seems that maintaining adequate zinc levels could be crucial for reducing oxidative stress and damage in rheumatoid arthritis patients.
Read More
9
We explored the potential benefits of a new treatment involving zinc ferrite nanoparticles (ZFN) for individuals suffering from gouty arthritis (GA). This form of arthritis can be painful and complex, affecting people of all ages. Traditional treatments often come with side effects, prompting a search for more effective and safer alternatives.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
Read More
Most Useful Reviews
9
Remarkable improvement
92 people found this helpful
My father struggled to get around due to arthritis and eventually needed a walker. After taking this vitamin daily for two weeks, he could walk unaided. My husband also takes this vitamin; whenever he feels unwell, he takes it and within 24 hours, he feels normal again.
Read More
7.5
Essential for stomatitis
My family experienced stomatitis due to rheumatoid arthritis, and using zinc greatly helped, making it a vital supplement for us. I plan to try a lower dosage next time, as 50mg may be too much.
Read More
7.5
Aids arthritis relief
Zinc, a vital trace mineral present in nearly every cell, plays a critical role in controlling bodily processes. It is particularly effective in boosting immunity and combating colds. Zinc not only inhibits bacteria formation but also helps with rheumatoid arthritis and offers antioxidant effects. The recommended dosage varies: for children, 5-8 mg and for men, 30-45 mg.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
- All Researches
9
We explored the potential benefits of a new treatment involving zinc ferrite nanoparticles (ZFN) for individuals suffering from gouty arthritis (GA). This form of arthritis can be painful and complex, affecting people of all ages. Traditional treatments often come with side effects, prompting a search for more effective and safer alternatives.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
Read More
9
We explored the potential benefits of zinc oxide nanoparticles combined with curcumin in aiding recovery from rheumatoid arthritis (RA) in experimental rabbits. The study began by inducing RA in the rabbits with a specific solution and then administering various treatments, including the mix of zinc and curcumin.
By analyzing blood samples from both control and treated rabbits, we observed the levels of important biological markers related to RA and antioxidant health. The outcomes were quite promising—after treatment, there was a notable reduction in markers indicative of RA, such as rheumatoid factor and C-reactive protein, indicating improved health in the treated rabbits.
Among the treatments, the zinc oxide nanoparticles-doped curcumin exhibited the most significant improvement by lowering markers of oxidative stress while enhancing antioxidant activity. This suggests that the combined therapy may be a viable option for managing RA, offering a new avenue in our ongoing search for effective treatments.
By analyzing blood samples from both control and treated rabbits, we observed the levels of important biological markers related to RA and antioxidant health. The outcomes were quite promising—after treatment, there was a notable reduction in markers indicative of RA, such as rheumatoid factor and C-reactive protein, indicating improved health in the treated rabbits.
Among the treatments, the zinc oxide nanoparticles-doped curcumin exhibited the most significant improvement by lowering markers of oxidative stress while enhancing antioxidant activity. This suggests that the combined therapy may be a viable option for managing RA, offering a new avenue in our ongoing search for effective treatments.
Read More
8
We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.
The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.
Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.
The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.
Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.
Read More
8
We explored the relationship between dietary zinc intake and the development of osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Utilizing data from a well-known health and nutrition survey, we employed statistical methods to determine if higher zinc intake could lead to better bone health outcomes for those suffering from RA.
Our findings revealed an interesting trend: higher dietary zinc intake seems to be linked with a lower incidence of osteopenia and osteoporosis in these patients. This suggests that adequate zinc may play a protective role when it comes to bone density and overall health for individuals with RA.
However, we believe that more comprehensive studies, including randomized trials, are needed to further validate these results and uncover the mechanisms at work. For now, it appears that ensuring sufficient zinc in the diet could potentially benefit bone health in those dealing with this chronic condition.
Our findings revealed an interesting trend: higher dietary zinc intake seems to be linked with a lower incidence of osteopenia and osteoporosis in these patients. This suggests that adequate zinc may play a protective role when it comes to bone density and overall health for individuals with RA.
However, we believe that more comprehensive studies, including randomized trials, are needed to further validate these results and uncover the mechanisms at work. For now, it appears that ensuring sufficient zinc in the diet could potentially benefit bone health in those dealing with this chronic condition.
