Overview

SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
USERS' SCORE
Good
Based on 6 Reviews
8.3
Supplement Facts
Serving Size: 5 Drops
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
L.reuteriDSM 17938(L. reuteriProtectis®)
100 million CFU

Top Medical Research Studies

8
Vitamin D reduces eczema severity
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.

Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.

Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Read More
8
Neonatal vitamin D influences eczema
We observed the potential effects of early-life vitamin D levels on the risk of developing eczema in children over a 25-year period. Our study involved measuring the levels of 25(OH)D3 from dried blood spots in 223 children at high risk for allergies. We then used statistical methods to assess different types of eczema that might occur as the children grew.

The findings revealed that higher levels of neonatal vitamin D were linked to a reduced risk of persistent eczema that starts early in life. Specifically, for every 10 nmol/L increase in vitamin D, there was about a 26% lower chance of developing early-onset persistent eczema. Conversely, these higher levels also seemed to increase the odds of early-onset-resolving eczema by around 30%.

However, it’s important to note that we did not find strong evidence connecting neonatal vitamin D levels with current eczema or other distinct eczema-related sensitization patterns. Overall, our results suggest that ensuring adequate vitamin D levels during pregnancy could potentially benefit the long-term skin health of children, particularly regarding the emergence of certain eczema types.
Read More
We investigated how oral vitamin D3 supplements influence eczema, specifically in children with atopic dermatitis (AD). Over six weeks, we administered weekly doses of vitamin D3 to a group of 22 children suffering from moderate to severe AD.

Before and after the treatment, we measured several key factors: serum vitamin D levels, the presence of Staphylococcus aureus on the skin, and the overall severity of eczema, assessed through the SCORAD index.

Remarkably, we found that vitamin D supplementation raised vitamin D levels in the children and led to significant improvements in eczema severity. The SCORAD scores dropped notably, indicating less severe symptoms. Additionally, we saw an increase in the expression of vital skin proteins, specifically Cathelicidin, in affected areas after treatment.

However, while the treatment was beneficial for overall skin condition, the expression of Thymic Stromal Lymphopoietin did not change. Importantly, our findings highlight the direct effects of vitamin D on skin health in children with AD, providing insight into its potential as a supportive treatment for eczema.
Read More

Most Useful Reviews

9
Great for eczema
Superb! This has been a fantastic probiotic for my daughter, who suffers from eczema. It helps relieve her itch at night!
Read More
9
Effective against issues
It worked! When my son had gas problems alongside eczema, we tried this, and both issues disappeared by the time we finished the bottle. I mixed it with baby food, and he took it without any problems. Just ensure to shake it well before use.
Read More
7.5
Less gassy baby
1 people found this helpful
My baby has become less gassy since starting this weeks ago. It's easy to drop in her mouth, with no need to force-feed or chew tablets. It’s simple and fuss-free! Moreover, it contains good strains of bacteria that help keep her eczema at bay.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
  • All Researches
8
Vitamin D's role in eczema severity
We investigated the levels of vitamin D and other related factors in children suffering from eczema to better understand their relationship with the severity of this condition. Our analysis included 159 children, categorized by the severity of their eczema symptoms into mild, moderate, and severe groups.

Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.

Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.

Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
Read More
8
Vitamin D reduces eczema severity
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.

Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.

Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Read More
8
Maternal vitamin D influences infant eczema
We examined the relationship between maternal vitamin D levels during early pregnancy and the occurrence of atopic dermatitis (AD), commonly known as eczema, in infants. Our study involved 4,051 woman-infant pairs, focusing on those with singleton pregnancies. We looked closely at the vitamin D levels of mothers in their first trimester and analyzed how these levels, along with vitamin D supplementation during pregnancy, influenced the likelihood of infants developing AD.

The results showed that infants born to mothers with low vitamin D levels faced a significantly higher risk of developing eczema. Specifically, mothers with vitamin D deficiency had a 77% increased risk of their infants developing AD. Interestingly, this heightened risk was mostly observed in naturally conceived pregnancies, while those conceived through assisted reproductive techniques didn't show the same association.

Additionally, we found that mothers who took vitamin D or multivitamin supplements during pregnancy had a lower risk of having infants with AD. This suggests that adequate vitamin D intake may play a protective role against eczema in infants. Our findings underscore the importance of monitoring vitamin D levels in expectant mothers, as doing so could help reduce the risk of eczema in their future children.
Read More
8
Vitamin D's unclear role in eczema
We explored the effectiveness of dietary interventions, particularly vitamin D, in treating eczema symptoms in children without food allergies. Our systematic review included several randomized controlled trials (RCTs) that assessed various treatments. Among these, vitamin D was analyzed alongside other therapies like probiotics and evening primrose oil.

