5/27/2025
Last update
5/27/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 35 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Wafer
Amount Per Serving
%DV
Total Carbohydrate
1 g
<1%**
Total Sugars
<1 g
***
Includes <1 g Added Sugars
1%**
Lactobacillus BlendWhich contains 1 Billion Live Culture CFULactobacillus acidophilus La-14® and Bifidobacterium lactis BI-04
4.5 mg
***
Top Medical Research Studies
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
8
Probiotics help rheumatoid arthritis symptoms
This study explored how probiotic supplementation affects patients with rheumatoid arthritis (RA) over eight weeks.
We analyzed the results from sixty patients, split into groups receiving either probiotics or placebo.
The findings showed that those taking probiotics experienced a notable improvement in joint health, as well as reductions in insulin levels and inflammation markers.
We observed that the probiotics had a positive impact on overall metabolic health, significantly benefitting those with RA.
We analyzed the results from sixty patients, split into groups receiving either probiotics or placebo.
The findings showed that those taking probiotics experienced a notable improvement in joint health, as well as reductions in insulin levels and inflammation markers.
We observed that the probiotics had a positive impact on overall metabolic health, significantly benefitting those with RA.
Read More
9
We studied the effects of BD400 in a collagen-induced arthritis rat model, aiming to understand if it could delay rheumatoid arthritis (RA). Through monitoring arthritis signs, measuring gut health, and assessing immune responses, we found that BD400 significantly reduced swelling and clinical scores in the rats.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Read More
Most Useful Reviews
9
Supports intestine health
I used to buy these waffles in bulk for children during winter, and they felt marvellous. I struggled to find them last winter as they were withdrawn from sales, but this year I discovered they’ve returned in a new version with a different taste. Despite the smaller quantity, I was thrilled as I give them to the children monthly—they truly act as a spa treatment for the intestines. Having recognised that a well-functioning gut is vital, I highly recommend them, especially for those with stomach issues or autoimmune disorders.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 35 Researches
8
- All Researches
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
9
We investigated the effects of combining lactic acid (LA) with Tacrolimus (Tac) on treating lupus in mice. By administering both treatments, we observed an improvement in gut health and a balanced ratio of T cell subsets.
The combination therapy significantly decreased harmful autoantibody levels and improved kidney health. Additionally, it boosted regulatory T (Treg) cells while reducing T helper 17 (Th17) cells, ultimately enhancing the effectiveness of Tac for managing lupus-like conditions.
The combination therapy significantly decreased harmful autoantibody levels and improved kidney health. Additionally, it boosted regulatory T (Treg) cells while reducing T helper 17 (Th17) cells, ultimately enhancing the effectiveness of Tac for managing lupus-like conditions.
Read More
9
We assessed how Lactobacillus casei, a type of probiotic bacteria, impacted autoimmune responses in rats with rheumatoid arthritis. The treatment showed promise, significantly reducing joint swelling and preventing bone destruction by restoring the gut microbiome.
The analysis revealed that L. casei not only helped correct microbiome imbalances but also lowered inflammation indicators. Though these results are promising, further investigation is needed to confirm the effectiveness of probiotics in human arthritis treatment.
The analysis revealed that L. casei not only helped correct microbiome imbalances but also lowered inflammation indicators. Though these results are promising, further investigation is needed to confirm the effectiveness of probiotics in human arthritis treatment.
Read More
9
Synbiotics improve rheumatoid arthritis outcomes
We examined how synbiotic supplementation impacts patients with rheumatoid arthritis over 8 weeks. In our double-blind, placebo-controlled trial involving 54 participants, we found that those taking synbiotics experienced significant improvements. These included lower inflammation markers such as hs-CRP and better joint pain scores on the DAS-28 and VAS.
Additionally, improvements were noted in insulin resistance and oxidative stress markers, hinting at potential metabolic benefits. Overall, our findings suggest that synbiotic treatment could play a role in managing some aspects of rheumatoid arthritis effectively.
Additionally, improvements were noted in insulin resistance and oxidative stress markers, hinting at potential metabolic benefits. Overall, our findings suggest that synbiotic treatment could play a role in managing some aspects of rheumatoid arthritis effectively.
