Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.2
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Wafer
Amount Per Serving
%DV
Total Carbohydrate
1 g
<1%**
Total Sugars
<1 g
***
Includes <1 g Added Sugars
1%**
Lactobacillus BlendWhich contains 1 Billion Live Culture CFULactobacillus acidophilus La-14® and Bifidobacterium lactis BI-04
4.5 mg
***
Top Medical Research Studies
9
We investigated how the probiotic strain CCFM1274 can help alleviate allergic asthma symptoms. Using a mouse model, we administered CCFM1274 alongside ovalbumin, a common allergen, and observed positive results.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
Read More
9
Bifidobacterium lactis reduces asthma symptoms
We explored how Bifidobacterium lactis, a probiotic, might impact asthma symptoms. In a mice study, newborns were given this probiotic every other day for eight weeks while being exposed to allergens. The results showed that this treatment effectively reduced airway inflammation and allergic reactions associated with asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Read More
9
We aimed to investigate whether Lactococcus lactis NZ9000 could reduce asthmatic airway inflammation and lung tissue changes in rats while also supporting gut health.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Read More
Most Useful Reviews
9
Improved asthma control
4 people found this helpful
I have been using this probiotic brand for over five years, and it has significantly bolstered my immune system and bowel health. The new formulation, suitable for children from four years and upwards, has been effective for my six-year-old grandson, who suffers from asthma. He has experienced no breathing issues from the cold air since starting it this past month. I highly recommend this product; you will be very pleased you tried it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.2
- All Researches
9
We aimed to explore the potential benefits of a novel herbal medicine, MA, and its fermented version, MA128, on asthma treatment. This involved inducing asthma in mice and administering these treatments regularly for four weeks.
Our findings revealed that both MA and MA128 successfully reduced inflammation and airway hyperresponsiveness. Notably, the fermentation process with Lactobacillus acidophilus enhanced the effectiveness of the herbal remedy, influencing immune responses positively.
This indicates a promising avenue for asthma management through natural products, though further research is needed for clear clinical applications.
Our findings revealed that both MA and MA128 successfully reduced inflammation and airway hyperresponsiveness. Notably, the fermentation process with Lactobacillus acidophilus enhanced the effectiveness of the herbal remedy, influencing immune responses positively.
This indicates a promising avenue for asthma management through natural products, though further research is needed for clear clinical applications.
Read More
9
We investigated how the probiotic strain CCFM1274 can help alleviate allergic asthma symptoms. Using a mouse model, we administered CCFM1274 alongside ovalbumin, a common allergen, and observed positive results.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
This treatment not only reduced weight loss and mortality but also improved inflammatory responses in the lungs. Notably, there was a decrease in specific immune markers, indicating CCFM1274 might adjust gut tryptophan metabolism beneficially, highlighting potential new strategies for asthma management.
Read More
9
Bifidobacterium lactis reduces asthma symptoms
We explored how Bifidobacterium lactis, a probiotic, might impact asthma symptoms. In a mice study, newborns were given this probiotic every other day for eight weeks while being exposed to allergens. The results showed that this treatment effectively reduced airway inflammation and allergic reactions associated with asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Although both Bifidobacterium lactis and another probiotic demonstrated benefits, the exact mechanisms remain to be fully understood. Nevertheless, it appears that these probiotics could play a role in fostering a healthier immune response against asthma.
Read More
9
We aimed to investigate whether Lactococcus lactis NZ9000 could reduce asthmatic airway inflammation and lung tissue changes in rats while also supporting gut health.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Through careful testing, we found that L. lactis lowered pro-inflammatory cells in the lungs and improved the intestinal barrier. The treatment led to less collagen buildup in lung tissue and enhanced immune function.
Overall, while L. lactis showed promising results in improving asthma symptoms in rats, further research is needed to confirm its effectiveness in humans.
Read More
9
We explored the impact of Lactococcus lactis producing mycobacterial heat shock protein 65 (LLHsp65) on allergic asthma using a mouse model. Over ten days, OVA-challenged mice received oral LLHsp65, which showed promising results.
The treatment notably reduced airway inflammation, mucus production, and eosinophil levels. It also shifted immune responses to favor protective responses while increasing regulatory T cells and cytokines like IL-6 and IL-10.
These outcomes suggest that LLHsp65 offers a hopeful new strategy for managing allergic asthma effectively.
The treatment notably reduced airway inflammation, mucus production, and eosinophil levels. It also shifted immune responses to favor protective responses while increasing regulatory T cells and cytokines like IL-6 and IL-10.
