Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Teaspoon (5 ml)
Amount Per Serving
%DV
Calories
40
Total Fat
4.5 g
6%**
Saturated Fat
0.5 g
3%**
Cholesterol
15 mg
5%
Vitamin A (from cod liver oil and retinyl palmitate)
255 mcg RAE(850 IU)
28%
Vitamin D (from cod liver oil and cholecalciferol)
10 mcg (400 IU)
50%
Vitamin E (as d-alpha tocopherol)
6.7 mg
45%
Norwegian Cod Liver Oil
4.6 g
†
Total Omega-3 Fatty Acids*
1,100 mg
†
DHA (Docosahexaenoic Acid)*
500 mg
†
EPA (Eicosapentaenoic Acid)*
370 mg
†
DPA (Docosapentaenoic Acid)*
50 mg
†
Top Medical Research Studies
9
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Read More
9
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on the health of our liver, especially regarding nonalcoholic fatty liver disease (NAFLD). Using a zebrafish model with a specific mutation that prevents the production of DHA, we aimed to understand how this absence affects liver lipid balance and overall liver health.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
Read More
9
We observed how docosapentaenoic acid (DPA) supplementation can impact liver health in mice fed a high-fat diet. The study involved 4-month-old male C57BL/6J mice, where it was found that those on a high-fat diet showed signs of fatty liver, obesity, and insulin resistance after just six weeks. However, when they were given DPA, interesting changes occurred.
The results revealed that DPA not only prevented the development of fatty liver but also kept serum cholesterol and glucose levels in check. It significantly improved insulin resistance, which was not the case for eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Additionally, DPA helped maintain healthy levels of a hormone called adiponectin, which is crucial for metabolic health.
Furthermore, DPA supplementation also reduced increased liver enzyme levels, suggesting fewer inflammation and damage to the liver. These impressive benefits seem to stem from DPA's unique ability to influence important pathways in the liver that control fat production and inflammation.
Overall, it appears that DPA stands out in providing liver protection against the negative effects of a high-fat diet, making it a noteworthy contender in the fight against liver disease.
The results revealed that DPA not only prevented the development of fatty liver but also kept serum cholesterol and glucose levels in check. It significantly improved insulin resistance, which was not the case for eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Additionally, DPA helped maintain healthy levels of a hormone called adiponectin, which is crucial for metabolic health.
Furthermore, DPA supplementation also reduced increased liver enzyme levels, suggesting fewer inflammation and damage to the liver. These impressive benefits seem to stem from DPA's unique ability to influence important pathways in the liver that control fat production and inflammation.
Overall, it appears that DPA stands out in providing liver protection against the negative effects of a high-fat diet, making it a noteworthy contender in the fight against liver disease.
Read More
Most Useful Reviews
9
Promising recovery
10 people found this helpful
To be honest, it is excellent in all its flavours. I ordered it a month ago to address my liver disease and related stomach issues. My immunity is low, and my weight has drastically dropped. Since using it, I’ve felt better, and I’ve started eating more. I will continue to buy it until I am fully healed. It assists in healing, but if the taste is too strong, one can use empty capsules, filling them and storing them properly. I wish for a speedy recovery for all.
Read More
9
Pain relief achieved
2 people found this helpful
After breaking both my feet, I developed arthritis, and since starting cod liver oil three months ago, it has reduced most of the pain. I feel generally better and more active now, which is a relief.
