' 
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
100 mcg (4,000 IU)
500%
Top Medical Research Studies
8
Vitamin D's effect on acne
Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis.
Direct investigation of vitamin D
We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
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8
Vitamin D and acne relationship examined
Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis.
Highly relevant to acne treatment
We sought to understand the connection between vitamin D levels and acne, along with how vitamin D supplementation might help those suffering from this common skin condition. Our investigation included various studies from a range of databases, focusing on the serum levels of a specific form of vitamin D—25(OH)D—and the effectiveness of vitamin D supplements for acne patients.
In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.
Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.
In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.
Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.
Read More
8
VDR gene effects on acne
The Impact of Vitamin D Receptor Gene Polymorphisms () in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome.
Directly investigates VDR and acne
We investigated the intriguing link between vitamin D receptor (VDR) gene variations and acne in women experiencing polycystic ovary syndrome (PCOS). This study involved a careful comparison of 46 women with PCOS and 39 controls that matched in age and body mass index. We focused on acne and other skin conditions, along with measuring hormones and oxidative stress levels to understand their interplay.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
Read More
Most Useful Reviews
10
Cured adult acne
This helped cure my adult acne and gave me energy! Two months ago, I visited the doctor regarding my adult acne and learned I was Vitamin D deficient. After switching to Carlson's Vitamin D3 supplements, I immediately noticed a difference. My acne is completely gone, including painful jawline cysts! I now take two softgels with breakfast, and I feel amazing.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
- All Researches
8
Vitamin D reduces acne inflammation
Correlation Between Reduced IL-1β Levels in Acne Lesions and the Decrease in Acne Inflammatory Lesions Following Topical Vitamin D Administration: A Double-Blind Randomized Controlled Trial.
Effectiveness of vitamin D in acne
We conducted a double-blind, randomized controlled trial to explore how topical vitamin D affects acne vulgaris (AV). Our study involved 64 participants, who were split into two groups—one receiving a vitamin D treatment and the other a placebo. After 8 weeks, we observed significant changes in the inflammatory markers, specifically a reduction in interleukin-1 beta (IL-1β) levels, which plays a role in acne inflammation.
Participants in the vitamin D group showed a noticeable reduction in the number of inflammatory acne lesions compared to those using the placebo. This indicates that topical vitamin D can effectively lower inflammation associated with acne lesions.
It's essential to note that all participants also received topical adapalene, an established acne treatment. This could make it challenging to determine the exact effect of vitamin D alone. Nonetheless, the findings suggest that vitamin D has potential benefits in managing acne when included as part of a treatment regimen.
Participants in the vitamin D group showed a noticeable reduction in the number of inflammatory acne lesions compared to those using the placebo. This indicates that topical vitamin D can effectively lower inflammation associated with acne lesions.
It's essential to note that all participants also received topical adapalene, an established acne treatment. This could make it challenging to determine the exact effect of vitamin D alone. Nonetheless, the findings suggest that vitamin D has potential benefits in managing acne when included as part of a treatment regimen.
Read More
8
VDR gene effects on acne
The Impact of Vitamin D Receptor Gene Polymorphisms () in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome.
Directly investigates VDR and acne
We investigated the intriguing link between vitamin D receptor (VDR) gene variations and acne in women experiencing polycystic ovary syndrome (PCOS). This study involved a careful comparison of 46 women with PCOS and 39 controls that matched in age and body mass index. We focused on acne and other skin conditions, along with measuring hormones and oxidative stress levels to understand their interplay.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
The findings revealed that certain genetic variations in the VDR gene, particularly the FokI CC genotype, seemed to play a protective role against acne development. Women with this genotype were significantly less likely to experience acne compared to those with different genotypes. Moreover, we noticed that the TaqI dominant genotype also appeared to reduce oxidative stress levels in these patients.
Overall, our research provides compelling evidence suggesting that vitamin D’s influence, particularly through its receptor, could be an important factor in managing acne for women with PCOS. It's an exciting step towards understanding how our genes and environment can affect our skin health.
Read More
8
Vitamin D aids mild acne treatment
Role of vitamin D supplement adjunct to topical benzoyl peroxide in acne: a randomized double-blinded controlled study.
Score reflects strong study relevance
We embarked on a journey to understand how vitamin D might help with acne, particularly when combined with the standard treatment of benzoyl peroxide. Our study involved a well-structured approach, including a randomized, double-blind, placebo-controlled trial. This involved subjects diagnosed with mild to moderate acne, all applying benzoyl peroxide twice daily for 12 weeks.
During this time, participants were split into two groups—one receiving a weekly dose of 40,000 IU of vitamin D2, while the other group received a placebo. All subjects had low levels of vitamin D at the onset of the study, allowing us to investigate whether supplementation could make a difference.
As we analyzed the results, we noticed significant improvements in acne conditions for both groups. However, what stood out was the vitamin D2 group, which showed a statistically significant reduction in inflammatory lesions during the follow-up phase. Importantly, no adverse effects or unwanted biochemical changes were reported, highlighting the safety of this treatment.
