Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.5
Supplement Facts
Serving Size: 5 Drops
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
L.reuteriDSM 17938(L. reuteriProtectis®)
100 million CFU
†
Top Medical Research Studies
9.5
We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Read More
9
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Read More
8
We set out to investigate how vitamin D levels, particularly serum 25-hydroxyvitamin D, might affect the risk of developing irritable bowel syndrome (IBS). Using a sophisticated approach called Mendelian randomization, we analyzed data collected from large biobanks. This method allows us to draw more robust conclusions about causality, especially given the controversies surrounding previous observational studies.
Our analysis focused on a substantial number of participants and examined the genetic factors associated with both vitamin D levels and IBS. While we found no significant causal relationship between vitamin D intake and IBS, we discovered an intriguing result regarding 25-hydroxyvitamin D. Specifically, higher levels of this form of vitamin D seemed to correlate with a decreased risk of IBS. More precisely, each additional standard deviation increase in genetically determined 25-hydroxyvitamin D was linked to a 16.8% lower risk of developing IBS.
Nevertheless, it's important to acknowledge the complexity of these findings. Although we observed a negative causal relationship between 25-hydroxyvitamin D and IBS, the same could not be said for vitamin D intake or functional dyspepsia (FD). This study brushes against the broader conversation about the potential health benefits of vitamin D while acknowledging that further research is necessary to fully understand these dynamics.
Our analysis focused on a substantial number of participants and examined the genetic factors associated with both vitamin D levels and IBS. While we found no significant causal relationship between vitamin D intake and IBS, we discovered an intriguing result regarding 25-hydroxyvitamin D. Specifically, higher levels of this form of vitamin D seemed to correlate with a decreased risk of IBS. More precisely, each additional standard deviation increase in genetically determined 25-hydroxyvitamin D was linked to a 16.8% lower risk of developing IBS.
Nevertheless, it's important to acknowledge the complexity of these findings. Although we observed a negative causal relationship between 25-hydroxyvitamin D and IBS, the same could not be said for vitamin D intake or functional dyspepsia (FD). This study brushes against the broader conversation about the potential health benefits of vitamin D while acknowledging that further research is necessary to fully understand these dynamics.
Read More
Most Useful Reviews
7.5
Improves bowel movement
7 people found this helpful
Amazing! It is wonderful. I give it to my children after their course of antibiotics as it kills both beneficial and harmful bacteria. I also used it for both of my children, who suffer from constipation due to formula milk. The taste is fine, and they accept it. The quality is good, and the package lasts a long time as it is not used daily. It helps improve bowel movement and relaxes the children. Suitable from 2 months old or more.
Read More
10
Effective for constipation
5 people found this helpful
I used it after consulting my doctor for my 4-month-old, who had no bowel movements without an enema. The results were immediate, with regular bowel movements occurring daily.
Read More
9
Convenient for infants
1 people found this helpful
There is no taste, and it is oily, but my child's bowel movements are normal after eating. The effects are noticeable with no more flatulence or constipation. My children no longer cry, and it includes vitamin D3, which is particularly recommended for breastfed babies. It’s very convenient, as I can drop 5 drops directly into the mouth every day. I'm going to buy it again.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9.5
We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Read More
9
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Read More
9
We conducted a study to understand how probiotic 35624 affects irritable bowel syndrome (IBS) in children and adolescents aged 8 to 18. This real-world study, carried out in Chile, involved 64 young participants over a span of 12 weeks, during which we closely monitored their gastrointestinal symptoms.
Throughout the study, participants showed significant improvements in various IBS symptoms measured by specific scoring systems. By week 6 and again at week 12, we saw strong positive changes with 98.3% of them experiencing improvements in three or more IBS domains. This shift was impressive, as the severity of their IBS symptoms moved from moderate or severe to mild or in remission.
Interestingly, the study also looked into vitamin D levels, as vitamin D deficiency is prevalent among children in Latin America. However, we found that low baseline serum vitamin D levels did not correlate with the severity of IBS symptoms or the response to the probiotic treatment. While the improvements were promising, they did not last after a two-week washout period, highlighting the need for more research to understand these effects fully, particularly regarding vitamin D's influence.
Throughout the study, participants showed significant improvements in various IBS symptoms measured by specific scoring systems. By week 6 and again at week 12, we saw strong positive changes with 98.3% of them experiencing improvements in three or more IBS domains. This shift was impressive, as the severity of their IBS symptoms moved from moderate or severe to mild or in remission.
