We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
8
Vitamin C may lower hypothyroidism risk
Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Read More
Most Useful Reviews
9
No stomach issues
4 people found this helpful
Not all vitamin C is effective, but this water-soluble form proves ideal. I experience no burning or acid discomfort, even at higher doses, enabling me to avoid illness all winter long!
Read More
9
Immune system support
3 people found this helpful
My doctor recommended Ester-C, a vitamin C formulation that supports immune function by enhancing absorption with metabolites. I take 1000 mg daily, and it helps maintain my immune system for 24 hours. Given my autoimmune disorder, this vitamin is crucial for my well-being.
Read More
9
Essential for health
1 people found this helpful
THIS VITAMIN C IS MY REGULAR PURCHASE! I have an autoimmune disease, getting ill frequently. Ester-C along with Rutin has been a lifesaver; taking it consistently from November to February has significantly helped my health.
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C aids rheumatoid arthritis treatment
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis.
This study investigated the effects of a specially formulated hydrogel that combines vitamin C with 9-aminoacridine (9AA) on a model of rheumatoid arthritis (RA). We saw that this hydrogel is not only bioactive but also biodegradable, making it a potential candidate for treating this chronic autoimmune condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
9
Ascorbyl palmitate targets inflammation
Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome.
We examined the effects of ascorbyl palmitate (AP), a derivative of vitamin C, on the NLRP3 inflammasome, which plays a significant role in various autoimmune disorders. The research shows that AP effectively inhibits the activation of this inflammasome, suggesting it could be a powerful tool in managing inflammation-driven diseases.
Notably, AP showed greater potency and specificity in inhibiting the inflammasome compared to regular vitamin C. It appears to achieve this by scavenging harmful reactive oxygen species and disrupting key interactions necessary for inflammasome assembly.
Furthermore, we found that AP exhibited more pronounced protective effects in models of systemic inflammation and conditions like colitis and autoimmune encephalomyelitis than standard vitamin C treatments. This strengthens the case that AP could be a viable therapeutic option for combating NLRP3-driven diseases, presenting an exciting avenue for further research and potential clinical applications.
Read More
9
Vitamin C's Role in Inflammation
Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy.
We observed a fascinating case involving an 11-year-old boy suffering from symptoms of scurvy, a condition arising from severe vitamin C deficiency. This boy had multiple issues, including iron-deficiency anemia, symptoms resembling bone infections, and muscle inflammation, particularly in his legs. His selective diet, likely due to a mild developmental disorder, led to a significant deficiency in vitamin C.
After he was diagnosed, we administered intravenous and oral vitamin C, which remarkably eased his joint and muscle pain within just a week. Following four months of supplementation, he showed complete recovery with no lingering symptoms or abnormal lab findings.
Notably, we found high levels of certain pro-inflammatory markers, specifically interleukin-6, IL-17A, and IL-23, likely linked to an immune response involving T-helper 17 cells. This association presents an intriguing insight into the inflammatory processes that might be involved in scurvy and, potentially, in other autoimmune disorders.
Our observations hint that vitamin C might play a pivotal role in addressing inflammation linked to autoimmune conditions, paving the way for enhanced understanding and treatment options in the future.
Not all vitamin C is effective, but this water-soluble form proves ideal. I experience no burning or acid discomfort, even at higher doses, enabling me to avoid illness all winter long!
Read More
9
Immune system support
3 people found this helpful
My doctor recommended Ester-C, a vitamin C formulation that supports immune function by enhancing absorption with metabolites. I take 1000 mg daily, and it helps maintain my immune system for 24 hours. Given my autoimmune disorder, this vitamin is crucial for my well-being.
Read More
9
Essential for health
1 people found this helpful
THIS VITAMIN C IS MY REGULAR PURCHASE! I have an autoimmune disease, getting ill frequently. Ester-C along with Rutin has been a lifesaver; taking it consistently from November to February has significantly helped my health.
Read More
7.5
Immediate efficiency
1 people found this helpful
This vitamin is high-quality and works efficiently! I take it regularly, increasing the dosage when I’m unwell, and it helps immediately. Unlike more expensive alternatives, this one truly delivers.
Read More
7.5
Prevention and recovery
1 people found this helpful
This super-antioxidant vitamin C is my continual order. It’s excellent and lasts up to 8 hours. I take 2 grams daily and increase the dose when ill; it helps prevent sickness and speeds up recovery.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Ester-C is a patented form of vitamin C (ascorbic acid) that is known for its unique formulation, which includes calcium ascorbate. This makes Ester-C less acidic than standard vitamin C, making it gentler on the stomach for those who may experience gastrointestinal discomfort from regular vitamin C supplementation. One of the key features touted by manufacturers of Ester-C is that it is better absorbed by the body and stays in the immune system longer, although scientific research on these claims can be mixed.
