Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.5
Top Medical Research Studies
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
Read More
8
We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
Read More
7
Effectiveness of Vitamin C on Colds
We explored the effects of vitamin C on the common cold and pneumonia by examining a range of studies. Interestingly, research on animals suggests that vitamin C may have protective effects against infections. However, when it comes to preventing colds in the general population, taking more than 1 gram of vitamin C per day didn’t show significant benefits.
But there's a twist! Participants engaged in heavy physical activities saw their cold incidence reduced by half with vitamin C supplementation. Additionally, regular intake of 1 gram or more daily was linked to a 15% decrease in cold severity. While some therapeutic trials showed inconsistent results when vitamin C was taken after cold symptoms appeared, two studies did indicate that larger doses (6-8 grams per day) could effectively shorten the duration of colds compared to lower doses.
Our investigation also looked into pneumonia, but the studies were conducted in unique settings, such as a boarding school and military recruits. This makes it hard to generalize the findings to the wider population. Yet, some trials suggested benefits for pneumonia patients. Finally, the role of vitamin C in treating COVID-19 and sepsis remains unclear, with mixed results.
Given that vitamin C seems to alleviate symptoms and shorten the duration of colds, while being safe and affordable, it might be worth considering a dose of 6-8 grams per day to see if it helps at an individual level.
But there's a twist! Participants engaged in heavy physical activities saw their cold incidence reduced by half with vitamin C supplementation. Additionally, regular intake of 1 gram or more daily was linked to a 15% decrease in cold severity. While some therapeutic trials showed inconsistent results when vitamin C was taken after cold symptoms appeared, two studies did indicate that larger doses (6-8 grams per day) could effectively shorten the duration of colds compared to lower doses.
Our investigation also looked into pneumonia, but the studies were conducted in unique settings, such as a boarding school and military recruits. This makes it hard to generalize the findings to the wider population. Yet, some trials suggested benefits for pneumonia patients. Finally, the role of vitamin C in treating COVID-19 and sepsis remains unclear, with mixed results.
Given that vitamin C seems to alleviate symptoms and shorten the duration of colds, while being safe and affordable, it might be worth considering a dose of 6-8 grams per day to see if it helps at an individual level.
Read More
Most Useful Reviews
10
Stops frequent colds
4 people found this helpful
These Really Work! Honestly, the person who developed this product is a genius! They truly work and it's simply fantastic! Before I started taking them, I was constantly catching colds, but now I haven't even had a sniffle! If you were like me and used to get sick often, then these are for you! Trust me, buy this product; you won't regret it! Although I think they are rather pricey, the results keep me purchasing them!
Read More
10
Prevents colds
1 people found this helpful
The best immune system vitamins! We have relied on this exact gummy vitamin since Autumn 2019. My daughter used to suffer from frequent colds while in childcare, but since using these (and kids Xyzal), she has not required tubes in her ears. She hasn’t had a cold since then and has avoided severe illness twice. We never miss a dose and recommend them to everyone we know.
Read More
6
Alleviates symptoms
2 people found this helpful
Helps during cold season. I love the convenience of these gummies and their grape flavour! I frequently take them during the cold and flu season, and they seem to help alleviate symptoms effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
- All Researches
9
We explored the effects of ascorbic acid, commonly known as vitamin C, on cold tolerance in tomato seedlings. In our study, we discovered that applying vitamin C significantly boosts the seedlings' ability to handle cold stress.
By enhancing the antioxidant defense system, vitamin C treatment increased the enzyme activity in the seedlings' leaves. Additionally, it raised levels of important compounds such as proline, sugar, and abscisic acid, all of which play crucial roles in plant stress responses.
Our observations showed that vitamin C also protects the photosynthesis system of tomato seedlings. This implies that it helps maintain chlorophyll function, which is critical for the plant's overall health, especially under cold conditions.
Moreover, we found that vitamin C treatments led to increased expression of genes linked to antioxidant enzymes and cold response mechanisms. Overall, our findings suggest that exogenous vitamin C is a beneficial approach to improve cold tolerance in tomatoes and may provide helpful insights for farmers looking to cultivate hardier varieties during colder months.
By enhancing the antioxidant defense system, vitamin C treatment increased the enzyme activity in the seedlings' leaves. Additionally, it raised levels of important compounds such as proline, sugar, and abscisic acid, all of which play crucial roles in plant stress responses.
Our observations showed that vitamin C also protects the photosynthesis system of tomato seedlings. This implies that it helps maintain chlorophyll function, which is critical for the plant's overall health, especially under cold conditions.
Moreover, we found that vitamin C treatments led to increased expression of genes linked to antioxidant enzymes and cold response mechanisms. Overall, our findings suggest that exogenous vitamin C is a beneficial approach to improve cold tolerance in tomatoes and may provide helpful insights for farmers looking to cultivate hardier varieties during colder months.
Read More
9
We explored the impact of zinc-amino acids chelate on cold stress resistance in machine-transplanted early rice. Our investigation included other cold-resistant agents like uniconazole and abscisic acid, but we found zinc to be particularly effective. When applied during the regreening stage, zinc notably enhanced rice growth by promoting tillering and increasing the leaf area, which led to better yields.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
Read More
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
Read More
8
We explored the impact of regular gargling with an antimicrobial mouthwash that contains both cetylpyridinium chloride and zinc on upper respiratory symptoms. A total of 150 participants were split into two groups; one group just brushed their teeth, while the other group brushed and gargled with the mouthwash twice a day over three months.
Our findings revealed that those using the mouthwash experienced a 21.5% reduction in the frequency and an 11% decrease in the severity of respiratory symptoms. This strongly suggests that incorporating zinc, alongside cetylpyridinium chloride, can provide benefits for those suffering from cold-related symptoms.
However, it’s important to note that this study’s design involved multiple components, and we can’t isolate zinc’s effectiveness from the impact of the other ingredients. Still, the results encourage us to view mouthwash with these ingredients as a helpful addition to our daily hygiene routines, especially during cold and flu season.
Ultimately, this research indicates that gargling with a mouthwash containing zinc and cetylpyridinium chloride can indeed help alleviate some unpleasant cold symptoms, but we should be mindful of the combination's effects when interpreting these outcomes.
Our findings revealed that those using the mouthwash experienced a 21.5% reduction in the frequency and an 11% decrease in the severity of respiratory symptoms. This strongly suggests that incorporating zinc, alongside cetylpyridinium chloride, can provide benefits for those suffering from cold-related symptoms.
However, it’s important to note that this study’s design involved multiple components, and we can’t isolate zinc’s effectiveness from the impact of the other ingredients. Still, the results encourage us to view mouthwash with these ingredients as a helpful addition to our daily hygiene routines, especially during cold and flu season.
Ultimately, this research indicates that gargling with a mouthwash containing zinc and cetylpyridinium chloride can indeed help alleviate some unpleasant cold symptoms, but we should be mindful of the combination's effects when interpreting these outcomes.
Read More
8
We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Stops frequent colds
4 people found this helpful
These Really Work! Honestly, the person who developed this product is a genius! They truly work and it's simply fantastic! Before I started taking them, I was constantly catching colds, but now I haven't even had a sniffle! If you were like me and used to get sick often, then these are for you! Trust me, buy this product; you won't regret it! Although I think they are rather pricey, the results keep me purchasing them!
Read More
10
Prevents colds
1 people found this helpful
The best immune system vitamins! We have relied on this exact gummy vitamin since Autumn 2019. My daughter used to suffer from frequent colds while in childcare, but since using these (and kids Xyzal), she has not required tubes in her ears. She hasn’t had a cold since then and has avoided severe illness twice. We never miss a dose and recommend them to everyone we know.
Read More
6
Alleviates symptoms
2 people found this helpful
Helps during cold season. I love the convenience of these gummies and their grape flavour! I frequently take them during the cold and flu season, and they seem to help alleviate symptoms effectively.
Read More
9
Impressive results
1 people found this helpful
Love these! They have a fantastic flavour, and I have not experienced the usual sinus cold that I get every year. I am so impressed that I subscribed to receive them each month.
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7.5
Keeps cold-free
1 people found this helpful
Great flavour, easy to chew. I enjoy the taste and genuinely believe this product helps me stay cold-free. I only contracted a brief bout of flu this winter and take them regularly.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hemilä H, Chalker E. Vitamin C for the common cold and pneumonia. Pol Arch Intern Med. 2025;135. doi:10.20452/pamw.16926
- Wang X, Ran C, Fu Y, Han L, Yang X, et al. Application of Exogenous Ascorbic Acid Enhances Cold Tolerance in Tomato Seedlings through Molecular and Physiological Responses. Int J Mol Sci. 2024;25. doi:10.3390/ijms251810093
- Marusca LM, Reddy G, Blaj M, Prathipati R, Rosca O, et al. The Effects of Vitamin D Supplementation on Respiratory Infections in Children under 6 Years Old: A Systematic Review. Diseases. 2023;11. doi:10.3390/diseases11030104
- Carboo JA, Dolman-Macleod RC, Malan L, Lombard MJ. High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis. Nutr Rev. 2024;82:579. doi:10.1093/nutrit/nuad082
- Kisla Ekinci RM, Taskin Karacay IE, Celik U. Serum vitamin B12 and D levels in children with Primary Raynaud Phenomenon: a retrospective cohort study. Eur J Clin Nutr. 2022;76:1615. doi:10.1038/s41430-022-01151-0
- Harrison SE, Oliver SJ, Kashi DS, Carswell AT, Edwards JP, et al. Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training. Med Sci Sports Exerc. 2021;53:1505. doi:10.1249/MSS.0000000000002604
- Shimizu Y, Ito Y, Uotsu N, Yui K. Intake of 25-Hydroxyvitamin D May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study. Nutrients. 2020;12. doi:10.3390/nu12123769
- Muniz FWMG, Casarin M, Pola NM, Rösing CK, Silveira TMD, et al. Efficacy of regular gargling with a cetylpyridinium chloride plus zinc containing mouthwash can reduce upper respiratory symptoms. PLoS One. 2025;20:e0316807. doi:10.1371/journal.pone.0316807
- Wieland LS. Zinc for prevention and treatment of the common cold: Summary of a Cochrane review. Explore (NY). 2025;21:103111. doi:10.1016/j.explore.2025.103111
- Yuan S, Qin S, Shi Q, Chen P, Tu N, et al. Effects of different cold-resistant agents and application methods on yield and cold-resistance of machine-transplanted early rice. Front Plant Sci. 2024;15:1422374. doi:10.3389/fpls.2024.1422374