Read More
7
This study investigated how zinc levels relate to arthritis severity and oxidative DNA damage among individuals with rheumatoid arthritis. We gathered data from 264 patients and 192 healthy individuals to understand the interplay between zinc levels, disease activity, and oxidative stress markers like 8-hydroxy-2-deoxyguanosine (8-OHdG).
Our findings revealed that patients with rheumatoid arthritis had notably higher levels of 8-OHdG, which indicates increased oxidative DNA damage. Alarmingly, these patients also exhibited lower zinc levels compared to the healthy group. Those with diminished zinc levels showed even more significant DNA damage than those with normal zinc levels.
Additionally, we noticed that patients with lower disease activity experienced less oxidative DNA damage. Interestingly, there was a significant negative correlation between serum zinc levels and disease activity scores, suggesting that higher zinc levels may be linked to better disease management. Thus, it seems that maintaining adequate zinc levels could be crucial for reducing oxidative stress and damage in rheumatoid arthritis patients.
Our findings revealed that patients with rheumatoid arthritis had notably higher levels of 8-OHdG, which indicates increased oxidative DNA damage. Alarmingly, these patients also exhibited lower zinc levels compared to the healthy group. Those with diminished zinc levels showed even more significant DNA damage than those with normal zinc levels.
Additionally, we noticed that patients with lower disease activity experienced less oxidative DNA damage. Interestingly, there was a significant negative correlation between serum zinc levels and disease activity scores, suggesting that higher zinc levels may be linked to better disease management. Thus, it seems that maintaining adequate zinc levels could be crucial for reducing oxidative stress and damage in rheumatoid arthritis patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Remarkable improvement
92 people found this helpful
My father struggled to get around due to arthritis and eventually needed a walker. After taking this vitamin daily for two weeks, he could walk unaided. My husband also takes this vitamin; whenever he feels unwell, he takes it and within 24 hours, he feels normal again.
Read More
7.5
Essential for stomatitis
My family experienced stomatitis due to rheumatoid arthritis, and using zinc greatly helped, making it a vital supplement for us. I plan to try a lower dosage next time, as 50mg may be too much.
Read More
7.5
Aids arthritis relief
Zinc, a vital trace mineral present in nearly every cell, plays a critical role in controlling bodily processes. It is particularly effective in boosting immunity and combating colds. Zinc not only inhibits bacteria formation but also helps with rheumatoid arthritis and offers antioxidant effects. The recommended dosage varies: for children, 5-8 mg and for men, 30-45 mg.
Read More
6
Supports arthritis health
Zinc is crucial for many bodily functions and is often inadequate in the body when assimilation decreases. Zinc gluconate is a highly bioavailable form that causes minimal gastrointestinal side effects. It is indicated for conditions such as rheumatoid arthritis. Studies show that zinc can improve mood and increase brain efficiency, with its anti-inflammatory properties also being beneficial for acne.
Read More
6
Prevents arthritis symptoms
My nails and hair have improved significantly; hair loss and brittle nails have ceased, and my skin no longer peels. This mineral also aids diabetics, and I take it as a preventive measure against arthritis and arthrosis.
Read More
Frequently Asked Questions
9
Remarkable improvement
92 people found this helpful
My father struggled to get around due to arthritis and eventually needed a walker. After taking this vitamin daily for two weeks, he could walk unaided. My husband also takes this vitamin; whenever he feels unwell, he takes it and within 24 hours, he feels normal again.
7.5
Aids arthritis relief
Zinc, a vital trace mineral present in nearly every cell, plays a critical role in controlling bodily processes. It is particularly effective in boosting immunity and combating colds. Zinc not only inhibits bacteria formation but also helps with rheumatoid arthritis and offers antioxidant effects. The recommended dosage varies: for children, 5-8 mg and for men, 30-45 mg.
7.5
Essential for stomatitis
My family experienced stomatitis due to rheumatoid arthritis, and using zinc greatly helped, making it a vital supplement for us. I plan to try a lower dosage next time, as 50mg may be too much.
6
Prevents arthritis symptoms
My nails and hair have improved significantly; hair loss and brittle nails have ceased, and my skin no longer peels. This mineral also aids diabetics, and I take it as a preventive measure against arthritis and arthrosis.