In addition to its purported benefits, Ester-C is often marketed as a supplement that supports immune health, collagen production, and serves as an antioxidant, helping to combat free radicals and oxidative stress. It's available in various forms, including capsules, tablets, and powders, making it easy to incorporate into your daily routine. While some users report positive effects and tolerance of Ester-C, it's essential to consult with a healthcare professional before adding any new supplement to your regimen, especially if you have existing conditions or are taking other medications.
Based on user reviews, the timeline for seeing results from taking supplements for autoimmune disorders can vary considerably. Many users report that they experience significant health improvements when taking vitamin C regularly, particularly formulations like Ester-C. For instance, one user mentioned that taking Ester-C consistently from November to February has "significantly helped my health" as they manage their autoimmune disease Read Review. Another user noted immediate effects when increasing dosage during illness, indicating that prompt improvements can be achievable under certain circumstances Read Review.
However, other users emphasize the importance of consistent usage over time, suggesting that sustained intake may be necessary to maintain immune health effectively. One reviewer stated that taking vitamin C helps maintain their immune system for a full 24 hours Read Review. Overall, while some may notice improvements relatively quickly, a majority suggest regular and prolonged use is vital for optimal results, especially in the context of managing autoimmune conditions.
Recent scientific research suggests that vitamin C may play a supportive role in managing autoimmune disorders. For instance, a study highlighted that vitamin C can help delay the onset and reduce the severity of rheumatoid arthritis (RA) in a mouse model by minimizing the production of harmful autoantibodies and influencing immune response mechanisms [3]. Another study noted that vitamin C intake was inversely correlated with hypothyroidism in patients with Hashimoto's thyroiditis, suggesting that higher vitamin C consumption might help mitigate this autoimmune condition [2].
Moreover, the antioxidant properties of vitamin C can potentially regulate cytokine responses and combat inflammation connected to disorders such as Systemic Lupus Erythematosus [4]. Though the evidence remains promising, the isolated effects of vitamin C on autoimmune diseases are still being explored, and more research is necessary. As such, while there is encouraging data supporting vitamin C's role in alleviating symptoms associated with autoimmune disorders, definitive conclusions regarding its clinical effectiveness are yet to be established.
Based on user reviews, many individuals report considerable improvements in their symptoms after taking vitamin C, particularly in the form of Ester-C. Users have noted that this specific formulation enhances absorption and helps maintain their immune system throughout the day. For instance, one user found that taking 1000 mg daily is crucial for their well-being, especially considering their autoimmune disorder, as it effectively supports immune function for a full 24 hours Read Review. Others have shared that they experience no gastrointestinal discomfort, allowing them to take higher doses without adverse effects, which contributes to improved health during the winter months when illness is prevalent Read Review.
Additionally, several users reported that increasing their vitamin C intake during periods of illness led to rapid improvements, aiding in both the prevention of sickness and the recovery process. One reviewer specifically highlighted a positive experience of feeling better within hours of increased dosage during illness, demonstrating the supplement's immediate efficacy Read Review, while another mentioned that their regular use helped combat colds effectively Read Review. While these anecdotal experiences provide encouraging insights, it's important to note that individual results may vary.
Based on user reviews, many individuals report positive results when combining this vitamin C supplement with other formulations, particularly Rutin, to manage autoimmune disorders. One user noted that taking Ester-C alongside Rutin has been a "lifesaver," significantly improving their health during the winter months when they are more prone to illness due to their autoimmune condition Read Review. This combination has resulted in enhanced immune support, showcasing the potential benefits of stacking supplements for better outcomes.
Additionally, multiple users emphasize the importance of adjusting dosage based on their health status. Some have reported that increasing their intake of vitamin C during periods of illness leads to rapid improvement, suggesting a synergistic effect when combined with other supportive supplements Read Review. Users have found that consistent use of vitamin C not only helps prevent illness but also aids in quicker recovery, further underlining the value of complementary supplementation Read Review. Overall, while individual experiences vary, many users advocate for a coordinated approach to supplementing, especially for those managing autoimmune conditions.
Users report a range of dosages for Ester-C when managing autoimmune disorders, with many finding 1000 mg daily to be beneficial. One user mentioned this specific dosage helps maintain their immune system support around the clock Read Review. Others have increased their intake during periods of illness, indicating flexibility in dosing based on individual health needs. For example, one reviewer noted taking 2 grams daily allows them to combat sickness effectively and aid in recovery Read Review.
