Last update
3/13/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.9
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from 1,250 mg Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
9
We examined the effects of acetyl L-carnitine (ALC) on motor function in mice with a demyelinating condition, simulating aspects of multiple sclerosis. In this study, some mice were treated with ALC while others were not, allowing us to compare their recovery.
The results were promising; ALC not only enhanced balance and motor coordination but also supported myelin repair by lowering oxidative stress. Key genes associated with myelin were positively regulated, indicating ALC's potential as a therapeutic agent in managing autoimmune disorders like MS.
The results were promising; ALC not only enhanced balance and motor coordination but also supported myelin repair by lowering oxidative stress. Key genes associated with myelin were positively regulated, indicating ALC's potential as a therapeutic agent in managing autoimmune disorders like MS.
Read More
9
We examined how acetyl-L-carnitine (ALCAR) might help in cases of peripheral neuropathy linked to autoimmune conditions. In a controlled study involving rat subjects, we observed that ALCAR effectively reduced signs of nerve cell death, unlike other treatments.
By limiting apoptosis mechanisms—like the release of harmful proteins and the activation of cell death pathways—ALCAR showcased a protective effect. Overall, these findings suggest ALCAR could be a promising option for managing nerve damage related to autoimmune disorders.
By limiting apoptosis mechanisms—like the release of harmful proteins and the activation of cell death pathways—ALCAR showcased a protective effect. Overall, these findings suggest ALCAR could be a promising option for managing nerve damage related to autoimmune disorders.
Read More
8
ALCAR shows promise for MS fatigue
We examined the effects of acetyl L-carnitine (ALCAR) on fatigue in multiple sclerosis patients by conducting a randomized, double-blind, crossover trial with 36 participants. After comparing ALCAR with amantadine, a common fatigue treatment for MS, we found that ALCAR was significantly more effective in reducing fatigue severity.
While ALCAR showed better tolerance and positive results according to the Fatigue Severity Scale, secondary measures like the Fatigue Impact Scale and Beck Depression Inventory didn't indicate significant benefits. Overall, ALCAR may provide a valuable alternative for managing fatigue in MS patients.
While ALCAR showed better tolerance and positive results according to the Fatigue Severity Scale, secondary measures like the Fatigue Impact Scale and Beck Depression Inventory didn't indicate significant benefits. Overall, ALCAR may provide a valuable alternative for managing fatigue in MS patients.
Read More
Most Useful Reviews
7.5
Improved brain function
135 people found this helpful
I have been ordering for several years, 500 ml of 100 pills. This product from Now is perfectly balanced. The capsules are not large and white, and the composition helps my brain function more efficiently; my drowsiness has alleviated and my overall mood has improved. I highly recommend this high-quality product.
Read More
7.5
Improved normalcy
17 people found this helpful
Acetyl-L-Carnitine was purchased for my dad to enhance his overall condition. Following a doctor's advice, he took 1 capsule twice daily. Initially, he was quite irritable and suffered from high blood pressure. However, after a month, his nerves settled, and his blood pressure returned to normal. His well-being improved significantly. We appreciated the quality, ingredients, and beneficial composition of the product.
Read More
9
Boosted energy levels
6 people found this helpful
I’ve been feeling utterly exhausted for the past four months, even upon waking. I decided to try this supplement, and after just two weeks, I felt an immediate surge of energy. It truly revitalised me. If you find my review helpful, I’d appreciate a click on YES.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
- All Researches
9
We examined the effects of acetyl L-carnitine (ALC) on motor function in mice with a demyelinating condition, simulating aspects of multiple sclerosis. In this study, some mice were treated with ALC while others were not, allowing us to compare their recovery.
The results were promising; ALC not only enhanced balance and motor coordination but also supported myelin repair by lowering oxidative stress. Key genes associated with myelin were positively regulated, indicating ALC's potential as a therapeutic agent in managing autoimmune disorders like MS.
The results were promising; ALC not only enhanced balance and motor coordination but also supported myelin repair by lowering oxidative stress. Key genes associated with myelin were positively regulated, indicating ALC's potential as a therapeutic agent in managing autoimmune disorders like MS.
Read More
9
We examined how acetyl-L-carnitine (ALCAR) might help in cases of peripheral neuropathy linked to autoimmune conditions. In a controlled study involving rat subjects, we observed that ALCAR effectively reduced signs of nerve cell death, unlike other treatments.
By limiting apoptosis mechanisms—like the release of harmful proteins and the activation of cell death pathways—ALCAR showcased a protective effect. Overall, these findings suggest ALCAR could be a promising option for managing nerve damage related to autoimmune disorders.
By limiting apoptosis mechanisms—like the release of harmful proteins and the activation of cell death pathways—ALCAR showcased a protective effect. Overall, these findings suggest ALCAR could be a promising option for managing nerve damage related to autoimmune disorders.
Read More
8
ALCAR shows promise in MS therapy
We investigated how acetyl L-carnitine (ALCAR) could affect autoimmune disorders like multiple sclerosis (MS). In our study, we treated rats with relapsing-remitting experimental autoimmune encephalomyelitis using various approaches, including ALCAR alone and in combination with dexamethasone, a standard treatment.
The results showed that when combined with dexamethasone, ALCAR significantly reduced damaging compounds and boosted protective ones. This combination improved overall motor function and reduced harmful immune responses compared to untreated rats.
Thus, ALCAR appears promising as a supplementary treatment alongside traditional therapies for MS.
