Last update
6/11/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
USERS' SCORE
Good
Based on 20 Reviews
8
Supplement Facts
Serving Size: 2 tablets
Serving Per Container: 90
Amount Per Serving
%DV
Calcium (as calcium hydroxyapatite, calcium citrate, calcium aspartate) †
1,000 mg
77%
Phosphorus (as calcium hydroxyapatite) †
500 mg
40%
Magnesium (as magnesium oxide, magnesium citrate, magnesium aspartate, magnesium taurinate) †
500 mg
119%
Top Medical Research Studies
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
Most Useful Reviews
10
Effective for osteoporosis
2 people found this helpful
Very effective product! I've been using this complex for quite a while on my doctor's recommendation for calcium at a dosage of 1000 mg. It's challenging to find a good supplement with such a dosage in pharmacies. My tests indicated almost osteoporosis of the bones, but after taking it for some time, a densitometry analysis showed improvement, and the diagnosis was completely revoked. This product certainly works; I highly recommend it!
Read More
9
Bone density improvement
2 people found this helpful
After being diagnosed with osteoporosis due to prolonged steroid use, managing my condition became essential. My doctor recommended a combination of calcium and magnesium alongside regular walking. I chose Country Life for its reputation, and I'm pleased with my results. My recent bone density test returned to normal. Following a fall, I was relieved my bones held strong due to this product!
Read More
9
Improved bone density
1 people found this helpful
I ordered this complex for my mother, aged 65, who was diagnosed with incipient osteoporosis. The doctor recommended a daily calcium dose of 1000 mg, but such products were hard to find and costly. After taking this supplement intermittently, her next bone density test showed significant improvement, and the doctor lifted the previous diagnosis! This is definitely an effective product!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
- All Researches
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Effective for osteoporosis
2 people found this helpful
Very effective product! I've been using this complex for quite a while on my doctor's recommendation for calcium at a dosage of 1000 mg. It's challenging to find a good supplement with such a dosage in pharmacies. My tests indicated almost osteoporosis of the bones, but after taking it for some time, a densitometry analysis showed improvement, and the diagnosis was completely revoked. This product certainly works; I highly recommend it!
Read More
9
Bone density improvement
2 people found this helpful
After being diagnosed with osteoporosis due to prolonged steroid use, managing my condition became essential. My doctor recommended a combination of calcium and magnesium alongside regular walking. I chose Country Life for its reputation, and I'm pleased with my results. My recent bone density test returned to normal. Following a fall, I was relieved my bones held strong due to this product!
Read More
9
Improved bone density
1 people found this helpful
I ordered this complex for my mother, aged 65, who was diagnosed with incipient osteoporosis. The doctor recommended a daily calcium dose of 1000 mg, but such products were hard to find and costly. After taking this supplement intermittently, her next bone density test showed significant improvement, and the doctor lifted the previous diagnosis! This is definitely an effective product!
Read More
6
Recovery of bone mass
7 people found this helpful
During a combined diet and exercise plan, I noticed a decrease in bone mass, which worried me. Upon starting this supplement, my estimated bone mass gradually increased, helping me recover to my pre-diet levels. I plan to continue taking it while on a diet.
Read More
7.5
Noticed improvement
3 people found this helpful
Of high quality, this supplement is rich in content, addressing calcium deficiency effectively. As bones become brittle with age, I've observed improvement after taking the first pill. The blend positively affects the entire body, and I also combine it with vitamins D3 and K2 for better absorption. I highly recommend it!
Read More
Frequently Asked Questions
9
Improved bone density
1 people found this helpful
I ordered this complex for my mother, aged 65, who was diagnosed with incipient osteoporosis. The doctor recommended a daily calcium dose of 1000 mg, but such products were hard to find and costly. After taking this supplement intermittently, her next bone density test showed significant improvement, and the doctor lifted the previous diagnosis! This is definitely an effective product!
7.5
Noticed improvement
3 people found this helpful
Of high quality, this supplement is rich in content, addressing calcium deficiency effectively. As bones become brittle with age, I've observed improvement after taking the first pill. The blend positively affects the entire body, and I also combine it with vitamins D3 and K2 for better absorption. I highly recommend it!
7.5
Effective calcium source
2 people found this helpful
This product is of good quality, replenishing calcium deficiency for all ages. I've noticed improvements from the first pill, making it suitable for everyone. It positively impacts overall health, and I recommend taking it alongside vitamins D3 and K2 for enhanced absorption.
9
Bone density improvement
2 people found this helpful
After being diagnosed with osteoporosis due to prolonged steroid use, managing my condition became essential. My doctor recommended a combination of calcium and magnesium alongside regular walking. I chose Country Life for its reputation, and I'm pleased with my results. My recent bone density test returned to normal. Following a fall, I was relieved my bones held strong due to this product!
10
Effective for osteoporosis
2 people found this helpful
Very effective product! I've been using this complex for quite a while on my doctor's recommendation for calcium at a dosage of 1000 mg. It's challenging to find a good supplement with such a dosage in pharmacies. My tests indicated almost osteoporosis of the bones, but after taking it for some time, a densitometry analysis showed improvement, and the diagnosis was completely revoked. This product certainly works; I highly recommend it!
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
References
- von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593. PubMed
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129. PubMed
