Last update
3/21/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Polyunsaturated Fat
1 g
***
Evening Primrose Oil
1,000 mg (1 g)
***
Cis-Linoleic Acid (LA)
730 mg
***
Gamma-Linolenic Acid (GLA)
90 mg
***
Top Medical Research Studies
4
We looked at how evening primrose oil, rich in gamma-linolenic acid, might help patients with rheumatoid arthritis. In a 6-month double-blind study, 40 participants took either evening primrose oil or a placebo. While some mild improvements were noted in morning stiffness for those on the supplement, overall, the benefits were not significant. Interestingly, olive oil also showed notable effects in reducing pain by the study's end. Therefore, evening primrose oil may offer some benefits, but olive oil deserves attention for its own positive outcomes.
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8
Dietary supplements in multiple sclerosis
We explored how evening primrose oil, along with hemp seed oil and a specific diet, can influence relapsing remitting multiple sclerosis (RRMS). In a double-blind, randomized trial, 100 patients were divided into three groups to receive varying supplements over six months.
Our findings indicated that co-supplementation with evening primrose and hemp seed oils, combined with a Hot-natured diet, could improve clinical symptoms and regulate certain enzymes linked to the condition. This suggests a potential dietary approach for managing RRMS.
Our findings indicated that co-supplementation with evening primrose and hemp seed oils, combined with a Hot-natured diet, could improve clinical symptoms and regulate certain enzymes linked to the condition. This suggests a potential dietary approach for managing RRMS.
Read More
8
Evening primrose oil aids arthritis management
We aimed to understand how evening primrose oil (EPO) affects rheumatoid arthritis, a chronic inflammatory condition. This was investigated through a study involving male albino rats injected with an arthritis-inducing agent.
EPO, alone or with traditional drugs like aspirin and celecoxib, appeared to help normalize body weight and decrease inflammatory markers. Notably, treatment with EPO led to reduced joint inflammation and damage, highlighting its potential as an effective supplement alongside standard medications.
While results are encouraging, the study indicates a blend of EPO and analgesics might be ideal for managing arthritis symptoms.
EPO, alone or with traditional drugs like aspirin and celecoxib, appeared to help normalize body weight and decrease inflammatory markers. Notably, treatment with EPO led to reduced joint inflammation and damage, highlighting its potential as an effective supplement alongside standard medications.
While results are encouraging, the study indicates a blend of EPO and analgesics might be ideal for managing arthritis symptoms.
Read More
Most Useful Reviews
9
Cycle established
4 people found this helpful
Established a cycle the first time! All my life I had an irregular cycle, at least 32 days, sometimes even up to 40. I took capsules from the 1st to the 14th day of my cycle, three times daily. The cycle became 28 days immediately. After finishing the jar, I continued for several months and it’s been regular ever since. Now, I'm ordering a second jar for support. Miracles!
Read More
7.5
Cycle restored
2 people found this helpful
Amazing product! After stopping the pill, my period disappeared. I took progesterone for three months, but when I stopped, my period didn’t return. I wanted to avoid hormones again, so I ordered primrose oil out of curiosity. After just two days of taking it, my period arrived! I have hormonal imbalances and this gives me hope it can be fixed naturally, without birth control. I also hope for skin improvement.
Read More
7.5
Hot flashes diminished
6 people found this helpful
I read about the benefits of primrose oil for women's health and decided to try it. I took one capsule daily, and after two weeks, I noticed a significant reduction in daytime hot flashes, and any that occurred were less bothersome. The capsules are easy to swallow with no taste, and I plan to continue using this.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
- All Researches
9
Evening primrose oil shows potential
We investigated how evening primrose and hemp seed oil might help manage autoimmune disorders using a mouse model of multiple sclerosis. After triggering the disease in mice, we observed that the oil treatment significantly reduced disease severity.
It also altered gene expression related to inflammation and immune response in a favorable way. Notably, the oil decreased certain inflammatory gene activities while boosting protective ones, suggesting potential therapeutic benefits for autoimmune conditions like multiple sclerosis.
It also altered gene expression related to inflammation and immune response in a favorable way. Notably, the oil decreased certain inflammatory gene activities while boosting protective ones, suggesting potential therapeutic benefits for autoimmune conditions like multiple sclerosis.