These outcomes suggest that LLHsp65 offers a hopeful new strategy for managing allergic asthma effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved asthma control
4 people found this helpful
I have been using this probiotic brand for over five years, and it has significantly bolstered my immune system and bowel health. The new formulation, suitable for children from four years and upwards, has been effective for my six-year-old grandson, who suffers from asthma. He has experienced no breathing issues from the cold air since starting it this past month. I highly recommend this product; you will be very pleased you tried it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Kim DS, Kim SH, Kim BK, Yang MC, Ma JY. Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128. Evid Based Complement Alternat Med. 2012;2012:769508. doi:10.1155/2012/769508
- Park EK, Sung JH, Trinh HT, Bae EA, Yun HK, et al. Lactic acid bacterial fermentation increases the antiallergic effects of Ixeris dentata. J Microbiol Biotechnol. 2008;18:308.
- Mastrandrea F, Coradduzza G, Serio G, Minardi A, Manelli M, et al. Probiotics reduce the CD34+ hemopoietic precursor cell increased traffic in allergic subjects. Eur Ann Allergy Clin Immunol. 2004;36:118.
- Wang H, He Y, Dang D, Feng L, Huang L, et al. subsp. CCFM1274 relieved allergic asthma symptoms by modifying intestinal tryptophan metabolism in mice. Food Funct. 2024;15:8810. doi:10.1039/d4fo01079e
- Uwaezuoke SN, Ayuk AC, Eze JN, Odimegwu CL, Ndiokwelu CO, et al. Postnatal probiotic supplementation can prevent and optimize treatment of childhood asthma and atopic disorders: A systematic review of randomized controlled trials. Front Pediatr. 2022;10:956141. doi:10.3389/fped.2022.956141
- Liu A, Ma T, Xu N, Jin H, Zhao F, et al. Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome. Microbiol Spectr. 2021;9:e0085921. doi:10.1128/Spectrum.00859-21
- Lundelin K, Poussa T, Salminen S, Isolauri E. Long-term safety and efficacy of perinatal probiotic intervention: Evidence from a follow-up study of four randomized, double-blind, placebo-controlled trials. Pediatr Allergy Immunol. 2017;28:170. doi:10.1111/pai.12675
- Hougee S, Vriesema AJ, Wijering SC, Knippels LM, Folkerts G, et al. Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study. Int Arch Allergy Immunol. 2010;151:107. doi:10.1159/000236000
- Feleszko W, Jaworska J, Rha RD, Steinhausen S, Avagyan A, et al. Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy. 2007;37:498.
- Lee DH, Park HK, Lee HR, Sohn H, Sim S, et al. Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma. Clin Transl Allergy. 2022;12:e12138. doi:10.1002/clt2.12138
- Lee MF, Chiang CH, Lin SJ, Wu CS, Chen YH. Effectiveness and safety of oral lactococci-based vaccine encoding triple common allergens to prevent airway allergy in mice. PLoS One. 2021;16:e0261333. doi:10.1371/journal.pone.0261333
- Cervantes-García D, Jiménez M, Rivas-Santiago CE, Gallegos-Alcalá P, Hernández-Mercado A, et al. Lactococcus lactis NZ9000 Prevents Asthmatic Airway Inflammation and Remodelling in Rats through the Improvement of Intestinal Barrier Function and Systemic TGF-β Production. Int Arch Allergy Immunol. 2021;182:277. doi:10.1159/000511146
- de Lacerda LB, Rios WM, Masson AP, Brandão IT, Milani TM, et al. Oral administration of Hsp65-producing Lactococcus lactis attenuates allergic asthma in a murine model. J Appl Microbiol. 2021;130:2075. doi:10.1111/jam.14913
- Ghasemi Z, Varasteh AR, Moghadam M, Jalali SA, Anissian A, et al. Sublingual Immunotherapy with Sal k1 Expressing Lactococcus lactis Down-regulates Th2 Immune Responses in Balb/c Mice. Iran J Allergy Asthma Immunol. 2018;17:281.
- Ai C, Zhang Q, Ding J, Ren C, Wang G, et al. Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model. Appl Microbiol Biotechnol. 2015;99:4309. doi:10.1007/s00253-015-6407-6
- Fischer K, Vinogradov E, Lindner B, Heine H, Holst O. The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121. Biol Chem. 2012;393:749. doi:10.1515/hsz-2012-0142
- Marinho FA, Pacífico LG, Miyoshi A, Azevedo V, Le Loir Y, et al. An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model. Clin Exp Allergy. 2010;40:1541. doi:10.1111/j.1365-2222.2010.03502.x
- Daniel C, Repa A, Wild C, Pollak A, Pot B, et al. Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1. Allergy. 2006;61:812.
- Wu C, Yang G, Bermúdez-Humarán LG, Pang Q, Zeng Y, et al. Immunomodulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice. Int Immunopharmacol. 2006;6:610.
