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SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 1 Teaspoon (5 ml)
Amount Per Serving
%DV
Calories
40
Total Fat
4.5 g
6%**
Saturated Fat
0.5 g
3%**
Cholesterol
15 mg
5%
Vitamin A (from cod liver oil and retinyl palmitate)
255 mcg RAE(850 IU)
28%
Vitamin D (from cod liver oil and cholecalciferol)
10 mcg (400 IU)
50%
Vitamin E (as d-alpha tocopherol)
6.7 mg
45%
Norwegian Cod Liver Oil
4.6 g
†
Total Omega-3 Fatty Acids*
1,100 mg
†
DHA (Docosahexaenoic Acid)*
500 mg
†
EPA (Eicosapentaenoic Acid)*
370 mg
†
DPA (Docosapentaenoic Acid)*
50 mg
†
Top Medical Research Studies
9
Cod liver oil reduces arthritis symptoms
Effect of cod liver oil on symptoms of rheumatoid arthritis.
Directly addresses study effectiveness
In a recent study, we examined the effectiveness of cod liver oil in alleviating symptoms of rheumatoid arthritis. Forty-three participants took 1 gram of cod liver oil daily for three months. The results were promising.
We observed significant reductions in morning stiffness, with an impressive 52.4% improvement. Additionally, patients reported a 42.7% decrease in painful joints and a 40% reduction in swollen joints. Pain intensity also saw a notable decline of 67.5%.
When asked about their experience, 68% of patients rated the treatment as "good" or "very good" in terms of effectiveness, and an impressive 95% found it tolerable. While some patients reported nonsevere side effects, three of those reactions might have been linked to the cod liver oil.
Overall, we find that cod liver oil could be a beneficial addition to treatment options for those suffering from rheumatoid arthritis.
We observed significant reductions in morning stiffness, with an impressive 52.4% improvement. Additionally, patients reported a 42.7% decrease in painful joints and a 40% reduction in swollen joints. Pain intensity also saw a notable decline of 67.5%.
When asked about their experience, 68% of patients rated the treatment as "good" or "very good" in terms of effectiveness, and an impressive 95% found it tolerable. While some patients reported nonsevere side effects, three of those reactions might have been linked to the cod liver oil.
Overall, we find that cod liver oil could be a beneficial addition to treatment options for those suffering from rheumatoid arthritis.
Read More
8
Cod liver oil as NSAID supplement
Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis.
Directly relates to arthritis treatment
We explored the potential of cod liver oil as a supportive treatment for rheumatoid arthritis (RA) patients, particularly focusing on its ability to lessen the daily need for non-steroidal anti-inflammatory drugs (NSAIDs). In a well-structured, dual-center study that spanned nine months, we involved ninety-seven RA patients. They were divided into two groups: one received 10 grams of cod liver oil loaded with omega-3 fatty acids, while the other group took placebo capsules.
Throughout the study, we carefully documented changes in NSAID consumption, disease activity, and safety outcomes at several points—initially, and then at 4, 12, 24, and 36 weeks. Notably, patients were encouraged to gradually decrease, and if possible, stop their NSAID intake by the 12-week mark.
At the end of the study, we discovered that 39% of participants taking cod liver oil reduced their NSAID dosage by more than 30%, compared to only 10% in the placebo group. However, there were no significant differences in disease activity or side effects between the two groups. This suggests that cod liver oil may indeed serve as a helpful adjunct in managing RA by lessening dependence on NSAIDs.
Throughout the study, we carefully documented changes in NSAID consumption, disease activity, and safety outcomes at several points—initially, and then at 4, 12, 24, and 36 weeks. Notably, patients were encouraged to gradually decrease, and if possible, stop their NSAID intake by the 12-week mark.
At the end of the study, we discovered that 39% of participants taking cod liver oil reduced their NSAID dosage by more than 30%, compared to only 10% in the placebo group. However, there were no significant differences in disease activity or side effects between the two groups. This suggests that cod liver oil may indeed serve as a helpful adjunct in managing RA by lessening dependence on NSAIDs.