Interestingly, the study also looked into vitamin D levels, as vitamin D deficiency is prevalent among children in Latin America. However, we found that low baseline serum vitamin D levels did not correlate with the severity of IBS symptoms or the response to the probiotic treatment. While the improvements were promising, they did not last after a two-week washout period, highlighting the need for more research to understand these effects fully, particularly regarding vitamin D's influence.
Read More
9
We investigated the impacts of a combination treatment involving probiotics and vitamin D on individuals with irritable bowel syndrome (IBS), specifically those experiencing diarrhea-predominant IBS (IBS-D) or mixed bowel movements (IBS-M). The study involved 246 adults followed by private gastroenterologists, who were given a daily dose of probiotics along with vitamin D over a period of 42 days.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
Read More
9
We aimed to understand how vitamin D treatment affects individuals with irritable bowel syndrome (IBS) who didn’t have any identifiable stressors contributing to their symptoms. For this study, we provided vitamin D supplements to patients over a three-month period. Of the patients, 97 had their vitamin D levels checked again, showing sufficient improvement, while 14 were lost to follow-up.
Our approach suggested that intramuscular injections were the best form of treatment, but interestingly, we found that 34 of the participants opted for oral supplements. Those taking oral vitamin D displayed a lesser increase in serum vitamin D levels compared to those receiving injections.
The results were promising: over half, specifically 56.7%, reported complete relief from their IBS symptoms after vitamin D replacement. Additionally, 36.1% experienced significant improvement, and 6.2% noted moderate relief. The study also highlighted that even though many found relief, we need to consider the 14 individuals lost to follow-up when interpreting the overall effectiveness.
Our approach suggested that intramuscular injections were the best form of treatment, but interestingly, we found that 34 of the participants opted for oral supplements. Those taking oral vitamin D displayed a lesser increase in serum vitamin D levels compared to those receiving injections.
The results were promising: over half, specifically 56.7%, reported complete relief from their IBS symptoms after vitamin D replacement. Additionally, 36.1% experienced significant improvement, and 6.2% noted moderate relief. The study also highlighted that even though many found relief, we need to consider the 14 individuals lost to follow-up when interpreting the overall effectiveness.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improves bowel movement
7 people found this helpful
Amazing! It is wonderful. I give it to my children after their course of antibiotics as it kills both beneficial and harmful bacteria. I also used it for both of my children, who suffer from constipation due to formula milk. The taste is fine, and they accept it. The quality is good, and the package lasts a long time as it is not used daily. It helps improve bowel movement and relaxes the children. Suitable from 2 months old or more.
Read More
10
Effective for constipation
5 people found this helpful
I used it after consulting my doctor for my 4-month-old, who had no bowel movements without an enema. The results were immediate, with regular bowel movements occurring daily.
Read More
9
Convenient for infants
1 people found this helpful
There is no taste, and it is oily, but my child's bowel movements are normal after eating. The effects are noticeable with no more flatulence or constipation. My children no longer cry, and it includes vitamin D3, which is particularly recommended for breastfed babies. It’s very convenient, as I can drop 5 drops directly into the mouth every day. I'm going to buy it again.
Read More
9
Magic results
1 people found this helpful
Works like magic! Our 2-month-old son started having significantly more bowel movements, averaging 1-2 a day instead of once every 7-10 days.
Read More
9
Reduced discomfort
1 people found this helpful
This has significantly aided my 2-month-old son with his bowel movements. Before I introduced the Biogaia drops, he experienced considerable discomfort between feedings, often squirming and crying. Since starting him on a probiotic, his movements have become much more regular and he's less gassy. I appreciate that Vitamin D is included as I breastfeed; it saves me an extra step!
Read More
Frequently Asked Questions
7.5
Obvious improvement
3 people found this helpful
I tried it for a week, and I have observed significant improvement in my child’s stomach and intestines, with daily bowel movements. The taste is neutral, and the child accepted it easily. I recommend keeping one at home for convenience.
10
Effective for constipation
5 people found this helpful
I used it after consulting my doctor for my 4-month-old, who had no bowel movements without an enema. The results were immediate, with regular bowel movements occurring daily.
7.5
Reduced vomiting
4 people found this helpful
Buying directly from this platform is much cheaper. After nearly two months of use, my baby's vomiting has improved, and bowel movements are smooth. I highly recommend buying it.
