Last update
3/13/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.9
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from 1,250 mg Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
9
We investigated the impacts of acetyl L-carnitine (ALC) on chronic fatigue in elderly patients, examining 96 individuals aged 70 and above. The study utilized fatigue scales to assess changes after treatment.
Results indicated that ALC significantly reduced both physical and mental fatigue while improving cognitive function and overall physical status. Participants reported a notable decrease in muscle pain and sleep disorders, alongside improvements in fatigue severity.
Overall, ALC shows promise as a treatment option for alleviating chronic fatigue in older adults.
Results indicated that ALC significantly reduced both physical and mental fatigue while improving cognitive function and overall physical status. Participants reported a notable decrease in muscle pain and sleep disorders, alongside improvements in fatigue severity.
Overall, ALC shows promise as a treatment option for alleviating chronic fatigue in older adults.
Read More
7
We explored the impact of acetyl L-carnitine, propionyl L-carnitine, and their combination on chronic fatigue syndrome (CFS) in a group of 90 patients over 24 weeks.
The results indicated significant improvements in fatigue and attention concentration, with acetyl L-carnitine particularly benefiting mental fatigue and propionyl L-carnitine focused on general fatigue.
However, those receiving both treatments showed less improvement. It’s also worth noting that many patients experienced a return of fatigue after treatment ended.
The results indicated significant improvements in fatigue and attention concentration, with acetyl L-carnitine particularly benefiting mental fatigue and propionyl L-carnitine focused on general fatigue.
However, those receiving both treatments showed less improvement. It’s also worth noting that many patients experienced a return of fatigue after treatment ended.
Read More
7
We analyzed a study that compared duloxetine and acetyl L-carnitine in treating female patients with fibromyalgia syndrome (FMS).
Over 12 weeks, the 65 participants took either duloxetine or acetyl L-carnitine, with evaluations conducted to assess their symptoms.
While both treatments improved overall well-being and pain levels, only duloxetine showed significant effects on anxiety and psychological aspects of quality of life.
Thus, acetyl L-carnitine shows promise but may not offer significant benefits for anxiety improvement in FMS patients.
Over 12 weeks, the 65 participants took either duloxetine or acetyl L-carnitine, with evaluations conducted to assess their symptoms.
While both treatments improved overall well-being and pain levels, only duloxetine showed significant effects on anxiety and psychological aspects of quality of life.
Thus, acetyl L-carnitine shows promise but may not offer significant benefits for anxiety improvement in FMS patients.
Read More
Most Useful Reviews
10
Significant improvement.
81 people found this helpful
I suspect I have CFS, and this product improved my condition remarkably within a day. I reduced my sleep requirement from 9.5 hours to about 8.5 hours and felt more energetic with fewer headaches. Discovering that I had symptoms of CFS was surprising; I always thought I had depression, but anti-depressants weren't effective. This treatment has been a miracle for me. If you're persistently tired, give it a go—you have nothing to lose but a bit of money.
Read More
9
Increased physical endurance
3 people found this helpful
Battery Energizer is always with me! I highly recommend it for enhancing physical endurance. I take 2 capsules in the morning. Although the instructions allow for up to 4 tablets daily, I found that 2 gives me so much energy that I feel I can do anything! I no longer feel fatigued, even in the evenings. If you wish to keep pace, buy and take this—you won't regret it!
Read More
9
Energy boost
1 people found this helpful
After reading many positive reviews about this supplement, I decided to try it. To my delight, my fatigue has decreased since I started taking it. I feel motivated to do more and move around, which is truly wonderful. I plan to continue taking these vitamins. Please give a thumbs up if you like my review!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
- All Researches
9
We investigated the impacts of acetyl L-carnitine (ALC) on chronic fatigue in elderly patients, examining 96 individuals aged 70 and above. The study utilized fatigue scales to assess changes after treatment.
Results indicated that ALC significantly reduced both physical and mental fatigue while improving cognitive function and overall physical status. Participants reported a notable decrease in muscle pain and sleep disorders, alongside improvements in fatigue severity.
Overall, ALC shows promise as a treatment option for alleviating chronic fatigue in older adults.
Results indicated that ALC significantly reduced both physical and mental fatigue while improving cognitive function and overall physical status. Participants reported a notable decrease in muscle pain and sleep disorders, alongside improvements in fatigue severity.
Overall, ALC shows promise as a treatment option for alleviating chronic fatigue in older adults.