Read More
8
Evening primrose oil shows potential
We evaluated how evening primrose oil (EPO) and hemp seed oil (HSO) might aid in managing autoimmune disorders like multiple sclerosis. Our research involved inducing experimental autoimmune encephalomyelitis (EAE) in mice and comparing the effects of EPO/HSO with rapamycin, a known mTOR inhibitor.
The results showed that EPO/HSO treatment notably improved the repair of myelin, reducing cell infiltration and promoting regeneration. Although our study indicated some beneficial effects, it's essential to acknowledge that the advantages reported were not as pronounced as those seen with rapamycin treatment.
The results showed that EPO/HSO treatment notably improved the repair of myelin, reducing cell infiltration and promoting regeneration. Although our study indicated some beneficial effects, it's essential to acknowledge that the advantages reported were not as pronounced as those seen with rapamycin treatment.
Read More
8
Evening primrose oil benefits rheumatoid arthritis
We explored the effects of omega-3 fatty acids and evening primrose oil in a study involving 60 patients with active rheumatoid arthritis. Over 12 weeks, participants were divided into three groups—some received fish oil, others received a combination of fish oil and evening primrose oil, while a control group got no supplementation.
Results showed that both the fish oil and the combined treatment led to significant reductions in disease activity scores and tender joints. This improvement highlights the potential of these supplements, particularly when paired, to enhance the management of rheumatoid arthritis.
Results showed that both the fish oil and the combined treatment led to significant reductions in disease activity scores and tender joints. This improvement highlights the potential of these supplements, particularly when paired, to enhance the management of rheumatoid arthritis.
Read More
8
Dietary supplements in multiple sclerosis
We explored how evening primrose oil, along with hemp seed oil and a specific diet, can influence relapsing remitting multiple sclerosis (RRMS). In a double-blind, randomized trial, 100 patients were divided into three groups to receive varying supplements over six months.
Our findings indicated that co-supplementation with evening primrose and hemp seed oils, combined with a Hot-natured diet, could improve clinical symptoms and regulate certain enzymes linked to the condition. This suggests a potential dietary approach for managing RRMS.
Our findings indicated that co-supplementation with evening primrose and hemp seed oils, combined with a Hot-natured diet, could improve clinical symptoms and regulate certain enzymes linked to the condition. This suggests a potential dietary approach for managing RRMS.
Read More
8
Evening primrose oil aids arthritis management
We aimed to understand how evening primrose oil (EPO) affects rheumatoid arthritis, a chronic inflammatory condition. This was investigated through a study involving male albino rats injected with an arthritis-inducing agent.
EPO, alone or with traditional drugs like aspirin and celecoxib, appeared to help normalize body weight and decrease inflammatory markers. Notably, treatment with EPO led to reduced joint inflammation and damage, highlighting its potential as an effective supplement alongside standard medications.
While results are encouraging, the study indicates a blend of EPO and analgesics might be ideal for managing arthritis symptoms.
EPO, alone or with traditional drugs like aspirin and celecoxib, appeared to help normalize body weight and decrease inflammatory markers. Notably, treatment with EPO led to reduced joint inflammation and damage, highlighting its potential as an effective supplement alongside standard medications.
While results are encouraging, the study indicates a blend of EPO and analgesics might be ideal for managing arthritis symptoms.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cycle established
4 people found this helpful
Established a cycle the first time! All my life I had an irregular cycle, at least 32 days, sometimes even up to 40. I took capsules from the 1st to the 14th day of my cycle, three times daily. The cycle became 28 days immediately. After finishing the jar, I continued for several months and it’s been regular ever since. Now, I'm ordering a second jar for support. Miracles!
Read More
7.5
Cycle restored
2 people found this helpful
Amazing product! After stopping the pill, my period disappeared. I took progesterone for three months, but when I stopped, my period didn’t return. I wanted to avoid hormones again, so I ordered primrose oil out of curiosity. After just two days of taking it, my period arrived! I have hormonal imbalances and this gives me hope it can be fixed naturally, without birth control. I also hope for skin improvement.
