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After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.
The results revealed that zinc significantly reduced the occurrence of genital ulcers and inflammation markers like NLRP3 and caspase-1. In fact, zinc supplementation improved clinical conditions and decreased inflammatory markers, showing promise as an additional therapy for managing Behçet's disease.
We found that polaprezinc's healing effectiveness was comparable to that of rebamipide, with healing rates at 90.3% and 91.4% respectively. This means that while both treatments are effective, we didn’t observe a significant advantage of one over the other in promoting ulcer healing.
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The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.
We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.
Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.
Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
The combination of zinc with chlorogenic acid and indocyanine green promotes a healing environment by reducing inflammation and oxidative stress at the ulcer site. This hydrogel is designed to release its active ingredients right where they’re needed, and we found that it significantly enhances the expression of proteins important for blood vessel formation, including VEGF and CD31.
In our experiments, both in the lab and in real-life conditions, this zinc-enriched hydrogel showed promising results. It effectively inhibited the growth of the common bacteria Staphylococcus aureus after applying laser treatment and helped wounds remodel within 14 days.
This study suggests that incorporating zinc into wound care strategies could significantly improve treatment outcomes for patients suffering from DFUs. Overall, our findings open up new avenues for managing this challenging health issue.
The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.
Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.
While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.
Interestingly, we also examined how the combination of Polaprezinc with Aspergillusidone G could enhance these effects. When we treated the microglia with both substances, the results were promising. The duo improved the inhibition of nitric oxide generation from about 30% to an impressive 80%. This indicates a possible synergistic anti-inflammatory effect that could offer new approaches in managing neuroinflammatory conditions.
Overall, our findings shed light on the importance of zinc's role in the therapeutic effects of Polaprezinc, especially when paired with other compounds like Aspergillusidone G. This combination opens up exciting avenues for research into treatments for neurodegenerative diseases, highlighting the crucial connection between inflammation and zinc in the context of ulcer management.
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Frequently Asked Questions
An ulcer is a sore that develops on the lining of the stomach, small intestine, or colon. It occurs when the digestive tract is damaged or inflamed, often due to an imbalance between stomach acid and the protective factors in the digestive system. The most common types of ulcers include peptic ulcers, which can be further categorized into gastric ulcers (located in the stomach) and duodenal ulcers (found in the first part of the small intestine). Symptoms may include burning stomach pain, bloating, and nausea, which can vary in intensity based on the severity of the condition.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is known to play a role in immune function and wound healing, which can be beneficial for those suffering from ulcers. Research indicates that zinc may help reduce inflammation and promote cell repair, contributing to the healing process of gastric and peptic ulcers. It's important to note that while zinc can support overall gut health and immune function, it should not be viewed as a standalone treatment for ulcers. Instead, it may act as a complementary supplement to other conventional therapies.
Before adding zinc or any supplement to your regimen, it's best to consult with a healthcare provider. They can provide guidance on the appropriate dosage and ensure it won't interact with any medications you may be taking for your ulcer. Furthermore, maintaining a balanced diet rich in antioxidants, vitamins, and minerals is crucial for supporting ulcer healing. While zinc can certainly be a helpful addition to your overall health strategy, relying solely on it without proper medical advice may not yield the desired results.
Based on user reviews, the timeframe for seeing results when taking zinc for mouth ulcers can vary. Many users report experiencing a significant reduction in mouth ulcers shortly after starting the supplement. For instance, a reviewer noted that they haven’t experienced any mouth ulcers after beginning zinc supplementation, which they attributed to the supplement's effectiveness ((Read Review)). Another user indicated improved healing times, stating mouth ulcers heal very quickly after starting zinc ((Read Review)).
Others mentioned the importance of consistent use, with one reviewer noting improvements after several weeks of taking zinc, even though they did not take it every day ((Read Review)). Some users indicated that taking zinc before an ulcer appears can prevent them from worsening, emphasizing its potential effectiveness when started early. Overall, you can expect to see results generally within a few weeks to a couple of months, but consistent use seems to play a crucial role in maintaining those benefits.
