Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Good
Based on 26 Reviews
8.4
Supplement Facts
Serving Size: 5 Drops
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
L.reuteriDSM 17938(L. reuteriProtectis®)
100 million CFU

Top Medical Research Studies

We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.

Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.

Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Read More
We explored the connection between vitamin D levels and obstructive sleep apnea (OSA) severity in a group of 262 adults who were diagnosed with OSA through polysomnography (a type of sleep study). Our aim was to understand if vitamin D deficiency could influence the severity of sleep apnea symptoms, particularly given the growing evidence linking these two health issues.

In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.

Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.

This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.

Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
Read More
7
Vitamin D and sleep apnea explored
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.

Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.

We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Read More

Most Useful Reviews

9
Improved sleep quality
184 people found this helpful
In what way was the effect expressed: the child became noticeably calmer, less blushed and strained, and most importantly, the quality of sleep improved (oh God, not to jinx it). I began to sleep for 4.5 hours, waking without feeding, before sleeping for another 3 hours, then feeding again and sleeping for another 2.5 hours. As a result, we wake up at 10 o'clock in the morning. It's fantastic! Considering that with the older ones, mornings started at 6.
Read More
7.5
Useful gift suggestion
54 people found this helpful
It’s a pity I didn’t know about this remedy three years ago when my daughter suffered from colic. It would have made my life so much easier. Recently, my nephew faced the same issue, and I decided to gift this remedy. Now they are content, and the baby sleeps peacefully at night, only waking for feeds. The inclusion of vitamin D is a great bonus. I definitely recommend it.
Read More
7.5
Eases crying significantly
14 people found this helpful
After a month and a half of using it, I found the product excellent. My daughter used to be unsettled at night, crying continuously, but now thanks to these drops, she has fallen asleep and relaxed. The gases have come out, and she is now well-rested.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
  • All Researches
We embarked on an intriguing study to see how an eight-week weight loss and lifestyle intervention could influence vitamin D levels in men suffering from obstructive sleep apnea (OSA). Our group of 89 men was split into two; one group received usual care, while the second group engaged in the lifestyle program alongside their standard treatment.

After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.

Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.

In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
Read More
We embarked on a large-scale study to understand how vitamin D influences obstructive sleep apnea (OSA), especially in those who are obese. Analyzing data from nearly 445,000 participants from the UK Biobank, we focused on individuals who had no previous diagnosis of OSA. The key outcome was the development of new cases of OSA over an average follow-up of 12 years.

What we found was intriguing: higher serum levels of 25-hydroxyvitamin D, the main form of vitamin D in the bloodstream, were associated with a reduced risk of developing new-onset OSA, particularly in participants struggling with obesity. Those with both a body mass index (BMI) of 25 or higher and waist circumference measurements of 90 cm or more showed a significant inverse relationship. This suggests that those with these characteristics might benefit more from maintaining higher vitamin D levels.

The results indicate that while vitamin D supplementation on its own wasn't tested, our findings certainly highlight its potential role in preventing OSA, particularly in at-risk populations. It's a reminder of the importance of monitoring and maintaining adequate vitamin D levels, especially for those dealing with obesity.
Read More
7
We conducted a study aimed at understanding how vitamin D3 might influence obstructive sleep apnea (OSA), particularly in hypertensive, obese patients. The research carefully examined the potential benefits of combining vitamin D3 with a medication called Dapagliflozin, a type of SGLT-2 inhibitor known for its additional cardiovascular advantages.

Over 16 weeks, participants were divided into four groups: those receiving Dapagliflozin, those receiving vitamin D3, those receiving both treatments, and a control group that received no treatment. We looked at a range of health parameters, including weight, blood sugar levels, and quality of life scores, to assess the overall impact of these treatments.

Our findings revealed positive outcomes from using vitamin D3 alongside SGLT-2 inhibitors, suggesting that this combination therapy could help improve cardiac and metabolic health, as well as quality of life in patients struggling with OSA. However, we acknowledged the need for further studies to isolate the specific effects of vitamin D on sleep apnea independently from the benefits provided by the medication.
Read More
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.

Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.

Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Read More
7
Vitamin D and sleep apnea explored
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.

Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.

We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
Read More

User Reviews

USERS' SCORE
Good
Based on 26 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Improved sleep quality
184 people found this helpful
In what way was the effect expressed: the child became noticeably calmer, less blushed and strained, and most importantly, the quality of sleep improved (oh God, not to jinx it). I began to sleep for 4.5 hours, waking without feeding, before sleeping for another 3 hours, then feeding again and sleeping for another 2.5 hours. As a result, we wake up at 10 o'clock in the morning. It's fantastic! Considering that with the older ones, mornings started at 6.
Read More
7.5
Useful gift suggestion
54 people found this helpful
It’s a pity I didn’t know about this remedy three years ago when my daughter suffered from colic. It would have made my life so much easier. Recently, my nephew faced the same issue, and I decided to gift this remedy. Now they are content, and the baby sleeps peacefully at night, only waking for feeds. The inclusion of vitamin D is a great bonus. I definitely recommend it.
Read More
7.5
Eases crying significantly
14 people found this helpful
After a month and a half of using it, I found the product excellent. My daughter used to be unsettled at night, crying continuously, but now thanks to these drops, she has fallen asleep and relaxed. The gases have come out, and she is now well-rested.
Read More
9
Saved from colic
5 people found this helpful
This is salvation from colic! You won't regret it! Very high-quality probiotics, bought on the recommendation of a paediatrician. My son was saved from colic, and he slept like an angel. The drops not only help with colic but also facilitate proper bowel movements. I recommend this to all mothers!
Read More
9
Miracle remedy
4 people found this helpful
Taking a chance on this expensive product was worth it! With my third son due soon, I wanted to be prepared for potential colic. Now, at 2 months old, my child has managed colic without irritation and sleeps well at night. I applied the drops effectively, and they worked wonders in alleviating gas. I wholeheartedly recommend this miracle remedy, especially since my older children struggled immensely with colic.
Read More

Frequently Asked Questions

9
Happy child
1 people found this helpful
This is the only remedy that helped my baby. After a week of use, we all started sleeping through the night, only waking up once. No more colic and a very happy child!
6
Probiotics for crying
I purchased this upon hearing that probiotics help with night crying. My baby began crying every hour at four months due to sleep regression, but after two weeks, it improved. Although I'm unsure if this product was the reason, it did aid in bowel movements more than in alleviating crying.
9
Improved sleep quality
184 people found this helpful
In what way was the effect expressed: the child became noticeably calmer, less blushed and strained, and most importantly, the quality of sleep improved (oh God, not to jinx it). I began to sleep for 4.5 hours, waking without feeding, before sleeping for another 3 hours, then feeding again and sleeping for another 2.5 hours. As a result, we wake up at 10 o'clock in the morning. It's fantastic! Considering that with the older ones, mornings started at 6.
9
Miracle for sleep
1 people found this helpful
This is just a miracle for colic! When other remedies failed, this one worked like a charm. My child fell asleep immediately, and my husband and I enjoyed 5 hours of uninterrupted sleep! I highly recommend this to all parents!
7.5
Calmer baby
6 people found this helpful
It worked for our baby. Colic began shortly after birth, disturbing his sleep. Standard drops provided only short-lived relief. After consulting a paediatrician, we started this supplement. While it didn't eliminate colic, it eased the symptoms, and the baby became calmer, which improved our sleep as well.
7.5
Extended sleep
1 people found this helpful
Both products work great! My baby boy fussed every night, but the Mommy’s Bliss Night Time Gripe Water works almost instantly, helping him to sleep longer. Since using the BioGaia probiotics drops, he clears his bowel daily. Highly recommended!
9
Effective colic relief
5 people found this helpful
This really helped reduce colic significantly. Although the size is small, 5 drops daily are enough for my baby to relax and sleep comfortably. It has a pleasant taste and contains vitamin D, which my doctor recommended. It's much better than alternatives I've tried, and I've advised friends to use it.
9
Effective remedy
1 people found this helpful
I truly believe these drops work well! Since starting them at 3 weeks old, my baby, now 2 months, has had minimal tummy troubles. Although the price is higher at the pharmacy, the value of uninterrupted nights of sleep is priceless! The dispenser is handy too; I administer it directly into his mouth, and he swallows without fuss.
9
Improved sleep
2 people found this helpful
This is our salvation! Excellent drops. I hesitated due to the small volume and high price, but it's worth it. Once we started using them, my baby’s tummy troubles disappeared, and he sleeps well. After a couple of days without them, problems arose. Now we take them daily, which should last 2-2.5 months.
7
Vitamin D and sleep apnea explored
We delved into the intriguing link between vitamin D deficiency and obstructive sleep apnea (OSA). Our investigation revealed that many individuals with OSA also struggle with low vitamin D levels, no matter where they are located around the globe. This finding suggests that there may be underlying factors contributing to vitamin D deficiency beyond just insufficient sunlight exposure.

Furthermore, we observed that reduced levels of vitamin D might correlate with more severe cases of OSA. This led us to consider whether boosting vitamin D levels through supplementation could serve as a potential treatment for OSA. Notably, some studies pointed out that patients who took vitamin D supplements reported improvements in sleep quality and a decrease in the severity of their OSA symptoms.

We proposed several potential mechanisms for how vitamin D might influence OSA. These included its role in reducing inflammation and oxidative stress, improving immune function, affecting muscle function, and even involving genetic factors related to vitamin D receptors. However, we underline the need for further research to better understand these connections and to figure out the best dosages and treatment durations for vitamin D supplementation.
We explored the connection between vitamin D levels and obstructive sleep apnea (OSA) severity in a group of 262 adults who were diagnosed with OSA through polysomnography (a type of sleep study). Our aim was to understand if vitamin D deficiency could influence the severity of sleep apnea symptoms, particularly given the growing evidence linking these two health issues.

In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.

Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.

This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.

Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
7
We conducted a study aimed at understanding how vitamin D3 might influence obstructive sleep apnea (OSA), particularly in hypertensive, obese patients. The research carefully examined the potential benefits of combining vitamin D3 with a medication called Dapagliflozin, a type of SGLT-2 inhibitor known for its additional cardiovascular advantages.

Over 16 weeks, participants were divided into four groups: those receiving Dapagliflozin, those receiving vitamin D3, those receiving both treatments, and a control group that received no treatment. We looked at a range of health parameters, including weight, blood sugar levels, and quality of life scores, to assess the overall impact of these treatments.

Our findings revealed positive outcomes from using vitamin D3 alongside SGLT-2 inhibitors, suggesting that this combination therapy could help improve cardiac and metabolic health, as well as quality of life in patients struggling with OSA. However, we acknowledged the need for further studies to isolate the specific effects of vitamin D on sleep apnea independently from the benefits provided by the medication.

References

  1. Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. 10.1186/s12967-025-06312-w
  2. Vázquez-Lorente H, Herrera-Quintana L, Ruiz JR, Amaro-Gahete FJ, Carneiro-Barrera A. Impact of weight loss and lifestyle intervention on vitamin D in men with obstructive sleep apnea: The INTERAPNEA trial. Sleep Med. 2025;128:37. 10.1016/j.sleep.2025.01.011
  3. Archontogeorgis K, Economou NT, Bargiotas P, Nena E, Voulgaris A, et al. Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea. Healthcare (Basel). 2024;12. 10.3390/healthcare12060698
  4. Yao N, Ma C, Dou R, Shen C, Yuan Y, et al. Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review. J Sleep Res. 2024;33:e14166. 10.1111/jsr.14166
  5. Kechribari I, Kontogianni MD, Georgoulis M, Lamprou K, Perraki E, et al. Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea. Life (Basel). 2024;14. 10.3390/life14020275
  6. Zhang Y, Zhang Y, Ye Z, Zhou C, Yang S, et al. Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea. Int J Obes (Lond). 2024;48:218. 10.1038/s41366-023-01402-5
  7. Locci C, Ruiu A, Saderi L, Sotgiu G, Bassu S, et al. Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study. J Clin Med. 2023;12. 10.3390/jcm12031242
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