This vitamin C formulation is praised for its high tolerance, even when dosing is ramped up—making it a preferred choice for those with autoimmune conditions. Several users also appreciate that they experience fewer gastrointestinal issues with Ester-C, enabling them to maintain a routine intake Read Review. Overall, user feedback suggests that a daily dose of 1000 mg or higher may be effective, particularly when carefully adjusted in response to health changes.
9
Essential for health
1 people found this helpful
THIS VITAMIN C IS MY REGULAR PURCHASE! I have an autoimmune disease, getting ill frequently. Ester-C along with Rutin has been a lifesaver; taking it consistently from November to February has significantly helped my health.
7.5
Immediate efficiency
1 people found this helpful
This vitamin is high-quality and works efficiently! I take it regularly, increasing the dosage when I’m unwell, and it helps immediately. Unlike more expensive alternatives, this one truly delivers.
9
Immune system support
3 people found this helpful
My doctor recommended Ester-C, a vitamin C formulation that supports immune function by enhancing absorption with metabolites. I take 1000 mg daily, and it helps maintain my immune system for 24 hours. Given my autoimmune disorder, this vitamin is crucial for my well-being.
9
No stomach issues
4 people found this helpful
Not all vitamin C is effective, but this water-soluble form proves ideal. I experience no burning or acid discomfort, even at higher doses, enabling me to avoid illness all winter long!
7.5
Cold symptom relief
50 people found this helpful
I order vitamin C regularly; it’s an excellent remedy! When I feel unwell, I increase the daily dose, which helps my body combat colds effectively.
7.5
Prevention and recovery
1 people found this helpful
This super-antioxidant vitamin C is my continual order. It’s excellent and lasts up to 8 hours. I take 2 grams daily and increase the dose when ill; it helps prevent sickness and speeds up recovery.
7.5
Reduced gastrointestinal issues
Esther has fewer gastrointestinal issues.
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
8
Vitamin C may lower hypothyroidism risk
Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
7
Vitamin C's potential in autoimmune treatment
Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy.
We explored the potential of vitamin C as a treatment option for autoimmune disorders, particularly focusing on its benefits for conditions like Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). Our review of existing literature revealed a growing body of evidence suggesting that vitamin C supplementation can positively influence immune responses, which may help in managing these diseases.
The research indicates that vitamin C regulates the cytokine environment, which is essential for maintaining a balanced immune system. By modulating the immune response to autoantigens, vitamin C can potentially lessen the harmful effects of these autoimmune disorders. Furthermore, the antioxidant properties of vitamin C play a role in managing oxidative stress, a factor often associated with autoimmune conditions.
We also noted that vitamin C might enhance the effects of conventional therapies, such as chemotherapy and radiation treatment, when applied to hematological neoplasms. This suggests that vitamin C could serve as a beneficial adjuvant in standard treatment protocols, although its isolated effects on autoimmune diseases are still being understood.
References
Zhang H, Zhang Y, Zhang Y, Wei H, Jin S, et al. Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis. Food Funct. 2025;16:673. 10.1039/d4fo03096f
Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. 10.1017/S0007114524001715
Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. 10.1186/s12964-024-01756-x
Isola S, Gammeri L, Furci F, Gangemi S, Pioggia G, et al. Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int J Mol Sci. 2024;25. 10.3390/ijms25137284
Ali A, Jori C, Kumar A, Vyawahare A, Kumar J, et al. A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis. Biomater Sci. 2024;12:3389. 10.1039/d4bm00243a
Zhang Y, Zhen S, Xu H, Sun S, Wang Z, et al. Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance. Biosci Trends. 2024;18:187. 10.5582/bst.2024.01037
Zhang L, Li G, Lin B, He H, Zhou R, et al. Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome. Int Immunopharmacol. 2024;131:111915. 10.1016/j.intimp.2024.111915
Santiworakul C, Saisorn W, Siripen N, Leelahavanichkul A, Rianthavorn P. Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency. Pediatr Nephrol. 2024;39:1135. 10.1007/s00467-023-06189-1
Mungan S, Guzel I, Demirdogen BC. Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis. Braz J Med Biol Res. 2023;56:e12776. 10.1590/1414-431X2023e12776
Farasati Far B, Behnoush AH, Ghondaghsaz E, Habibi MA, Khalaji A. The interplay between vitamin C and thyroid. Endocrinol Diabetes Metab. 2023;6:e432. 10.1002/edm2.432
Ueki M, Sakamoto K, Nishioka N, Ohata H, Nobuta T, et al. Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy. Mod Rheumatol Case Rep. 2023;7:302. 10.1093/mrcr/rxac059