The scientific research indicates that zinc supplementation may have beneficial effects on various types of ulcers, including those associated with ulcerative colitis and chronic wounds. For instance, one study highlighted how zinc hyaluronate (ZnHA) significantly alleviated symptoms of ulcerative colitis in a mouse model by reducing inflammatory markers and enhancing gut health [1]. Additionally, the combination of zinc with other natural compounds showed promise in treating and managing ulcerative colitis by improving gut barrier function and reducing inflammation [9].
However, the overall evidence regarding zinc's efficacy in ulcer treatment remains mixed. While some studies suggest that zinc enhances healing, such as through oral nutritional formulas, others indicate inconsistent benefits when used alone [10]. Specific applications, such as in managing Helicobacter pylori-associated ulcers, show improved treatment outcomes when zinc is part of a combined therapy but do not isolate its effects [5]. Hence, while zinc's supportive role in ulcer treatment is gaining recognition, more research is needed to determine its effectiveness as a standalone treatment.
Based on user reviews, many individuals report significant improvements in their mouth ulcer symptoms after starting zinc supplementation. Users like the one who experienced a severe mouth ulcer episode noted that after six months of zinc tablets, their ulcers have not returned, demonstrating lasting benefits ((Read Review)). Other reviewers echoed this sentiment, with one parent stating their son has not suffered from mouth ulcers at all since beginning to take zinc supplements ((Read Review)).
Users also highlight the rapid healing of mouth ulcers once they occur. One reviewer mentioned that their mouth ulcers healed very quickly after starting zinc ((Read Review)). Some users even reported a preventative effect, stating that taking zinc before ulcers develop can prevent them from worsening or appearing at all ((Read Review)). While the experiences detailed by users suggest a promising potential for zinc in managing mouth ulcer symptoms, it is important to note that individual results can vary greatly depending on personal health conditions and adherence to supplementation.
Based on user reviews, many individuals reported positive outcomes when combining zinc supplementation with other health practices for managing mouth ulcers. Users emphasized that taking zinc helped to reduce the frequency of mouth ulcers and, when they did appear, the ulcers healed more quickly. One reviewer mentioned that simply consuming zinc reduced the likelihood of mouth ulcers occurring and that halting the supplement led to a resurgence of stomatitis symptoms ((Read Review)). Another user highlighted the effectiveness of zinc in aiding recovery, stating they experienced rapid healing of ulcers after introduction of the supplement into their diet ((Read Review)).
In addition, users shared their routine adjustments, such as taking zinc at higher doses or increasing frequency during flare-ups. For instance, one individual took 50 mg every two days as a preventive measure and noticed a significant decrease in ulcer occurrences ((Read Review)). Another reviewer suggested that taking zinc before the appearance of an ulcer could help halt its escalation, further supporting the idea that strategic combination and timing of supplements may enhance overall results ((Read Review)). Overall, these experiences indicate that users find zinc complementary to other approaches in managing mouth ulcer symptoms.
Based on user reviews, the appropriate dose of zinc for treating mouth ulcers appears to vary among individuals, with some finding success at higher dosages. For instance, one user reported taking a hefty dose of 50 mg every two days and noted that it helped prevent tongue ulcers, which would vanish the next day if they occurred (Read Review). Conversely, another user mentioned initially believing their dosage was too high and opted to reduce the frequency, taking the supplement every other day instead (Read Review).
Users consistently report that zinc is effective in combating mouth ulcers. One reviewer shared that after switching to zinc tablets, their blood tests showed normal levels, and their ulcers didn't return (Read Review). Others echoed similar sentiments, reporting a noticeable reduction in the severity and frequency of their mouth ulcers after starting zinc supplements (Read Review). Overall, while higher doses seem beneficial for some, others achieve good results with less frequent use, emphasizing the importance of individual experimentation to find the right dose.
Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.
Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.
Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
Our findings revealed that QDTP-Zn significantly improved the symptoms of UC. We observed a reduction in disease activity, which indicates that the treatment was effective. Furthermore, QDTP-Zn seemed to enhance the health of colon tissues by increasing levels of important proteins while simultaneously reducing inflammatory markers.