Read More
7
We analyzed a study that compared duloxetine and acetyl L-carnitine in treating female patients with fibromyalgia syndrome (FMS).
Over 12 weeks, the 65 participants took either duloxetine or acetyl L-carnitine, with evaluations conducted to assess their symptoms.
While both treatments improved overall well-being and pain levels, only duloxetine showed significant effects on anxiety and psychological aspects of quality of life.
Thus, acetyl L-carnitine shows promise but may not offer significant benefits for anxiety improvement in FMS patients.
Over 12 weeks, the 65 participants took either duloxetine or acetyl L-carnitine, with evaluations conducted to assess their symptoms.
While both treatments improved overall well-being and pain levels, only duloxetine showed significant effects on anxiety and psychological aspects of quality of life.
Thus, acetyl L-carnitine shows promise but may not offer significant benefits for anxiety improvement in FMS patients.
Read More
7
We explored the impact of acetyl L-carnitine, propionyl L-carnitine, and their combination on chronic fatigue syndrome (CFS) in a group of 90 patients over 24 weeks.
The results indicated significant improvements in fatigue and attention concentration, with acetyl L-carnitine particularly benefiting mental fatigue and propionyl L-carnitine focused on general fatigue.
However, those receiving both treatments showed less improvement. It’s also worth noting that many patients experienced a return of fatigue after treatment ended.
The results indicated significant improvements in fatigue and attention concentration, with acetyl L-carnitine particularly benefiting mental fatigue and propionyl L-carnitine focused on general fatigue.
However, those receiving both treatments showed less improvement. It’s also worth noting that many patients experienced a return of fatigue after treatment ended.
Read More
7
ALCAR improves MS fatigue tolerance
We conducted a clinical trial to see how acetyl L-carnitine (ALCAR) stacks up against amantadine for treating fatigue in multiple sclerosis patients. In this study, 36 patients were given either ALCAR or amantadine for three months and then switched to the other treatment after a washout period.
We found that ALCAR showed greater effectiveness in reducing fatigue, as measured by the Fatigue Severity Scale. However, it did not show significant benefits in other areas like depression or social experiences. Overall, ALCAR was better tolerated than amantadine, making it a promising option for managing fatigue.
We found that ALCAR showed greater effectiveness in reducing fatigue, as measured by the Fatigue Severity Scale. However, it did not show significant benefits in other areas like depression or social experiences. Overall, ALCAR was better tolerated than amantadine, making it a promising option for managing fatigue.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Significant improvement.
81 people found this helpful
I suspect I have CFS, and this product improved my condition remarkably within a day. I reduced my sleep requirement from 9.5 hours to about 8.5 hours and felt more energetic with fewer headaches. Discovering that I had symptoms of CFS was surprising; I always thought I had depression, but anti-depressants weren't effective. This treatment has been a miracle for me. If you're persistently tired, give it a go—you have nothing to lose but a bit of money.
Read More
9
Increased physical endurance
3 people found this helpful
Battery Energizer is always with me! I highly recommend it for enhancing physical endurance. I take 2 capsules in the morning. Although the instructions allow for up to 4 tablets daily, I found that 2 gives me so much energy that I feel I can do anything! I no longer feel fatigued, even in the evenings. If you wish to keep pace, buy and take this—you won't regret it!
Read More
9
Energy boost
1 people found this helpful
After reading many positive reviews about this supplement, I decided to try it. To my delight, my fatigue has decreased since I started taking it. I feel motivated to do more and move around, which is truly wonderful. I plan to continue taking these vitamins. Please give a thumbs up if you like my review!
Read More
9
Strength improvement
L-Carnitine significantly helped with my chronic fatigue syndrome, increasing my energy and strength just within the first week of use. Wishing good health to all!
Read More
9
Mental clarity
NOW Foods Acetyl-L-Carnitine has been beneficial for improving cognitive function and boosting energy. The 500 mg dosage is effective, and the veggie capsules are easy to swallow. I have noticed increased mental clarity and less fatigue since starting this supplement.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Leombruni P, Miniotti M, Colonna F, Sica C, Castelli L, et al. A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: preliminary data. Clin Exp Rheumatol. 2015;33:S82. PubMed
- Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46:181. PubMed
- Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004;66:276. PubMed
- Tomassini V, Pozzilli C, Onesti E, Pasqualetti P, Marinelli F, et al. Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. J Neurol Sci. 2004;218:103. PubMed
Data last updated:
