Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: One (1) Tablet
Amount Per Serving
%DV
Calories
0
 
Total Carbohydrate
<1 g
<1%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
 
0%+
Xylitol
<1 g
**
Lactobacillus rhamnosus GG
53 mg (10 billion CFUs)
**

Top Medical Research Studies

9
Lactobacillus reduces diarrhea in children
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.

The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
Read More
9
LRa05 probiotic helps reduce diarrhea
We investigated how the probiotic LRa05 affects acute watery diarrhea in young children. In a randomized controlled trial with 57 children receiving LRa05 and 54 on a placebo, we observed that those in the LRa05 group experienced a significantly shorter duration of diarrhea and improved fecal consistency.

These children also showed better gut microbiome changes. Specifically, more of them reported improvement compared to the placebo group. Overall, LRa05 proved to be a promising treatment option for easing diarrhea in children.
Read More
5
Lactobacillus safe but not significant
This pilot study evaluated whether lactobacillus GG (LGG) can help prevent antibiotic-associated diarrhea (AAD) in children receiving prolonged antibiotic treatment in the pediatric intensive care unit.

In a controlled setting, we administered LGG or a placebo to eligible patients and monitored diarrhea symptoms. While the data suggested a reduction in AAD occurrence, with 30% in the LGG group compared to 55.5% in the placebo group, the difference wasn't statistically significant.

Nevertheless, LGG proved safe for pediatric patients, encouraging us to think positively about its future use in similar cases.
Read More

Most Useful Reviews

8.8
Colitis improvement noted
GREAT stuff! After being diagnosed with Colitis, I found that the medication made my condition worse. I began using Culturelle, and within a week, I felt significantly better. Even my dog, who suffered from bloody diarrhea, improved swiftly after I gave her one of my probiotics.
Read More
9.5
Effective probiotic use
This is a proven probiotic for addressing bad bacteria and is excellent for c. diff too. We take 3-6 capsules at night when bad bacteria invade. It effectively stops diarrhea and can also help if you’re constipated. We give it to our children and elderly parents.
Read More
0
Probiotic caution
STAY AWAY if your gut is generally healthy. I tried probiotics, and within an hour, I developed severe diarrhea. I haven’t been able to keep food down for even half an hour since. This has negatively impacted my gut.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
  • All Researches
9.5
Lactobacillus improves H. pylori treatment
We examined the impact of Lactobacillus spp. on diarrhea related to Helicobacter pylori infections through a comprehensive analysis of 26 studies. Our findings suggest that using Lactobacillus significantly improves H. pylori eradication rates and reduces gastrointestinal side effects, including diarrhea.

Supplementation was particularly effective when paired with standard triple therapy, showing promising results, especially in children. This positions Lactobacillus as a valuable adjunct treatment option for managing these infections while reducing discomfort.
Read More
9
Probiotics reinforce intestinal barriers
We explored the potential of a multi-strain probiotic blend (Serobioma) in improving gut health for individuals with Irritable Bowel Syndrome (IBS).

Using samples from 28 IBS patients and 7 healthy controls, we examined how this probiotic affects the intestinal barrier.

The results were promising: Serobioma significantly strengthened the intestinal lining and countered permeability changes caused by IBS-related substances. This was especially true for IBS patients who primarily experienced diarrhea, suggesting that probiotics could be a useful addition to their treatment plans.
Read More
9
Turcz. mitigates antibiotic-induced diarrhea
We explored how Turcz. (TCT) can alleviate antibiotic-associated diarrhea (AAD) in a mouse model. Through various research methods, we observed that TCT significantly improved gut health by enhancing microbiota diversity and regulating specific signaling pathways.

Treatment with TCT led to less inflammation, indicated by lower levels of IL-6 and TNF-α, and improved colon tissue structure. Notably, TCT increased beneficial bacteria like Lactobacillus. This study highlights a promising approach to managing AAD through natural compounds.
Read More
9
Lactobacillus reduces diarrhea in children
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.

The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
Read More
9
Effective probiotic for poultry diarrhea
We explored the impact of Lactobacillus plantarum (LP) probiotics on reducing diarrhea caused by Salmonella in broiler chickens. Our study used different growth media for LP, revealing that the MRS medium yielded a probiotic formulation that significantly boosted body weight and reduced diarrhea by up to 86.45%.

This impressive outcome suggests that LP not only strengthens gut health but also helps combat harmful bacteria. Our findings indicate that LP could be a safe and eco-friendly option for improving poultry health and productivity.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8.8
Colitis improvement noted
GREAT stuff! After being diagnosed with Colitis, I found that the medication made my condition worse. I began using Culturelle, and within a week, I felt significantly better. Even my dog, who suffered from bloody diarrhea, improved swiftly after I gave her one of my probiotics.
Read More
9.5
Effective probiotic use
This is a proven probiotic for addressing bad bacteria and is excellent for c. diff too. We take 3-6 capsules at night when bad bacteria invade. It effectively stops diarrhea and can also help if you’re constipated. We give it to our children and elderly parents.
Read More
0
Probiotic caution
STAY AWAY if your gut is generally healthy. I tried probiotics, and within an hour, I developed severe diarrhea. I haven’t been able to keep food down for even half an hour since. This has negatively impacted my gut.
Read More

Frequently Asked Questions

Diarrhea is a condition characterized by the frequent passage of loose or watery stools, which can occur due to various factors, including infections, dietary choices, and underlying health conditions. It often results from the body's response to an irritation of the gastrointestinal tract, which can be caused by viruses, bacteria, parasites, or certain medications. While most cases tend to be short-lived and resolve on their own, diarrhea can lead to dehydration, especially in vulnerable populations such as young children and the elderly.

Managing diarrhea typically involves staying hydrated by drinking clear fluids and, when necessary, replenishing lost electrolytes. In some cases, over-the-counter medications may provide relief, although it’s essential to consult a healthcare professional for persistent or severe symptoms. A focus on bland, easy-to-digest foods can also help during recovery. Remember, if diarrhea persists for more than a couple of days or is accompanied by other concerning symptoms—like high fever, severe abdominal pain, or blood in stools—seeking medical attention is crucial.

Lactobacillus is a genus of bacteria that plays a crucial role in the fermentation of various foods and is found naturally in the human gut. Known for their probiotic properties, strains of Lactobacillus are commonly utilized in the production of yogurt, sauerkraut, and other fermented products. They are characterized by their rod-shaped structure and ability to convert sugars into lactic acid, which not only helps preserve food but also contributes to the tangy flavor of fermented foods.

In addition to their culinary uses, Lactobacillus bacteria can offer several health benefits. They are known to support gut health by enhancing the balance of beneficial bacteria in the microbiome, potentially aiding in digestion and alleviating symptoms of issues like irritable bowel syndrome (IBS). Regular consumption of Lactobacillus-containing foods or supplements may also bolster the immune system and improve overall digestive health. With a growing interest in gut health, Lactobacillus remains a key player in both dietary and therapeutic contexts.

Lactobacillus, a type of beneficial bacteria found in probiotics, has been studied for its potential role in alleviating diarrhea. Research indicates that certain strains of Lactobacillus can effectively help manage and reduce the duration of diarrhea, particularly in cases related to antibiotic use or viral infections. The probiotics work by restoring the natural balance of gut flora, which may be disrupted during bouts of diarrhea. By promoting a healthier gut environment, Lactobacillus can enhance the body's natural defenses against pathogens and improve overall digestive health.

When considering Lactobacillus for diarrhea management, it's essential to select products that contain specific strains known for their efficacy. Look for probiotics labeled with the genus and species, such as Lactobacillus rhamnosus GG or Lactobacillus reuteri, which have shown promise in clinical studies. Additionally, while Lactobacillus can be beneficial, it is advisable to consult with a healthcare professional, particularly if diarrhea is severe or persists beyond a couple of days. They can provide guidance tailored to your situation and help determine the best course of treatment.

