Infographics 
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8.8
Top Medical Research Studies
9.5
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Read More
9
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
Read More
9
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Read More
Most Useful Reviews
10
Almost flawless skin
180 people found this helpful
IT REALLY WORKS—thank God for Vitamin A. This was my last resort before seeing a dermatologist. I’ve been seeking ways to clear my skin and keep it clear, especially since I believe I suffer from hormonal acne. I’ve tried many products, including Proactive, with mixed results. However, this is my hero. After 1-2 weeks on Vitamin A, my skin is nearly flawless. I used to wear foundation and concealer daily, but now I feel confident without! I hope this continues working as I will keep it in my diet for life.
Read More
10
Significantly clearer skin
97 people found this helpful
Amazing for acne! My skin is much better than before using these "magic vitamins." My ex-boyfriend suggested them, and I had to try. I have PCOS and suffer from hormonal acne and severe breakouts. After starting these daily, my skin began to clear up within a week. Now, I only take them two or three times a week, and my skin remains clearer. I highly recommend them!
Read More
9
Smooth skin achieved
25 people found this helpful
Get ready for smooth skin! I've been taking this supplement for eight months and am a firm believer in its effectiveness! I began using Vitamin A to help my terrible skin, inspired by the fact that Accutane's main ingredient is a Vitamin A derivative. I saw results almost immediately! My hormonal acne has improved significantly. Despite having ADHD and struggling to remember to take pills, I never forget this one, thanks to my skin's fantastic transformation! My husband confirms the difference too!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9.5
Impact of Isotretinoin on Liver Function
We conducted a retrospective study to understand how vitamin A, particularly in the form of oral isotretinoin, impacts acne treatment. This powerful medication is often prescribed for severe cases of acne that don’t respond to other treatments.
Our research reviewed medical records of 50 patients aged between 13 and 40 years who received isotretinoin at Ibri Polyclinic from 2012 to 2022. Over the treatment period, we observed notable changes in liver function and lipid profiles among the patients.
Specifically, after treatment, there were increases in liver enzymes indicating changes in liver function, as well as fluctuations in cholesterol and triglyceride levels. These findings suggest potential risks associated with isotretinoin, highlighting the need for careful monitoring.
While isotretinoin does show effectiveness in treating severe acne, there’s an evident impact on liver health and lipid metabolism that we must consider when prescribing this medication. More research is necessary to fully unravel these effects and guide future treatments.
Our research reviewed medical records of 50 patients aged between 13 and 40 years who received isotretinoin at Ibri Polyclinic from 2012 to 2022. Over the treatment period, we observed notable changes in liver function and lipid profiles among the patients.
Specifically, after treatment, there were increases in liver enzymes indicating changes in liver function, as well as fluctuations in cholesterol and triglyceride levels. These findings suggest potential risks associated with isotretinoin, highlighting the need for careful monitoring.
While isotretinoin does show effectiveness in treating severe acne, there’s an evident impact on liver health and lipid metabolism that we must consider when prescribing this medication. More research is necessary to fully unravel these effects and guide future treatments.
Read More
9.5
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Read More
9
We explored the effectiveness of retinoic acid, commonly known as vitamin A, for acne treatment using a unique delivery method that combines proliposomes and nanofibers. The goal was to assess how these specially formulated nanofibers, loaded with retinoic acid, could inhibit microbial biofilm formation, a common contributor to acne.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
Read More
9
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
Read More
9
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Almost flawless skin
180 people found this helpful
IT REALLY WORKS—thank God for Vitamin A. This was my last resort before seeing a dermatologist. I’ve been seeking ways to clear my skin and keep it clear, especially since I believe I suffer from hormonal acne. I’ve tried many products, including Proactive, with mixed results. However, this is my hero. After 1-2 weeks on Vitamin A, my skin is nearly flawless. I used to wear foundation and concealer daily, but now I feel confident without! I hope this continues working as I will keep it in my diet for life.
Read More
10
Significantly clearer skin
97 people found this helpful
Amazing for acne! My skin is much better than before using these "magic vitamins." My ex-boyfriend suggested them, and I had to try. I have PCOS and suffer from hormonal acne and severe breakouts. After starting these daily, my skin began to clear up within a week. Now, I only take them two or three times a week, and my skin remains clearer. I highly recommend them!
Read More
9
Smooth skin achieved
25 people found this helpful
Get ready for smooth skin! I've been taking this supplement for eight months and am a firm believer in its effectiveness! I began using Vitamin A to help my terrible skin, inspired by the fact that Accutane's main ingredient is a Vitamin A derivative. I saw results almost immediately! My hormonal acne has improved significantly. Despite having ADHD and struggling to remember to take pills, I never forget this one, thanks to my skin's fantastic transformation! My husband confirms the difference too!