The findings revealed an overall trend suggesting that probiotics, especially when combined with prebiotics, could lead to a notable reduction in eczema symptoms as measured by standard scoring systems. However, the evidence specifically highlighting vitamin D's role in alleviating eczema was limited. This indicates that while some dietary approaches show promise, the impact of vitamin D alone remains less clear.

Thus, we recognize the need for more focused research that can specifically examine the effects of vitamin D on eczema, ideally isolating it from other dietary factors. Well-structured studies are essential to deepen our understanding and develop effective treatment strategies for managing eczema in children.
Read More
8
Neonatal vitamin D influences eczema
We observed the potential effects of early-life vitamin D levels on the risk of developing eczema in children over a 25-year period. Our study involved measuring the levels of 25(OH)D3 from dried blood spots in 223 children at high risk for allergies. We then used statistical methods to assess different types of eczema that might occur as the children grew.

The findings revealed that higher levels of neonatal vitamin D were linked to a reduced risk of persistent eczema that starts early in life. Specifically, for every 10 nmol/L increase in vitamin D, there was about a 26% lower chance of developing early-onset persistent eczema. Conversely, these higher levels also seemed to increase the odds of early-onset-resolving eczema by around 30%.

However, it’s important to note that we did not find strong evidence connecting neonatal vitamin D levels with current eczema or other distinct eczema-related sensitization patterns. Overall, our results suggest that ensuring adequate vitamin D levels during pregnancy could potentially benefit the long-term skin health of children, particularly regarding the emergence of certain eczema types.
Read More

User Reviews

USERS' SCORE
Good
Based on 6 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Great for eczema
Superb! This has been a fantastic probiotic for my daughter, who suffers from eczema. It helps relieve her itch at night!
Read More
9
Effective against issues
It worked! When my son had gas problems alongside eczema, we tried this, and both issues disappeared by the time we finished the bottle. I mixed it with baby food, and he took it without any problems. Just ensure to shake it well before use.
Read More
7.5
Less gassy baby
1 people found this helpful
My baby has become less gassy since starting this weeks ago. It's easy to drop in her mouth, with no need to force-feed or chew tablets. It’s simple and fuss-free! Moreover, it contains good strains of bacteria that help keep her eczema at bay.
Read More
7.5
Doctor recommended
Very good! I have made multiple repurchases due to my daughter's eczema, which the doctor recommended treating with this product. It's much more effective than local alternatives.
Read More
7.5
Recommended for eczema
Without any taste, it would be beneficial to consume it, and it has been effective in reducing eczema. I recommend it.
Read More

Frequently Asked Questions

9
Effective against issues
It worked! When my son had gas problems alongside eczema, we tried this, and both issues disappeared by the time we finished the bottle. I mixed it with baby food, and he took it without any problems. Just ensure to shake it well before use.
7.5
Less gassy baby
1 people found this helpful
My baby has become less gassy since starting this weeks ago. It's easy to drop in her mouth, with no need to force-feed or chew tablets. It’s simple and fuss-free! Moreover, it contains good strains of bacteria that help keep her eczema at bay.
7.5
Doctor recommended
Very good! I have made multiple repurchases due to my daughter's eczema, which the doctor recommended treating with this product. It's much more effective than local alternatives.
9
Great for eczema
Superb! This has been a fantastic probiotic for my daughter, who suffers from eczema. It helps relieve her itch at night!
7.5
Recommended for eczema
Without any taste, it would be beneficial to consume it, and it has been effective in reducing eczema. I recommend it.
8
Vitamin D reduces eczema severity
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.

Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.

Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
8
Vitamin D's role in eczema severity
We investigated the levels of vitamin D and other related factors in children suffering from eczema to better understand their relationship with the severity of this condition. Our analysis included 159 children, categorized by the severity of their eczema symptoms into mild, moderate, and severe groups.

Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.

Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.

Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
8
Neonatal vitamin D influences eczema
We observed the potential effects of early-life vitamin D levels on the risk of developing eczema in children over a 25-year period. Our study involved measuring the levels of 25(OH)D3 from dried blood spots in 223 children at high risk for allergies. We then used statistical methods to assess different types of eczema that might occur as the children grew.

The findings revealed that higher levels of neonatal vitamin D were linked to a reduced risk of persistent eczema that starts early in life. Specifically, for every 10 nmol/L increase in vitamin D, there was about a 26% lower chance of developing early-onset persistent eczema. Conversely, these higher levels also seemed to increase the odds of early-onset-resolving eczema by around 30%.

However, it’s important to note that we did not find strong evidence connecting neonatal vitamin D levels with current eczema or other distinct eczema-related sensitization patterns. Overall, our results suggest that ensuring adequate vitamin D levels during pregnancy could potentially benefit the long-term skin health of children, particularly regarding the emergence of certain eczema types.
4
Vitamin D and eczema link examined
We examined the relationship between vitamin D levels and the development of eczema in childhood through a systematic review and meta-analysis of several studies. This research highlighted the experiences of 43 articles, including six randomized controlled trials (RCTs) and several cohort studies, to gather comprehensive insights on this topic.

