Overview
Top Medical Research Studies
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
After the treatment, we observed that the children taking vitamin B experienced fewer headaches, lower headache severity, and less overall headache-related disability compared to the placebo group.
While the results are promising, indicating a potential benefit of vitamin B-complex, more research is necessary to validate these findings.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
Most Useful Reviews
Medical Researches
- All Researches
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
After administering anticoagulation therapy and B-vitamin supplements, her symptoms improved significantly within a month, with no headaches reported and reduced thrombosis. This case highlights the importance of checking for specific genetic factors when dealing with unusual CVT cases and underscores the potential for successful treatment.
Over 12 weeks, the vitamin groups also needed fewer abortive medications. While results are promising, further research with larger samples is necessary to confirm these findings and better understand the long-term benefits of B vitamins for migraine sufferers.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
While adverse events are minimal, caution is advised when considering other nutraceuticals like coenzyme Q10 and feverfew, as their effectiveness and safety require further research.
Overall, vitamin B2 shows promise for adults struggling with headaches, but more robust studies are needed to confirm its efficacy.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
A headache is a common condition characterized by pain or discomfort in the head, scalp, or neck. It can vary in intensity, frequency, and duration, and is often classified into two primary categories: primary and secondary headaches. Primary headaches, such as tension-type headaches, migraines, and cluster headaches, are not caused by other medical conditions. Instead, they are conditions in themselves, often resulting from factors like stress, hormonal changes, or environmental triggers. Secondary headaches, on the other hand, are symptoms of an underlying issue, such as an infection, injury, or other medical conditions.
The experience of a headache can differ widely among individuals. Depending on the type, headaches can be throbbing or constant and may be accompanied by other symptoms like nausea, sensitivity to light, or aura effects before the headache strikes. Effective management strategies vary by headache type and may include over-the-counter pain relievers, lifestyle changes, and in some cases, prescription medications. Understanding the specific triggers and patterns related to your headaches can be crucial for prevention and treatment, so maintaining a headache diary may be beneficial for those experiencing frequent or severe episodes.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Vitamin B Complex may have a beneficial role in addressing certain types of headaches, particularly those related to deficiencies in specific B vitamins. B vitamins, such as B2 (riboflavin), B6, and B12, have been studied for their potential impact on migraine prevention and headache management. Riboflavin, for instance, has shown promise in reducing the frequency and intensity of migraines in some individuals, while B12 is essential for maintaining nerve health, which may indirectly aid in headache management.
That said, it's important to note that while B vitamins can contribute to overall well-being and help alleviate headaches rooted in nutritional deficiencies, they are not a standalone solution for all types of headaches. If you experience chronic headaches, it’s best to consult a healthcare professional to determine the underlying cause and appropriate treatment options. Overall, maintaining a balanced diet that includes sufficient B vitamins might contribute to headache relief in some individuals.
Based on user reviews, the timeline for experiencing relief from headaches when taking this supplement can vary, but many users seem to find results relatively quickly. One user noted a significant improvement in their headaches alongside other symptoms in a manner that implies a prompt response to the supplement ((Read Review)). Another review emphasizes that the specific formulation does not exacerbate headaches, highlighting that it allows the user to take the supplements without negative effects, which could suggest a swift resolution of headache symptoms ((Read Review)).
While individual experiences may vary, the consensus from these reviews is that users have either felt an immediate improvement or have been able to incorporate the supplement successfully into their routine. The emphasis on the quality and tailored ingredients suggests that many users could potentially see positive results shortly after beginning the supplement, contingent on their unique circumstances and sensitivities.
Recent scientific research suggests that certain B vitamins, particularly riboflavin (Vitamin B2), may be effective in managing headaches, especially migraines. A systematic review indicated that a daily intake of 400 mg of riboflavin significantly reduced the number of migraine days and their associated severity among adult sufferers, highlighting its promise as a preventative treatment ([8]). Furthermore, another study found that increasing dietary intake of various B vitamins, particularly folate, was linked to a reduced risk of severe headaches in adults, indicating these nutrients could play a beneficial role in headache management ([4]).
For children, riboflavin has shown potential as well, with studies reporting reductions in the frequency and severity of migraines in pediatric patients ([9]). Nevertheless, while these findings are encouraging, researchers emphasize the need for further, larger-scale studies to confirm the efficacy and safety of B vitamins in headache treatment across different demographics. Thus, while riboflavin and other B vitamins are supported by preliminary research, definitive conclusions regarding their universal effectiveness for headaches remain to be established.
