Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: One (1) Tablet
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
<1 g
<1%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Xylitol
<1 g
**
Lactobacillus rhamnosus GG
53 mg (10 billion CFUs)
**
Top Medical Research Studies
9
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
Read More
9
We investigated how the probiotic LRa05 affects acute watery diarrhea in young children. In a randomized controlled trial with 57 children receiving LRa05 and 54 on a placebo, we observed that those in the LRa05 group experienced a significantly shorter duration of diarrhea and improved fecal consistency.
These children also showed better gut microbiome changes. Specifically, more of them reported improvement compared to the placebo group. Overall, LRa05 proved to be a promising treatment option for easing diarrhea in children.
These children also showed better gut microbiome changes. Specifically, more of them reported improvement compared to the placebo group. Overall, LRa05 proved to be a promising treatment option for easing diarrhea in children.
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5
Lactobacillus safe but not significant
This pilot study evaluated whether lactobacillus GG (LGG) can help prevent antibiotic-associated diarrhea (AAD) in children receiving prolonged antibiotic treatment in the pediatric intensive care unit.
In a controlled setting, we administered LGG or a placebo to eligible patients and monitored diarrhea symptoms. While the data suggested a reduction in AAD occurrence, with 30% in the LGG group compared to 55.5% in the placebo group, the difference wasn't statistically significant.
Nevertheless, LGG proved safe for pediatric patients, encouraging us to think positively about its future use in similar cases.
In a controlled setting, we administered LGG or a placebo to eligible patients and monitored diarrhea symptoms. While the data suggested a reduction in AAD occurrence, with 30% in the LGG group compared to 55.5% in the placebo group, the difference wasn't statistically significant.
Nevertheless, LGG proved safe for pediatric patients, encouraging us to think positively about its future use in similar cases.
Read More
Most Useful Reviews
8.8
Colitis improvement noted
GREAT stuff! After being diagnosed with Colitis, I found that the medication made my condition worse. I began using Culturelle, and within a week, I felt significantly better. Even my dog, who suffered from bloody diarrhea, improved swiftly after I gave her one of my probiotics.
Read More
9.5
Effective probiotic use
This is a proven probiotic for addressing bad bacteria and is excellent for c. diff too. We take 3-6 capsules at night when bad bacteria invade. It effectively stops diarrhea and can also help if you’re constipated. We give it to our children and elderly parents.
Read More
0
Probiotic caution
STAY AWAY if your gut is generally healthy. I tried probiotics, and within an hour, I developed severe diarrhea. I haven’t been able to keep food down for even half an hour since. This has negatively impacted my gut.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
- All Researches
9.5
Lactobacillus improves H. pylori treatment
We examined the impact of Lactobacillus spp. on diarrhea related to Helicobacter pylori infections through a comprehensive analysis of 26 studies. Our findings suggest that using Lactobacillus significantly improves H. pylori eradication rates and reduces gastrointestinal side effects, including diarrhea.
Supplementation was particularly effective when paired with standard triple therapy, showing promising results, especially in children. This positions Lactobacillus as a valuable adjunct treatment option for managing these infections while reducing discomfort.
Supplementation was particularly effective when paired with standard triple therapy, showing promising results, especially in children. This positions Lactobacillus as a valuable adjunct treatment option for managing these infections while reducing discomfort.
Read More
9
Probiotics reinforce intestinal barriers
We explored the potential of a multi-strain probiotic blend (Serobioma) in improving gut health for individuals with Irritable Bowel Syndrome (IBS).
Using samples from 28 IBS patients and 7 healthy controls, we examined how this probiotic affects the intestinal barrier.
The results were promising: Serobioma significantly strengthened the intestinal lining and countered permeability changes caused by IBS-related substances. This was especially true for IBS patients who primarily experienced diarrhea, suggesting that probiotics could be a useful addition to their treatment plans.
Using samples from 28 IBS patients and 7 healthy controls, we examined how this probiotic affects the intestinal barrier.
The results were promising: Serobioma significantly strengthened the intestinal lining and countered permeability changes caused by IBS-related substances. This was especially true for IBS patients who primarily experienced diarrhea, suggesting that probiotics could be a useful addition to their treatment plans.
Read More
9
Turcz. mitigates antibiotic-induced diarrhea
We explored how Turcz. (TCT) can alleviate antibiotic-associated diarrhea (AAD) in a mouse model. Through various research methods, we observed that TCT significantly improved gut health by enhancing microbiota diversity and regulating specific signaling pathways.
