Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.4
Top Medical Research Studies
9
Vitamin E aids menstrual migraine relief
We took a closer look at how vitamin E might help women suffering from menstrual migraines. In a double-blinded, placebo-controlled study with 72 participants, we compared the effects of vitamin E against a placebo over several months.
The results were promising, showing significant relief in headache severity and associated symptoms like photophobia and nausea when using vitamin E. Women reported less functional disability during this treatment. Overall, it appears that vitamin E could be a helpful option for managing menstrual migraines.
The results were promising, showing significant relief in headache severity and associated symptoms like photophobia and nausea when using vitamin E. Women reported less functional disability during this treatment. Overall, it appears that vitamin E could be a helpful option for managing menstrual migraines.
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8
Co-Q10 potentially benefits migraine patients
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
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8
Coenzyme Q10 shows promise in migraine
We explored the use of coenzyme Q10 as a preventive treatment for migraine headaches in children aged 5 to 15. Conducted as a randomized controlled trial with 72 participants, we aimed to compare how effectively coenzyme Q10 works against a commonly used medication, amitriptyline. Both treatments were assessed for their impact on the frequency, duration, and severity of migraines, as well as improvements in children's quality of life.
Our findings revealed that coenzyme Q10 offered encouraging long-term benefits for managing migraines, showing notable efficacy particularly over extended periods. While amitriptyline responded more quickly, the side effects were more pronounced in children taking this medication. Interestingly, after three months of treatment, both groups exhibited similar clinical outcomes and enhancements in quality of life.
Overall, we determined that coenzyme Q10 could serve as a viable alternative for migraine prophylaxis, given its favorable side effect profile and comparable effectiveness to traditional treatments like amitriptyline.
Our findings revealed that coenzyme Q10 offered encouraging long-term benefits for managing migraines, showing notable efficacy particularly over extended periods. While amitriptyline responded more quickly, the side effects were more pronounced in children taking this medication. Interestingly, after three months of treatment, both groups exhibited similar clinical outcomes and enhancements in quality of life.
Overall, we determined that coenzyme Q10 could serve as a viable alternative for migraine prophylaxis, given its favorable side effect profile and comparable effectiveness to traditional treatments like amitriptyline.
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Most Useful Reviews
7.5
Helpful for prevention
3 people found this helpful
High-quality product. I have been taking this since December 2021 as part of a migraine preventative (along with Riboflavin and Magnesium Glycinate) as recommended by my neurologist. It has proven very helpful for me, especially as I am allergic to many ingredients in other supplements. This one seems perfect for my needs, and I highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.2
- All Researches
9
Vitamin E aids menstrual migraine relief
We took a closer look at how vitamin E might help women suffering from menstrual migraines. In a double-blinded, placebo-controlled study with 72 participants, we compared the effects of vitamin E against a placebo over several months.
The results were promising, showing significant relief in headache severity and associated symptoms like photophobia and nausea when using vitamin E. Women reported less functional disability during this treatment. Overall, it appears that vitamin E could be a helpful option for managing menstrual migraines.
The results were promising, showing significant relief in headache severity and associated symptoms like photophobia and nausea when using vitamin E. Women reported less functional disability during this treatment. Overall, it appears that vitamin E could be a helpful option for managing menstrual migraines.
Read More
8
Vitamin E shows promise for migraine relief
We investigated the potential benefits of combined antioxidant therapy, which includes vitamin E, on migraine treatment. In a double-blind, randomized, sham-controlled pilot study in Australia, 35 adults suffering from multiple migraines per month received either the antioxidant treatment or a placebo over three months.
While there was a notable reduction in the mean number of headaches for those taking the antioxidant therapy, the difference was not statistically significant. However, we did observe that participants reported fewer monthly headache and migraine days along with decreased pain intensity. More in-depth research is needed to fully understand the effectiveness of antioxidant therapy for migraines.
While there was a notable reduction in the mean number of headaches for those taking the antioxidant therapy, the difference was not statistically significant. However, we did observe that participants reported fewer monthly headache and migraine days along with decreased pain intensity. More in-depth research is needed to fully understand the effectiveness of antioxidant therapy for migraines.
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8
We examined a unique case involving a 10-year-old girl who experienced eyebrow bleeding linked to her migraine episodes. Despite conducting thorough neurological examinations and imaging studies that returned normal results, the young patient faced recurrent, intense headaches accompanied by unusual symptoms such as bleeding around her eyebrows and red spots on her forehead.
These atypical signs suggest that her migraines may be influenced by underlying neurovascular and neuroinflammatory processes. Given the complexity of her symptoms, this case highlights the need for healthcare providers to remain vigilant and consider various manifestations of migraines.
Treatment involved using Coenzyme Q10 alongside Vitamin B2 and Cyproheptadine, leading to noticeable improvements in the frequency and intensity of her headaches. This case not only emphasizes the importance of recognizing uncommon migraine symptoms but also showcases how a combination of treatments could potentially benefit young patients suffering from migraines.
These atypical signs suggest that her migraines may be influenced by underlying neurovascular and neuroinflammatory processes. Given the complexity of her symptoms, this case highlights the need for healthcare providers to remain vigilant and consider various manifestations of migraines.