Read More
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Directly improves arthritis symptoms
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Read More
Most Useful Reviews
9.3
Visible improvements
Since I started taking Carlson's CLO a few weeks ago, I've seen visible improvements in my health. At 31, I've struggled with stiffness, especially in the morning and my back, as arthritis runs in my family. This CLO has eased my stiffness considerably, reducing the achiness I used to feel. I've also noticed better memory and focus due to the DHA in the oil. Surprisingly, this December, I haven’t felt the winter blues as I usually do. I highly recommend this oil, as it has greatly benefitted me.
Read More
6.8
Supporting arthritis pain
I'm using this product for my arthritis, and while it's still early days, it seems to be helping. The flavour isn’t off-putting, and the ease of use adds to its appeal.
Read More
8
Tolerable arthritis levels
Tastes much better than I anticipated and seems to maintain my arthritis at a tolerable level.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.2
9
Cod liver oil reduces arthritis symptoms
Effect of cod liver oil on symptoms of rheumatoid arthritis.
Directly addresses study effectiveness
In a recent study, we examined the effectiveness of cod liver oil in alleviating symptoms of rheumatoid arthritis. Forty-three participants took 1 gram of cod liver oil daily for three months. The results were promising.
We observed significant reductions in morning stiffness, with an impressive 52.4% improvement. Additionally, patients reported a 42.7% decrease in painful joints and a 40% reduction in swollen joints. Pain intensity also saw a notable decline of 67.5%.
When asked about their experience, 68% of patients rated the treatment as "good" or "very good" in terms of effectiveness, and an impressive 95% found it tolerable. While some patients reported nonsevere side effects, three of those reactions might have been linked to the cod liver oil.
Overall, we find that cod liver oil could be a beneficial addition to treatment options for those suffering from rheumatoid arthritis.
We observed significant reductions in morning stiffness, with an impressive 52.4% improvement. Additionally, patients reported a 42.7% decrease in painful joints and a 40% reduction in swollen joints. Pain intensity also saw a notable decline of 67.5%.
When asked about their experience, 68% of patients rated the treatment as "good" or "very good" in terms of effectiveness, and an impressive 95% found it tolerable. While some patients reported nonsevere side effects, three of those reactions might have been linked to the cod liver oil.
Overall, we find that cod liver oil could be a beneficial addition to treatment options for those suffering from rheumatoid arthritis.
Read More
9
Docosahexaenoic acid reduces arthritis
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Moderate relevance of findings
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
9
DHA's ambiguous role in arthritis
Very low calorie ketogenic diet and common rheumatic disorders: A case report.
Mixed effects noted on symptoms
We observed a fascinating case involving a 22-year-old woman with juvenile idiopathic arthritis who was put on a very low calorie ketogenic diet (VLCKD). This diet included high-biological-value protein preparations that featured docosahexaenoic acid (DHA), an omega-3 fatty acid known for its potential health benefits.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
Read More
9
l-Serine and EPA effective for pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study relevant for arthritis pain
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.3
Visible improvements
Since I started taking Carlson's CLO a few weeks ago, I've seen visible improvements in my health. At 31, I've struggled with stiffness, especially in the morning and my back, as arthritis runs in my family. This CLO has eased my stiffness considerably, reducing the achiness I used to feel. I've also noticed better memory and focus due to the DHA in the oil. Surprisingly, this December, I haven’t felt the winter blues as I usually do. I highly recommend this oil, as it has greatly benefitted me.
Read More
8
Tolerable arthritis levels
Tastes much better than I anticipated and seems to maintain my arthritis at a tolerable level.
6.8
Supporting arthritis pain
I'm using this product for my arthritis, and while it's still early days, it seems to be helping. The flavour isn’t off-putting, and the ease of use adds to its appeal.