Treatment with TCT led to less inflammation, indicated by lower levels of IL-6 and TNF-α, and improved colon tissue structure. Notably, TCT increased beneficial bacteria like Lactobacillus. This study highlights a promising approach to managing AAD through natural compounds.
Treatment with TCT led to less inflammation, indicated by lower levels of IL-6 and TNF-α, and improved colon tissue structure. Notably, TCT increased beneficial bacteria like Lactobacillus. This study highlights a promising approach to managing AAD through natural compounds.
Read More
9
We evaluated the effectiveness of Lactobacillus reuteri DSM 17938 as an addition to oral rehydration therapy for children suffering from acute gastroenteritis. This randomized, controlled trial took place in a pediatric emergency setting and included children aged 1 month to 5 years.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
The results indicated that those treated with Lactobacillus experienced a notable reduction in the duration and frequency of diarrhea compared to those given a placebo. With a safe profile at high doses, this probiotic shows promise as a simple, low-risk solution to alleviate diarrhea in young patients.
Read More
9
We explored the impact of Lactobacillus plantarum (LP) probiotics on reducing diarrhea caused by Salmonella in broiler chickens. Our study used different growth media for LP, revealing that the MRS medium yielded a probiotic formulation that significantly boosted body weight and reduced diarrhea by up to 86.45%.
This impressive outcome suggests that LP not only strengthens gut health but also helps combat harmful bacteria. Our findings indicate that LP could be a safe and eco-friendly option for improving poultry health and productivity.
This impressive outcome suggests that LP not only strengthens gut health but also helps combat harmful bacteria. Our findings indicate that LP could be a safe and eco-friendly option for improving poultry health and productivity.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Colitis improvement noted
GREAT stuff! After being diagnosed with Colitis, I found that the medication made my condition worse. I began using Culturelle, and within a week, I felt significantly better. Even my dog, who suffered from bloody diarrhea, improved swiftly after I gave her one of my probiotics.
Read More
9.5
Effective probiotic use
This is a proven probiotic for addressing bad bacteria and is excellent for c. diff too. We take 3-6 capsules at night when bad bacteria invade. It effectively stops diarrhea and can also help if you’re constipated. We give it to our children and elderly parents.
Read More
0
Probiotic caution
STAY AWAY if your gut is generally healthy. I tried probiotics, and within an hour, I developed severe diarrhea. I haven’t been able to keep food down for even half an hour since. This has negatively impacted my gut.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Mei LN, Wang ZJ, Duan Y, Shen JS, Ye HB, et al. 4-Hydroxyboesenbergin B of Alpinia japonica protected gastrointestinal tract by inhibiting vancomycin-resistant enterococcus and balancing intestinal microbiota. J Ethnopharmacol. 2025;347:119737. doi:10.1016/j.jep.2025.119737
- Barbaro MR, Bianco F, Cremon C, Marasco G, Stanghellini V, et al. A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1. Int J Mol Sci. 2025;26. doi:10.3390/ijms26062656
- Fan D, Jiao S, Fu Y, Zhang J, Zhuang Y, et al. improves intestinal microbiota and barrier function to alleviate diarrhea of neonatal goats. Anim Nutr. 2025;20:366. doi:10.1016/j.aninu.2024.10.008
- Xu H, Zhang F, Huang Y, Yao Q, Guan Y, et al. [ Turcz. alleviates antibiotic-associated diarrhea in mice by modulating gut microbiota structure and regulating the EGFR/PI3K/Akt signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2025;45:285. doi:10.12122/j.issn.1673-4254.2025.02.09
- Iramain R, Jara A, Ortiz J, Cardozo L, Morinigo R. Lactobacillus reuteri protectis DSM 17938 at high doses versus placebo in children with acute gastroenteritis in a Pediatric Emergency Department. J Pediatr Gastroenterol Nutr. 2025. doi:10.1002/jpn3.70026
- Wang Z, Zhao Y, Fan D, Zhang J, Diao Q, et al. Sheep-Derived M5 Enhances Immunity and Antioxidant Capacity, Alleviates Diarrhea, and Improves Intestinal Health in Early-Weaned Lambs. Microorganisms. 2025;13. doi:10.3390/microorganisms13020404
