Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 37 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8.1
Supplement Facts
Serving Size: Five (5) Drops
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%
Total Sugars
0 g
**
Incl. 0 g Added Sugars
**
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
Probiotic Blend
29 mg (2.5 billion CFUs)
Lactobacillus rhamnosus GG
**
Bifidobacterium animalis subsp. lactis (BB-12®)
**
Top Medical Research Studies
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
Most Useful Reviews
9
Effective treatment
1 people found this helpful
The probiotic started showing effects after 1.5 months. My colic has disappeared. It works well! I've ordered another package, although using a pipette constantly is rather inconvenient.
Read More
9
Effective treatment
Probiotics specifically for children to restore normal intestinal microflora. They have proven effective for my baby.
Read More
7.5
Improved bowel movements
15 people found this helpful
The only probiotics that have truly helped after many attempts. At two months old, my daughter had stool retention and went every three days. Doctor-prescribed probiotics did not improve the situation. A friend recommended this probiotic, and after three weeks, I saw a change. After the first dose, she started pooping twice daily, and within a few days, her tummy discomfort went away. Now she has regular, calm bowel movements. I recommend this to all mothers! A bottle lasts about a month.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 37 Researches
7.7
- All Researches
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
9
We explored the effectiveness of probiotics in treating inflammatory bowel disease (IBD) using a novel Gut-Ex-Vivo System (GEVS). Through careful examination, we found that probiotics notably counteracted the negative effects of colon inflammation caused by DNBS in mice.
Our results revealed that probiotics could significantly help restore gut health by promoting the remission of IBD symptoms. This innovative method presents a promising avenue for future research into IBD therapies while also being kind to animal subjects.
Our results revealed that probiotics could significantly help restore gut health by promoting the remission of IBD symptoms. This innovative method presents a promising avenue for future research into IBD therapies while also being kind to animal subjects.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective treatment
1 people found this helpful
The probiotic started showing effects after 1.5 months. My colic has disappeared. It works well! I've ordered another package, although using a pipette constantly is rather inconvenient.
Read More
9
Effective treatment
Probiotics specifically for children to restore normal intestinal microflora. They have proven effective for my baby.
Read More
7.5
Improved bowel movements
15 people found this helpful
The only probiotics that have truly helped after many attempts. At two months old, my daughter had stool retention and went every three days. Doctor-prescribed probiotics did not improve the situation. A friend recommended this probiotic, and after three weeks, I saw a change. After the first dose, she started pooping twice daily, and within a few days, her tummy discomfort went away. Now she has regular, calm bowel movements. I recommend this to all mothers! A bottle lasts about a month.
Read More
7.5
Calmer baby
2 people found this helpful
I ordered excellent probiotics for my child, starting from the third week of life. After receiving antibiotics at birth, my child suffered from dysbacteriosis with liquid stools and severe colic. We started the probiotics immediately, and within a week, the results were apparent; his stools became denser and less frequent, leading to improved calmness and better sleep.
Read More
9
Reduced constipation
1 people found this helpful
As a nutritional supplement, it should be used carefully. I ordered it for my daughter, as she was suffering from constipation. Starting at six months old, it helped her considerably. The company's ingredient quality is excellent.
Read More
Frequently Asked Questions
7.5
Improved bowel movements
15 people found this helpful
The only probiotics that have truly helped after many attempts. At two months old, my daughter had stool retention and went every three days. Doctor-prescribed probiotics did not improve the situation. A friend recommended this probiotic, and after three weeks, I saw a change. After the first dose, she started pooping twice daily, and within a few days, her tummy discomfort went away. Now she has regular, calm bowel movements. I recommend this to all mothers! A bottle lasts about a month.
7.5
Calmer baby
2 people found this helpful
I ordered excellent probiotics for my child, starting from the third week of life. After receiving antibiotics at birth, my child suffered from dysbacteriosis with liquid stools and severe colic. We started the probiotics immediately, and within a week, the results were apparent; his stools became denser and less frequent, leading to improved calmness and better sleep.
9
Effective treatment
1 people found this helpful
The probiotic started showing effects after 1.5 months. My colic has disappeared. It works well! I've ordered another package, although using a pipette constantly is rather inconvenient.
7.5
Stool improvement
1 people found this helpful
My children are formula-fed. I first used lactose and vitamin D separately but discovered this remedy while pregnant with my second child. After he was born a bit prematurely, I began giving him this product at one month. I appreciate that it's a 2in1 product, meaning I don't have to administer vitamin D and probiotics separately. While I didn’t check his vitamin D levels beforehand, I’ve observed better stool consistency and fewer stomach issues.