Read More
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports intestine health
I used to buy these waffles in bulk for children during winter, and they felt marvellous. I struggled to find them last winter as they were withdrawn from sales, but this year I discovered they’ve returned in a new version with a different taste. Despite the smaller quantity, I was thrilled as I give them to the children monthly—they truly act as a spa treatment for the intestines. Having recognised that a well-functioning gut is vital, I highly recommend them, especially for those with stomach issues or autoimmune disorders.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Goh RC, Maharajan MK, Gopinath D, Fang CM. The Therapeutic Effects of Probiotic on Systemic Lupus Erythematosus in Lupus Mice Models: A Systematic Review. Probiotics Antimicrob Proteins. 2025;17:35. 10.1007/s12602-024-10297-1
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. 10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. 10.3389/fimmu.2021.696074
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. 10.1016/j.nut.2021.111282
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. 10.1007/s00296-020-04558-9
- Pan H, Guo R, Ju Y, Wang Q, Zhu J, et al. A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis. Microbiome. 2019;7:107. 10.1186/s40168-019-0719-1
- Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. 10.1080/07315724.2017.1347074
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- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. 10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. 10.3389/fimmu.2020.01832
- Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. 10.3390/nu9111166
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. 10.3389/fimmu.2025.1518181
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. 10.3389/fendo.2022.754401
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. 10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. 10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. 10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. 10.1111/j.1365-2249.2008.03788.x
- Qian S, Zhang X, Zheng X, Li R, Hao X, et al. Development of interleukin-27 recombinant Lactococcus lactis and its efficacy in treating psoriasis and colitis in mice. Int J Biol Macromol. 2024;282:137113. 10.1016/j.ijbiomac.2024.137113
- Akgul A, Freguia CF, Maddaloni M, Hoffman C, Voigt A, et al. Treatment with a Lactococcus lactis that chromosomally express E. coli cfaI mitigates salivary flow loss in a Sjögren's syndrome-like disease. Sci Rep. 2023;13:19489. 10.1038/s41598-023-46557-3
- Mathieu C, Wiedeman A, Cerosaletti K, Long SA, Serti E, et al. A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab. Diabetologia. 2024;67:27. 10.1007/s00125-023-06014-2
- Sassi G, Licata G, Ventriglia G, Wouters A, Lemaitre P, et al. A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis-Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes. Diabetes. 2023;72:1470. 10.2337/db22-0852
- Guimaraes MAF, Pinheiro-Rosa N, Oliveira RP, Aguiar SLF, Miranda MCG, et al. Hsp65-producing Lactococcus lactis inhibits experimental autoimmune encephalomyelitis by preventing cell migration into spinal cord. Cell Immunol. 2023;384:104661. 10.1016/j.cellimm.2022.104661
- Nelson AS, Akgul A, Maddaloni M, Bhagyaraj E, Hoffman C, et al. Oral probiotic promotes indoleamine 2,3-dioxygenase- and TGF-β-Producing plasmacytoid dendritic cells to initiate protection against type 1 diabetes. Immunol Lett. 2021;239:12. 10.1016/j.imlet.2021.07.009
- Akgul A, Maddaloni M, Jun SM, Nelson AS, Odreman VA, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99. 10.1186/s13075-021-02475-1
- Preisser TM, da Cunha VP, Santana MP, Pereira VB, Cara DC, et al. Recombinant Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model. J Diabetes Res. 2021;2021:6697319. 10.1155/2021/6697319
- Gusmao-Silva G, Aguiar SLF, Miranda MCG, Guimarães MA, Alves JL, et al. Hsp65-Producing Prevents Antigen-Induced Arthritis in Mice. Front Immunol. 2020;11:562905. 10.3389/fimmu.2020.562905
- Cook DP, Cunha JPMCM, Martens PJ, Sassi G, Mancarella F, et al. Intestinal Delivery of Proinsulin and IL-10 via Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis. Front Immunol. 2020;11:1103. 10.3389/fimmu.2020.01103
- Nelson AS, Maddaloni M, Abbott JR, Hoffman C, Akgul A, et al. Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice. Sci Rep. 2020;10:6156. 10.1038/s41598-020-62881-4
- Maddaloni M, Kochetkova I, Hoffman C, Pascual DW. Delivery of IL-35 by Ameliorates Collagen-Induced Arthritis in Mice. Front Immunol. 2018;9:2691. 10.3389/fimmu.2018.02691
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- Kasarełło K, Szczepankowska A, Kwiatkowska-Patzer B, Lipkowski AW, Gadamski R, et al. Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis. Folia Neuropathol. 2016;54:249.
- Liu KF, Liu XR, Li GL, Lu SP, Jin L, et al. Oral administration of Lactococcus lactis-expressing heat shock protein 65 and tandemly repeated IA2P2 prevents type 1 diabetes in NOD mice. Immunol Lett. 2016;174:28. 10.1016/j.imlet.2016.04.008
