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SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin D3*
25 mcg (1000 IU)
125%
Magnesium**
300 mg
71%
Ancient Nutrients TCM BlendBeef Bone Broth, Bovine Liver, Organic Rhodiola Root Extract, Organic Turmeric Root Extract, Organic Stinging Nettle Root Extract, Chicken Bone Broth, Organic Cinnamon Bark Extract, Lion's Mane (Hericium erinaceus) Mushroom Extract, Organic Licorice Root Extract, Organic Skullcap Root Extract, Wild Hake Roe
450 mg
+
Top Medical Research Studies
8
Magnesium protects against bone erosion
Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.
High relevance to gout management
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Read More
9
Vitamin D3's role in OA prevention
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Strong relevance to vitamin D3 and OA
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
Read More
9
Magnesium alters arthritis-related gene expression
Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways.
Focus on magnesium's effect
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
Most Useful Reviews
6.8
Relieves arthritis pain
Magnesium is likely what you need. It helps with body aches and pains. This formula digests well and alleviates some finger arthritis. The Ancient Nutrition Formula also supports overall digestion and regularity. However, I’m unsure of the type of magnesium used, as it is not specified on the bottle or website.
Read More
8.8
Reduces joint pain
Taking this magnesium has helped me lessen the pain of arthritis in my joints.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8
9
Vitamin D3 may improve fatigue
The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
Scientifically relevant vitamin D effects.
We conducted an insightful study to explore how vitamin D3 supplementation might affect rheumatoid arthritis (RA) symptoms, particularly focusing on disease activity and fatigue. This research involved a total of 68 RA patients who were monitored over a period of 12 weeks.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Read More
9
Vitamin D3's role in OA prevention
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Strong relevance to vitamin D3 and OA
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
Read More
9
Magnesium alters arthritis-related gene expression
Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways.
Focus on magnesium's effect
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
Magnesium potentially alleviates OA
Engineered MgO nanoparticles for cartilage-bone synergistic therapy.
Moderate relevance to magnesium therapy.
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Read More
9
Magnesium chloride alleviates arthritis
Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis.
High relevance to arthritis treatment
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
8.8
Reduces joint pain
Taking this magnesium has helped me lessen the pain of arthritis in my joints.
6.8
Relieves arthritis pain
Magnesium is likely what you need. It helps with body aches and pains. This formula digests well and alleviates some finger arthritis. The Ancient Nutrition Formula also supports overall digestion and regularity. However, I’m unsure of the type of magnesium used, as it is not specified on the bottle or website.
Read More