Read More
7.5
Improved condition
2 people found this helpful
I’ve been taking Carlson cod liver oil for over two weeks as my doctor recommended it for my dry eyes, and it has really helped. My mother, who suffered from vitamin D deficiency and felt weak, started using it for a month and has noticed significant improvement. It’s a quality product that I’m quite pleased with.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.7
- All Researches
9
We examined the effects of cod liver oil on liver inflammation caused by sodium nitrite, a common food additive known for its harmful effects at high levels. In this study, we treated thirty-two adult male rats with sodium nitrite and observed the potential protective role of cod liver oil.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
Read More
9
We explored how cod liver oil may help protect the liver from damage caused by sodium nitrite, a substance known for its harmful effects. Thirty-two male rats were used in our study, where some received sodium nitrite alone while others were treated with both sodium nitrite and cod liver oil.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
Read More
9
We explored the effects of docosahexaenoic acid (DHA) on liver disease, specifically looking at its role in nonalcoholic fatty liver disease (NAFLD) and its potential connection to Alzheimer's disease. Our study conducted on APP/PS1 mice involved four groups of animals fed different diets—one with DHA, one with medium-chain triglycerides (MCTs), and one that combined both treatments.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Read More
9
We explored the effectiveness of docosahexaenoic acid (DHA), particularly when delivered via nanoparticles, in treating liver disease, specifically hepatocellular carcinoma (HCC), in three rodent models. Our focus was on understanding how DHA affects HCC lesions as well as the performance of weighted amide proton transfer (APT) MRI as a monitoring tool.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
Read More
9
Nutrient cocktail improves liver health
We conducted a study to understand how a specific mix of nutrients, including docosahexaenoic acid, impacts liver health in adults suffering from metabolic dysfunction-associated steatotic liver disease (MASLD) due to obesity. This involved a carefully controlled pilot clinical trial where participants were either given a nutrient cocktail or a placebo over three months.
The results were quite promising. Those who received the nutrient cocktail had notable reductions in liver fat content and fibrosis as indicated by improvements in their liver scans. Specifically, we observed an average reduction of 4% in the controlled attenuation parameter (CAP) and 7.8% in transient elastography (TE) scores among the treatment group.
Although docosahexaenoic acid was part of this nutrient blend, the study didn't isolate its effects. Therefore, while the overall findings suggest that such a supplementation might enhance liver health, the individual contribution of docosahexaenoic acid remains unclear. This points towards a need for more targeted research to fully understand its role in treating liver conditions.
The results were quite promising. Those who received the nutrient cocktail had notable reductions in liver fat content and fibrosis as indicated by improvements in their liver scans. Specifically, we observed an average reduction of 4% in the controlled attenuation parameter (CAP) and 7.8% in transient elastography (TE) scores among the treatment group.
Although docosahexaenoic acid was part of this nutrient blend, the study didn't isolate its effects. Therefore, while the overall findings suggest that such a supplementation might enhance liver health, the individual contribution of docosahexaenoic acid remains unclear. This points towards a need for more targeted research to fully understand its role in treating liver conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Promising recovery
10 people found this helpful
To be honest, it is excellent in all its flavours. I ordered it a month ago to address my liver disease and related stomach issues. My immunity is low, and my weight has drastically dropped. Since using it, I’ve felt better, and I’ve started eating more. I will continue to buy it until I am fully healed. It assists in healing, but if the taste is too strong, one can use empty capsules, filling them and storing them properly. I wish for a speedy recovery for all.
Read More
9
Pain relief achieved
2 people found this helpful
After breaking both my feet, I developed arthritis, and since starting cod liver oil three months ago, it has reduced most of the pain. I feel generally better and more active now, which is a relief.
Read More
7.5
Improved condition
2 people found this helpful
I’ve been taking Carlson cod liver oil for over two weeks as my doctor recommended it for my dry eyes, and it has really helped. My mother, who suffered from vitamin D deficiency and felt weak, started using it for a month and has noticed significant improvement. It’s a quality product that I’m quite pleased with.
Read More
7.5
Healthy improvement
1 people found this helpful
Carlson is my long-awaited find for heart and skin health. The fat from wild Norwegian cod liver is a genuine source of Omega-3. After regular use, I've noticed improvements in energy and well-being. I recommend it as a high-quality natural supplement for those looking to enhance their diet.
Read More
6
Joint support noted
Cod liver oil was recommended to me for my eyes and joints, and as a senior, it has indeed aided my joints. I'm still able to ride my bike in nice weather. I take a teaspoon daily, and on stressful days, I double the dosage.
Read More
Frequently Asked Questions
9
Promising recovery
10 people found this helpful
To be honest, it is excellent in all its flavours. I ordered it a month ago to address my liver disease and related stomach issues. My immunity is low, and my weight has drastically dropped. Since using it, I’ve felt better, and I’ve started eating more. I will continue to buy it until I am fully healed. It assists in healing, but if the taste is too strong, one can use empty capsules, filling them and storing them properly. I wish for a speedy recovery for all.