- Zhao Y, Liang S, Fu X, Guo Y, Wang Y, et al. Anti-Inflammatory and Antidiarrheal Effects of Two Strains of Lactic Acid Bacteria Isolated from Healthy Pets on K88-Induced Diarrhea in Mice. Microorganisms. 2025;13. doi:10.3390/microorganisms13020239
- Chung A, Sehgal M, Gavrilita C, Falkos S, Vidal R. in the Prevention of Antibiotic-Associated Diarrhea in the Pediatric Intensive Care Unit: A Prospective Randomized, Double-Blind Placebo Controlled Intervention. J Pediatr Pharmacol Ther. 2025;30:47. doi:10.5863/1551-6776-30.1.47
- Hai PV, Phuong HTA, Hung PHS, Na TT, Lai NH, et al. Selection of Lactobacillus strains from native chicken feces for the fermentation of purple onion ( L.) as an antibiotic alternative against spp. in chickens. Open Vet J. 2024;14:3525. doi:10.5455/OVJ.2024.v14.i12.35
- Lin Z, Feng Y, Wang J, Men Z, Ma X. Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea. Microbiome. 2025;13:36. doi:10.1186/s40168-024-02011-8
- Wei JJ, Zhang PH, Yang ZY, Liu LP, Lian TT, et al. Colonoscopic administration of probiotics to treat irritable bowel syndrome with predominant diarrhea: a randomized placebo-controlled clinical trial. Surg Endosc. 2025;39:1893. doi:10.1007/s00464-025-11542-6
- Mishra V, Dash D, Panda AK, Pathak SK. Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. Helicobacter. 2024;29:e70006. doi:10.1111/hel.70006
- Li S, Lu T, Lin Z, Zhang Y, Zhou X, et al. Supplementation with probiotics co-cultivation improves the reproductive performance in a sow-piglet model by mother-infant microbiota transmission and placental mTOR signaling. World J Microbiol Biotechnol. 2024;41:13. doi:10.1007/s11274-024-04222-5
- Mirsalami SM, Mirsalami M. Leveraging Lactobacillus plantarum probiotics to mitigate diarrhea and Salmonella infections in broiler chickens. AMB Express. 2024;14:137. doi:10.1186/s13568-024-01792-3
- Shah SA, Naz S, Jabeen F, Rashid MA, Rahman A, et al. COMPARISON OF BACTERIAL PROBIOTICS (BIFIDOBACTERIUM AND LACTOBACILLUS) VERSUS FUNGAL PROBIOTICS (SACCHAROMYCES) IN THE TREATMENT OF ACUTE DIARRHOEA IN CHILDREN AGED 6 MONTHS TO 5 YEARS. J Ayub Med Coll Abbottabad. 2024;36:537. doi:10.55519/JAMC-03-13464
- Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. doi:10.3389/fnut.2024.1479186
- Shin I, Kang Y, Ahn J, Kim Y, Nam J, et al. The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs. J Anim Sci. 2025. doi:10.1093/jas/skaf089
- Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. doi:10.3389/fnut.2024.1479186
- Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. doi:10.1111/jgh.16809
- Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. doi:10.7759/cureus.70881
- Shawky LM, Abo El Wafa SM, Behery M, Bahr MH, Abu Alnasr MT, et al. Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting. Mol Nutr Food Res. 2024;68:e2400295. doi:10.1002/mnfr.202400295
- Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. doi:10.1039/d3fo04653b
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. doi:10.1016/j.tmaid.2024.102703
- Abdulah DM, Sulaiman SJ, Ahmed ZW. Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial. Clin Exp Pediatr. 2024;67:203. doi:10.3345/cep.2023.01340
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. doi:10.1007/s12325-024-02783-3
- Saviano A, Petruzziello C, Cancro C, Macerola N, Petti A, et al. The Efficacy of a Mix of Probiotics ( LMG P-27481 and GG ATCC 53103) in Preventing Antibiotic-Associated Diarrhea and Infection in Hospitalized Patients: Single-Center, Open-Label, Randomized Trial. Microorganisms. 2024;12. doi:10.3390/microorganisms12010198
- Poeta M, Cioffi V, Tarallo A, Damiano C, Lo Vecchio A, et al. Postbiotic Preparation of against Diarrhea and Oxidative Stress Induced by Spike Protein of SARS-CoV-2 in Human Enterocytes. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12101878
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
- Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12 LGG in colorectal cancer patients. Front Oncol. 2023;13:1168654. doi:10.3389/fonc.2023.1168654
- Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. doi:10.3389/fphar.2023.1153070
- Niu H, Zhou X, Liu P, Wu Y, Lyu L, et al. Lactobacillus rhamnosus MN-431 Metabolic Tryptophan Alleviates Complementary Food-Induced Diarrhea through PXR-NF-κB Pathway and AHR-Th17 Cell Response Pathways. Mol Nutr Food Res. 2023;67:e2200530. doi:10.1002/mnfr.202200530
- Li J, Li Q, Wu Q, Gao N, Wang Z, et al. Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway. J Anim Sci Biotechnol. 2023;14:23. doi:10.1186/s40104-023-00830-7