Read More
10
Significant skin improvement
7 people found this helpful
Has helped so much with acne and more! I have loved taking these Vitamin A supplements! They are easy to swallow, very small and work wonders! I was on Accutane five years ago; although my acne cleared up, it has started to return. Unsure of what to do, I read that Vitamin A is excellent for skin and eyesight (I also have poor eyesight). Since I began taking these daily, my acne has reduced significantly, and my skin is now balanced. I am so happy with these and recommend them to everyone.
Read More
9
Breakthrough for acne
4 people found this helpful
Great for acne! This product is excellent; it hasn't upset my stomach or left an unpleasant aftertaste. I started taking it with Vitamin E and zinc for my cystic acne and in just two weeks my acne has beautifully cleared up. After two years of trying everything else, this is the first breakthrough I have found.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Abuallut II, Dibaji MQ, Assiri A, Mawkili W, Najmi AY, et al. Oral Isotretinoin-Associated Ocular Effects and Risk Factors: A Cross-Sectional Study. Clin Ophthalmol. 2024;18:4041. 10.2147/OPTH.S491757
- Yaqoubi WSAA, Touby SSJA, Hossain MA. Laboratory investigations of liver function and lipid profiles tests before and after oral isotretinoin treatment among Acne valgaris clients at Ibri Polyclinic: A retrospective study. Toxicol Rep. 2024;13:101799. 10.1016/j.toxrep.2024.101799
- Tort S, Öztürk ZC, Kaynak-Onurdağ F, Mutlu-Ağardan NB. Preparation and evaluation the effects of retinoic acid loaded proliposomal nanofibers on microbial biofilm inhibition. Pharm Dev Technol. 2024;29:955. 10.1080/10837450.2024.2411034
- Kulaklı S, Elmas Telli AC, Sarı İF, Oğuz ID, Kulaklı F. Increased femoral cartilage thickness in acne patients using isotretinoin: could it be a sign of early osteoarthritis?. Arch Dermatol Res. 2024;316:512. 10.1007/s00403-024-03264-x
- Powała K, Żołek T, Brown G, Kutner A. Molecular Interactions of Selective Agonists and Antagonists with the Retinoic Acid Receptor γ. Int J Mol Sci. 2024;25. 10.3390/ijms25126568
- Hussein RS, Dayel SB, Abahussein O. Prospective study of the effects of isotretinoin and vitamin D levels on severe acne vulgaris. Turk J Med Sci. 2023;53:1732. 10.55730/1300-0144.5742
- Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. 10.1007/s00403-024-02895-4
- Shahpar A, Nezhad NZ, Sahaf AS, Ahramiyanpour N. A review of isotretinoin in the treatment of frontal fibrosing alopecia. J Cosmet Dermatol. 2024;23:1956. 10.1111/jocd.16245
- Demir EY, Köse ÖK. Effects of oral isotretinoin treatment for acne vulgaris patients on anger responses and the relationship with temperament. Rev Assoc Med Bras (1992). 2023;70:e20230592. 10.1590/1806-9282.20230592
- Cao J, Xu M, Zhu L, Xiao S. Viaminate Inhibits Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade. Curr Drug Targets. 2023;24:1055. 10.2174/0113894501243867230928115205
- Tsai MJ, Lin CY, Trousil J, Sung CT, Lee MH, et al. Proteinase K/Retinoic Acid-Loaded Cationic Liposomes as Multifunctional Anti-Acne Therapy to Disorganize Biofilm and Regulate Keratinocyte Proliferation. Int J Nanomedicine. 2023;18:3879. 10.2147/IJN.S416966
- Gurel A, Gurel G, Fırat F, Ozgul E, Turkoglu IND, et al. Effect of systemic isotretinoin therapy on semen parameters. Ann Med. 2023;55:2207038. 10.1080/07853890.2023.2207038
- Cook MK, Perche PO, Feldman SR. The use of oral vitamin A in acne management: a review. Dermatol Online J. 2022;28. 10.5070/D328559239
- Cao J, Xu M, Zhu L, Xiao S. Viaminate ameliorates Propionibacterium acnes-induced acne via inhibition of the TLR2/NF-κB and MAPK pathways in rats. Naunyn Schmiedebergs Arch Pharmacol. 2023;396:1487. 10.1007/s00210-022-02379-0
- Kontzias C, Zaino M, Feldman SR. Tretinoin 0.1% and Benzoyl Peroxide 3% Cream for the Treatment of Facial Acne Vulgaris. Ann Pharmacother. 2023;57:1088. 10.1177/10600280221147338
- Kosmoski G, Miller D, Coret C, Atillasoy E. A Topical Combination Regimen of Benzoyl Peroxide and Retinol Moisturizer for Mild to Moderate Acne. J Drugs Dermatol. 2022;21:1340. 10.36849/JDD.6845