7.5
Improved condition
2 people found this helpful
I’ve been taking Carlson cod liver oil for over two weeks as my doctor recommended it for my dry eyes, and it has really helped. My mother, who suffered from vitamin D deficiency and felt weak, started using it for a month and has noticed significant improvement. It’s a quality product that I’m quite pleased with.
9
Pain relief achieved
2 people found this helpful
After breaking both my feet, I developed arthritis, and since starting cod liver oil three months ago, it has reduced most of the pain. I feel generally better and more active now, which is a relief.
7.5
Healthy improvement
1 people found this helpful
Carlson is my long-awaited find for heart and skin health. The fat from wild Norwegian cod liver is a genuine source of Omega-3. After regular use, I've noticed improvements in energy and well-being. I recommend it as a high-quality natural supplement for those looking to enhance their diet.
6
Joint support noted
Cod liver oil was recommended to me for my eyes and joints, and as a senior, it has indeed aided my joints. I'm still able to ride my bike in nice weather. I take a teaspoon daily, and on stressful days, I double the dosage.
9
We explored the effects of docosahexaenoic acid (DHA) on liver disease, specifically looking at its role in nonalcoholic fatty liver disease (NAFLD) and its potential connection to Alzheimer's disease. Our study conducted on APP/PS1 mice involved four groups of animals fed different diets—one with DHA, one with medium-chain triglycerides (MCTs), and one that combined both treatments.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
7
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on liver health, especially focusing on its role in metabolic dysfunction-associated steatotic liver disease (MASLD). This condition, which often arises in those with obesity and metabolic syndrome, can lead to serious complications if left unchecked. Our analysis looks at how various forms of omega-3 supplementation may influence fat build-up in the liver, and particularly how DHA has been studied in both animal models and human trials.
Interestingly, we found that the type of lipid used to deliver omega-3s could make a difference in their effectiveness. While traditional forms like triacylglycerols and ethyl esters are common, emerging evidence suggests that phospholipids and possibly wax esters might be more effective at combating liver fat accumulation. Although much of the current knowledge comes from preclinical studies, it raises the possibility that how we deliver omega-3s might matter as much as the omega-3s themselves.
Overall, our findings indicate that DHA holds promise in managing liver fat accumulation and sheds light on the need for advancing how we formulate these important supplements. However, further research is necessary to confirm these effects and better understand the mechanisms involved to ensure we are making the best dietary choices for liver health.
Interestingly, we found that the type of lipid used to deliver omega-3s could make a difference in their effectiveness. While traditional forms like triacylglycerols and ethyl esters are common, emerging evidence suggests that phospholipids and possibly wax esters might be more effective at combating liver fat accumulation. Although much of the current knowledge comes from preclinical studies, it raises the possibility that how we deliver omega-3s might matter as much as the omega-3s themselves.
Overall, our findings indicate that DHA holds promise in managing liver fat accumulation and sheds light on the need for advancing how we formulate these important supplements. However, further research is necessary to confirm these effects and better understand the mechanisms involved to ensure we are making the best dietary choices for liver health.
9
We examined the effects of cod liver oil on liver inflammation caused by sodium nitrite, a common food additive known for its harmful effects at high levels. In this study, we treated thirty-two adult male rats with sodium nitrite and observed the potential protective role of cod liver oil.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
9
We explored how cod liver oil may help protect the liver from damage caused by sodium nitrite, a substance known for its harmful effects. Thirty-two male rats were used in our study, where some received sodium nitrite alone while others were treated with both sodium nitrite and cod liver oil.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
