Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin D3*
25 mcg (1000 IU)
125%
Magnesium**
300 mg
71%
Ancient Nutrients TCM BlendBeef Bone Broth, Bovine Liver, Organic Rhodiola Root Extract, Organic Turmeric Root Extract, Organic Stinging Nettle Root Extract, Chicken Bone Broth, Organic Cinnamon Bark Extract, Lion's Mane (Hericium erinaceus) Mushroom Extract, Organic Licorice Root Extract, Organic Skullcap Root Extract, Wild Hake Roe
450 mg
+
Top Medical Research Studies
8
Magnesium protects against bone erosion
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Read More
9
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
Most Useful Reviews
6
Relieves arthritis pain
7 people found this helpful
Magnesium is likely what you need. It helps with body aches and pains. This formula digests well and alleviates some finger arthritis. The Ancient Nutrition Formula also supports overall digestion and regularity. However, I’m unsure of the type of magnesium used, as it is not specified on the bottle or website.
Read More
7.5
Reduces joint pain
1 people found this helpful
Taking this magnesium has helped me lessen the pain of arthritis in my joints.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8
- All Researches
9
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Read More
9
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
9
Magnesium reduces arthritis severity
We investigated how a high magnesium diet affects arthritis, focusing on its impact on inflammation and T cell development in two mouse models of rheumatoid arthritis. Our findings revealed that the mice receiving a diet rich in magnesium experienced less severe arthritis and reduced joint damage.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
Read More
9
We investigated how magnesium-containing glycosaminoglycans, or Mg-GAGs, might improve cartilage health and combat osteoarthritis (OA). The study highlighted that OA is largely characterized by the breakdown of key components in the extracellular matrix (ECM), including collagen and aggrecan. The objective was to find out if introducing Mg-GAGs could help restore this matrix and mitigate inflammation linked to OA.
Our findings were promising. We observed that Mg-GAGs not only encouraged chondrocyte (cartilage cell) growth but also helped activate genes important for cartilage formation while reducing inflammatory responses. In laboratory experiments, these glycosaminoglycans showed significant positive effects.
Furthermore, in an animal model of OA, Mg-GAGs eased synovial inflammation, lessened chondrocyte death, and helped protect the bone beneath cartilage. These outcomes suggest that Mg-GAGs might represent a new way to treat OA, focusing on ECM repair and addressing inflammation to improve joint health.
Our findings were promising. We observed that Mg-GAGs not only encouraged chondrocyte (cartilage cell) growth but also helped activate genes important for cartilage formation while reducing inflammatory responses. In laboratory experiments, these glycosaminoglycans showed significant positive effects.
Furthermore, in an animal model of OA, Mg-GAGs eased synovial inflammation, lessened chondrocyte death, and helped protect the bone beneath cartilage. These outcomes suggest that Mg-GAGs might represent a new way to treat OA, focusing on ECM repair and addressing inflammation to improve joint health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
6
Relieves arthritis pain
7 people found this helpful
Magnesium is likely what you need. It helps with body aches and pains. This formula digests well and alleviates some finger arthritis. The Ancient Nutrition Formula also supports overall digestion and regularity. However, I’m unsure of the type of magnesium used, as it is not specified on the bottle or website.
Read More
7.5
Reduces joint pain
1 people found this helpful
Taking this magnesium has helped me lessen the pain of arthritis in my joints.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- He J, Wu J, Zheng J, Xu Y, Li K, et al. Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment. ACS Appl Mater Interfaces. 2025;17:11898. 10.1021/acsami.4c22415
- Chathoth BM, Helmholz H, Angrisani N, Wiese B, Reifenrath J, et al. Investigating the Potential of Magnesium Microparticles on Cartilage and Bone Regeneration Utilizing an In Vitro Osteoarthritis Model. J Biomed Mater Res A. 2025;113:e37862. 10.1002/jbm.a.37862
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. 10.3390/nu16234247
- Li Y, Wang Y, Xu L, Liu C, Cui J, et al. Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1375871. 10.3389/fendo.2024.1375871
- Mei S, Jiang F, Liu N, Feng Z, Zheng Y, et al. Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis. Nanomedicine (Lond). 2024;19:1867. 10.1080/17435889.2024.2382421
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. 10.1186/s41043-024-00597-1
- Zheng L, Zhao S, Li Y, Xu J, Yan W, et al. Engineered MgO nanoparticles for cartilage-bone synergistic therapy. Sci Adv. 2024;10:eadk6084. 10.1126/sciadv.adk6084
- Pinto ACMD, de Melo Nunes R, de Freitas Carvalho WV, Girão VCC, Rocha FAC. Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis. Adv Rheumatol. 2024;64:6. 10.1186/s42358-023-00346-8
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. 10.1002/advs.202307094
- Yilmaz E, Ünver S. Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis. Magnes Res. 2023;36:40. 10.1684/mrh.2023.0515
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. 10.1186/s12889-023-16906-y
- Zheng Z, Luo H, Xu W, Shi L, Wang F, et al. Association between Elevated Magnesium Intake and Reduced Risk of Recurrent Falls and Frailty in Osteoarthritis: Data from the Osteoarthritis Initiative. J Nutr Health Aging. 2023;27:775. 10.1007/s12603-023-1979-9
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. 10.1016/j.ebiom.2023.104603
- Zhang Y, Chen T, Luo P, Li S, Zhu J, et al. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis. Nutrients. 2022;14. 10.3390/nu14173576
- Chen R, Li X, Sun Z, Yin J, Hu X, et al. Intra-bone marrow injection of magnesium isoglyrrhizinate inhibits inflammation and delays osteoarthritis progression through the NF-κB pathway. J Orthop Surg Res. 2022;17:400. 10.1186/s13018-022-03294-z
- Wu G, Ma F, Liu Z, Liu J, Xue Y, et al. Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair. Int J Biol Macromol. 2022;220:1104. 10.1016/j.ijbiomac.2022.08.071
- Ma R, Zhang C, Liu J, Ren J, Huang H, et al. Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study. Front Immunol. 2025;16:1512293. 10.3389/fimmu.2025.1512293
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Liu P, Zhou J, Cui H, Xu J, Ruan G, et al. 1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway. Clin Rheumatol. 2025;44:811. 10.1007/s10067-024-07281-z
- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. 10.2478/aite-2024-0023
- Elfituri S. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients. Reumatologia. 2024;62:109. 10.5114/reum/187391
- Kim S, Chen N, Reid P. Current and future advances in practice: aromatase inhibitor-induced arthralgia. Rheumatol Adv Pract. 2024;8:rkae024. 10.1093/rap/rkae024
- Tekeli SÖ, Köse Ö, Yapar D, Tekeli FY, Asoğlu MM, et al. Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects. Technol Health Care. 2024;32:3649. 10.3233/THC-230802
- Huovinen J, Palosaari S, Pesonen P, Huhtakangas JA, Lehenkari P. 1,25(OH)D and its analogue calcipotriol inhibit the migration of human synovial and mesenchymal stromal cells in a wound healing model - A comparison with glucocorticoids. J Steroid Biochem Mol Biol. 2023;233:106373. 10.1016/j.jsbmb.2023.106373
- Zhu W, Zhu Y, Zhang S, Zhang W, Si Z, et al. 1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. J Steroid Biochem Mol Biol. 2023;228:106251. 10.1016/j.jsbmb.2023.106251
- Chen J, Zhang J, Li J, Qin R, Lu N, et al. 1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice. Int J Biol Sci. 2023;19:610. 10.7150/ijbs.78785
- Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. 10.1007/s12026-022-09354-0
