Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
9.5
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
9
Eicosapentaenoic acid shows promise
We examined the link between chronic fatigue syndrome (CFS) and essential fatty acids, focusing specifically on eicosapentaenoic acid (EPA). This investigation arose from various studies highlighting the potential role essential fatty acids play in alleviating symptoms associated with CFS.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
0
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Most Useful Reviews
8
Increased vitality
2 people found this helpful
Super vitamins for us! I recently gave birth and was struggling with chronic fatigue syndrome from lack of sleep and exhaustion. After taking these vitamins, my energy levels improved significantly. I feel more cheerful and stronger! I've even recommended them to all my friends, and they are pleased with the results too. 
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
- All Researches
9.5
Vitamin D treatment enhances alertness
We explored the impact of vitamin D treatment on a case of excessive daytime sleepiness (EDS), specifically in the context of chronic fatigue syndrome. A 28-year-old woman was found to have low levels of vitamin D after experiencing four months of overwhelming fatigue and sleepiness, despite being tested for sleep disorders.
After starting vitamin D supplementation, her condition improved remarkably within just two weeks. Along with a boost in alertness, her associated symptoms like muscle pain and headaches began to fade. By the end of the treatment, her score on the Epworth Sleepiness Scale, which measures daytime sleepiness, dropped significantly, indicating much better daytime function.
This case suggests that vitamin D may play a role in improving symptoms commonly linked to chronic fatigue syndrome. While more research is needed to fully understand the mechanisms behind this improvement, our findings open the door to potentially screening patients with chronic fatigue for vitamin D deficiency to expedite treatment.
After starting vitamin D supplementation, her condition improved remarkably within just two weeks. Along with a boost in alertness, her associated symptoms like muscle pain and headaches began to fade. By the end of the treatment, her score on the Epworth Sleepiness Scale, which measures daytime sleepiness, dropped significantly, indicating much better daytime function.
This case suggests that vitamin D may play a role in improving symptoms commonly linked to chronic fatigue syndrome. While more research is needed to fully understand the mechanisms behind this improvement, our findings open the door to potentially screening patients with chronic fatigue for vitamin D deficiency to expedite treatment.
9.5
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
9
Essential fatty acids aid fatigue syndrome
We conducted a study to evaluate the effectiveness of essential fatty acids, particularly docosahexaenoic acid (DHA), in treating postviral fatigue syndrome, which affects many individuals after a viral infection.
In a double-blind, placebo-controlled setup involving 63 adults, we administered a mixture of essential fatty acids to half of the participants while the other half received a placebo. Each person received eight capsules daily for three months, and we checked their overall condition, fatigue, and other symptoms at various points throughout the study.
Excitingly, we observed significant improvements among those taking the active treatment. After just one month, 74% of participants in the DHA group felt better compared to only 23% in the placebo group. That number rose to 85% at the three-month mark, indicating that while the placebo group reverted to their initial state, those receiving essential fatty acids continued to improve.
Additionally, we saw that the fatty acid levels in patients’ blood cells normalized with treatment, and there were no adverse effects reported. Overall, our findings suggest that DHA, as part of a broader essential fatty acid approach, is a safe and beneficial option for those suffering from postviral fatigue syndrome.
In a double-blind, placebo-controlled setup involving 63 adults, we administered a mixture of essential fatty acids to half of the participants while the other half received a placebo. Each person received eight capsules daily for three months, and we checked their overall condition, fatigue, and other symptoms at various points throughout the study.
Excitingly, we observed significant improvements among those taking the active treatment. After just one month, 74% of participants in the DHA group felt better compared to only 23% in the placebo group. That number rose to 85% at the three-month mark, indicating that while the placebo group reverted to their initial state, those receiving essential fatty acids continued to improve.
Additionally, we saw that the fatty acid levels in patients’ blood cells normalized with treatment, and there were no adverse effects reported. Overall, our findings suggest that DHA, as part of a broader essential fatty acid approach, is a safe and beneficial option for those suffering from postviral fatigue syndrome.
9
Eicosapentaenoic acid shows promise
We examined the link between chronic fatigue syndrome (CFS) and essential fatty acids, focusing specifically on eicosapentaenoic acid (EPA). This investigation arose from various studies highlighting the potential role essential fatty acids play in alleviating symptoms associated with CFS.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
8
We conducted a double-blind, placebo-controlled trial to evaluate the effects of an oral food supplement (OFS) on long COVID patients, particularly focusing on chronic inflammation and fatigue. The supplement included components like rosehip, propolis, royal jelly, and zinc, with vitamin C being a key ingredient.
Through our two-month study, which involved giving participants either the OFS or a placebo, we made some interesting observations. Notably, patients who took the OFS experienced a significant reduction in inflammatory markers, which are often linked to chronic fatigue syndrome. This included improvements in the neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios.
We also noted a substantial increase in vitamin D levels among those taking the supplement, which correlated with enhanced quality of life and decreased fatigue as measured by the fatigue severity scale. Our findings suggest that the combination of ingredients in the OFS, particularly its vitamin D content, can help alleviate some symptoms associated with long COVID, especially chronic fatigue.
However, since the supplement included multiple active ingredients, isolating the specific impact of vitamin D on chronic fatigue syndrome is challenging. Still, the overall results indicate positive changes for patients dealing with the lingering effects of COVID.
Through our two-month study, which involved giving participants either the OFS or a placebo, we made some interesting observations. Notably, patients who took the OFS experienced a significant reduction in inflammatory markers, which are often linked to chronic fatigue syndrome. This included improvements in the neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios.
We also noted a substantial increase in vitamin D levels among those taking the supplement, which correlated with enhanced quality of life and decreased fatigue as measured by the fatigue severity scale. Our findings suggest that the combination of ingredients in the OFS, particularly its vitamin D content, can help alleviate some symptoms associated with long COVID, especially chronic fatigue.
However, since the supplement included multiple active ingredients, isolating the specific impact of vitamin D on chronic fatigue syndrome is challenging. Still, the overall results indicate positive changes for patients dealing with the lingering effects of COVID.
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Increased vitality
2 people found this helpful
Super vitamins for us! I recently gave birth and was struggling with chronic fatigue syndrome from lack of sleep and exhaustion. After taking these vitamins, my energy levels improved significantly. I feel more cheerful and stronger! I've even recommended them to all my friends, and they are pleased with the results too.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17040463
- Witham MD, Adams F, McSwiggan S, Kennedy G, Kabir G, et al. Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial. Nutr Metab Cardiovasc Dis. 2015;25:287. doi:10.1016/j.numecd.2014.10.007
- McCarty DE. Resolution of hypersomnia following identification and treatment of vitamin d deficiency. J Clin Sleep Med. 2010;6:605.
- Maes M, Mihaylova I, Leunis JC. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett. 2005;26:745.
- Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990;82:209.
- Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol. 2007;60:122.
- Puri BK, Holmes J, Hamilton G. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004;58:297.
- Puri BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prostaglandins Leukot Essent Fatty Acids. 2004;70:399.