References
- Sherif IO, Al-Gayyar MM. Cod liver oil in sodium nitrite induced hepatic injury: does it have a potential protective effect?. Redox Rep. 2015;20:11. 10.1179/1351000214Y.0000000097
- Salama MF, Abbas A, Darweish MM, El-Hawwary AA, Al-Gayyar MM. Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats. Pharm Biol. 2013;51:1435. 10.3109/13880209.2013.796564
- Zhang Z, Zhou Q, Li Z, Huang F, Mo K, et al. DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. Drug Resist Updat. 2025;81:101224. 10.1016/j.drup.2025.101224
- Zhang D, Wang Z, Wang X, Yue W, Zhang L, et al. Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice. Lipids. 2025. 10.1002/lipd.12436
- Wang X, Ishimatsu K, Li J, Wen X, Ou W, et al. APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage. Hepat Oncol. 2024;11:2389031. 10.1080/20450923.2024.2389031
- Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. 10.1039/d4fo04961f
- Joerg R, Itariu BK, Amor M, Bilban M, Langer F, et al. The effect of long-chain n-3 PUFA on liver transcriptome in human obesity. Prostaglandins Leukot Essent Fatty Acids. 2024;204:102663. 10.1016/j.plefa.2024.102663
- Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. 10.3390/nu16213614
- Zhang Y, Zhao Q, Zhao R, Lu Y, Jiang S, et al. Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice. Int Immunopharmacol. 2024;142:113154. 10.1016/j.intimp.2024.113154
- Yang J, Félix-Soriano E, Martínez-Gayo A, Ibañez-Santos J, Sáinz N, et al. SIRT1 and FOXO1 role on MASLD risk: effects of DHA-rich n-3 PUFA supplementation and exercise in aged obese female mice and in post-menopausal overweight/obese women. J Physiol Biochem. 2024;80:697. 10.1007/s13105-024-01044-9
- Perva IT, Simina IE, Bende R, Motofelea AC, Chirita Emandi A, et al. Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial. Medicina (Kaunas). 2024;60. 10.3390/medicina60081366
- Zhang H, Lu Y, Zhang Y, Dong J, Jiang S, et al. DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis. Int Immunopharmacol. 2024;140:112895. 10.1016/j.intimp.2024.112895
- Guo C, Liu Z, Fan H, Wang H, Zhang X, et al. Nonlinear relationships of circulating polyunsaturated fatty acids with the complications of liver cirrhosis: A prospective, longitudinal cohort study. Clin Nutr. 2024;43:2083. 10.1016/j.clnu.2024.07.027
- Sabinari I, Horakova O, Cajka T, Kleinova V, Wieckowski MR, et al. Influence of Lipid Class Used for Omega-3 Fatty Acid Supplementation on Liver Fat Accumulation in MASLD. Physiol Res. 2024;73:S295.
- Alkhouri N, McCarthy D, Bayne AV, Blonquist T, Yurko-Mauro K, et al. The effect of vitamin E and docosahexaenoic acid ethyl ester on Metabolic Dysfunction-Associated steatotic Liver Disease (MASLD)-A randomised, double-blind, placebo-controlled, parallel-group clinical trial (PUVENAFLD). Aliment Pharmacol Ther. 2024;60:552. 10.1111/apt.18149
- Palmina N, Kononikhin A, Chagovets V, Tokareva A, Antipova A, et al. Dietary liposomal complexes change the fatty acid composition of hepatic bioactive phospholipids in F1(C57blxDBA2\6) mice, as shown by a lipidomic approach. Biomater Sci. 2024;12:3956. 10.1039/d4bm00431k
- Sotoudeheian M, Azarbad R, Mirahmadi SM. Investigating the correlation between polyunsaturated fatty acids intake and non-invasive biomarkers of liver fibrosis. Clin Nutr ESPEN. 2024;63:46. 10.1016/j.clnesp.2024.06.016
- Li X, Liu C, Zhang R, Li Y, Ye D, et al. Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. J Biol Chem. 2024;300:107405. 10.1016/j.jbc.2024.107405
- Uthaiah NM, Venkataramareddy SR, Mudhol S, Sheikh AY. EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats. Food Res Int. 2025;202:115733. 10.1016/j.foodres.2025.115733
- MacLeod B, Wang C, Brown LH, Borkowski E, Nakamura MT, et al. Fads2 knockout mice reveal that ALA prevention of hepatic steatosis is dependent on delta-6 desaturase activity. J Lipid Res. 2024;65:100642. 10.1016/j.jlr.2024.100642
- Sumida W, Tainaka T, Shirota C, Makita S, Amano H, et al. Eicosapentaenoic acid administration ameliorates the progression of liver fibrosis after laparoscopic Kasai portoenterostomy. Pediatr Surg Int. 2024;40:239. 10.1007/s00383-024-05800-2
- Huang C, Yong Q, Lu Y, Wang L, Zheng Y, et al. Gentiopicroside improves non-alcoholic steatohepatitis by activating PPARα and suppressing HIF1. Front Pharmacol. 2024;15:1335814. 10.3389/fphar.2024.1335814
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