' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin D3*
25 mcg (1000 IU)
125%
Magnesium**
300 mg
71%
Ancient Nutrients TCM BlendBeef Bone Broth, Bovine Liver, Organic Rhodiola Root Extract, Organic Turmeric Root Extract, Organic Stinging Nettle Root Extract, Chicken Bone Broth, Organic Cinnamon Bark Extract, Lion's Mane (Hericium erinaceus) Mushroom Extract, Organic Licorice Root Extract, Organic Skullcap Root Extract, Wild Hake Roe
450 mg
+
Top Medical Research Studies
2
No significant benefit from vitamin D3
Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.
High relevance to diarrhea prevention
We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Read More
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Strong relevance to diarrhea treatment
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
TX527 improves IBD-related diarrhea
The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease.
Strong focus on diarrhea treatment
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
Most Useful Reviews
0
Caused severe illness
Do not purchase. This product did not suit me at all; I fell ill after taking just one capsule, resulting in particularly bad diarrhea. I’m relieved I didn't take the advised three capsules daily. I contacted Ancient Nutrients, which I believed to be a reputable company, but they were unhelpful and wouldn’t support this product with any recommendations. This turned out to be a waste of £24, and I wouldn’t recommend it to anyone. The seller refused a refund, leaving me questioning its authenticity.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Strong relevance to diarrhea treatment
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
Vitamin D3 mitigates diarrhea effects
Dietary 25-Hydroxyvitamin D Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs.
Significant but complex findings
We conducted a study to see how supplementing weaned pigs with 25-hydroxyvitamin D (25(OH)D) could help ease diarrhea linked to porcine epidemic diarrhea virus (PEDV) infection. Forty-two pigs were divided into six groups and fed different amounts of vitamin D3 for 26 days. On day 22, we introduced the virus to all but one control group, which only received saline.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Read More
9
TX527 improves IBD-related diarrhea
The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease.
Strong focus on diarrhea treatment
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
Highlights treatment complexities in patients
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
9
Magnesium reduces diarrhea incidence
Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets.
Potassium complicates magnesium effects
In our exploration of how potassium-magnesium sulfate (PMS) impacts diarrhea in weaned piglets, we set out to understand its effects on growth performance, immunity, and gut health. A total of 216 piglets were divided into six groups, with varying levels of PMS in their diets.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
0
Caused severe illness
Do not purchase. This product did not suit me at all; I fell ill after taking just one capsule, resulting in particularly bad diarrhea. I’m relieved I didn't take the advised three capsules daily. I contacted Ancient Nutrients, which I believed to be a reputable company, but they were unhelpful and wouldn’t support this product with any recommendations. This turned out to be a waste of £24, and I wouldn’t recommend it to anyone. The seller refused a refund, leaving me questioning its authenticity.
Read More