6
Improved regularity
3 people found this helpful
Since giving this to my baby from about 3 months old, they have transitioned from needing an enema to having regular bowel movements twice a day. I’ve observed fewer illnesses too, which is a bonus!
9
Magic results
1 people found this helpful
Works like magic! Our 2-month-old son started having significantly more bowel movements, averaging 1-2 a day instead of once every 7-10 days.
9
Reduced discomfort
1 people found this helpful
This has significantly aided my 2-month-old son with his bowel movements. Before I introduced the Biogaia drops, he experienced considerable discomfort between feedings, often squirming and crying. Since starting him on a probiotic, his movements have become much more regular and he's less gassy. I appreciate that Vitamin D is included as I breastfeed; it saves me an extra step!
0
Ineffective for constipation
This product had no effect on my 3-year-old son, who has suffered from stubborn constipation since he was 2. He was prescribed Laxoberon, but without significant improvement. I had to use an enema at times. I switched to gummy supplements, which proved more effective.
7.5
Improves bowel movement
7 people found this helpful
Amazing! It is wonderful. I give it to my children after their course of antibiotics as it kills both beneficial and harmful bacteria. I also used it for both of my children, who suffer from constipation due to formula milk. The taste is fine, and they accept it. The quality is good, and the package lasts a long time as it is not used daily. It helps improve bowel movement and relaxes the children. Suitable from 2 months old or more.
7.5
Supports gut health
7 people found this helpful
I give this to both my 4-year-old and my infant to support their gut health. Just a few drops daily works well, and I believe it helps improve their immunity for the long term.
7.5
Less flatulence
1 people found this helpful
After using this product, my baby's flatulence issue has greatly reduced, and bowel movements are now much smoother.
7.5
Convenient purchase
2 people found this helpful
Give your baby 5 drops daily. Thank you, iHerb, for providing good products at a favourable price. My baby is almost 4 months old and has regular bowel movements nearly every day, experiencing very little intestinal colic.
4
We explored the connection between vitamin D and irritable bowel syndrome (IBS) by analyzing data from twelve clinical trials that included 1331 IBS patients. Our goal was to see how vitamin D levels might relate to IBS symptoms and whether vitamin D supplementation can make a difference.
The findings revealed something interesting: patients with IBS tend to have lower levels of vitamin D in their blood. While vitamin D supplementation did show an improvement in the quality of life for these patients, it did not significantly affect the overall severity of their IBS symptoms.
This indicates that while vitamin D deficiency is linked to IBS and supplementation can enhance daily living, it may not directly relieve the main symptoms that trouble patients. Therefore, vitamin D could be a valuable part of the conversation around managing IBS, but it should not be seen as a standalone treatment for symptom relief.
The findings revealed something interesting: patients with IBS tend to have lower levels of vitamin D in their blood. While vitamin D supplementation did show an improvement in the quality of life for these patients, it did not significantly affect the overall severity of their IBS symptoms.
This indicates that while vitamin D deficiency is linked to IBS and supplementation can enhance daily living, it may not directly relieve the main symptoms that trouble patients. Therefore, vitamin D could be a valuable part of the conversation around managing IBS, but it should not be seen as a standalone treatment for symptom relief.
7
We sought to understand how vitamin D might affect the gastrointestinal symptoms of irritable bowel syndrome (IBS). IBS is a common condition affecting about 5% to 10% of people worldwide, and management options can be limited. To explore this, we examined recent studies and conducted a meta-analysis of randomized controlled trials.
By looking through several research databases, we identified six studies involving a total of 572 participants. Our analysis found that vitamin D supplementation significantly reduced the severity of IBS symptoms, with a measurable improvement in scores. However, interestingly, there was no significant change in the quality of life for the patients.
These findings suggest that while vitamin D could help in managing IBS symptoms, it may not necessarily enhance the overall well-being of those affected. It’s clear that for many individuals dealing with IBS, vitamin D supplementation could be a worthwhile option to discuss with healthcare professionals.
By looking through several research databases, we identified six studies involving a total of 572 participants. Our analysis found that vitamin D supplementation significantly reduced the severity of IBS symptoms, with a measurable improvement in scores. However, interestingly, there was no significant change in the quality of life for the patients.
These findings suggest that while vitamin D could help in managing IBS symptoms, it may not necessarily enhance the overall well-being of those affected. It’s clear that for many individuals dealing with IBS, vitamin D supplementation could be a worthwhile option to discuss with healthcare professionals.
