5/12/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
Top Medical Research Studies
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
Most Useful Reviews
9
Improved Vitamin D
10 people found this helpful
This product has an excellent formulation. I have been taking various Vitamin D supplements, but the Amazon Brand Solimo delivers better Vitamin D into my system. My blood work, monitored due to cancer, indicates higher Vitamin D levels. My Oncologist advised me to continue with this brand. Thank you, Amazon!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.3
- All Researches
9
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
Read More
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
We explored the effects of Dendrobium officinale, combined with vitamin B12, on patients suffering from oral mucositis due to radiotherapy for nasopharyngeal cancer. In a well-structured study conducted at Zhejiang Cancer Hospital, we involved sixty patients, dividing them into two groups. One group received Dendrobium tea alongside vitamin B12, while the other group was given vitamin B12 alone.
Our focus was to determine how this combination could help alleviate the harsh side effects of radiotherapy, particularly the inflammation and pain associated with oral mucositis. After a month of treatment, we evaluated several factors, such as salivary flow and levels of specific immune markers in the patients' blood and saliva.
Interestingly, we discovered that Dendrobium officinale showed potential in improving oral mucositis symptoms through better salivary gland function and modifications to the oral microbiome. Though vitamin B12 was part of the treatment, it wasn’t isolated in our findings. As a result, we cannot definitively speak about its specific benefits on its own without acknowledging the combined effects with Dendrobium.
Overall, our findings highlight the promise of Dendrobium officinale in addressing oral complications from cancer treatment, yet the role of vitamin B12 remains intertwined and less distinct in this context.
Our focus was to determine how this combination could help alleviate the harsh side effects of radiotherapy, particularly the inflammation and pain associated with oral mucositis. After a month of treatment, we evaluated several factors, such as salivary flow and levels of specific immune markers in the patients' blood and saliva.
Interestingly, we discovered that Dendrobium officinale showed potential in improving oral mucositis symptoms through better salivary gland function and modifications to the oral microbiome. Though vitamin B12 was part of the treatment, it wasn’t isolated in our findings. As a result, we cannot definitively speak about its specific benefits on its own without acknowledging the combined effects with Dendrobium.
Overall, our findings highlight the promise of Dendrobium officinale in addressing oral complications from cancer treatment, yet the role of vitamin B12 remains intertwined and less distinct in this context.
Read More
8
Combining treatments reduces HPV positivity
We explored how vitamin B12, alongside other natural compounds, impacts HPV positivity in women at risk of cervical cancer. Our study involved 163 women who had either tested positive for HPV or had a history of HPV infections. They were divided into two groups: one group received a specific oral treatment containing vitamin B12 along with other ingredients for three months, while the other group underwent standard clinical monitoring.
After this period, we found that the group receiving the combination treatment showed a significant decrease in HPV positivity compared to the control group. Importantly, not only did vitamin B12 play a role in the treatment, but it was the combination of all four components—EGCG, folic acid, vitamin B12, and hyaluronic acid—that appeared particularly effective in improving the condition of their cervical health.
While vitamin B12's isolated effect on cancer isn't directly measurable from this study, we observed considerable improvements in cervical lesions as well, suggesting that this regimen may help manage HPV-related risks. This highlights the potential for natural treatments in women's health, particularly in reducing the burden of HPV, which is a critical concern for cancer prevention.
After this period, we found that the group receiving the combination treatment showed a significant decrease in HPV positivity compared to the control group. Importantly, not only did vitamin B12 play a role in the treatment, but it was the combination of all four components—EGCG, folic acid, vitamin B12, and hyaluronic acid—that appeared particularly effective in improving the condition of their cervical health.
While vitamin B12's isolated effect on cancer isn't directly measurable from this study, we observed considerable improvements in cervical lesions as well, suggesting that this regimen may help manage HPV-related risks. This highlights the potential for natural treatments in women's health, particularly in reducing the burden of HPV, which is a critical concern for cancer prevention.