Overall, our findings suggest that adding weekly vitamin D2 to a topical benzoyl peroxide regime could effectively reduce the likelihood of acne flare-ups in those with mild to moderate acne. While more extensive studies are needed to fully understand vitamin D's role in acne treatment, this adjunctive approach shows promise.
During this time, participants were split into two groups—one receiving a weekly dose of 40,000 IU of vitamin D2, while the other group received a placebo. All subjects had low levels of vitamin D at the onset of the study, allowing us to investigate whether supplementation could make a difference.
As we analyzed the results, we noticed significant improvements in acne conditions for both groups. However, what stood out was the vitamin D2 group, which showed a statistically significant reduction in inflammatory lesions during the follow-up phase. Importantly, no adverse effects or unwanted biochemical changes were reported, highlighting the safety of this treatment.
Overall, our findings suggest that adding weekly vitamin D2 to a topical benzoyl peroxide regime could effectively reduce the likelihood of acne flare-ups in those with mild to moderate acne. While more extensive studies are needed to fully understand vitamin D's role in acne treatment, this adjunctive approach shows promise.
Read More
8
Calcipotriol shows promise for acne
Calcipotriol: A novel tool in treatment of acne vulgaris.
Vitamin D's impact on acne
We conducted a study to explore the effectiveness of calcipotriol, a vitamin D analogue, in treating acne vulgaris. The research involved forty participants who received topical calcipotriol cream on one side of their face and adapalene gel on the other. This split-face approach allowed us to directly compare the effects of each treatment.
After two months, we observed a significant reduction in acne lesions on both sides of the face, with improvements noted in both physician and patient assessments. Interestingly, the density of inflammatory cells in the skin showed a notable decrease with calcipotriol, hinting at its potential anti-inflammatory properties.
While both treatments were effective, the results suggest that calcipotriol can be a valuable addition to acne therapy, providing similar benefits to adapalene but with a slightly different mechanism of action. Overall, this study opens new avenues for utilizing vitamin D in acne management.
After two months, we observed a significant reduction in acne lesions on both sides of the face, with improvements noted in both physician and patient assessments. Interestingly, the density of inflammatory cells in the skin showed a notable decrease with calcipotriol, hinting at its potential anti-inflammatory properties.
While both treatments were effective, the results suggest that calcipotriol can be a valuable addition to acne therapy, providing similar benefits to adapalene but with a slightly different mechanism of action. Overall, this study opens new avenues for utilizing vitamin D in acne management.
Read More
8
Vitamin D's role in acne severity
Correlation of Serum 25-Hydroxy Vitamin D and Interleukin-17 Levels with Disease Severity in Acne Vulgaris.
Study relevance indicates partial insight
We looked into the relationship between vitamin D levels and acne severity by examining 50 patients diagnosed with acne compared to 30 healthy individuals. Our focus was on understanding how serum levels of 25-hydroxyvitamin D and interleukin-17 (IL-17) correlated with the severity of the acne condition.
Interestingly, we found that 28% of acne patients were vitamin D deficient, compared to just 6.7% of the healthy controls. Furthermore, the severity of acne was inversely associated with vitamin D levels, meaning that lower vitamin D levels tended to correlate with more severe acne cases.
On the other hand, we discovered that IL-17 levels were significantly higher in acne patients than in the control group, and these levels increased with the severity of the condition. Notably, there was a negative correlation between serum IL-17 levels and vitamin D, indicating that higher IL-17 levels were associated with lower vitamin D status in those with acne.
While our findings highlight the connection between vitamin D deficiency and increased IL-17 levels in acne patients, they do not definitively show that vitamin D treatment has a direct benefit on improving acne. Thus, we must continue to explore and understand whether vitamin D supplementation can effectively treat acne on its own.
Interestingly, we found that 28% of acne patients were vitamin D deficient, compared to just 6.7% of the healthy controls. Furthermore, the severity of acne was inversely associated with vitamin D levels, meaning that lower vitamin D levels tended to correlate with more severe acne cases.
On the other hand, we discovered that IL-17 levels were significantly higher in acne patients than in the control group, and these levels increased with the severity of the condition. Notably, there was a negative correlation between serum IL-17 levels and vitamin D, indicating that higher IL-17 levels were associated with lower vitamin D status in those with acne.
While our findings highlight the connection between vitamin D deficiency and increased IL-17 levels in acne patients, they do not definitively show that vitamin D treatment has a direct benefit on improving acne. Thus, we must continue to explore and understand whether vitamin D supplementation can effectively treat acne on its own.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Cured adult acne
This helped cure my adult acne and gave me energy! Two months ago, I visited the doctor regarding my adult acne and learned I was Vitamin D deficient. After switching to Carlson's Vitamin D3 supplements, I immediately noticed a difference. My acne is completely gone, including painful jawline cysts! I now take two softgels with breakfast, and I feel amazing.
Read More