7.5
Significant improvement
8 people found this helpful
Excellent! This is essential for mothers with children. I have a six-month-old son who struggled with loose stools and poor weight. The doctor advised vitamin D with beneficial bacteria, which I started a week ago. I've noticed a positive change in his body, as he now absorbs minerals and vitamins better. It's excellent! After two months of use, I feel encouraged by the results.
4
Colic risk
Culturell products are well-known. I ordered this to alternate with a Bioga product. It comes in a dropper and allows five drops a day. Suitable for newborns and infants, but one must be cautious since it contains vitamin D. However, this product has given me a bit of colic, so I am currently using it in reduced amounts.
9
Reduced constipation
1 people found this helpful
As a nutritional supplement, it should be used carefully. I ordered it for my daughter, as she was suffering from constipation. Starting at six months old, it helped her considerably. The company's ingredient quality is excellent.
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
7
Vitamin D's role in muscle health
We explored the connection between vitamin D levels and muscle health in patients with idiopathic inflammatory myopathies (IIM), a type of autoimmune disorder. The study included 46 IIM patients and 67 healthy individuals, assessing both groups to understand how vitamin D and its receptor (VDR) relate to disease symptoms, physical fitness, and lipid metabolism.
Through muscle biopsies and blood tests, we measured the vitamin D levels and gene expressions related to its metabolism. We found that lower levels of biologically active vitamin D in IIM patients suggest their bodies may not be effectively processing this vital nutrient. Moreover, regular exercise seemed to improve vitamin D levels, VDR expression, and linked muscle function with overall health outcomes for these patients.
Our findings emphasize the importance of vitamin D in managing muscle health and its potential role in enhancing physical fitness among individuals with autoimmune conditions. While the study presents promising insights, it is clear that ongoing research is needed to fully understand the relationship between vitamin D, muscle function, and autoimmune disorders.
Through muscle biopsies and blood tests, we measured the vitamin D levels and gene expressions related to its metabolism. We found that lower levels of biologically active vitamin D in IIM patients suggest their bodies may not be effectively processing this vital nutrient. Moreover, regular exercise seemed to improve vitamin D levels, VDR expression, and linked muscle function with overall health outcomes for these patients.
Our findings emphasize the importance of vitamin D in managing muscle health and its potential role in enhancing physical fitness among individuals with autoimmune conditions. While the study presents promising insights, it is clear that ongoing research is needed to fully understand the relationship between vitamin D, muscle function, and autoimmune disorders.
4
We set out to discover how effective vitamin D is in treating autoimmune disorders, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved looking at several studies examining various dietary supplements, including selenium and vitamin D, to see how they impact thyroid autoantibody levels and overall thyroid function.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
References
- Vernerová L, Vokurková M, Laiferová NA, Nemec M, Špiritović M, et al. Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. 2025;27:48. 10.1186/s13075-025-03516-9
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. 10.3389/fimmu.2025.1528707
- Chen X, Zhang Y, Lin L, Chen Y, Shen X, et al. A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study. BMC Endocr Disord. 2025;25:14. 10.1186/s12902-024-01823-x
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Casas R, Tompa A, Åkesson K, Teixeira PF, Lindqvist A, et al. Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial. Int J Mol Sci. 2025;26. 10.3390/ijms26010374
- Rasheed A, Khan G. Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Front Immunol. 2024;15:1503808. 10.3389/fimmu.2024.1503808
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. 10.1111/jocd.16740
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. 10.1007/s10067-024-07285-9
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. 10.3389/fendo.2024.1445878
- Balshi A, Leuenberger G, Dempsey J, Baber U, Sloane JA. Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort. Mult Scler Relat Disord. 2025;93:106229. 10.1016/j.msard.2024.106229
- Mourelatou NG, Kounatidis D, Jude EB, Rebelos E. Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management. Nutrients. 2024;16. 10.3390/nu16234072
- Huo R, Yang Y, Wei C, Huo X, Meng D, et al. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). Int J Mol Med. 2025;55. 10.3892/ijmm.2024.5471
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. 10.1111/apt.18438
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. 10.1002/fsn3.70068
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. 10.1039/d4fo03966a
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. 10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. 10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. 10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. 10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. 10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. 10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. 10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. 10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. 10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. 10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. 10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. 10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. 10.1002/jcp.26819
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. 10.3389/fimmu.2025.1518181
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. 10.3389/fendo.2022.754401
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. 10.1016/j.nut.2021.111282
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. 10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. 10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. 10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. 10.1111/j.1365-2249.2008.03788.x