Read More
7.5
Hot flashes diminished
6 people found this helpful
I read about the benefits of primrose oil for women's health and decided to try it. I took one capsule daily, and after two weeks, I noticed a significant reduction in daytime hot flashes, and any that occurred were less bothersome. The capsules are easy to swallow with no taste, and I plan to continue using this.
Read More
9
Natural remedy found
1 people found this helpful
This oil is one of my best discoveries on iHerb. If possible, I will reorder it. I'm pleased there's a natural remedy for improving women's health. I took it voluntarily and it helped me.
Read More
7.5
Hormonal balance restored
1 people found this helpful
Evening primrose oil is excellent for restoring hormonal functions in women experiencing reduced sex hormone levels. Regular use has shown to increase sex hormone synthesis and effectively treats skin conditions like eczema and psoriasis. The ingredients are of good quality, making it a worthy option for those with hormonal disorders.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Rezapour-Firouzi S, Mohammadian M, Sadeghzadeh M, Mehranfar S, Mazloomi E. The Effects of Evening Primrose/Hemp Seed Oil Compared to Rapamycin on the Gene Expression of Immunological Parameters in Experimental Autoimmune Encephalomyelitis Splenocytes. Iran J Allergy Asthma Immunol. 2020;19:183. 10.18502/ijaai.v19i2.2771
- Rezapour-Firouzi S, Kheradmand F, Shahabi S, Tehrani AA, Mazloomi E, et al. Regulatory effects of hemp seed/evening primrose oil supplement in comparison with rapamycin on the expression of the mammalian target of and genes in experimental autoimmune encephalomyelitis. Res Pharm Sci. 2019;14:36. 10.4103/1735-5362.251851
- Veselinovic M, Vasiljevic D, Vucic V, Arsic A, Petrovic S, et al. Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. Nutrients. 2017;9. 10.3390/nu9040325
- Vasiljevic D, Veselinovic M, Jovanovic M, Jeremic N, Arsic A, et al. Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis. Clin Rheumatol. 2016;35:1909. 10.1007/s10067-016-3168-2
- Rezapour-Firouzi S, Arefhosseini SR, Ebrahimi-Mamaghani M, Baradaran B, Sadeghihokmabad E, et al. Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complement Ther Med. 2015;23:652. 10.1016/j.ctim.2015.07.003
- Rezapour-Firouzi S, Arefhosseini SR, Ebrahimi-Mamaghani M, Baradaran B, Sadeghihokmabad E, et al. Activity of liver enzymes in multiple sclerosis patients with Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention. Complement Ther Med. 2014;22:986. 10.1016/j.ctim.2014.10.004
- El-Sayed RM, Moustafa YM, El-Azab MF. Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. Inflammopharmacology. 2014;22:305. 10.1007/s10787-014-0200-5
- Rezapour-Firouzi S, Arefhosseini SR, Ebrahimi-Mamaghani M, Farhoudi M, Baradaran B, et al. Erythrocyte membrane fatty acids in multiple sclerosis patients and hot-nature dietary intervention with co-supplemented hemp-seed and evening-primrose oils. Afr J Tradit Complement Altern Med. 2013;10:519. PubMed
- Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, Mehrangiz EM, Baradaran B, et al. Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complement Ther Med. 2013;21:473. 10.1016/j.ctim.2013.06.006
- Cameron M, Gagnier JJ, Chrubasik S. Herbal therapy for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2011. 10.1002/14651858.CD002948.pub2
- Theander E, Horrobin DF, Jacobsson LT, Manthorpe R. Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome. Scand J Rheumatol. 2002;31:72. PubMed
- Brzeski M, Madhok R, Capell HA. Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. Br J Rheumatol. 1991;30:370. PubMed
- Arisaka M, Arisaka O, Yamashiro Y. Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. Prostaglandins Leukot Essent Fatty Acids. 1991;43:197. PubMed
- Belch JJ, Ansell D, Madhok R, O'Dowd A, Sturrock RD. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. Ann Rheum Dis. 1988;47:96. PubMed
- Watson J, Godfrey D, Stimson WH, Belch JJ, Sturrock RD. The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse. Int J Immunopharmacol. 1988;10:467. PubMed
- Papanikolaou N. Alteration of mercuric chloride-induced autoimmune glomerulonephritis in brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor. Prostaglandins Leukot Med. 1987;27:129. PubMed
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