Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
8
Zinc transport's role in T cells
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More
Most Useful Reviews
9
Health improvement
112 people found this helpful
After starting this supplement, I noticed my health improved significantly. In the past, I would catch a sore throat and runny nose after every winter walk, but that is no longer the case. This supplement has made a significant difference in my well-being, and I would recommend it to others.
Read More
9
Quick recovery noted
6 people found this helpful
After contracting Corona and experiencing severe olfactory and taste disorders, I began taking zinc immediately upon hearing of its benefits. The effects were felt swiftly, and I've returned to my pre-illness state. I plan to give it to my children for their acne, as I can easily cut the tablets.
Read More
7.5
Skin inflammation reduced
4 people found this helpful
Some time ago, my skin was in poor condition, suffering from painful acne and allergies. I started taking zinc along with curcumin as daily supplements and noticed significant improvement within a week, with inflammation and redness having reduced. I hope that long-term use and better eating habits will help mitigate various inflammatory reactions in my body.
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
8
Zinc transport's role in T cells
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More
8
Zinc's role in alopecia areata
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.
The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.
Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
Read More
7
Zinc supplementation eases neutrophil activity
Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4.
We aimed to explore how zinc supplementation might influence immune responses, particularly focusing on neutrophil activity in the context of autoimmune diseases. To do this, we simulated inflammatory conditions typically seen in such disorders using specific cytokines, interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α.
Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.
Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
After starting this supplement, I noticed my health improved significantly. In the past, I would catch a sore throat and runny nose after every winter walk, but that is no longer the case. This supplement has made a significant difference in my well-being, and I would recommend it to others.
Read More
9
Quick recovery noted
6 people found this helpful
After contracting Corona and experiencing severe olfactory and taste disorders, I began taking zinc immediately upon hearing of its benefits. The effects were felt swiftly, and I've returned to my pre-illness state. I plan to give it to my children for their acne, as I can easily cut the tablets.
Read More
7.5
Skin inflammation reduced
4 people found this helpful
Some time ago, my skin was in poor condition, suffering from painful acne and allergies. I started taking zinc along with curcumin as daily supplements and noticed significant improvement within a week, with inflammation and redness having reduced. I hope that long-term use and better eating habits will help mitigate various inflammatory reactions in my body.
Read More
9
Significant lupus control
2 people found this helpful
Luar biasa! This is my first order and they packed it really well. I have been consuming this product alongside Vitamin D3, K2 MK-7, and Omega 3. I feel my body is so much better; my lupus is remarkably controlled within 2-3 months. I had a severe flare in June 2021, and all my lab results in September have improved. I'm thoroughly satisfied with my purchase and will buy this again from iHerb as it is trustworthy and original.
Read More
0
Unsuitable form encountered
2 people found this helpful
Zinc is crucial for immunity and disease management, yet this specific formulation did not work for me. After taking the tablet, I consistently suffered headaches and nausea. Despite trying to split the dosage, the symptoms persisted. Perhaps this particular form of zinc does not agree with me, so I would not recommend ordering such high dosages.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc plays a crucial role in immune function and has been studied for its potential benefits in managing autoimmune disorders. This mineral is essential for the development and function of immune cells, and adequate levels may help modulate inflammatory responses. Some studies suggest that zinc supplementation may help reduce the severity of symptoms in certain autoimmune conditions, like rheumatoid arthritis and lupus, by influencing immune responses and reducing oxidative stress.
However, it's important to note that while zinc may offer supportive benefits, it should not be regarded as a standalone treatment for autoimmune disorders. The relationship between zinc and autoimmune diseases is complex; excessive zinc intake can also lead to adverse effects, including interference with other essential minerals. Therefore, anyone considering zinc supplementation, especially those with autoimmune disorders, should consult a healthcare provider for personalized advice and to determine the appropriate dosage. Keeping a balanced diet rich in nutrients, including zinc, can contribute to overall immune health.
Based on user reviews, the timeline to see results from taking zinc supplements for autoimmune disorders can vary but tends to fall within a few weeks to a couple of months. For instance, one user reported significant improvements in her lupus management within 2-3 months, noting enhanced lab results and overall satisfaction with her recovery (Read Review). Another user mentioned noticeable changes in skin condition and acne within just two weeks of using zinc, suggesting that some individuals may experience benefits relatively quickly (Read Review).
On the other side, some users caution against the high dosages, as they can lead to side effects that may detract from the benefits sought from the supplement, indicating the importance of moderation and possibly seeking medical guidance (Read Review). Overall, while many users praise zinc for improvements in immunity and various health issues, individual experiences seem to vary, with some seeing results in weeks and others potentially taking longer to notice benefits.