Treatment involved using Coenzyme Q10 alongside Vitamin B2 and Cyproheptadine, leading to noticeable improvements in the frequency and intensity of her headaches. This case not only emphasizes the importance of recognizing uncommon migraine symptoms but also showcases how a combination of treatments could potentially benefit young patients suffering from migraines.
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8
We aimed to understand how coenzyme Q10 affects migraine symptoms. This review highlighted that low levels of essential nutrients, including coenzyme Q10, may influence the severity and frequency of migraine attacks.
Our investigation revealed that oxidative stress and inflammation contribute to migraines. Coenzyme Q10 is noted for its role in mitochondrial function, which is vital for energy production in our cells. By supporting these processes, coenzyme Q10 could potentially alleviate migraine episodes.
Evidence from various studies indicated that coenzyme Q10 supplementation could lead to a reduction in migraine frequency and intensity. While we saw promising results, it’s clear that further prospective studies are necessary to establish a more definitive understanding of its effects.
Our investigation revealed that oxidative stress and inflammation contribute to migraines. Coenzyme Q10 is noted for its role in mitochondrial function, which is vital for energy production in our cells. By supporting these processes, coenzyme Q10 could potentially alleviate migraine episodes.
Evidence from various studies indicated that coenzyme Q10 supplementation could lead to a reduction in migraine frequency and intensity. While we saw promising results, it’s clear that further prospective studies are necessary to establish a more definitive understanding of its effects.
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8
We conducted a questionnaire-based examination to understand the effects of nonprescription therapies, particularly focusing on coenzyme Q10, on vestibular migraine (VM) symptoms. Our research involved 82 participants diagnosed with VM who were given guidance on improving sleep, hydration, exercise, and nutrition, alongside a combination supplement that included coenzyme Q10.
After three months of treatment, we found that participants experienced a significant reduction in the severity and frequency of their symptoms. The results indicated improvements across various measures, suggesting that these nonprescription therapies, which included coenzyme Q10, could help manage VM symptoms.
Notably, half of the patients reported an improvement in their dizziness handicap and vertigo-specific symptoms. While the use of this supplement appears to offer benefits, it is essential to highlight that our study did not isolate the specific impact of coenzyme Q10 alone, making it difficult to draw definitive conclusions about its effectiveness in treating migraine.
Overall, our findings provide valuable insights that suggest the potential for nonprescription therapies in alleviating vestibular migraine symptoms, warranting further investigation into the specific contributions of each component, including coenzyme Q10.
After three months of treatment, we found that participants experienced a significant reduction in the severity and frequency of their symptoms. The results indicated improvements across various measures, suggesting that these nonprescription therapies, which included coenzyme Q10, could help manage VM symptoms.
Notably, half of the patients reported an improvement in their dizziness handicap and vertigo-specific symptoms. While the use of this supplement appears to offer benefits, it is essential to highlight that our study did not isolate the specific impact of coenzyme Q10 alone, making it difficult to draw definitive conclusions about its effectiveness in treating migraine.
Overall, our findings provide valuable insights that suggest the potential for nonprescription therapies in alleviating vestibular migraine symptoms, warranting further investigation into the specific contributions of each component, including coenzyme Q10.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helpful for prevention
3 people found this helpful
High-quality product. I have been taking this since December 2021 as part of a migraine preventative (along with Riboflavin and Magnesium Glycinate) as recommended by my neurologist. It has proven very helpful for me, especially as I am allergic to many ingredients in other supplements. This one seems perfect for my needs, and I highly recommend it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Visser EJ, Drummond PD, Lee-Visser JLA. Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N-acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham-Controlled Pilot Study. Pain Pract. 2020;20:737. doi:10.1111/papr.12902
- Ziaei S, Kazemnejad A, Sedighi A. The effect of vitamin E on the treatment of menstrual migraine. Med Sci Monit. 2009;15:CR16.
- Chayasirisobhon S. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication. Headache. 2006;46:788.
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. doi:10.1097/MS9.0000000000002655
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. doi:10.3389/fnut.2024.1433390
- Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Espada-Rubio S, Agúndez JAG. Oxidative Stress and Migraine. Mol Neurobiol. 2024;61:8344. doi:10.1007/s12035-024-04114-7
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. doi:10.1111/imj.16314
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. doi:10.7762/cnr.2023.12.4.257
- Ebrahimi A, Kamyab A, Hosseini S, Ebrahimi S, Ashkani-Esfahani S. Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases. Biochem Res Int. 2023;2023:5510874. doi:10.1155/2023/5510874
- Stearns SA, Xun H, Haddad A, Rinkinen J, Bustos VP, et al. Therapeutic Options for Migraines in the Microsurgical Patient: A Scoping Review. Plast Reconstr Surg. 2024;153:988e. doi:10.1097/PRS.0000000000010861
- Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. doi:10.4103/abr.abr_235_20
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. doi:10.1007/s11916-022-01019-9
- Grech O, Mollan SP, Wakerley BR, Fulton D, Lavery GG, et al. The Role of Metabolism in Migraine Pathophysiology and Susceptibility. Life (Basel). 2021;11. doi:10.3390/life11050415
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. doi:10.7759/cureus.14868
- Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis. BMJ Open. 2021;11:e039358. doi:10.1136/bmjopen-2020-039358
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. doi:10.3390/jcm10010067
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