The time it takes to see results from taking Lactobacillus for diarrhea can vary based on several factors, including the severity of the condition, the specific strain of Lactobacillus used, and an individual's overall health. Generally, many users report noticing improvements within 24 to 72 hours after starting a probiotic regimen. However, in some cases, it may take a week or more for the beneficial effects to manifest. It's important to be consistent with the dosage and to combine it with other healthy lifestyle choices, such as staying hydrated and consuming a balanced diet, for optimal results.

As with any supplement, individual responses can differ. Factors such as the underlying cause of diarrhea, whether it's due to antibiotics, stress, or infections, will also play a role in how quickly Lactobacillus can help. Consulting a healthcare professional is advisable if symptoms persist beyond a few days, to rule out any serious conditions and to get personalized recommendations on the best approach to recovery.

This supplement appears to be well-supported by scientific research for its role in managing diarrhea, primarily through the use of probiotic strains like Lactobacillus. For instance, a study demonstrated that Lactobacillus reuteri DSM 17938, when added to oral rehydration therapy, significantly reduced the duration and frequency of diarrhea in children suffering from acute gastroenteritis [5]. Similarly, Lactobacillus rhamnosus has shown promise in alleviating symptoms associated with both antibiotic-associated diarrhea (AAD) and irritable bowel syndrome (IBS), making it a valuable option for various types of diarrheal issues [28], [2].

Moreover, a comparison of different probiotic interventions has indicated that Lactobacillus strains successfully help reduce diarrhea in young children and those undergoing antibiotic treatments [18]. They also demonstrate effectiveness in improving gut health, enhancing beneficial bacteria, and reducing inflammation related to intestinal disturbances [11], [20]. These findings solidify the role of Lactobacillus-based supplements as a potential therapeutic avenue for managing diarrhea.

The recommended dose of Lactobacillus for treating diarrhea typically ranges from 5 billion to 10 billion colony-forming units (CFUs) per day. This dosage has been found effective in various studies, particularly in cases of antibiotic-associated diarrhea and viral gastroenteritis in children. However, it's important to note that the specific strain of Lactobacillus can influence efficacy, so it's beneficial to choose a product that is well-studied for your particular condition. Always consult with a healthcare professional before starting any new probiotic regimen, especially for children or individuals with underlying health conditions.

When it comes to using Lactobacillus for treating diarrhea, the research highlights that a high-dose regimen can significantly benefit young patients. Specifically, a study focused on Lactobacillus reuteri DSM 17938 indicated that children further benefited from supplementation alongside oral rehydration therapy, experiencing a notable reduction in the duration and frequency of diarrhea episodes compared to placebo recipients [5]. This suggests that a targeted therapeutic approach with Lactobacillus can serve as an effective and low-risk solution for alleviating diarrhea, especially in pediatric cases.

Moreover, other studies emphasizing Lactobacillus rhamnosus revealed that it effectively reduced diarrhea severity and abdominal pain, particularly in children suffering from conditions like irritable bowel syndrome and antibiotic-associated diarrhea [28]. While the optimal dose may vary depending on individual factors and the specific formulation, these findings indicate that utilizing high doses of Lactobacillus in clinical practice holds considerable promise for managing diarrhea across various populations, particularly in younger children.

9
Lactobacillus reduces diarrhea in children
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.

The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
9
Probiotic improves diarrhea symptoms
We evaluated how well the probiotic Neobiotic Lactobalance®, containing Lactobacillus rhamnosus, helps relieve diarrhea linked to irritable bowel syndrome (IBS) and antibiotic-associated diarrhea (AAD).

In our study of 54 patients, we noted significant reductions in diarrhea severity and abdominal pain after 21 days of daily probiotic intake. For those with IBS, symptoms decreased nearly threefold, while AAD patients saw even greater improvements.

