Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 drop (0.001 fl oz/ 0.028 ml)
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
Top Medical Research Studies
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
8
We explored the connection between vitamin D levels and the management of Graves' disease, an autoimmune disorder characterized by overactive thyroid function. Through our research with 171 patients, we aimed to see if pre-treatment levels of 25-hydroxyvitamin D could influence the reduction of thyrotropin receptor antibodies (TRAB) during treatment.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Read More
8
Our investigation focused on the role of vitamin D in the autoimmune disorder known as alopecia areata (AA). We delved into data from various studies, including a meta-analysis of 34 papers covering nearly 5,000 participants from multiple countries.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
Read More
Most Useful Reviews
9.5
No reaction observed
I ordered this vitamin D for my daughter when she was three months old. I didn't observe any negative reactions. I find it very good and would certainly recommend it!
Read More
7.5
Notable positive effects
I didn't have high expectations, but I was pleasantly surprised. I've ordered it a second time because it genuinely has a noticeable effect. I observed improvements even before finishing the first jar. I'm planning to purchase more.
Read More
8.8
Recommended dosage needed
Good vitamin D in an easy-to-use form for children. It's simply a matter of dripping a few drops. When taking, ensure an appropriate dosage; I mistakenly gave my child vitamin D in the evening instead of the morning, leading to overexcitement. I suggest passing an analysis to determine the correct dosage for your child. After adjusting her intake, my child's hair grew, and there were no signs of allergies or hyperactivity. I've now reduced her dose while continuing to take it myself.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
- All Researches
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
8
We explored the connection between vitamin D levels and the management of Graves' disease, an autoimmune disorder characterized by overactive thyroid function. Through our research with 171 patients, we aimed to see if pre-treatment levels of 25-hydroxyvitamin D could influence the reduction of thyrotropin receptor antibodies (TRAB) during treatment.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Read More
8
Calcitriol enhances MSCs in RA
We investigated the effects of calcitriol, an active form of vitamin D, on mesenchymal stem cells (MSCs) in the context of rheumatoid arthritis (RA), a chronic inflammatory disease affecting joints. Using BALB/c mice, we induced RA with collagen and Freund's complete adjuvant and divided the mice into three groups: untreated, treated with untreated MSCs, and treated with calcitriol-exposed MSCs.
Our findings revealed that MSCs treated with calcitriol showcased enhanced regulatory functions, particularly regarding immune responses from splenocytes. This treatment also resulted in reduced inflammatory markers. Importantly, we observed how calcitriol modulated the production of certain cytokines, increasing levels of IL-4, IL-10, and TGF-β, while decreasing INF-γ and IL-17 compared to the positive control group.
Overall, this study highlights the potential of calcitriol treated MSCs in improving immune regulation, offering promising insights for future advanced therapies in autoimmune disorders like RA.
Our findings revealed that MSCs treated with calcitriol showcased enhanced regulatory functions, particularly regarding immune responses from splenocytes. This treatment also resulted in reduced inflammatory markers. Importantly, we observed how calcitriol modulated the production of certain cytokines, increasing levels of IL-4, IL-10, and TGF-β, while decreasing INF-γ and IL-17 compared to the positive control group.
Overall, this study highlights the potential of calcitriol treated MSCs in improving immune regulation, offering promising insights for future advanced therapies in autoimmune disorders like RA.
Read More
8
Our investigation focused on the role of vitamin D in the autoimmune disorder known as alopecia areata (AA). We delved into data from various studies, including a meta-analysis of 34 papers covering nearly 5,000 participants from multiple countries.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
Read More
8
We explored the significant role of vitamin D in managing rheumatoid arthritis (RA), a chronic autoimmune disorder characterized by joint inflammation and damage. The evidence points to a common deficiency in vitamin D among RA patients, which can be linked to increased severity of the disease.
Our observations suggest that vitamin D may help modulate the immune response and reduce inflammation. There has been promising data showing that vitamin D supplementation can lead to improvements in disease activity, as well as a decrease in inflammatory markers among patients.
In addition to its immune-boosting properties, we recognized that managing vitamin D levels might also alleviate some of the symptoms associated with RA, such as fatigue, which can be exacerbated by deficiencies. Overall, the compelling findings underline the potential benefits of vitamin D as a therapeutic option for patients dealing with autoimmune disorders like RA.
Our observations suggest that vitamin D may help modulate the immune response and reduce inflammation. There has been promising data showing that vitamin D supplementation can lead to improvements in disease activity, as well as a decrease in inflammatory markers among patients.
In addition to its immune-boosting properties, we recognized that managing vitamin D levels might also alleviate some of the symptoms associated with RA, such as fatigue, which can be exacerbated by deficiencies. Overall, the compelling findings underline the potential benefits of vitamin D as a therapeutic option for patients dealing with autoimmune disorders like RA.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
No reaction observed
I ordered this vitamin D for my daughter when she was three months old. I didn't observe any negative reactions. I find it very good and would certainly recommend it!
Read More
7.5
Notable positive effects
I didn't have high expectations, but I was pleasantly surprised. I've ordered it a second time because it genuinely has a noticeable effect. I observed improvements even before finishing the first jar. I'm planning to purchase more.
Read More
8.8
Recommended dosage needed
Good vitamin D in an easy-to-use form for children. It's simply a matter of dripping a few drops. When taking, ensure an appropriate dosage; I mistakenly gave my child vitamin D in the evening instead of the morning, leading to overexcitement. I suggest passing an analysis to determine the correct dosage for your child. After adjusting her intake, my child's hair grew, and there were no signs of allergies or hyperactivity. I've now reduced her dose while continuing to take it myself.
Read More
8.8
Therapeutic dose required
I ordered these drops after my daughter's vitamin D3 analysis revealed a deficiency of just 14 units. We are now taking a therapeutic dose of 2000 units. We'll recheck her levels in autumn to assess the efficacy of this supplement, and my daughter takes them with pleasure.
Read More
2.5
Allergic reaction experienced
I ordered this on someone's recommendation, but unfortunately, it didn't work for us. The inclusion of coconut and palm oil caused an immediate allergic reaction. Be careful if trying this product.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Vernerová L, Vokurková M, Laiferová NA, Nemec M, Špiritović M, et al. Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. 2025;27:48. doi:10.1186/s13075-025-03516-9
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. doi:10.3389/fimmu.2025.1528707
- Chen X, Zhang Y, Lin L, Chen Y, Shen X, et al. A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study. BMC Endocr Disord. 2025;25:14. doi:10.1186/s12902-024-01823-x
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. doi:10.1016/j.transproceed.2024.12.020
- Casas R, Tompa A, Åkesson K, Teixeira PF, Lindqvist A, et al. Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial. Int J Mol Sci. 2025;26. doi:10.3390/ijms26010374
- Rasheed A, Khan G. Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Front Immunol. 2024;15:1503808. doi:10.3389/fimmu.2024.1503808
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Balshi A, Leuenberger G, Dempsey J, Baber U, Sloane JA. Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort. Mult Scler Relat Disord. 2025;93:106229. doi:10.1016/j.msard.2024.106229
- Mourelatou NG, Kounatidis D, Jude EB, Rebelos E. Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management. Nutrients. 2024;16. doi:10.3390/nu16234072
- Huo R, Yang Y, Wei C, Huo X, Meng D, et al. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). Int J Mol Med. 2025;55. doi:10.3892/ijmm.2024.5471
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. doi:10.1111/apt.18438
