5/26/2025
Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.5
Top Medical Research Studies
8
We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
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8
We sought to understand the connection between vitamin D levels and acne, along with how vitamin D supplementation might help those suffering from this common skin condition. Our investigation included various studies from a range of databases, focusing on the serum levels of a specific form of vitamin D—25(OH)D—and the effectiveness of vitamin D supplements for acne patients.
In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.
Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.
In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.
Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.
Read More
We investigated the intriguing link between vitamin D receptor (VDR) gene variations and acne in women experiencing polycystic ovary syndrome (PCOS). This study involved a careful comparison of 46 women with PCOS and 39 controls that matched in age and body mass index. We focused on acne and other skin conditions, along with measuring hormones and oxidative stress levels to understand their interplay.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
Read More
Most Useful Reviews
9
Cleared hormonal acne
10 people found this helpful
Great product with hidden benefits! It cleared up my hormonal acne that I had for years, even Accutane didn't help. I won’t use another brand as this was recommended by my mother's doctor for better absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7
- All Researches
9
We explored the effectiveness of combining microfocused ultrasound with a calcium hydroxylapatite dermal filler for treating acne scars. This approach was evaluated in a group of healthy adults aged 35-55, who had moderate to severe facial scars from acne.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
Read More
8
Vitamin D reduces acne inflammation
We conducted a double-blind, randomized controlled trial to explore how topical vitamin D affects acne vulgaris (AV). Our study involved 64 participants, who were split into two groups—one receiving a vitamin D treatment and the other a placebo. After 8 weeks, we observed significant changes in the inflammatory markers, specifically a reduction in interleukin-1 beta (IL-1β) levels, which plays a role in acne inflammation.
Participants in the vitamin D group showed a noticeable reduction in the number of inflammatory acne lesions compared to those using the placebo. This indicates that topical vitamin D can effectively lower inflammation associated with acne lesions.
It's essential to note that all participants also received topical adapalene, an established acne treatment. This could make it challenging to determine the exact effect of vitamin D alone. Nonetheless, the findings suggest that vitamin D has potential benefits in managing acne when included as part of a treatment regimen.
Participants in the vitamin D group showed a noticeable reduction in the number of inflammatory acne lesions compared to those using the placebo. This indicates that topical vitamin D can effectively lower inflammation associated with acne lesions.
It's essential to note that all participants also received topical adapalene, an established acne treatment. This could make it challenging to determine the exact effect of vitamin D alone. Nonetheless, the findings suggest that vitamin D has potential benefits in managing acne when included as part of a treatment regimen.
Read More
We investigated the intriguing link between vitamin D receptor (VDR) gene variations and acne in women experiencing polycystic ovary syndrome (PCOS). This study involved a careful comparison of 46 women with PCOS and 39 controls that matched in age and body mass index. We focused on acne and other skin conditions, along with measuring hormones and oxidative stress levels to understand their interplay.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
Read More
8
We embarked on a journey to understand how vitamin D might help with acne, particularly when combined with the standard treatment of benzoyl peroxide. Our study involved a well-structured approach, including a randomized, double-blind, placebo-controlled trial. This involved subjects diagnosed with mild to moderate acne, all applying benzoyl peroxide twice daily for 12 weeks.
During this time, participants were split into two groups—one receiving a weekly dose of 40,000 IU of vitamin D2, while the other group received a placebo. All subjects had low levels of vitamin D at the onset of the study, allowing us to investigate whether supplementation could make a difference.
As we analyzed the results, we noticed significant improvements in acne conditions for both groups. However, what stood out was the vitamin D2 group, which showed a statistically significant reduction in inflammatory lesions during the follow-up phase. Importantly, no adverse effects or unwanted biochemical changes were reported, highlighting the safety of this treatment.
Overall, our findings suggest that adding weekly vitamin D2 to a topical benzoyl peroxide regime could effectively reduce the likelihood of acne flare-ups in those with mild to moderate acne. While more extensive studies are needed to fully understand vitamin D's role in acne treatment, this adjunctive approach shows promise.
During this time, participants were split into two groups—one receiving a weekly dose of 40,000 IU of vitamin D2, while the other group received a placebo. All subjects had low levels of vitamin D at the onset of the study, allowing us to investigate whether supplementation could make a difference.
As we analyzed the results, we noticed significant improvements in acne conditions for both groups. However, what stood out was the vitamin D2 group, which showed a statistically significant reduction in inflammatory lesions during the follow-up phase. Importantly, no adverse effects or unwanted biochemical changes were reported, highlighting the safety of this treatment.
Overall, our findings suggest that adding weekly vitamin D2 to a topical benzoyl peroxide regime could effectively reduce the likelihood of acne flare-ups in those with mild to moderate acne. While more extensive studies are needed to fully understand vitamin D's role in acne treatment, this adjunctive approach shows promise.
Read More
8
We conducted a study to explore the effectiveness of calcipotriol, a vitamin D analogue, in treating acne vulgaris. The research involved forty participants who received topical calcipotriol cream on one side of their face and adapalene gel on the other. This split-face approach allowed us to directly compare the effects of each treatment.
After two months, we observed a significant reduction in acne lesions on both sides of the face, with improvements noted in both physician and patient assessments. Interestingly, the density of inflammatory cells in the skin showed a notable decrease with calcipotriol, hinting at its potential anti-inflammatory properties.