Interestingly, while some cohort studies indicated that higher vitamin D levels in cord blood were associated with a reduced risk of eczema, the RCTs revealed no significant effect of vitamin D supplementation during pregnancy or infancy on eczema rates. In fact, the pooled odds ratio from four of these trials pointed toward no notable impact, suggesting that vitamin D alone might not be a reliable preventive measure for eczema.

Moreover, three RCTs tested vitamin D's role in food allergies but found no positive associations there either. So, while we observed a potential link between higher vitamin D at birth and lower eczema prevalence, the evidence from clinical trials indicates that vitamin D supplementation isn't a guaranteed solution for preventing eczema in children.

Overall, it seems that the role of vitamin D in childhood eczema requires further investigation, particularly through additional trials focusing on supplementation for mothers and infants.
8
Prenatal vitamin D reduces eczema risk
We explored the potential impact of maternal vitamin D supplementation during pregnancy on the risk of developing atopic eczema in children up to four years old. In this well-structured study, pregnant women were randomly assigned to receive either 1000 IU of cholecalciferol, a form of vitamin D, or a placebo from around 14 weeks of gestation until delivery.

By assessing the prevalence of atopic eczema in their children at 12, 24, and 48 months, we aimed to gather solid evidence in a field where existing research has mostly stemmed from observational studies. Our findings indicate a notable protective effect of prenatal vitamin D supplementation against the risk of eczema in infants, suggesting that this supplement may improve breast milk cholecalciferol levels, which could benefit the child's skin health.

Overall, our data provide the first randomized controlled trial evidence supporting the idea that maternal vitamin D intake during pregnancy can play a role in reducing the incidence of eczema in young children. This opens the door for potentially important perinatal interventions that could positively affect children's health.

References

  1. Li Y, Wang Z, Li X, Ma K, Shi Z. Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema. Arch Dermatol Res. 2025;317:375. doi:10.1007/s00403-025-03887-8
  2. Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128
  3. Zhang Q, Yang D, Shen Q, Li W, Li R, et al. Correlation of Maternal Vitamin D Status in Early Pregnancy and Vitamin D Supplementation during Pregnancy with Atopic Dermatitis in Infants: A Prospective Birth Cohort Study. Nutrients. 2024;16. doi:10.3390/nu16132168
  4. McCarthy RL, Tawfik SS, Theocharopoulos I, Atkar R, McDonald B, et al. Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: A cross-sectional study. Skin Health Dis. 2024;4:e358. doi:10.1002/ski2.358
  5. Vassilopoulou E, Comotti A, Douladiris N, Konstantinou GΝ, Zuberbier T, et al. A systematic review and meta-analysis of nutritional and dietary interventions in randomized controlled trials for skin symptoms in children with atopic dermatitis and without food allergy: An EAACI task force report. Allergy. 2024;79:1708. doi:10.1111/all.16160
  6. Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. doi:10.3390/nu16091303
  7. Ding YJ, Li XN, Xiao Z, Li CY, Jia LH. Low vitamin D during pregnancy is associated with infantile eczema by up-regulation of PI3K/AKT/mTOR signaling pathway and affecting FOXP3 expression: A bidirectional cohort study. J Nutr Biochem. 2024;124:109516. doi:10.1016/j.jnutbio.2023.109516
  8. Ziyab AH, Al-Taiar A, Al-Sabah R, Shaban L, Almousa Z, et al. Sex and obesity status modify the association between vitamin D and eczema among adolescents. Pediatr Res. 2023;94:1235. doi:10.1038/s41390-023-02641-y
  9. Zeng R, Li Y, Shen S, Qiu X, Chang CL, et al. Is antenatal or early-life vitamin D associated with eczema or food allergy in childhood? A systematic review. Clin Exp Allergy. 2023;53:511. doi:10.1111/cea.14281
  10. Cabalín C, Pérez-Mateluna G, Iturriaga C, Camargo CA, Borzutzky A. Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis. Arch Dermatol Res. 2023;315:761. doi:10.1007/s00403-022-02416-1
  11. Li Q, Zhou Q, Zhang G, Tian X, Li Y, et al. Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis. Nutrients. 2022;14. doi:10.3390/nu14193947
  12. Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, et al. Prenatal and child vitamin D levels and allergy and asthma in childhood. Pediatr Res. 2023;93:1745. doi:10.1038/s41390-022-02256-9
  13. El-Heis S, D'Angelo S, Curtis EM, Healy E, Moon RJ, et al. Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial. Br J Dermatol. 2022;187:659. doi:10.1111/bjd.21721
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