6
Hard to dissolve tablets
These tablets are tough to use in my arthritis remedy. I mix Epsom salt, a zinc tablet, and others in oatmeal. Unfortunately, I must crush the tablets for proper absorption; other brands dissolve more readily.
8
We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.
The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.
Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.
The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.
Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.
9
We explored the potential benefits of a new treatment involving zinc ferrite nanoparticles (ZFN) for individuals suffering from gouty arthritis (GA). This form of arthritis can be painful and complex, affecting people of all ages. Traditional treatments often come with side effects, prompting a search for more effective and safer alternatives.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
8
We explored the relationship between dietary zinc intake and the development of osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Utilizing data from a well-known health and nutrition survey, we employed statistical methods to determine if higher zinc intake could lead to better bone health outcomes for those suffering from RA.
Our findings revealed an interesting trend: higher dietary zinc intake seems to be linked with a lower incidence of osteopenia and osteoporosis in these patients. This suggests that adequate zinc may play a protective role when it comes to bone density and overall health for individuals with RA.
However, we believe that more comprehensive studies, including randomized trials, are needed to further validate these results and uncover the mechanisms at work. For now, it appears that ensuring sufficient zinc in the diet could potentially benefit bone health in those dealing with this chronic condition.
Our findings revealed an interesting trend: higher dietary zinc intake seems to be linked with a lower incidence of osteopenia and osteoporosis in these patients. This suggests that adequate zinc may play a protective role when it comes to bone density and overall health for individuals with RA.
However, we believe that more comprehensive studies, including randomized trials, are needed to further validate these results and uncover the mechanisms at work. For now, it appears that ensuring sufficient zinc in the diet could potentially benefit bone health in those dealing with this chronic condition.
7
This study investigated how zinc levels relate to arthritis severity and oxidative DNA damage among individuals with rheumatoid arthritis. We gathered data from 264 patients and 192 healthy individuals to understand the interplay between zinc levels, disease activity, and oxidative stress markers like 8-hydroxy-2-deoxyguanosine (8-OHdG).
Our findings revealed that patients with rheumatoid arthritis had notably higher levels of 8-OHdG, which indicates increased oxidative DNA damage. Alarmingly, these patients also exhibited lower zinc levels compared to the healthy group. Those with diminished zinc levels showed even more significant DNA damage than those with normal zinc levels.
Additionally, we noticed that patients with lower disease activity experienced less oxidative DNA damage. Interestingly, there was a significant negative correlation between serum zinc levels and disease activity scores, suggesting that higher zinc levels may be linked to better disease management. Thus, it seems that maintaining adequate zinc levels could be crucial for reducing oxidative stress and damage in rheumatoid arthritis patients.
Our findings revealed that patients with rheumatoid arthritis had notably higher levels of 8-OHdG, which indicates increased oxidative DNA damage. Alarmingly, these patients also exhibited lower zinc levels compared to the healthy group. Those with diminished zinc levels showed even more significant DNA damage than those with normal zinc levels.
Additionally, we noticed that patients with lower disease activity experienced less oxidative DNA damage. Interestingly, there was a significant negative correlation between serum zinc levels and disease activity scores, suggesting that higher zinc levels may be linked to better disease management. Thus, it seems that maintaining adequate zinc levels could be crucial for reducing oxidative stress and damage in rheumatoid arthritis patients.
References
- Zhang F, Gan Y, Xie W, Lu S, Zha Y, et al. A novel zinc ferrite nanoparticle protects against MSU-induced gout arthritis via Nrf2/NF-κB/NLRP3 pathway. Life Sci. 2025;366-367:123475. 10.1016/j.lfs.2025.123475
- Hasan M, Yadav P, Ansari MA, Ali S, Khan HA. Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04439-3
- Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. 10.1186/s12891-024-07768-5
- Azeez S, Fatima M, Gul O, Rehman H, Shad MA, et al. Zinc oxide nanoparticles-doped curcumin-assisted recovery of rheumatoid arthritis and antioxidant status in experimental rabbits. Biomedicine (Taipei). 2024;14:49. 10.37796/2211-8039.1446
- Hassan WM. Oxidative DNA Damage and Zinc Status in Patients With Rheumatoid Arthritis in Duhok, Iraq. Cureus. 2024;16:e52860. 10.7759/cureus.52860