While both treatments were effective, the results suggest that calcipotriol can be a valuable addition to acne therapy, providing similar benefits to adapalene but with a slightly different mechanism of action. Overall, this study opens new avenues for utilizing vitamin D in acne management.
After two months, we observed a significant reduction in acne lesions on both sides of the face, with improvements noted in both physician and patient assessments. Interestingly, the density of inflammatory cells in the skin showed a notable decrease with calcipotriol, hinting at its potential anti-inflammatory properties.
While both treatments were effective, the results suggest that calcipotriol can be a valuable addition to acne therapy, providing similar benefits to adapalene but with a slightly different mechanism of action. Overall, this study opens new avenues for utilizing vitamin D in acne management.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cleared hormonal acne
10 people found this helpful
Great product with hidden benefits! It cleared up my hormonal acne that I had for years, even Accutane didn't help. I won’t use another brand as this was recommended by my mother's doctor for better absorption.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Dahlan NH, Sitohang IBS, Indriatmi W, Wibowo H, Enggy LE. Correlation Between Reduced IL-1β Levels in Acne Lesions and the Decrease in Acne Inflammatory Lesions Following Topical Vitamin D Administration: A Double-Blind Randomized Controlled Trial. Clin Cosmet Investig Dermatol. 2024;17:2183. 10.2147/CCID.S475068
- Talida V, Tudor SS, Mihaela I, Daniela-Rodica M, Gabriela A F, et al. The Impact of Vitamin D Receptor Gene Polymorphisms () in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome. Medicina (Kaunas). 2024;60. 10.3390/medicina60091501
- Ruikchuchit T, Juntongjin P. Role of vitamin D supplement adjunct to topical benzoyl peroxide in acne: a randomized double-blinded controlled study. Int J Womens Dermatol. 2024;10:e163. 10.1097/JW9.0000000000000163
- Hussein RS, Dayel SB, Abahussein O. Prospective study of the effects of isotretinoin and vitamin D levels on severe acne vulgaris. Turk J Med Sci. 2023;53:1732. 10.55730/1300-0144.5742
- Mahran A, Ghazally A, Ali AS, Bakr RM. Efficacy and safety of calcipotriol as a potential topical treatment of acne vulgaris: a randomized, controlled, triple blinded, split-face clinical trial. Clin Exp Dermatol. 2024;49:348. 10.1093/ced/llad371
- Iqbal T, Asim SA, Bhatti S, Sajid M, Mirza R, et al. Association of Vitamin D with Moderate to Severe Acne Vulgaris. J Coll Physicians Surg Pak. 2023;33:527. 10.29271/jcpsp.2023.05.527
- Abdel-Wahab HM, Ali AK, Ragaie MH. Calcipotriol: A novel tool in treatment of acne vulgaris. Dermatol Ther. 2022;35:e15690. 10.1111/dth.15690
- Rasti SD, Dewinta NR, Kamal RH, Adissadah AF, Madanny AE, et al. Correlation between Serum 25-Hydroxy Vitamin D Levels and the Severity of Acne Vulgaris: A Systematic Review. Indian J Dermatol. 2022;67:31. 10.4103/ijd.ijd_871_21
- Shrestha S, Agrawal S, Lamsal M. Vitamin D level in patients with moderate-to-severe acne: A case-control study combined with prospective study following oral isotretinoin treatment. J Cosmet Dermatol. 2022;21:5127. 10.1111/jocd.14996
- Singh A, Khurana A, Sardana K, Dixit N, Chitkara A. Correlation of Serum 25-Hydroxy Vitamin D and Interleukin-17 Levels with Disease Severity in Acne Vulgaris. Indian J Dermatol. 2021;66:291. 10.4103/ijd.IJD_551_19
- Hasamoh Y, Thadanipon K, Juntongjin P. Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis. Dermatology. 2022;238:404. 10.1159/000517514
- Wang M, Zhou Y, Yan Y. Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis. J Cosmet Dermatol. 2021;20:3802. 10.1111/jocd.14057
- Singh A, Dorjay K, Sinha S, Chitkara A. The interplay of vitamin D and body mass index in acne patients vs. controls. J Cosmet Dermatol. 2021;20:3689. 10.1111/jocd.14034
- Kemeriz F, Tuncer SÇ, Acar EM, Tuğrul B. Evaluation of 25-hydroxy vitamin D levels and disease severity in patients with acne vulgaris. Dermatol Ther. 2020;33:e13393. 10.1111/dth.13393
- Li X, Zeng X, Kim D, Jiang J, Wei F, et al. Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1. Biochem Biophys Res Commun. 2023;667:146. 10.1016/j.bbrc.2023.05.043
- Antonino A, Francesco A. Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate-to-severe acne scars. J Cosmet Dermatol. 2021;20:53. 10.1111/jocd.13472
- Ahn B, Lee SH, Kim JH, Goh A, Park SG, et al. Identification and validation of amino acid-based mild exfoliating agents through a de novo screening method. J Cosmet Dermatol. 2019;18:1404. 10.1111/jocd.12871
- Casabona G. Combined use of microfocused ultrasound and a calcium hydroxylapatite dermal filler for treating atrophic acne scars: A pilot study. J Cosmet Laser Ther. 2018;20:301. 10.1080/14764172.2017.1406606
- Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, et al. Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo. Acta Derm Venereol. 2017;97:313. 10.2340/00015555-2525
