Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Moderately Good
Based on 29 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (from 405 mg Zinc Gluconate)
50 mg
455%

Top Medical Research Studies

9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.

What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.

Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.

Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More

Most Useful Reviews

9
Health improvement
112 people found this helpful
After starting this supplement, I noticed my health improved significantly. In the past, I would catch a sore throat and runny nose after every winter walk, but that is no longer the case. This supplement has made a significant difference in my well-being, and I would recommend it to others.
Read More
9
Quick recovery noted
6 people found this helpful
After contracting Corona and experiencing severe olfactory and taste disorders, I began taking zinc immediately upon hearing of its benefits. The effects were felt swiftly, and I've returned to my pre-illness state. I plan to give it to my children for their acne, as I can easily cut the tablets.
Read More
7.5
Skin inflammation reduced
4 people found this helpful
Some time ago, my skin was in poor condition, suffering from painful acne and allergies. I started taking zinc along with curcumin as daily supplements and noticed significant improvement within a week, with inflammation and redness having reduced. I hope that long-term use and better eating habits will help mitigate various inflammatory reactions in my body.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
  • All Researches
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.

What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.

Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.

Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More
8
Zinc's role in alopecia areata
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.

The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.

Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
Read More
7
Zinc supplementation eases neutrophil activity
We aimed to explore how zinc supplementation might influence immune responses, particularly focusing on neutrophil activity in the context of autoimmune diseases. To do this, we simulated inflammatory conditions typically seen in such disorders using specific cytokines, interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α.

Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.

Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 29 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Health improvement
112 people found this helpful
After starting this supplement, I noticed my health improved significantly. In the past, I would catch a sore throat and runny nose after every winter walk, but that is no longer the case. This supplement has made a significant difference in my well-being, and I would recommend it to others.
Read More
9
Quick recovery noted
6 people found this helpful
After contracting Corona and experiencing severe olfactory and taste disorders, I began taking zinc immediately upon hearing of its benefits. The effects were felt swiftly, and I've returned to my pre-illness state. I plan to give it to my children for their acne, as I can easily cut the tablets.
Read More
7.5
Skin inflammation reduced
4 people found this helpful
Some time ago, my skin was in poor condition, suffering from painful acne and allergies. I started taking zinc along with curcumin as daily supplements and noticed significant improvement within a week, with inflammation and redness having reduced. I hope that long-term use and better eating habits will help mitigate various inflammatory reactions in my body.
Read More
9
Significant lupus control
2 people found this helpful
Luar biasa! This is my first order and they packed it really well. I have been consuming this product alongside Vitamin D3, K2 MK-7, and Omega 3. I feel my body is so much better; my lupus is remarkably controlled within 2-3 months. I had a severe flare in June 2021, and all my lab results in September have improved. I'm thoroughly satisfied with my purchase and will buy this again from iHerb as it is trustworthy and original.
Read More
0
Unsuitable form encountered
2 people found this helpful
Zinc is crucial for immunity and disease management, yet this specific formulation did not work for me. After taking the tablet, I consistently suffered headaches and nausea. Despite trying to split the dosage, the symptoms persisted. Perhaps this particular form of zinc does not agree with me, so I would not recommend ordering such high dosages.
Read More