The results showed that when combined with dexamethasone, ALCAR significantly reduced damaging compounds and boosted protective ones. This combination improved overall motor function and reduced harmful immune responses compared to untreated rats.
Thus, ALCAR appears promising as a supplementary treatment alongside traditional therapies for MS.
Read More
8
ALCAR shows promise for MS fatigue
We examined the effects of acetyl L-carnitine (ALCAR) on fatigue in multiple sclerosis patients by conducting a randomized, double-blind, crossover trial with 36 participants. After comparing ALCAR with amantadine, a common fatigue treatment for MS, we found that ALCAR was significantly more effective in reducing fatigue severity.
While ALCAR showed better tolerance and positive results according to the Fatigue Severity Scale, secondary measures like the Fatigue Impact Scale and Beck Depression Inventory didn't indicate significant benefits. Overall, ALCAR may provide a valuable alternative for managing fatigue in MS patients.
While ALCAR showed better tolerance and positive results according to the Fatigue Severity Scale, secondary measures like the Fatigue Impact Scale and Beck Depression Inventory didn't indicate significant benefits. Overall, ALCAR may provide a valuable alternative for managing fatigue in MS patients.
Read More
7
We explored the effects of acetyl-L-carnitine and nicotinamide on children at risk for type 1 diabetes. These children were carefully monitored over time, with some showing significant improvement in their diabetic markers after treatment.
Out of the nine participants, four experienced a return to normal parameters, while two continued treatment with positive outcomes. Unfortunately, one child did progress to diabetes after a delayed start. Overall, this treatment appears to delay or even reverse the development of type 1 diabetes in at-risk children.
Out of the nine participants, four experienced a return to normal parameters, while two continued treatment with positive outcomes. Unfortunately, one child did progress to diabetes after a delayed start. Overall, this treatment appears to delay or even reverse the development of type 1 diabetes in at-risk children.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved brain function
135 people found this helpful
I have been ordering for several years, 500 ml of 100 pills. This product from Now is perfectly balanced. The capsules are not large and white, and the composition helps my brain function more efficiently; my drowsiness has alleviated and my overall mood has improved. I highly recommend this high-quality product.
Read More
7.5
Improved normalcy
17 people found this helpful
Acetyl-L-Carnitine was purchased for my dad to enhance his overall condition. Following a doctor's advice, he took 1 capsule twice daily. Initially, he was quite irritable and suffered from high blood pressure. However, after a month, his nerves settled, and his blood pressure returned to normal. His well-being improved significantly. We appreciated the quality, ingredients, and beneficial composition of the product.
Read More
9
Boosted energy levels
6 people found this helpful
I’ve been feeling utterly exhausted for the past four months, even upon waking. I decided to try this supplement, and after just two weeks, I felt an immediate surge of energy. It truly revitalised me. If you find my review helpful, I’d appreciate a click on YES.
Read More
7.5
Good results noted
4 people found this helpful
My husband has been using it alongside other medications and has seen great results. The protein content is substantial, providing us with plenty for an extended period. We always reorder when we run low. It gives energy and lifts mood. The taste is acceptable.
Read More
6
Improved confidence
3 people found this helpful
Based on the description and reviews, I ordered these capsules after gaining weight and feeling unable to exercise. They provide confidence during workouts and improve my endurance, allowing me to fully engage in the exercises. The effect is subtle yet effective, and I wholeheartedly recommend them.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Gharighnia S, Omidi A, Ragerdi Kashani I, Sepand MR, Pour Beiranvand S. Ameliorative effects of acetyl-L-carnitine on corpus callosum and functional recovery in demyelinated mouse model. Int J Neurosci. 2024;134:409. 10.1080/00207454.2022.2107515
- Zidan A, Hedya SE, Elfeky DM, Abdin AA. The possible anti-apoptotic and antioxidant effects of acetyl l-carnitine as an add-on therapy on a relapsing-remitting model of experimental autoimmune encephalomyelitis in rats. Biomed Pharmacother. 2018;103:1302. 10.1016/j.biopha.2018.04.173
- Yang TT, Wang L, Deng XY, Yu G. Pharmacological treatments for fatigue in patients with multiple sclerosis: A systematic review and meta-analysis. J Neurol Sci. 2017;380:256. 10.1016/j.jns.2017.07.042
- Fernandez IC, Del Carmen Camberos M, Passicot GA, Martucci LC, Cresto JC. Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide - case reports. J Pediatr Endocrinol Metab. 2013;26:347. 10.1515/jpem-2012-0128
- Di Cesare Mannelli L, Ghelardini C, Calvani M, Nicolai R, Mosconi L, et al. Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral neuropathy. Eur J Neurosci. 2007;26:820. PubMed
- Lebrun C, Alchaar H, Candito M, Bourg V, Chatel M. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Mult Scler. 2006;12:321. PubMed
- Hao Y, Basile AS, Chen G, Zhang L. Glutamate-induced over-expression of GAD is down-regulated by acetyl-L-carnitine in rat islet cells. Endocr Res. 2004;30:107. PubMed
- Tomassini V, Pozzilli C, Onesti E, Pasqualetti P, Marinelli F, et al. Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. J Neurol Sci. 2004;218:103. PubMed
- Calabrese V, Scapagnini G, Ravagna A, Bella R, Butterfield DA, et al. Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine. Neurochem Res. 2003;28:1321. PubMed
- Seidman MD, Khan MJ, Bai U, Shirwany N, Quirk WS. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. Am J Otol. 2000;21:161. PubMed
Data last updated:
