We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
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Ebselen delays blood clot formationAnti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression.
Relevant to oxidative stress research
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
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Selenium polymer reduces blood clotsMultifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications.
High relevance in medical devices
We explored the effectiveness of a new polymer infused with selenium in tackling blood clots and infections associated with medical devices. This SNAP-Se-1 composite works by releasing nitric oxide (NO), a natural defender against both issues. We found that it remarkably reduced platelet adhesion by 85.5% while also displaying antibacterial properties. Importantly, this innovative approach minimizes the need for traditional antibiotic treatments. Overall, while we see promising results in lab settings, further research is needed to confirm these benefits in real-world applications.
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Enhanced imaging for carotid thrombosisHigh Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging.
High relevance for stroke diagnosis
We investigated how selenium-based nanomaterials boost photoacoustic imaging to identify carotid artery blood clots more effectively. By using a thrombosis model in mice, we found that these nanocomposites significantly enhanced imaging signals—up to 5 times greater—which helps diagnose the extent of carotid atherosclerosis.
This research suggests that selenium/polypyrrole nanoparticles may be a promising tool for improving the detection and diagnosis of carotid thrombosis, potentially leading to better stroke prevention strategies.
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Antioxidants may aid cardiovascular healthEffect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.
High relevance to cardiovascular research
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
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