The scientific research surrounding zinc supplementation and its potential benefits for autoimmune disorders is compelling. Various studies have highlighted the role of zinc in T cell function and its implications for diseases like inflammatory bowel disease and multiple sclerosis. Specifically, one study found that zinc transport plays a crucial role in T cell health and could potentially lead to new therapeutic strategies for managing T cell-related autoimmune conditions [1]. Moreover, another study demonstrated that dietary zinc supplementation might alleviate symptoms associated with multiple sclerosis, indicating zinc's protective effects in this particular autoimmune disorder [4].
However, the research also emphasizes caution regarding zinc intake, particularly concerning autoimmune thyroiditis. Excessive dietary zinc intake was identified as an independent risk factor for autoimmune thyroiditis, indicating that balance is essential when considering zinc supplementation [2]. Furthermore, studies suggest the potential benefits of zinc supplementation for conditions such as alopecia areata and rheumatoid arthritis, as adequate zinc levels seem to improve immune function and bone health in these populations [3][5]. Overall, while zinc supplementation shows promise as a supportive treatment for some autoimmune disorders, careful consideration of dosage and individual risk factors is warranted to ensure safety and efficacy.
According to user reviews, many individuals have experienced notable improvements in various health symptoms after incorporating zinc supplements into their routines. For example, one user reported a marked reduction in winter illnesses, such as sore throats and runny noses, attributing this positive change to the supplement (Read Review). Others have seen quick benefits in skin conditions; one reviewer noted significant improvement in her acne within just a week after starting zinc and curcumin supplements (Read Review). Additionally, individuals recovering from illnesses, such as COVID-19, reported swift returns to their pre-illness health, with one user successfully regaining senses of taste and smell after starting zinc supplements (Read Review).
While many report these positive outcomes, it's crucial to note that individual responses to zinc supplementation can vary. Some users experienced adverse effects, such as nausea and headaches, particularly at higher dosages, which may influence their overall experience with the supplement (Read Review). Nonetheless, numerous testimonials praise zinc for its role in bolstering immunity, improving skin conditions, and even restoring menstrual cycles in those with irregularities (Read Review). Therefore, while many find relief and health improvements, it may be essential to monitor responses and consult a healthcare provider when considering supplementation.
Users have reported various experiences when combining zinc supplements with other supplements to manage autoimmune disorders. One review highlighted that by taking zinc alongside vitamins D3, K2 MK-7, and Omega 3, the user noticed significant control over their lupus symptoms, with improved lab results within a few months (Read Review). Another user mentioned that zinc, when paired with vitamin C and D3, helped expedite recovery during viral illnesses, amplifying the immune-boosting benefits of the supplements used together (Read Review).
Despite these positive reports, users also expressed caution regarding potential side effects, particularly with high doses of zinc. One reviewer mentioned that their symptoms, such as nausea and headaches, persisted even after trying to adjust the dosage (Read Review). Thus, while combining zinc with other supplements may offer benefits for those dealing with autoimmune disorders, individuals should consult healthcare providers to tailor their approach and mitigate any adverse reactions.
Based on user reviews, it seems that the effective dosage of Zinc for treating Autoimmune Disorders can vary significantly among individuals. A common report among users is the consumption of higher doses, often around 50 mg, which many users found beneficial. For instance, one user mentioned that taking zinc alongside other vitamins helped control their lupus effectively within 2-3 months of use Read Review. However, caution is advised, as some users reported negative experiences with high dosages, such as nausea and headaches Read Review, suggesting that this particular dosage may not work for everyone.
Another user noted that while 50 mg seemed effective initially, they also raised concerns about possible long-term safety and the risk of side effects Read Review. It appears that taking zinc with food can help mitigate some of the side effects associated with high doses, such as nausea Read Review. In conclusion, while higher doses may offer benefits for some users dealing with autoimmune issues, it's crucial to approach with caution and monitor for any adverse effects, potentially consulting a healthcare provider for personalized guidance.
9
Significant lupus control
2 people found this helpful
Luar biasa! This is my first order and they packed it really well. I have been consuming this product alongside Vitamin D3, K2 MK-7, and Omega 3. I feel my body is so much better; my lupus is remarkably controlled within 2-3 months. I had a severe flare in June 2021, and all my lab results in September have improved. I'm thoroughly satisfied with my purchase and will buy this again from iHerb as it is trustworthy and original.