Based on user reviews, many have reported significant improvements in various symptoms after using this supplement. One user specifically highlighted that after treatment, they experienced a remarkable elimination of symptoms such as hot flashes, headaches, tinnitus, and irritability, resulting in enhanced energy and a more enjoyable life ((Read Review)). Another user noted that the formulation allows them to take B vitamins without suffering from bad headaches, which is often a problem they encounter with other brands, suggesting that this product effectively alleviates headaches while providing the necessary nutrients ((Read Review)).
Additionally, another review emphasized the clean ingredients and quality of the product, stating that it aligns with their doctor's recommendations for treating headaches, indicating a professional endorsement of its efficacy ((Read Review)). While individual results can vary, the anecdotal experiences shared in these reviews suggest that many users have found relief from headaches and other symptoms, contributing to an overall improved quality of life.
Users report a positive experience when combining this supplement with other vitamins, particularly B vitamins, for handling headaches. One user specifically mentioned that they typically experience bad headaches with B vitamin intake, but this formulation allows them to avoid negative effects while still receiving the necessary nutrients ((Read Review)). This suggests that the supplement's carefully balanced ingredients enable safe co-administration with other supplements, making it a viable option for those looking to mitigate headaches without compromising their nutrient intake.
Moreover, several reviews highlight that the supplement adheres to professional recommendations for headache treatment. One user noted that the clean ingredients align with their doctor's advice, reinforcing the supplement's efficacy in addressing headaches and other associated symptoms ((Read Review)). Collectively, these insights from users illustrate that many are finding success in managing headaches while incorporating this supplement into broader health regimens.
When it comes to tackling headaches, Vitamin B Complex—specifically Riboflavin (Vitamin B2)—has shown promising potential. A systematic review and meta-analysis involving over 670 participants highlighted that a daily dose of 400 mg of Vitamin B2 for three months significantly reduced the frequency, duration, and intensity of migraines [8]. This suggests that individuals suffering from chronic migraines might benefit from this dosage to help alleviate symptoms, although more robust studies are necessary for conclusive evidence.
Additionally, vitamin B intake, including other B vitamins and folate, has been associated with a decreased likelihood of severe headaches. Higher intake of these nutrients was linked to a lower risk of experiencing migraines, indicating that maintaining adequate levels could be beneficial for headache management [2]. However, the response to vitamin B supplementation can vary among individuals, underscoring the importance of consulting with a healthcare professional before starting any new supplement regimen.
We discovered that a daily dose of 400 mg of Vitamin B2 for three months notably reduced the number of migraine days, their duration, frequency, and pain intensity. These findings support the potential of Vitamin B2 as an effective supplement for those suffering from migraines.
Specifically, those with higher folate levels reported fewer severe headache episodes, particularly women aged 20-50, who could benefit from increased folate awareness. These findings suggest that diet could play a role in headache management.
Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.
Specifically, individuals who consumed adequate amounts of vitamin B and folate had significantly reduced chances of migraines. These findings suggest that these vitamins might be valuable in managing headache symptoms, but they don’t guarantee relief for everyone.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. doi:10.1016/j.nutres.2023.11.008
- Sadeghvand S, Barzegar M, Shiva S, Tarmahi V, Hamed H, et al. The Effects of Vitamin B-Complex Supplementation on Serum Homocysteine Levels and Migraine Severity in Children A Randomized Controlled Trial. Iran J Child Neurol. 2023;17:143. doi:10.22037/ijcn.v17i3.40053
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. doi:10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. doi:10.1111/head.14384
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. doi:10.18502/cjn.v21i2.10494
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. doi:10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Chutko LS, Surushkina SY, Yakovenko EA, Rozhkova AV, Volov MB, et al. [Possibilities of using Cytoflavin in the treatment of cognitive and emotional disorders in patients with tension headaches]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119:32. doi:10.17116/jnevro201911911132
- Bravaccio C, Terrone G, Rizzo R, Gulisano M, Tosi M, et al. Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study. Minerva Pediatr. 2020;72:30. doi:10.23736/S0026-4946.19.05533-6
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. doi:10.1186/s13052-019-0624-z