Read More
8
We explored the potential benefits of a vitamin D analog in treating prostate cancer, which is a major cause of cancer-related deaths among men. Our work focused on understanding how this vitamin D form impacts cancer resistance and the tumor microenvironment. We used the Pten mouse model to observe the therapeutic effects of the vitamin D analog.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved Vitamin D
10 people found this helpful
This product has an excellent formulation. I have been taking various Vitamin D supplements, but the Amazon Brand Solimo delivers better Vitamin D into my system. My blood work, monitored due to cancer, indicates higher Vitamin D levels. My Oncologist advised me to continue with this brand. Thank you, Amazon!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- El-Najjar SE, Naser IA, Al-Wahidi KM. Is Functional Vitamin B12 Deficiency a Risk Factor for the Development of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients?. Asian Pac J Cancer Prev. 2025;26:375. 10.31557/APJCP.2025.26.2.375
- Zhang Y, Xia H, Yang S, Yu W, Liu M, et al. Dietary factors and the risk of gastric and colorectal cancers: A Mendelian randomization study. Medicine (Baltimore). 2025;104:e41610. 10.1097/MD.0000000000041610
- Yang J, Liu Y, Yao H, Sun M, Tong Y, et al. Effect of Dendrobium Officinale on Radioactive Oral Mucositis of Nasopharyngeal Carcinoma and Changes of Oral Microecology. Integr Cancer Ther. 2025;24:15347354251313524. 10.1177/15347354251313524
- Munteanu C, Mârza SM, Papuc I. The immunomodulatory effects of vitamins in cancer. Front Immunol. 2024;15:1464329. 10.3389/fimmu.2024.1464329
- Tinelli A, Gustapane S, Licchelli M, Coluccia AC, Panese G, et al. Treatment with Epigallocatechin Gallate, Folic Acid, Vitamin B12, and Hyaluronic Acid Decreases HPV Positivity in Women Attending Regional Screening in Puglia. Microorganisms. 2024;12. 10.3390/microorganisms12091897
- Rong YY, Liu PC, Huang XB, Chen GA. Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization. Expert Rev Hematol. 2024;17:833. 10.1080/17474086.2024.2410009
- Len-Tayon K, Metzger D, Laverny G. [New insights of vitamin D-based therapy for prostate cancer]. Med Sci (Paris). 2025;41:154. 10.1051/medsci/2025011
- Soni D, Tiwari A, Kushwah PS, Dubey S, Khan S. Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study. Cureus. 2025;17:e78283. 10.7759/cureus.78283
- Peixoto D, Ravasco JM, Blanco-Fernandez B, Veiga F, Concheiro A, et al. Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy. Mater Today Bio. 2025;31:101555. 10.1016/j.mtbio.2025.101555
- Xu N, Lin H, Ding X, Wang P, Lin JM. Isotope tracing-assisted chip-based solid-phase extraction mass spectrometry for monitoring metabolic changes and vitamin D3 regulation in cells. Talanta. 2025;288:127754. 10.1016/j.talanta.2025.127754
- Jo Y, Kushram P, Bose S. Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration. Biomater Sci. 2025. 10.1039/d4bm01188k
- Ezcurra-Hualde M, Zalba S, Bella Á, Arrizabalaga L, Risson A, et al. Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth. Front Immunol. 2025;16:1529007. 10.3389/fimmu.2025.1529007
- Wang L, Xu R, Wang M, Wang M, Su S, et al. Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors. Onco Targets Ther. 2025;18:129. 10.2147/OTT.S495066
- Evans H, Greenhough A, Perry L, Lasanta G, Gonzalez CM, et al. Hypoxia Compromises the Differentiation of Human Osteosarcoma Cells to CAR-R, a Hydroxylated Derivative of Lithocholic Acid and Potent Agonist of the Vitamin D Receptor. Int J Mol Sci. 2025;26. 10.3390/ijms26010365
- Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. 10.1248/cpb.c24-00598
- He W, Lv W, Liu L, Gong Y, Song K, et al. Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform. ACS Nano. 2024;18:35559. 10.1021/acsnano.4c13470
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16223960
- Maturana-Ramiìrez A, Aitken-Saavedra J, Rojas-Zúñiga G, Rojas-Alcayaga G, Espinoza-Santander I, et al. Hypovitaminosis D in patients with oral squamous cell carcinoma: Is a risk factor of developing this neoplasia?. Med Oral Patol Oral Cir Bucal. 2025;30:e24. 10.4317/medoral.26692
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial. Clin Nutr ESPEN. 2025;65:64. 10.1016/j.clnesp.2024.11.014
- García-Martínez JM, Chocarro-Calvo A, Martínez-Useros J, Regueira-Acebedo N, Fernández-Aceñero MJ, et al. SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells. Int J Biol Sci. 2024;20:5495. 10.7150/ijbs.95875