7.5
Clean skin achieved
2 people found this helpful
I've been taking zinc for two weeks, and my skin has become remarkably clean. Despite trying numerous remedies for my acne, this zinc has yielded visible results in a short time. However, it can induce nausea if taken on an empty stomach, a problem I solve by postponing it until after a hearty dinner. I cannot comment on its efficacy regarding immunity, as I have not fallen ill.
2
High dosage concerns
6 people found this helpful
I purchased Now Zinc and noticed the dosage is quite high at 50 mg per tablet, which I later realised could be unsafe long-term. Such doses may lead to side effects and mineral deficiencies that weaken immunity. This high dosage should strictly be supervised by a medical professional in the case of significant deficiency. I regret not catching this before ordering, and I believe there should be clearer warnings regarding potential risks associated with excessive zinc intake.
9
Health improvement
112 people found this helpful
After starting this supplement, I noticed my health improved significantly. In the past, I would catch a sore throat and runny nose after every winter walk, but that is no longer the case. This supplement has made a significant difference in my well-being, and I would recommend it to others.
7.5
Skin inflammation reduced
4 people found this helpful
Some time ago, my skin was in poor condition, suffering from painful acne and allergies. I started taking zinc along with curcumin as daily supplements and noticed significant improvement within a week, with inflammation and redness having reduced. I hope that long-term use and better eating habits will help mitigate various inflammatory reactions in my body.
9
Quick recovery noted
6 people found this helpful
After contracting Corona and experiencing severe olfactory and taste disorders, I began taking zinc immediately upon hearing of its benefits. The effects were felt swiftly, and I've returned to my pre-illness state. I plan to give it to my children for their acne, as I can easily cut the tablets.
0
Unsuitable form encountered
2 people found this helpful
Zinc is crucial for immunity and disease management, yet this specific formulation did not work for me. After taking the tablet, I consistently suffered headaches and nausea. Despite trying to split the dosage, the symptoms persisted. Perhaps this particular form of zinc does not agree with me, so I would not recommend ordering such high dosages.
9
Menstrual cycle restored
1 people found this helpful
Following my gynaecologist's advice, I took it to restore my menstrual cycle, as I have PCOS. Previously, my periods were irregular, arriving every 4-5 months. After consuming various vitamins, including zinc, for 45 days, my menstruation returned on its own, something I had not experienced before. My overall health has improved, with increased energy levels and even skin tone. Surprisingly, I've not gained weight despite stopping contraceptives, which previously led to weight gain and emotional instability.
7.5
Virus protection
9 people found this helpful
Zinc serves as antiviral protection and strengthens immunity and hair growth. During viral outbreaks, zinc is essential, paired with vitamin C and D3, to expedite recovery. However, caution is needed with high dosages due to the risk of flushing copper from the body. I ensure I take it after meals to mitigate side effects. This supplement is standard-sized and easy to swallow and is always within my first-aid kit for emergencies.
8
Zinc transport's role in T cells
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
9
Zinc supplementation benefits MS models
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
4
Zinc intake influences autoimmune risk
Higher dietary zinc intake increases the risk of autoimmune thyroiditis.
We examined the connection between dietary zinc intake and the risk of autoimmune thyroiditis (AIT), particularly focusing on Hashimoto's thyroiditis. The study analyzed data from the 2007-2008 National Health and Nutrition Examination Survey, including nearly 5,500 participants—273 with AIT and 5,194 without it.
Our findings revealed that higher dietary zinc intake is associated with an increased risk of AIT, acting as an independent risk factor. This is concerning, as excessive zinc could disrupt our immune balance, potentially leading to other autoimmune disorders.
While it’s clear that zinc plays a role in thyroid health, we must be cautious about how much we consume. The study suggests that dietary zinc should be carefully monitored in those at risk for AIT, and it highlights the need for further research to establish safe consumption levels.
8
Zinc's role in alopecia areata
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.
The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.
Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
9
Zinc intake benefits RA bone health
The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
References
Shao Y, Mu Q, Wang R, Luo H, Song Z, et al. SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease. Sci China Life Sci. 2025. 10.1007/s11427-024-2817-y
Chen L, Yan C, Huang C, Jiang Z, Lin R, et al. Higher dietary zinc intake increases the risk of autoimmune thyroiditis. Postgrad Med J. 2025. 10.1093/postmj/qgae202
Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. 10.1111/jocd.16740
Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. 10.1016/j.jtemb.2024.127540
Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. 10.1186/s12891-024-07768-5
Cheng J, Rink L, Wessels I. Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4. Mol Nutr Food Res. 2024;68:e2400013. 10.1002/mnfr.202400013