Additionally, microbiological analysis confirmed that the probiotic improved gut health by increasing beneficial bacteria. Overall, we found Neobiotic Lactobalance® effective in normalizing gut flora and alleviating diarrhea symptoms.
9
Probiotics reinforce intestinal barriers
We explored the potential of a multi-strain probiotic blend (Serobioma) in improving gut health for individuals with Irritable Bowel Syndrome (IBS).

Using samples from 28 IBS patients and 7 healthy controls, we examined how this probiotic affects the intestinal barrier.

The results were promising: Serobioma significantly strengthened the intestinal lining and countered permeability changes caused by IBS-related substances. This was especially true for IBS patients who primarily experienced diarrhea, suggesting that probiotics could be a useful addition to their treatment plans.
9
LRa05 effective for diarrhea in children
We examined the effectiveness of LRa05, a probiotic, in treating acute watery diarrhea in children. In a randomized controlled trial, 57 children received LRa05 while 54 received a placebo. Our findings showed that those who took LRa05 had shorter diarrhea durations and improved fecal consistency compared to the control group. Additionally, LRa05 improved gut microbiome composition and boosted levels of beneficial gut proteins. Overall, using LRa05 can be a helpful addition to managing diarrhea in young children.
7
Probiotics improve IBS-D symptoms
We investigated the impact of colonoscopic probiotics on irritable bowel syndrome with predominant diarrhea (IBS-D) in a randomized trial. Twenty-two IBS-D patients received either probiotics or a placebo during colonoscopy at a medical center. After two weeks, those who took probiotics showed improvements in defecation frequency and abdominal pain. By four weeks, overall symptoms and quality of life also improved significantly. However, gut microbiota diversity remained unchanged, indicating that while probiotics can help alleviate symptoms, they may not significantly alter gut flora.
9
Probiotics reduce antibiotic-related diarrhea
We conducted a multi-hospital study to tackle the common issue of antibiotic-associated diarrhea (AAD). By comparing probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, with a placebo among 340 adult patients, we aimed to find out if these friendly bacteria could help.

Our findings revealed that probiotics significantly lowered both the incidence and duration of AAD compared to the placebo group. Patients reported positive outcomes, indicating high adherence to the treatment as well.

References

  1. Mei LN, Wang ZJ, Duan Y, Shen JS, Ye HB, et al. 4-Hydroxyboesenbergin B of Alpinia japonica protected gastrointestinal tract by inhibiting vancomycin-resistant enterococcus and balancing intestinal microbiota. J Ethnopharmacol. 2025;347:119737. doi:10.1016/j.jep.2025.119737
  2. Barbaro MR, Bianco F, Cremon C, Marasco G, Stanghellini V, et al. A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1. Int J Mol Sci. 2025;26. doi:10.3390/ijms26062656
  3. Fan D, Jiao S, Fu Y, Zhang J, Zhuang Y, et al. improves intestinal microbiota and barrier function to alleviate diarrhea of neonatal goats. Anim Nutr. 2025;20:366. doi:10.1016/j.aninu.2024.10.008
  4. Xu H, Zhang F, Huang Y, Yao Q, Guan Y, et al. [ Turcz. alleviates antibiotic-associated diarrhea in mice by modulating gut microbiota structure and regulating the EGFR/PI3K/Akt signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2025;45:285. doi:10.12122/j.issn.1673-4254.2025.02.09
  5. Iramain R, Jara A, Ortiz J, Cardozo L, Morinigo R. Lactobacillus reuteri protectis DSM 17938 at high doses versus placebo in children with acute gastroenteritis in a Pediatric Emergency Department. J Pediatr Gastroenterol Nutr. 2025. doi:10.1002/jpn3.70026
  6. Wang Z, Zhao Y, Fan D, Zhang J, Diao Q, et al. Sheep-Derived M5 Enhances Immunity and Antioxidant Capacity, Alleviates Diarrhea, and Improves Intestinal Health in Early-Weaned Lambs. Microorganisms. 2025;13. doi:10.3390/microorganisms13020404
  7. Zhao Y, Liang S, Fu X, Guo Y, Wang Y, et al. Anti-Inflammatory and Antidiarrheal Effects of Two Strains of Lactic Acid Bacteria Isolated from Healthy Pets on K88-Induced Diarrhea in Mice. Microorganisms. 2025;13. doi:10.3390/microorganisms13020239
  8. Chung A, Sehgal M, Gavrilita C, Falkos S, Vidal R. in the Prevention of Antibiotic-Associated Diarrhea in the Pediatric Intensive Care Unit: A Prospective Randomized, Double-Blind Placebo Controlled Intervention. J Pediatr Pharmacol Ther. 2025;30:47. doi:10.5863/1551-6776-30.1.47
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  11. Wei JJ, Zhang PH, Yang ZY, Liu LP, Lian TT, et al. Colonoscopic administration of probiotics to treat irritable bowel syndrome with predominant diarrhea: a randomized placebo-controlled clinical trial. Surg Endosc. 2025;39:1893. doi:10.1007/s00464-025-11542-6
  12. Mishra V, Dash D, Panda AK, Pathak SK. Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. Helicobacter. 2024;29:e70006. doi:10.1111/hel.70006
  13. Li S, Lu T, Lin Z, Zhang Y, Zhou X, et al. Supplementation with probiotics co-cultivation improves the reproductive performance in a sow-piglet model by mother-infant microbiota transmission and placental mTOR signaling. World J Microbiol Biotechnol. 2024;41:13. doi:10.1007/s11274-024-04222-5
  14. Mirsalami SM, Mirsalami M. Leveraging Lactobacillus plantarum probiotics to mitigate diarrhea and Salmonella infections in broiler chickens. AMB Express. 2024;14:137. doi:10.1186/s13568-024-01792-3
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  18. Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. doi:10.3389/fnut.2024.1479186
  19. Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. doi:10.1111/jgh.16809
  20. Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. doi:10.7759/cureus.70881
  21. Shawky LM, Abo El Wafa SM, Behery M, Bahr MH, Abu Alnasr MT, et al. Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting. Mol Nutr Food Res. 2024;68:e2400295. doi:10.1002/mnfr.202400295
  22. Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. doi:10.1039/d3fo04653b
  23. Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. doi:10.1016/j.tmaid.2024.102703
  24. Abdulah DM, Sulaiman SJ, Ahmed ZW. Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial. Clin Exp Pediatr. 2024;67:203. doi:10.3345/cep.2023.01340
  25. Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. doi:10.1007/s12325-024-02783-3
  26. Saviano A, Petruzziello C, Cancro C, Macerola N, Petti A, et al. The Efficacy of a Mix of Probiotics ( LMG P-27481 and GG ATCC 53103) in Preventing Antibiotic-Associated Diarrhea and Infection in Hospitalized Patients: Single-Center, Open-Label, Randomized Trial. Microorganisms. 2024;12. doi:10.3390/microorganisms12010198
  27. Poeta M, Cioffi V, Tarallo A, Damiano C, Lo Vecchio A, et al. Postbiotic Preparation of against Diarrhea and Oxidative Stress Induced by Spike Protein of SARS-CoV-2 in Human Enterocytes. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12101878
  28. Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
  29. Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12 LGG in colorectal cancer patients. Front Oncol. 2023;13:1168654. doi:10.3389/fonc.2023.1168654
  30. Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. doi:10.3389/fphar.2023.1153070
  31. Niu H, Zhou X, Liu P, Wu Y, Lyu L, et al. Lactobacillus rhamnosus MN-431 Metabolic Tryptophan Alleviates Complementary Food-Induced Diarrhea through PXR-NF-κB Pathway and AHR-Th17 Cell Response Pathways. Mol Nutr Food Res. 2023;67:e2200530. doi:10.1002/mnfr.202200530
  32. Li J, Li Q, Wu Q, Gao N, Wang Z, et al. Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway. J Anim Sci Biotechnol. 2023;14:23. doi:10.1186/s40104-023-00830-7
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