Last update
5/2/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 2 Caplets
Amount Per Serving
%DV
Calories
5
Total Sugars
0 g
**
Includes 0 g Added Sugars
0%*
Sugar Alcohol
0 g
**
Vitamin D
25 mcg (1,000 IU)
125%
Calcium
650 mg
50%
Zinc
5.5 mg
50%
Copper
0.45 mg
50%
Manganese
1.15 mg
50%
Sodium
5 mg
<1%
Top Medical Research Studies
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
9
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
Most Useful Reviews
9
Normal BMD range
1 people found this helpful
My Bone Mineral Density (BMD) tests showed I was osteopenic, but after several years of taking calcium and vitamin D along with Prolia injections, my BMD is now back in the normal range. I’m pleased to know I've sufficient calcium for the vitamin D to aid absorption.
Read More
9
Supports bone health
It has everything you need for healthy bones. Vitamin D is crucial, and the quality of this product is high. The ingredients match perfectly. Overall, I recommend this product as it’s solidly great for treating bone pain.
Read More
7.5
Helps strengthen bones
4 people found this helpful
I am already ordering the second can. I really like these vitamins and take 2 tablets daily to support my bones. Although the tablets are large, they are easy to swallow. The formulation includes calcium citrate, manganese, copper, and D3—everything necessary to support bone mass. I definitely recommend.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
- All Researches
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
9
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
8
We explored a unique case of a 3-year-old Iranian girl with Juvenile Paget's disease (JPD) linked to a new mutation and vitamin D deficiency. This rare condition led to her experiencing significant bone pain, fractures, and deformities from an early age.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Read More
8
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normal BMD range
1 people found this helpful
My Bone Mineral Density (BMD) tests showed I was osteopenic, but after several years of taking calcium and vitamin D along with Prolia injections, my BMD is now back in the normal range. I’m pleased to know I've sufficient calcium for the vitamin D to aid absorption.
Read More
9
Supports bone health
It has everything you need for healthy bones. Vitamin D is crucial, and the quality of this product is high. The ingredients match perfectly. Overall, I recommend this product as it’s solidly great for treating bone pain.
Read More
7.5
Helps strengthen bones
4 people found this helpful
I am already ordering the second can. I really like these vitamins and take 2 tablets daily to support my bones. Although the tablets are large, they are easy to swallow. The formulation includes calcium citrate, manganese, copper, and D3—everything necessary to support bone mass. I definitely recommend.
Read More
6
Effective for absorption
2 people found this helpful
Well-formulated for strengthening bones, and there’s no competing magnesium for absorption. I found this drug uniquely beneficial on iHerb. It's convenient to take, and I appreciate the large volume.
Read More
9
Improves bone density
1 people found this helpful
I take High Vit D3 twice daily along with Citracal, providing a total of 1500 IU, which is vital for my bones. My mother has seen an improvement in her bone density after years of osteoporosis. Her recent test showed BMD results of osteopenia. We have been consistently taking these supplements alongside her Prolia jab.
Read More
Frequently Asked Questions
9
Normal BMD range
1 people found this helpful
My Bone Mineral Density (BMD) tests showed I was osteopenic, but after several years of taking calcium and vitamin D along with Prolia injections, my BMD is now back in the normal range. I’m pleased to know I've sufficient calcium for the vitamin D to aid absorption.
7.5
Stops bone density decline
1 people found this helpful
Great stuff! I’ve been taking 4 each day for two years, and for the first time in a decade, my bone density test has improved slightly instead of declining. I also take Boron, and I believe this combination has been successful in addressing my bone pain.
9
Improves bone density
1 people found this helpful
I take High Vit D3 twice daily along with Citracal, providing a total of 1500 IU, which is vital for my bones. My mother has seen an improvement in her bone density after years of osteoporosis. Her recent test showed BMD results of osteopenia. We have been consistently taking these supplements alongside her Prolia jab.
7.5
Helps strengthen bones
4 people found this helpful
I am already ordering the second can. I really like these vitamins and take 2 tablets daily to support my bones. Although the tablets are large, they are easy to swallow. The formulation includes calcium citrate, manganese, copper, and D3—everything necessary to support bone mass. I definitely recommend.
8
We explored a unique case of a 3-year-old Iranian girl with Juvenile Paget's disease (JPD) linked to a new mutation and vitamin D deficiency. This rare condition led to her experiencing significant bone pain, fractures, and deformities from an early age.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
8
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
References
- Saki F, Karamizadeh Z, Nasirabadi S, Mumm S, McAlister WH, et al. Juvenile paget's disease in an Iranian kindred with vitamin D deficiency and novel homozygous TNFRSF11B mutation. J Bone Miner Res. 2013;28:1501. 10.1002/jbmr.1868
- Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31. PubMed
- Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. 10.5704/MOJ.2411.002
- Han K, Wang X. Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study. Medicine (Baltimore). 2024;103:e40171. 10.1097/MD.0000000000040171
- von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