8
We explored the relationship between vitamin D and irritable bowel syndrome (IBS), a common digestive condition that affects a significant number of adults. The findings suggest that vitamin D plays an important role in combating IBS symptoms through its effects on gut microbiota and immune regulation.
Vitamin D appears to improve gut health by promoting a balanced microbiome and enhancing the body's immune responses, which could potentially alleviate the inflammation often associated with IBS. With fewer side effects compared to other treatments, vitamin D supplementation shines as a promising option for those suffering from IBS.
Moving forward, we see a need for more in-depth studies, including epidemiological research and clinical trials, to better understand how vitamin D can be tailored to effectively improve IBS for patients. Additionally, investigating the specific mechanisms by which vitamin D alleviates symptoms may offer new insights into managing this complex disorder.
Vitamin D appears to improve gut health by promoting a balanced microbiome and enhancing the body's immune responses, which could potentially alleviate the inflammation often associated with IBS. With fewer side effects compared to other treatments, vitamin D supplementation shines as a promising option for those suffering from IBS.
Moving forward, we see a need for more in-depth studies, including epidemiological research and clinical trials, to better understand how vitamin D can be tailored to effectively improve IBS for patients. Additionally, investigating the specific mechanisms by which vitamin D alleviates symptoms may offer new insights into managing this complex disorder.
7
We aimed to explore the potential benefits of vitamin D supplementation for individuals suffering from irritable bowel syndrome (IBS), a condition marked by chronic stomach pain and changes in bowel habits. Through a systematic review and meta-analysis, we pulled together data from several studies involving a total of 685 patients to see how vitamin D might affect IBS symptoms and quality of life.
Our findings revealed that vitamin D supplementation seemed to significantly improve symptom severity, evidenced by a marked decrease in IBS symptom scores. The results showed a standardized mean difference (SMD) of -0.77, meaning patients reported feeling better after treatment. Although we also looked into quality of life measures through the IBS-QoL scores, the improvements weren't statistically significant, suggesting that while vitamin D might help with symptoms, its effect on overall well-being is less clear.
Despite promising results, we noted some limitations in the studies, such as small participant groups, limited ethnic diversity, and varying dosing strategies of vitamin D. Such factors could influence how broadly our findings can be applied. Although we see the potential of incorporating vitamin D into our treatment plans for IBS, further well-designed clinical trials are necessary to confirm its long-term efficacy and safety.
Our findings revealed that vitamin D supplementation seemed to significantly improve symptom severity, evidenced by a marked decrease in IBS symptom scores. The results showed a standardized mean difference (SMD) of -0.77, meaning patients reported feeling better after treatment. Although we also looked into quality of life measures through the IBS-QoL scores, the improvements weren't statistically significant, suggesting that while vitamin D might help with symptoms, its effect on overall well-being is less clear.
Despite promising results, we noted some limitations in the studies, such as small participant groups, limited ethnic diversity, and varying dosing strategies of vitamin D. Such factors could influence how broadly our findings can be applied. Although we see the potential of incorporating vitamin D into our treatment plans for IBS, further well-designed clinical trials are necessary to confirm its long-term efficacy and safety.
8
We set out to investigate how vitamin D levels, particularly serum 25-hydroxyvitamin D, might affect the risk of developing irritable bowel syndrome (IBS). Using a sophisticated approach called Mendelian randomization, we analyzed data collected from large biobanks. This method allows us to draw more robust conclusions about causality, especially given the controversies surrounding previous observational studies.
Our analysis focused on a substantial number of participants and examined the genetic factors associated with both vitamin D levels and IBS. While we found no significant causal relationship between vitamin D intake and IBS, we discovered an intriguing result regarding 25-hydroxyvitamin D. Specifically, higher levels of this form of vitamin D seemed to correlate with a decreased risk of IBS. More precisely, each additional standard deviation increase in genetically determined 25-hydroxyvitamin D was linked to a 16.8% lower risk of developing IBS.
Nevertheless, it's important to acknowledge the complexity of these findings. Although we observed a negative causal relationship between 25-hydroxyvitamin D and IBS, the same could not be said for vitamin D intake or functional dyspepsia (FD). This study brushes against the broader conversation about the potential health benefits of vitamin D while acknowledging that further research is necessary to fully understand these dynamics.
Our analysis focused on a substantial number of participants and examined the genetic factors associated with both vitamin D levels and IBS. While we found no significant causal relationship between vitamin D intake and IBS, we discovered an intriguing result regarding 25-hydroxyvitamin D. Specifically, higher levels of this form of vitamin D seemed to correlate with a decreased risk of IBS. More precisely, each additional standard deviation increase in genetically determined 25-hydroxyvitamin D was linked to a 16.8% lower risk of developing IBS.