Frequently Asked Questions

9
Significant lupus control
2 people found this helpful
Luar biasa! This is my first order and they packed it really well. I have been consuming this product alongside Vitamin D3, K2 MK-7, and Omega 3. I feel my body is so much better; my lupus is remarkably controlled within 2-3 months. I had a severe flare in June 2021, and all my lab results in September have improved. I'm thoroughly satisfied with my purchase and will buy this again from iHerb as it is trustworthy and original.
7.5
Clean skin achieved
2 people found this helpful
I've been taking zinc for two weeks, and my skin has become remarkably clean. Despite trying numerous remedies for my acne, this zinc has yielded visible results in a short time. However, it can induce nausea if taken on an empty stomach, a problem I solve by postponing it until after a hearty dinner. I cannot comment on its efficacy regarding immunity, as I have not fallen ill.
2
High dosage concerns
6 people found this helpful
I purchased Now Zinc and noticed the dosage is quite high at 50 mg per tablet, which I later realised could be unsafe long-term. Such doses may lead to side effects and mineral deficiencies that weaken immunity. This high dosage should strictly be supervised by a medical professional in the case of significant deficiency. I regret not catching this before ordering, and I believe there should be clearer warnings regarding potential risks associated with excessive zinc intake.
9
Health improvement
112 people found this helpful
After starting this supplement, I noticed my health improved significantly. In the past, I would catch a sore throat and runny nose after every winter walk, but that is no longer the case. This supplement has made a significant difference in my well-being, and I would recommend it to others.
7.5
Skin inflammation reduced
4 people found this helpful
Some time ago, my skin was in poor condition, suffering from painful acne and allergies. I started taking zinc along with curcumin as daily supplements and noticed significant improvement within a week, with inflammation and redness having reduced. I hope that long-term use and better eating habits will help mitigate various inflammatory reactions in my body.
9
Quick recovery noted
6 people found this helpful
After contracting Corona and experiencing severe olfactory and taste disorders, I began taking zinc immediately upon hearing of its benefits. The effects were felt swiftly, and I've returned to my pre-illness state. I plan to give it to my children for their acne, as I can easily cut the tablets.
0
Unsuitable form encountered
2 people found this helpful
Zinc is crucial for immunity and disease management, yet this specific formulation did not work for me. After taking the tablet, I consistently suffered headaches and nausea. Despite trying to split the dosage, the symptoms persisted. Perhaps this particular form of zinc does not agree with me, so I would not recommend ordering such high dosages.
9
Menstrual cycle restored
1 people found this helpful
Following my gynaecologist's advice, I took it to restore my menstrual cycle, as I have PCOS. Previously, my periods were irregular, arriving every 4-5 months. After consuming various vitamins, including zinc, for 45 days, my menstruation returned on its own, something I had not experienced before. My overall health has improved, with increased energy levels and even skin tone. Surprisingly, I've not gained weight despite stopping contraceptives, which previously led to weight gain and emotional instability.
7.5
Virus protection
9 people found this helpful
Zinc serves as antiviral protection and strengthens immunity and hair growth. During viral outbreaks, zinc is essential, paired with vitamin C and D3, to expedite recovery. However, caution is needed with high dosages due to the risk of flushing copper from the body. I ensure I take it after meals to mitigate side effects. This supplement is standard-sized and easy to swallow and is always within my first-aid kit for emergencies.
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.

Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.

Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
4
Zinc intake influences autoimmune risk
We examined the connection between dietary zinc intake and the risk of autoimmune thyroiditis (AIT), particularly focusing on Hashimoto's thyroiditis. The study analyzed data from the 2007-2008 National Health and Nutrition Examination Survey, including nearly 5,500 participants—273 with AIT and 5,194 without it.

Our findings revealed that higher dietary zinc intake is associated with an increased risk of AIT, acting as an independent risk factor. This is concerning, as excessive zinc could disrupt our immune balance, potentially leading to other autoimmune disorders.

While it’s clear that zinc plays a role in thyroid health, we must be cautious about how much we consume. The study suggests that dietary zinc should be carefully monitored in those at risk for AIT, and it highlights the need for further research to establish safe consumption levels.
8
Zinc's role in alopecia areata
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.

The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.

Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
9
Zinc intake benefits RA bone health
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.

What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.

References

  1. Shao Y, Mu Q, Wang R, Luo H, Song Z, et al. SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease. Sci China Life Sci. 2025. 10.1007/s11427-024-2817-y
  2. Chen L, Yan C, Huang C, Jiang Z, Lin R, et al. Higher dietary zinc intake increases the risk of autoimmune thyroiditis. Postgrad Med J. 2025. 10.1093/postmj/qgae202
  3. Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. 10.1111/jocd.16740
  4. Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. 10.1016/j.jtemb.2024.127540
  5. Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. 10.1186/s12891-024-07768-5
  6. Cheng J, Rink L, Wessels I. Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4. Mol Nutr Food Res. 2024;68:e2400013. 10.1002/mnfr.202400013
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