Interestingly, the treatment influenced the makeup of gut microbiota and boosted levels of short-chain fatty acids, which are essential for gut health. This suggests that zinc, when combined with QDTP, plays a role in strengthening gut barriers, reducing inflammation, and promoting beneficial microbial populations.
In conclusion, our research highlights the promise of QDTP-Zn as a potential food supplement that could be used for both the prevention and management of ulcerative colitis, showcasing the therapeutic power of combining zinc with natural polysaccharides.
Among the studies we examined, some suggested that a hypercaloric and hyperproteic formula enriched with zinc, along with important vitamins A, C, and E, could promote wound healing effectively. Specifically, four studies indicated that these enriched formulas led to a noticeable reduction in wound area, showcasing an increase in healing rates.
However, it's worth noting that two studies reported no significant differences in healing rates when zinc was incorporated into the treatment. Additionally, other approaches featuring combinations like arginine and glutamine did not show significant improvements over the control groups, further complicating the picture.
This indicates that while zinc might play a beneficial role, the evidence isn't uniformly strong regarding its isolated effect on ulcer healing. Overall, we found that a desirable formula for promoting healing seems to focus on high calories, protein content, and antioxidants, which may include zinc as part of a larger cocktail of nutrients.
The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.
We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
References
- Zhang L, Fu X, Li J, Xiao W, Xiong X, et al. Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice. J Microbiol Biotechnol. 2025;35:e2408050. doi:10.4014/jmb.2408.08050
- Seo HR, Chung KB, Kim DY. The Possible Impact of Zinc-Enriched Multivitamins on Treatment-Naïve Recurrent Aphthous Stomatitis Patients. J Clin Med. 2025;14. doi:10.3390/jcm14010260
- Wu Z, Wu W, Zhang C, Zhang W, Li Y, et al. Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects. Carbohydr Polym. 2025;347:122740. doi:10.1016/j.carbpol.2024.122740
- Grimm K, Fiedler A, Kröger C. Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds. J Dairy Sci. 2025;108:1869. doi:10.3168/jds.2024-25134
- Laudanno O, Ahumaran G, Thome M, Adami P, Ustares F, et al. [Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment]. Medicina (B Aires). 2024;84:884.
- Huang Y, Shang S, Du H. Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study. Skin Res Technol. 2024;30:e13904. doi:10.1111/srt.13904
- Ban F, Zhou L, Yang Z, Liu Y, Zhang Y. Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study. Mar Drugs. 2024;22. doi:10.3390/md22070324
- Govindarasu M, Vaiyapuri M, Kim JC. Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model. Bioprocess Biosyst Eng. 2024;47:1393. doi:10.1007/s00449-024-03047-8
- Zheng M, Xie C, Ye D, Chen Y, Wang Z, et al. Qingzhuan dark tea polysaccharides-zinc alleviates dextran sodium sulfate-induced ulcerative colitis. J Sci Food Agric. 2024;104:7617. doi:10.1002/jsfa.13597
- Santo ACSDE, Sugizaki CSA, de Morais Junior AC, Costa NA, Bachion MM, et al. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Nutrition. 2024;124:112449. doi:10.1016/j.nut.2024.112449
- Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999
- Faghfouri AH, Baradaran B, Khabbazi A, Abdoli Shadbad M, Papi S, et al. Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial. Int Immunopharmacol. 2022;109:108825. doi:10.1016/j.intimp.2022.108825
- Jung DH, Park JC, Lee YC, Lee SK, Shin SK, et al. Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers. J Clin Gastroenterol. 2021;55:233. doi:10.1097/MCG.0000000000001357
- Scheid PL, Lâm TT, Sinsch U, Balczun C. Vermamoeba vermiformis as etiological agent of a painful ulcer close to the eye. Parasitol Res. 2019;118:1999. doi:10.1007/s00436-019-06312-y
- Ficarra G, Cicchi P, Amorosi A, Piluso S. Oral Crohn's disease and pyostomatitis vegetans. An unusual association. Oral Surg Oral Med Oral Pathol. 1993;75:220.
- Cho CH, Ogle CW, Dai S. Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats. Eur J Pharmacol. 1976;38:337.