Nevertheless, it's important to acknowledge the complexity of these findings. Although we observed a negative causal relationship between 25-hydroxyvitamin D and IBS, the same could not be said for vitamin D intake or functional dyspepsia (FD). This study brushes against the broader conversation about the potential health benefits of vitamin D while acknowledging that further research is necessary to fully understand these dynamics.
9
We investigated the impacts of a combination treatment involving probiotics and vitamin D on individuals with irritable bowel syndrome (IBS), specifically those experiencing diarrhea-predominant IBS (IBS-D) or mixed bowel movements (IBS-M). The study involved 246 adults followed by private gastroenterologists, who were given a daily dose of probiotics along with vitamin D over a period of 42 days.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
References
- Qi S, Zhao M, Sun Y, Boro S, Arora B, et al. Impact of vitamin D supplementation on symptom severity and quality of life in patients with irritable bowel syndrome: A meta-analysis. Adv Clin Exp Med. 2025. 10.17219/acem/191463
- Cara KC, Taylor SF, Alhmly HF, Wallace TC. The effects of vitamin D intake and status on symptom severity and quality-of-life in adults with irritable bowel syndrome (IBS): a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2024. 10.1080/10408398.2024.2400603
- Cruchet Muñoz S, Verbeke Palma S, Lera Marqués L, Espinosa Pizarro MN, Malig Mechasqui J, et al. Effects of 35624 in Children and Adolescents with Irritable Bowel Syndrome. Nutrients. 2024;16. 10.3390/nu16121967
- Jouët P, Altman C, Bruley DES Varannes S, Juhel C, Henri F. Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Minerva Gastroenterol (Torino). 2024;70:332. 10.23736/S2724-5985.24.03581-2
- Uberti F, Trotta F, Cavalli R, Galla R, Caldera F, et al. Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut-Brain Axes in Physiology and IBS Syndrome. Int J Mol Sci. 2024;25. 10.3390/ijms25042189
- Xu S, Luo Q, He J, Chen X, Li S, et al. Causal associations of 25-hydroxyvitamin D with functional gastrointestinal disorders: a two-sample Mendelian randomization study. Genes Nutr. 2023;18:14. 10.1186/s12263-023-00734-1
- Kesavan C, Das A, Goyal P, Jackson CS, Strong DD, et al. Vitamin D Deficiency (VDD) and Benefits of Supplementation in Veterans with IBS-D. Diagnostics (Basel). 2023;13. 10.3390/diagnostics13172807
- Yan C, Hu C, Chen X, Jia X, Zhu Z, et al. Vitamin D improves irritable bowel syndrome symptoms: A meta-analysis. Heliyon. 2023;9:e16437. 10.1016/j.heliyon.2023.e16437
- Yu XL, Wu QQ, He LP, Zheng YF. Role of in vitamin D in irritable bowel syndrome. World J Clin Cases. 2023;11:2677. 10.12998/wjcc.v11.i12.2677
- Alvi H, Ali G, Iqbal S, Ahsan MN, Siddiqui MA, et al. Role of 25-hydroxyvitamin D in irritable bowel syndrome patients. J Family Med Prim Care. 2022;11:7975. 10.4103/jfmpc.jfmpc_1336_22
- Abdelmalak MFL, Abdelrahim DS, George Michael TMA, Abdel-Maksoud OM, Labib JMW. Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy. Cell Biochem Funct. 2023;41:211. 10.1002/cbf.3774
- Grozić A, Coker K, Dussik CM, Sabir MS, Sabir Z, et al. Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by vitamin D. PLoS One. 2022;17:e0275683. 10.1371/journal.pone.0275683
- Abuelazm M, Muhammad S, Gamal M, Labieb F, Amin MA, et al. The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022;14. 10.3390/nu14132618
- Bin Y, Kang L, Lili Y. Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: a systematic review and meta-analysis. Nutr Hosp. 2022;39:1144. 10.20960/nh.04044
- Huang H, Lu L, Chen Y, Zeng Y, Xu C. The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis. Nutr J. 2022;21:24. 10.1186/s12937-022-00777-x
- Chong RIH, Yaow CYL, Loh CYL, Teoh SE, Masuda Y, et al. Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2022;37:993. 10.1111/jgh.15852
